Gckr (glucokinase regulator) - Rat Genome Database

Name: Gckr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gckr (glucokinase regulator) Rattus norvegicus

Analyze

Symbol:

Gckr

Name:

glucokinase regulator

RGD ID:

2671

Description:

Enables several functions, including carbohydrate binding activity; enzyme binding activity; and enzyme inhibitor activity. Involved in negative regulation of glucokinase activity; protein import into nucleus; and response to fructose. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator); PARTICIPATES IN glycogen metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

68-kDa regulatory protein; GKRP; GLRE; glucokinase (hexokinase 4) regulator; glucokinase regulatory protein; MGC93611

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCKR (glucokinase regulator)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Gckr (glucokinase regulatory protein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GCKR (glucokinase regulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gckr (glucokinase regulatory protein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gckr (glucokinase (hexokinase 4) regulator)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	25,044,592 - 25,075,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,045,100 - 25,075,654 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,345,943 - 25,376,501 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,661,829 - 25,692,391 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	25,141,212 - 25,171,764 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	26,355,296 - 26,385,761 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,355,296 - 26,385,761 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,175,967 - 36,205,241 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	24,538,242 - 24,568,355 (-)	NCBI		Celera
RH 3.4 Map	6	93.5	RGD
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

end stage renal disease (ISO)

genetic disease (ISO)

Hypertriglyceridemia (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

short-rib thoracic dysplasia 10 with or without polydactyly (ISO)

Tatton-Brown-Rahman syndrome (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

alloxan (ISO)

amiodarone (EXP)

amitriptyline (EXP)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

clofibric acid (EXP)

clomipramine (EXP)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

endosulfan (EXP)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

fructose (EXP)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

imipramine (EXP)

ketoconazole (EXP)

lipopolysaccharide (ISO)

metformin (ISO)

methapyrilene (EXP)

methidathion (ISO)

Muraglitazar (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

p-toluidine (EXP)

paclitaxel (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

propanal (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

rotenone (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

senecionine (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sotorasib (ISO)

tauroursodeoxycholic acid (EXP)

Tesaglitazar (EXP)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trametinib (ISO)

triphenyl phosphate (EXP)

troglitazone (EXP)

urethane (ISO)

ursodeoxycholic acid (EXP)

valproic acid (EXP,ISO)

vanillic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate derivative metabolic process (IEA)

detection of glucose (NAS)

glucose homeostasis (IBA)

glucose metabolic process (TAS)

intracellular glucose homeostasis (ISO)

negative regulation of glucokinase activity (IBA,IDA,ISO)

negative regulation of hexokinase activity (IDA)

positive regulation of glucokinase activity (ISO)

protein import into nucleus (IDA,ISO)

protein localization to nucleus (ISO)

response to fructose (IBA,IDA,ISO)

triglyceride homeostasis (ISO)

urate metabolic process (ISO)

Cellular Component

cytoplasm (IDA)

cytosol (IBA,ISO)

mitochondrion (IBA)

nucleoplasm (IBA,IDA,ISO)

nucleus (IDA,ISO)

Molecular Function

carbohydrate binding (IBA,IDA,IMP)

enzyme binding (IBA,IMP,IPI)

enzyme inhibitor activity (IBA,IDA)

fructose-6-phosphate binding (IBA,ISO,ISS)

protein binding (IPI,ISO)

protein domain specific binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

glycogen metabolic pathway (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Glucokinase regulatory protein is associated with mitochondria in hepatocytes.	Arden C, etal., FEBS Lett. 2006 Apr 3;580(8):2065-70. Epub 2006 Mar 10.
2.	Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme.	Baltrusch S, etal., Diabetes. 2005 Oct;54(10):2829-37.
3.	Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.	Baltrusch S, etal., J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.
4.	Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.	Boger CA, etal., PLoS Genet. 2011 Sep;7(9):e1002292. doi: 10.1371/journal.pgen.1002292. Epub 2011 Sep 29.
5.	Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.	Bonetti S, etal., Diabetes Care. 2011 May;34(5):1205-10. doi: 10.2337/dc10-2218. Epub 2011 Mar 16.
6.	Differences in regulatory properties between human and rat glucokinase regulatory protein.	Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
7.	Cloning and sequencing of rat liver cDNAs encoding the regulatory protein of glucokinase.	Detheux M, etal., FEBS Lett 1993 Apr 26;321(2-3):111-5.
8.	Intracellular distribution of hepatic glucokinase and glucokinase regulatory protein during the fasted to refed transition in rats.	Fernandez-Novell JM, etal., FEBS Lett. 1999 Oct 8;459(2):211-4.
9.	Defect in glucokinase translocation in Zucker diabetic fatty rats.	Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
10.	Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.	Galan M, etal., Biochem J. 2006 Jan 1;393(Pt 1):389-96.
11.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
13.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
15.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
16.	Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.	Qi Q, etal., Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.
17.	GOA pipeline	RGD automated data pipeline
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain.	Roncero I, etal., J Neuroendocrinol. 2009 Dec;21(12):973-81. doi: 10.1111/j.1365-2826.2009.01919.x. Epub 2009 Oct 6.
21.	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	Shiota C, etal., J Biol Chem. 1999 Dec 24;274(52):37125-30.
22.	Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.	Slosberg ED, etal., Diabetes. 2001 Aug;50(8):1813-20.
23.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24.	Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.	Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
25.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26.	Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.	van der Harst P, etal., Hum Mol Genet. 2010 Jan 15;19(2):387-95. doi: 10.1093/hmg/ddp489. Epub 2009 Oct 27.
27.	The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.	Vaxillaire M, etal., Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.
28.	Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase.	Veiga-da-Cunha M and Van Schaftingen E, J Biol Chem 2002 Mar 8;277(10):8466-73. Epub 2001 Dec 27.
29.	Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians.	Veiga-da-Cunha M, etal., Diabetologia. 2003 May;46(5):704-11. Epub 2003 May 9.

Additional References at PubMed

PMID:1300209	PMID:8112473	PMID:10588736	PMID:10713097	PMID:15489334	PMID:18199594	PMID:18809676	PMID:19503597	PMID:19526250	PMID:20668700	PMID:22044397	PMID:23621087

Genomics

Comparative Map Data

Gckr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	6	25,044,592 - 25,075,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,045,100 - 25,075,654 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,345,943 - 25,376,501 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,661,829 - 25,692,391 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	6	25,141,212 - 25,171,764 (-)	NCBI	Rnor_WKY
Rnor_6.0	6	26,355,296 - 26,385,761 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,355,296 - 26,385,761 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,175,967 - 36,205,241 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	24,538,242 - 24,568,355 (-)	NCBI		Celera
RH 3.4 Map	6	93.5	RGD
Cytogenetic Map	6	q14	NCBI

GCKR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,496,839 - 27,523,684 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	27,496,839 - 27,523,684 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,719,706 - 27,746,551 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,573,210 - 27,600,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	27,631,356 - 27,658,199	NCBI
Celera	2	27,565,881 - 27,592,728 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,461,595 - 27,488,434 (+)	NCBI		HuRef
CHM1_1	2	27,649,617 - 27,676,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,539,204 - 27,566,046 (+)	NCBI		T2T-CHM13v2.0

Gckr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,454,594 - 31,484,646 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,454,787 - 31,484,658 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	31,297,266 - 31,327,302 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	31,297,443 - 31,327,314 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,599,954 - 31,629,675 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,574,162 - 31,603,883 (+)	NCBI		MGSCv36	mm8
Celera	5	28,776,863 - 28,806,281 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.27	NCBI

Gckr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	9,461,848 - 9,484,707 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	9,461,541 - 9,485,034 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCKR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	2A	98,991,561 - 99,020,392 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,497,938 - 27,530,650 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,587,077 - 27,613,927 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,587,077 - 27,613,927 (+)	Ensembl	panpan1.1		panPan2

GCKR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,431,113 - 21,460,143 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	21,434,200 - 21,459,935 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	21,325,464 - 21,351,412 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,748,359 - 21,780,870 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,755,097 - 21,780,825 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,441,647 - 21,467,181 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,451,118 - 21,476,635 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,499,397 - 21,525,150 (+)	NCBI		UU_Cfam_GSD_1.0

Gckr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,735,931 - 65,759,598 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,080,559 - 5,101,892 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936493	5,080,517 - 5,101,892 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCKR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	111,649,539 - 111,676,772 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	111,649,557 - 111,683,539 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	118,789,323 - 118,823,342 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCKR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,069,662 - 80,124,038 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,100,436 - 80,123,686 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	32,031,883 - 32,058,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gckr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	9,552,386 - 9,574,082 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	9,552,260 - 9,574,082 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gckr
199 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	177
Count of miRNA genes:	136
Interacting mature miRNAs:	146
Transcripts:	ENSRNOT00000073228
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738023	Alc17	Alcohol consumption QTL 17	3.1	0.003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	6	1	27574569	Rat
1354616	Despr12	Despair related QTL 12		0.0012	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	6	1	27574569	Rat
1549905	Stresp10	Stress response QTL 10	6.83	0.0066	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	6	1	27574569	Rat
2300176	Bmd51	Bone mineral density QTL 51	11.7	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	6	1	27574569	Rat
2300190	Bmd52	Bone mineral density QTL 52	11.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	6	1	27574569	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
1359023	Bp272	Blood pressure QTL 272	2.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	16536140	27261739	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat

Markers in Region

RH129432

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	25,045,127 - 25,045,309 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,355,328 - 26,355,509	NCBI	Rnor6.0
Rnor_5.0	6	36,175,999 - 36,176,180	UniSTS	Rnor5.0
Celera	6	24,538,274 - 24,538,455	UniSTS

RH94779

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	25,045,127 - 25,045,233 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	26,355,328 - 26,355,433	NCBI	Rnor6.0
Rnor_5.0	6	36,175,999 - 36,176,104	UniSTS	Rnor5.0
Celera	6	24,538,274 - 24,538,379	UniSTS
RH 3.4 Map	6	93.5	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		2	27	27		27						10
Low		29	16	14	2	14	2	2	50		18	1	2
Below cutoff	1	8	14		17		5	5	24	30	23		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039111814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000164	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KJ026952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X68497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000073228 ⟹ ENSRNOP00000064260

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	25,045,100 - 25,075,654 (-)	Ensembl
Rnor_6.0 Ensembl	6	26,355,296 - 26,385,761 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000076268

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	26,355,536 - 26,358,341 (-)	Ensembl

RefSeq Acc Id:

NM_013120 ⟹ NP_037252

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	25,045,096 - 25,075,654 (-)	NCBI
Rnor_6.0	6	26,355,296 - 26,385,761 (-)	NCBI
Rnor_5.0	6	36,175,967 - 36,205,241 (-)	NCBI
Celera	6	24,538,242 - 24,568,355 (-)	RGD

Sequence:

show sequence

CAGGAAAGGGCATTGAAGAGAGGGGCATAGGGGTGGTGCTCTGAGAGGCAGGGTTCTTAGGTTA
ATCATCTCCATAGCTCAGATAAGACCCTGCCAACTGGAAGCAAAGTTATTGGGAGCAGAACAGT
TTGTGTGACTGCACAGGCAGGCAGGTCGGAGGGTCCACAGTGTGGGACCATGCCAGGCACCAAA
CGATATCAGCATGTGATCGAGACCCCTGAGCCTGGTGAATGGGAGTTGTCAGGGTATGAAGCGG
CTGTGCCAATCACAGAGAAATCCAACCCACTGACCCGAAACCTGGACAAAGCAGATGCAGAGAA
AATTGTCAAACTGCTGGGGCAGTGTGATGCTGAGATATTCCAGGAGGAGGGGCAGATTGTGCCC
ACCTACCAGCGACTATACAGCGAATCAGTTCTGACCACCATGTTGCAAGTGGCTGGAAAAGTCC
AGGAAGTTCTGAAGGAGCCAGATGGGGGTCTGGTAGTGCTGAGTGGAGGGGGAACCTCTGGTCG
TATGGCATTTCTCATGTCTGTGTCTTTCAACCAGCTGATGAAAGGCCTGGGACAAAAGCCTCTT
TACACCTACCTCATTGCAGGAGGTGACAGGTCTGTTGTGGCCTCTCGTGAACAGACAGAAGATA
GCGCCCTACACGGGATCGAGGAGCTGAAGAAGGTGGCTGCTGGGAAGAAGAGAGTGGTCGTCAT
AGGCATCTCTGTGGGACTCTCTGCGCCCTTTGTGGCAGGTCAGATGGACTACTGCATGGATAAC
ACAGCCGTCTTCTTGCCGGTTCTGGTTGGCTTCAATCCAGTGAGCATGGCCAGAAATGACCCCA
TTGAAGACTGGAGATCAACATTCCGGCAAGTGGCAGAGCGGATGCAAAAGATGCAGGAGAAACA
GGAAGCTTTTGTGCTCAATCCTGCCATCGGGCCCGAGGGGCTCAGCGGCTCTTCCCGAATGAAA
GGTGGAGGTGCCACCAAGATTCTACTGGAAACCCTGCTACTAGCAGCCCATAAGACTGTGGACC
AGGGTGTTGTGTCCTCTCAAAGATGCCTTCTGGAAATCCTGAGGACATTTGAGCGGGCTCATCA
GGTGACCTACAGTCAAAGTTCCAAAATTGCCACGCTGATGAAACAAGTCGGCATCAGCCTGGAG
AAGAAAGGCCGAGTGCACTTGGTTGGCTGGCAGACTCTCGGCATCATTGCCATTATGGACGGAG
TAGAGTGCATCCACACTTTTGGTGCTGATTTCCAAGATATCCGTGGCTTTCTTATTGGTGACCA
CAGTGACATGTTTAACCAGAAGGATGAACTCACCAACCAGGGTCCCCAGTTCACCTTCTCCCAG
GATGACTTCCTGACTTCCATCCTGCCATCCCTCACGGAGACTGACACCGTGGTCTTCATTTTTA
CCCTGGATGATAACCTCACAGAAGTACAGGCCCTGGCAGAAAGAGTGAGAGAGAAGTGCCAGAA
CATCCAGGCCCTGGTGCACAGCACTGTGGGGCAGTCCTTGCCGGCCCCTCTAAAGAAACTCTTT
CCCTCACTCATCAGTATCACGTGGCCACTTCTTTTCTTCGATTATGAAGGGACCTATGTTCAGA
AGTTCCAGCGTGAGTTAAGCACCAAGTGGGTGTTGAATACAGTGAGTACTGGGGCCCATGTACT
GCTGGGGAAGATCCTACAGAACCACATGCTGGACCTCCGCATCGCCAACTCCAAGCTCTTCTGG
AGGGCGCTGGCCATGTTGCAGAGGTTCTCTGGACAGTCCAAGGCTCGCTGCATTGAGAGCCTCC
TTCAAGCAATCCACTTTCCTCAACCACTGTCGGATGATGTCCGCGCCGCTCCCATCTCCTGCCA
CGTCCAGGTTGCCCACGAGAAGGAAAAGGTGATCCCCACAGCCTTGCTGAGCCTCCTACTCCGG
TGCTCCATCTCTGAGGCTAAGGCACGCCTGTCTGCAGCTTCTTCAGTCTGTGAGGTTGTTAGGA
GCGCCCTCTCTGGGCCGGGTCAGAAGCGCAGCACGCAAGCCCTTGAAGACCCTCCCGCCTGTGG
GACCCTGAATTGATATTTCTAGAACCATGGAGGGGCAGAGTCTCCGTCCACTTCCAAGGGGACA
TGTGCCAGCAGTACACGCTGTGGGAAGAACTCAGTTTCGGGTGGGTGGGGCCTAACTGCCCAGA
ATTGGGGAAGAGCCCTGTTCTCAACCGGATTATTTCCATTTTTACTGGTGTCTTCTGAACTCAG
AAATAAAACTAAATGTCTTGTTTTGGAACATAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039111814 ⟹ XP_038967742

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	6	25,044,592 - 25,075,834 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_037252	(Get FASTA)	NCBI Sequence Viewer
	XP_038967742	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81843	(Get FASTA)	NCBI Sequence Viewer
	AHN15397	(Get FASTA)	NCBI Sequence Viewer
	CAA48511	(Get FASTA)	NCBI Sequence Viewer
	EDM02910	(Get FASTA)	NCBI Sequence Viewer
	EDM02911	(Get FASTA)	NCBI Sequence Viewer
	EDM02912	(Get FASTA)	NCBI Sequence Viewer
	Q07071	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_037252 ⟸ NM_013120

- UniProtKB:

Q07071 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEE
GQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGL
GQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMD
YCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSG
SSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQV
GISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQ
FTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAP
LKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIAN
SKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALL
SLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACGTLN

hide sequence

RefSeq Acc Id:

ENSRNOP00000064260 ⟸ ENSRNOT00000073228

RefSeq Acc Id:	XP_038967742 ⟸ XM_039111814
- Peptide Label:	isoform X1

Protein Domains

SIS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q07071-F1-model_v2	AlphaFold	Q07071	1-627	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694435

Promoter ID:

EPDNEW_R4960

Type:

multiple initiation site

Name:

Gckr_1

Description:

glucokinase regulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	26,385,650 - 26,385,710	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2671	AgrOrtholog
BioCyc Gene	G2FUF-38357	BioCyc
Ensembl Genes	ENSRNOG00000048874	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000064260	ENTREZGENE
	ENSRNOP00000064260.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000073228	ENTREZGENE
	ENSRNOT00000073228.3	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.8.1080	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.12620	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7096237	IMAGE-MGC_LOAD
InterPro	Glucokinase_regulatory_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MURQ/GCKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25658	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93611	IMAGE-MGC_LOAD
NCBI Gene	25658	ENTREZGENE
PANTHER	GLUCOKINASE REGULATORY PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10088	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	GCKR	RGD
PhenoGen	Gckr	PhenoGen
PROSITE	GCKR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53697	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC221963
UniProt	GCKR_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	X2G4G4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	Gckr	glucokinase regulator	Gckr	glucokinase (hexokinase 4) regulator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-03-09	Gckr	glucokinase (hexokinase 4) regulator	Gckr	glucokinase regulatory protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Gckr	Glucokinase regulatory protein			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binding to fructose 6-phosphate increases Gckr regulatory activity, while fructose 1-phosphate binding decreases Gckr activity	1300209

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations