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Gene: Gckr (glucokinase regulator) Rattus norvegicus
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Symbol: Gckr
Name: glucokinase regulator
Description: Exhibits several functions, including carbohydrate binding activity; enzyme binding activity; and enzyme inhibitor activity. Involved in negative regulation of glucokinase activity; protein import into nucleus; and response to fructose. Localizes to the cytosol; mitochondrion; and nucleoplasm. Human ortholog(s) of this gene implicated in end stage renal failure and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator); PARTICIPATES IN glycogen metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GLRE; glucokinase (hexokinase 4) regulator; glucokinase regulatory protein; MGC93611
Orthologs:
Homo sapiens (human) : GCKR (glucokinase regulator)  HGNC  Alliance
Mus musculus (house mouse) : Gckr (glucokinase regulatory protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gckr (glucokinase regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : GCKR (glucokinase regulator)
Canis lupus familiaris (dog) : GCKR (glucokinase regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gckr (glucokinase regulator)
Sus scrofa (pig) : GCKR (glucokinase regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0626,355,296 - 26,385,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0636,175,967 - 36,205,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera624,538,242 - 24,568,355 (-)NCBICelera
Cytogenetic Map6q14NCBI
RH 3.4 Map693.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gckr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2671
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.