Gckr (glucokinase regulator) - Rat Genome Database

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Gene: Gckr (glucokinase regulator) Rattus norvegicus
Analyze
Symbol: Gckr
Name: glucokinase regulator
RGD ID: 2671
Description: Enables several functions, including glucose sensor activity; kinase binding activity; and kinase inhibitor activity. Involved in protein import into nucleus; response to fructose; and response to glucose. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator); PARTICIPATES IN glycogen metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 68-kDa regulatory protein; GKRP; GLRE; glucokinase (hexokinase 4) regulator; glucokinase regulatory protein; MGC93611
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,765,071 - 30,795,627 (-)NCBIGRCr8
mRatBN7.2625,044,592 - 25,075,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,045,100 - 25,075,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,345,943 - 25,376,501 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,661,829 - 25,692,391 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,141,212 - 25,171,764 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,355,296 - 26,385,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,355,296 - 26,385,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,175,967 - 36,205,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera624,538,242 - 24,568,355 (-)NCBICelera
RH 3.4 Map693.5RGD
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
alloxan  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
endosulfan  (EXP)
ethylparaben  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
imipramine  (EXP)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trametinib  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO)
mitochondrion  (IEA)
nucleoplasm  (IBA,IDA,ISO)
nucleus  (IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Glucokinase regulatory protein is associated with mitochondria in hepatocytes. Arden C, etal., FEBS Lett. 2006 Apr 3;580(8):2065-70. Epub 2006 Mar 10.
2. Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. Baltrusch S, etal., Diabetes. 2005 Oct;54(10):2829-37.
3. Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. Baltrusch S, etal., J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.
4. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. Boger CA, etal., PLoS Genet. 2011 Sep;7(9):e1002292. doi: 10.1371/journal.pgen.1002292. Epub 2011 Sep 29.
5. Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2. Bonetti S, etal., Diabetes Care. 2011 May;34(5):1205-10. doi: 10.2337/dc10-2218. Epub 2011 Mar 16.
6. Differences in regulatory properties between human and rat glucokinase regulatory protein. Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
7. Cloning and sequencing of rat liver cDNAs encoding the regulatory protein of glucokinase. Detheux M, etal., FEBS Lett 1993 Apr 26;321(2-3):111-5.
8. Intracellular distribution of hepatic glucokinase and glucokinase regulatory protein during the fasted to refed transition in rats. Fernandez-Novell JM, etal., FEBS Lett. 1999 Oct 8;459(2):211-4.
9. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
10. Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability. Galan M, etal., Biochem J. 2006 Jan 1;393(Pt 1):389-96.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Qi Q, etal., Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.
17. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain. Roncero I, etal., J Neuroendocrinol. 2009 Dec;21(12):973-81. doi: 10.1111/j.1365-2826.2009.01919.x. Epub 2009 Oct 6.
22. Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. Shiota C, etal., J Biol Chem. 1999 Dec 24;274(52):37125-30.
23. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein. Slosberg ED, etal., Diabetes. 2001 Aug;50(8):1813-20.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. van der Harst P, etal., Hum Mol Genet. 2010 Jan 15;19(2):387-95. doi: 10.1093/hmg/ddp489. Epub 2009 Oct 27.
28. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Vaxillaire M, etal., Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.
29. Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase. Veiga-da-Cunha M and Van Schaftingen E, J Biol Chem 2002 Mar 8;277(10):8466-73. Epub 2001 Dec 27.
30. Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. Veiga-da-Cunha M, etal., Diabetologia. 2003 May;46(5):704-11. Epub 2003 May 9.
31. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
Additional References at PubMed
PMID:1300209   PMID:8112473   PMID:10588736   PMID:10713097   PMID:15489334   PMID:18199594   PMID:18809676   PMID:19503597   PMID:19526250   PMID:20668700   PMID:22044397   PMID:23621087  


Genomics

Comparative Map Data
Gckr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,765,071 - 30,795,627 (-)NCBIGRCr8
mRatBN7.2625,044,592 - 25,075,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,045,100 - 25,075,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,345,943 - 25,376,501 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,661,829 - 25,692,391 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,141,212 - 25,171,764 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,355,296 - 26,385,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,355,296 - 26,385,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,175,967 - 36,205,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera624,538,242 - 24,568,355 (-)NCBICelera
RH 3.4 Map693.5RGD
Cytogenetic Map6q14NCBI
GCKR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,496,839 - 27,523,684 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,496,839 - 27,523,684 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,719,706 - 27,746,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,573,210 - 27,600,055 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,631,356 - 27,658,199NCBI
Celera227,565,881 - 27,592,728 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,461,595 - 27,488,434 (+)NCBIHuRef
CHM1_1227,649,617 - 27,676,462 (+)NCBICHM1_1
T2T-CHM13v2.0227,539,204 - 27,566,046 (+)NCBIT2T-CHM13v2.0
Gckr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,454,594 - 31,484,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,454,787 - 31,484,658 (+)EnsemblGRCm39 Ensembl
GRCm38531,297,266 - 31,327,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,297,443 - 31,327,314 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,599,954 - 31,629,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,574,162 - 31,603,883 (+)NCBIMGSCv36mm8
Celera528,776,863 - 28,806,281 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
Gckr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,461,848 - 9,484,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,461,541 - 9,485,034 (+)NCBIChiLan1.0ChiLan1.0
GCKR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21298,988,257 - 99,016,423 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A98,991,561 - 99,020,392 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,497,938 - 27,530,650 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,587,077 - 27,613,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,587,077 - 27,613,927 (+)Ensemblpanpan1.1panPan2
GCKR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,431,113 - 21,460,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,434,200 - 21,459,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,325,464 - 21,351,412 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,748,359 - 21,780,870 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,755,097 - 21,780,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,441,647 - 21,467,181 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,451,118 - 21,476,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,499,397 - 21,525,150 (+)NCBIUU_Cfam_GSD_1.0
Gckr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,735,931 - 65,759,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,080,559 - 5,101,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,080,517 - 5,101,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCKR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,649,539 - 111,676,772 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,649,557 - 111,683,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,789,323 - 118,823,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCKR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,069,662 - 80,124,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,100,436 - 80,123,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,031,883 - 32,058,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gckr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,552,386 - 9,574,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,552,260 - 9,574,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gckr
262 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:136
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000073228
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH129432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,045,127 - 25,045,309 (+)MAPPERmRatBN7.2
Rnor_6.0626,355,328 - 26,355,509NCBIRnor6.0
Rnor_5.0636,175,999 - 36,176,180UniSTSRnor5.0
Celera624,538,274 - 24,538,455UniSTS
RH94779  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2625,045,127 - 25,045,233 (+)MAPPERmRatBN7.2
Rnor_6.0626,355,328 - 26,355,433NCBIRnor6.0
Rnor_5.0636,175,999 - 36,176,104UniSTSRnor5.0
Celera624,538,274 - 24,538,379UniSTS
RH 3.4 Map693.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 27 27 10
Low 29 16 14 2 14 2 2 50 18 1 2
Below cutoff 1 8 14 17 5 5 24 30 23 5

Sequence


RefSeq Acc Id: ENSRNOT00000073228   ⟹   ENSRNOP00000064260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl625,045,100 - 25,075,654 (-)Ensembl
Rnor_6.0 Ensembl626,355,296 - 26,385,761 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl626,355,536 - 26,358,341 (-)Ensembl
RefSeq Acc Id: NM_013120   ⟹   NP_037252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,765,071 - 30,795,627 (-)NCBI
mRatBN7.2625,045,096 - 25,075,654 (-)NCBI
Rnor_6.0626,355,296 - 26,385,761 (-)NCBI
Rnor_5.0636,175,967 - 36,205,241 (-)NCBI
Celera624,538,242 - 24,568,355 (-)RGD
Sequence:
RefSeq Acc Id: NP_037252   ⟸   NM_013120
- UniProtKB: Q07071 (UniProtKB/Swiss-Prot),   A6HA55 (UniProtKB/TrEMBL),   X2G4G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064260   ⟸   ENSRNOT00000073228
Protein Domains
SIS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07071-F1-model_v2 AlphaFold Q07071 1-627 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694435
Promoter ID:EPDNEW_R4960
Type:multiple initiation site
Name:Gckr_1
Description:glucokinase regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,385,650 - 26,385,710EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2671 AgrOrtholog
BioCyc Gene G2FUF-38357 BioCyc
Ensembl Genes ENSRNOG00000048874 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018634 UniProtKB/Swiss-Prot
  ENSRNOG00060013089 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073228 ENTREZGENE
  ENSRNOT00000073228.3 UniProtKB/Swiss-Prot
  ENSRNOT00055031719 UniProtKB/Swiss-Prot
  ENSRNOT00060022320 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.1080 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096237 IMAGE-MGC_LOAD
InterPro Glucokinase_regulatory_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MURQ/GCKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25658 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93611 IMAGE-MGC_LOAD
NCBI Gene 25658 ENTREZGENE
PANTHER GLUCOKINASE REGULATORY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10088 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GKRP-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GCKR RGD
PhenoGen Gckr PhenoGen
PROSITE GCKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048874 RatGTEx
  ENSRNOG00055018634 RatGTEx
  ENSRNOG00060013089 RatGTEx
Superfamily-SCOP SSF53697 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221963
UniProt A6HA55 ENTREZGENE, UniProtKB/TrEMBL
  A6HA56_RAT UniProtKB/TrEMBL
  GCKR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  X2G4G4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Gckr  glucokinase regulator  Gckr  glucokinase (hexokinase 4) regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-09 Gckr  glucokinase (hexokinase 4) regulator  Gckr  glucokinase regulatory protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gckr  Glucokinase regulatory protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binding to fructose 6-phosphate increases Gckr regulatory activity, while fructose 1-phosphate binding decreases Gckr activity 1300209