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Gene: Gckr (glucokinase regulatory protein) Mus musculus

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Symbol:

Gckr

Name:

glucokinase regulatory protein

RGD ID:

69131

MGI Page

MGI

Description:

Enables kinase inhibitor activity. Acts upstream of or within intracellular glucose homeostasis; negative regulation of glucokinase activity; and protein import into nucleus. Located in nucleus. Is expressed in diencephalon lateral wall mantle layer; liver left lobe; liver right lobe; midbrain mantle layer; and retina. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GK; GKRP; glucokinase regulator; MGC19300

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCKR (glucokinase regulator)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCKR (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gckr (glucokinase regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gckr (glucokinase regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GCKR (glucokinase regulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gckr (glucokinase (hexokinase 4) regulator)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid\|ZFIN)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,454,594 - 31,484,646 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,454,787 - 31,484,658 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	31,297,266 - 31,327,302 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	31,297,443 - 31,327,314 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,599,954 - 31,629,675 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,574,162 - 31,603,883 (+)	NCBI		MGSCv36	mm8
Celera	5	28,776,863 - 28,806,281 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.27	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

end stage renal disease (ISO)

Hypertriglyceridemia (ISO)

Metabolic Syndrome (ISO)

obesity (ISO)

short-rib thoracic dysplasia 10 with or without polydactyly (ISO)

Tatton-Brown-Rahman syndrome (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1-naphthyl isothiocyanate (ISO)

17beta-estradiol (EXP,ISO)

2,3,4,7,8-Pentachlorodibenzofuran (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4-dinitrotoluene (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (ISO)

3H-1,2-dithiole-3-thione (ISO)

4,4'-diaminodiphenylmethane (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

aflatoxin B1 (EXP,ISO)

alloxan (EXP)

amiodarone (ISO)

amitriptyline (ISO)

amitrole (ISO)

azathioprine (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bromuconazole (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

clofibric acid (ISO)

clomipramine (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

Cuprizon (ISO)

cyclosporin A (EXP,ISO)

endosulfan (ISO)

ethylparaben (ISO)

fenthion (EXP)

flutamide (ISO)

folic acid (EXP)

fructose (ISO)

furan (ISO)

gentamycin (ISO)

glafenine (ISO)

imipramine (ISO)

ketoconazole (ISO)

lipopolysaccharide (ISO)

metformin (ISO)

methapyrilene (ISO)

methidathion (EXP)

methimazole (ISO)

Muraglitazar (ISO)

N-nitrosodiethylamine (ISO)

nefazodone (ISO)

nimesulide (ISO)

okadaic acid (ISO)

p-toluidine (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (EXP)

propanal (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

senecionine (EXP)

sodium arsenite (ISO)

sodium dichromate (ISO)

sotorasib (ISO)

sulfadimethoxine (ISO)

tauroursodeoxycholic acid (ISO)

Tesaglitazar (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

trametinib (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

ursodeoxycholic acid (ISO)

valproic acid (EXP,ISO)

vanillic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate derivative metabolic process (IEA)

intracellular glucose homeostasis (IBA,IMP)

negative regulation of glucokinase activity (IMP,ISO,ISS)

negative regulation of hexokinase activity (ISO)

protein import into nucleus (IMP,ISO)

protein localization to nucleus (IBA,IMP)

response to fructose (IEA,ISO)

response to glucose (IEA,ISO)

triglyceride homeostasis (ISO)

urate metabolic process (ISO)

Cellular Component

cytoplasm (ISO,ISS)

cytosol (IEA)

mitochondrion (IEA)

nucleoplasm (IBA,ISO,ISS)

nucleus (IDA,ISO)

Molecular Function

carbohydrate binding (IEA,ISO)

enzyme binding (ISO)

enzyme inhibitor activity (ISO)

fructose-6-phosphate binding (IBA,ISO,ISS)

glucose sensor activity (IBA,IEA,ISO)

kinase binding (IEA,ISO)

kinase inhibitor activity (IBA,IMP,ISO)

protein binding (ISO)

protein domain specific binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycogen metabolic pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal enzyme/coenzyme level (IAGP)

abnormal glucose homeostasis (IAGP)

decreased circulating insulin level (IAGP)

decreased glucokinase activity (IAGP)

decreased liver glycogen level (IAGP)

impaired glucose tolerance (IAGP)

increased blood urea nitrogen level (IEA)

increased circulating creatinine level (IEA)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

insulin resistance (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.	Boger CA, etal., PLoS Genet. 2011 Sep;7(9):e1002292. doi: 10.1371/journal.pgen.1002292. Epub 2011 Sep 29.
2.	Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2.	Bonetti S, etal., Diabetes Care. 2011 May;34(5):1205-10. doi: 10.2337/dc10-2218. Epub 2011 Mar 16.
3.	Differences in regulatory properties between human and rat glucokinase regulatory protein.	Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
4.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
5.	MGDs mouse GO annotations	MGD data from the GO Consortium
6.	MGD IEA	MGD IEA
7.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8.	Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.	Qi Q, etal., Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.
9.	A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia.	Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
10.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.	Slosberg ED, etal., Diabetes. 2001 Aug;50(8):1813-20.
14.	Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms.	van der Harst P, etal., Hum Mol Genet. 2010 Jan 15;19(2):387-95. doi: 10.1093/hmg/ddp489. Epub 2009 Oct 27.
15.	The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.	Vaxillaire M, etal., Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.
16.	Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians.	Veiga-da-Cunha M, etal., Diabetologia. 2003 May;46(5):704-11. Epub 2003 May 9.
17.	The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma.	Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.

Additional References at PubMed

PMID:9271679	PMID:10349636	PMID:10588736	PMID:10614646	PMID:10713097	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:15489334	PMID:16141072	PMID:16141073
PMID:21267068	PMID:21677750	PMID:21873635	PMID:23341629	PMID:24333860	PMID:24879641	PMID:26620281	PMID:27146480	PMID:29296001	PMID:29925374	PMID:37031802	PMID:38355793
PMID:38972375	PMID:39173844

Genomics

Comparative Map Data

Gckr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	31,454,594 - 31,484,646 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	31,454,787 - 31,484,658 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	31,297,266 - 31,327,302 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	31,297,443 - 31,327,314 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	31,599,954 - 31,629,675 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	31,574,162 - 31,603,883 (+)	NCBI		MGSCv36	mm8
Celera	5	28,776,863 - 28,806,281 (+)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.27	NCBI

GCKR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	27,496,839 - 27,523,684 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	27,496,839 - 27,523,684 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	27,719,706 - 27,746,551 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	27,573,210 - 27,600,055 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	27,631,356 - 27,658,199	NCBI
Celera	2	27,565,881 - 27,592,728 (+)	NCBI		Celera
Cytogenetic Map	2	p23.3	NCBI
HuRef	2	27,461,595 - 27,488,434 (+)	NCBI		HuRef
CHM1_1	2	27,649,617 - 27,676,462 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	27,539,204 - 27,566,046 (+)	NCBI		T2T-CHM13v2.0

Gckr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	30,765,071 - 30,795,627 (-)	NCBI		GRCr8
mRatBN7.2	6	25,044,592 - 25,075,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	25,045,100 - 25,075,654 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	25,345,943 - 25,376,501 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	25,661,829 - 25,692,391 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	25,141,212 - 25,171,764 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	26,355,296 - 26,385,761 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	26,355,296 - 26,385,761 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	36,175,967 - 36,205,241 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	6	24,538,242 - 24,568,355 (-)	NCBI		Celera
RH 3.4 Map	6	93.5	RGD
Cytogenetic Map	6	q14	NCBI

Gckr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	9,461,848 - 9,484,707 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	9,461,541 - 9,485,034 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCKR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	98,988,257 - 99,016,423 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	98,991,561 - 99,020,392 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	27,497,938 - 27,530,650 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	27,587,077 - 27,613,927 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	27,587,077 - 27,613,927 (+)	Ensembl	panpan1.1		panPan2

GCKR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	21,431,113 - 21,460,143 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	21,434,200 - 21,459,935 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	21,325,464 - 21,351,412 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	21,748,359 - 21,780,870 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	21,755,097 - 21,780,825 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	21,441,647 - 21,467,181 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	21,451,118 - 21,476,635 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	21,499,397 - 21,525,150 (+)	NCBI		UU_Cfam_GSD_1.0

Gckr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	65,735,931 - 65,759,598 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	5,080,559 - 5,101,892 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	5,080,517 - 5,101,892 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCKR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	111,649,539 - 111,676,772 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	111,649,557 - 111,683,539 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	118,789,323 - 118,823,342 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCKR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	80,069,662 - 80,124,038 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	80,100,436 - 80,123,686 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	32,031,883 - 32,058,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gckr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	9,552,386 - 9,574,082 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	9,552,260 - 9,574,082 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gckr
1923 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	91
Interacting mature miRNAs:	93
Transcripts:	ENSMUST00000072228
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301555	Alcp10_m	alcohol preference locus 10 (mouse)			Not determined		5	31024275	65024480	Mouse
1301776	Skts3_m	skin tumor susceptibility 3 (mouse)			Not determined		5	21667295	55667403	Mouse
1301685	Estq2_m	estradiol regulated response QTL 2 (mouse)			Not determined		5	15634084	49634190	Mouse
11537367	Hmtb11_m	hemostasis and thrombosis 11 (mouse)					5	22100823	64806579	Mouse
4141207	Imrfq1_m	immune response to Factor IX QTL 1 (mouse)			Not determined		5	8124117	42124239	Mouse
11537368	Hmtb10_m	hemostasis and thrombosis 10 (mouse)					5	22100823	54500318	Mouse
1301403	Alcp9_m	alcohol preference locus 9 (mouse)			Not determined		5	31024275	65024480	Mouse
7394748	Mom5_m	modifier of Min 5 (mouse)			Not determined		5	8847672	33475637	Mouse
15039371	Nmrs21_m	NAFLD-associated magnetic resonance shift 21 (mouse)					5	3504823	37504823	Mouse
1301693	Sle6_m	systemic lupus erythematosus susceptibility 6 (mouse)			Not determined		5	8890693	87841837	Mouse
1300701	Cd8ts1_m	CD8 T cell subset 1 (mouse)			Not determined		5	27215348	61215451	Mouse
1357478	Kdnw1_m	kidney weight 1 (mouse)			Not determined		5	8915949	40529869	Mouse
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
14696730	Kidlq1_m	kidney weight, left QTL 1 (mouse)					5	13563152	47563152	Mouse
10401122	Pgia41_m	proteoglycan induced arthritis 41 (mouse)			Not determined		5	823144	34823280	Mouse
1300719	Iba5_m	induction of brown adipocytes 5 (mouse)			Not determined		5	20686993	54687134	Mouse
1301806	Actd2_m	activity-distance traveled 2 (mouse)			Not determined		5	5384520	39384652	Mouse

Markers in Region

26.mHAa8b2.seq

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	31,327,459 - 31,327,612	UniSTS	GRCm38
MGSCv37	5	31,629,832 - 31,629,985	UniSTS	GRCm37
Celera	5	28,806,438 - 28,806,591	UniSTS
Cytogenetic Map	5	B1	UniSTS
cM Map	5	18.1	UniSTS
Whitehead_YAC	12		UniSTS

Gckr

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	31,302,045 - 31,302,243	UniSTS	GRCm38
MGSCv37	5	31,604,418 - 31,604,616	UniSTS	GRCm37
Celera	5	28,781,146 - 28,781,344	UniSTS
Cytogenetic Map	5	B1	UniSTS
cM Map	5	18.1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001374741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_144909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006503882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006503883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC012412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000072228 ⟹ ENSMUSP00000072084

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,454,925 - 31,484,646 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,297,581 - 31,327,302 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000201166 ⟹ ENSMUSP00000144202

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,454,787 - 31,484,658 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,297,443 - 31,327,314 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000201675 ⟹ ENSMUSP00000144568

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,454,956 - 31,457,927 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,297,612 - 31,300,583 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000202242

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,483,575 - 31,484,641 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,326,231 - 31,327,297 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000202312

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,456,045 - 31,463,942 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,298,701 - 31,306,598 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000202456

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,456,850 - 31,462,848 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,299,506 - 31,305,504 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000202909

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	31,454,898 - 31,484,639 (+)	Ensembl
GRCm38.p6 Ensembl	5	31,297,554 - 31,327,295 (+)	Ensembl

RefSeq Acc Id:

NM_001374741 ⟹ NP_001361670

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,454,907 - 31,484,646 (+)	NCBI
GRCm38	5	31,297,563 - 31,327,302 (+)	NCBI

Sequence:

show sequence

AGAACAGATTGCGTGAGTGCAGAGGCAGGCGGGTTGGAGAGTCTGCAGTGTGGGACCATGCCAA
GCACCAAGCGGTATCAGCATGTGATCGAGACCCCTGAGCCTGGGGAATGGGAGTTGTCAGGGTA
TGAAGCAGCTGTGCCAATCACAGAGAAGTCCAACCCACTGACCCGGAACTTGGACAAAGCAGAT
GCAGAGAAAATTGTTCAACTGCTGGGGCAGTGTGATGCTGAGATATTCCAGGAGGAGGGGCAAA
TCATGCCCACCTACCAGCGACTGTACAGTGAGTCAGTTCTGACCACCATGTTGCAAGTGGCTGG
CAAGGTCCAGGAAGTGCTGAAGGAGCCAGATGGGGGCCTGGTGGTGCTGAGTGGAGGGGGCACC
TCTGGTCGTATGGCATTCCTTATGTCTGTGTCTTTCAACCAGCTGATGAAAGGTCTGGGACAAA
AACCTCTTTACACATACCTCATTGCAGGGGGTGACAGGTCTGTTGTAGCCTCTCGGGAACGGAC
AGAAGATAGCGCCCTACACGGAATCGAGGAGCTGAAGAAGGTGGCTGCTGGGAAAAAGAGAGTG
GTCGTTATAGGCATTTCCGTGGGACTCTCTGCGCCCTTTGTGGCAGGCCAGATGGACTACTGCA
TGGATAACACAGCTGTCTTCTTGCCGGTCCTGGTTGGCTTCAATCCGGTGAGCATGGCCAGAAA
TGATCCCATTGAAGACTGGAGATCGACATTCCGACAAGTGGCAGAGCGGATGCAGAAGATGCAG
GAGAAACAGGAAGCCTTTGTGCTCAATCCTGCCATCGGGCCTGAGGGGCTCAGTGGCTCTTCCC
GAATGAAAGGTGGAAGCGCCACCAAGATTCTACTGGAAACCCTGCTACTAGCAGCCCATAAGAC
TGTGGACCAGGGTGTTGTGTCCTCTCAAAGATGCCTTCTGGAAATCCTGAGGACATTTGAGCGG
GCTCATCAGGTAACCTACAGTCAAAGTTCCAAAATTGCCACTCTGACGAAGCAAGTTGGCATCA
GCCTGGAGAAAAAAGGCCACGTGCACTTGGTTGGCTGGCAGACCCTCGGTATCATCGCCATTAT
GGATGGGGTAGAGTGTATCCACACTTTTGGTGCTGATTTCCGAGATATCCGTGGCTTTCTTATT
GGTGACCACAATGACATGTTTAACCAGAAGGATGAGCTCAGCAATCAGGGTCCCCAGTTCACCT
TCTCTCAGGATGACTTCCTGACTTCTGTTCTGCCATCCCTTACGGAAATTGACACTGTGGTCTT
CATTTTTACCCTGGATGATAACCTCGCAGAAGTACAGGCCCTGGCAGAAAGGGTGAGGGAGAAG
AGTTGGAACATCCAGGCCCTGGTGCACAGCACAGTGGGGCAGTCCTTGCCAGCTCCTCTAAAGA
AGCTCTTTCCCTCGCTCATCAGCATCACATGGCCACTTCTTTTCTTCGATTATGAAGGGAGCTA
CGTTCAGAAGTTCCAGCGTGAGTTAAGCACCAAGTGGGTGTTGAATACAGTGAGTACTGGGGCC
CATGTGCTGCTGGGGAAGATCCTACAGAACCACATGCTGGACCTCCGCATCGCCAACTCCAAAC
TCTTCTGGAGGGCACTGGCCATGTTGCAGAGGTTCTCAGGACAGTCCAAGGCTCGCTGCATTGA
GAGTCTTCTTCAAGTGATACATTTCCCTCAACCGCTGTCGAATGATGTCCGCGCGGCCCCCATC
TCCTGCCATGTCCAGGTTGCCCACGAGAAGGAAAAGGTGATCCCCACAGCCTTGCTGAGTCTCC
TACTCAGGTGCTCCATCACTGAGGCTAAGGAACGCCTGGCTGCAGCTTCTTCAGTCTGTGAGGT
TGTTAGGAGCGCCCTCTCTGGGCCAGGTCAGAAACGCAGCATCCAAGCCTTTGGAGACCCTGTG
GTGCCCTGAATTGATGTTTCTGTGACCATTGAAAAGTCTCCATCCACTTCTGAGGGGACTTGTG
CCAGTAATACACGTTGCAGGACAGACTCAGTTCCGGTGGGTGGGGCACTAACAGCCCAGAATTG
AGGAAGAGTCCTGTTCTCAGCTGGATCATTTCCATTTTTACTGGCATCTTCTGATCTTAGGAAT
AAAACTAAATGTCTTGTTTTGAACCCAA

hide sequence

RefSeq Acc Id:

NM_144909 ⟹ NP_659158

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,454,907 - 31,484,646 (+)	NCBI
GRCm38	5	31,297,563 - 31,327,302 (+)	NCBI
MGSCv37	5	31,599,954 - 31,629,675 (+)	RGD
Celera	5	28,776,863 - 28,806,281 (+)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

AGAACAGATTGCGTGAGTGCAGAGGCAGGCGGGTTGGAGAGTCTGCAGTGTGGGACCATGCCAA
GCACCAAGCGGTATCAGCATGTGATCGAGACCCCTGAGCCTGGGGAATGGGAGTTGTCAGGGTA
TGAAGCAGCTGTGCCAATCACAGAGAAGTCCAACCCACTGACCCGGAACTTGGACAAAGCAGAT
GCAGAGAAAATTGTTCAACTGCTGGGGCAGTGTGATGCTGAGATATTCCAGGAGGAGGGGCAAA
TCATGCCCACCTACCAGCGACTGTACAGTGAGTCAGTTCTGACCACCATGTTGCAAGTGGCTGG
CAAGGTCCAGGAAGTGCTGAAGGAGCCAGATGGGGGCCTGGTGGTGCTGAGTGGAGGGGGCACC
TCTGGTCGTATGGCATTCCTTATGTCTGTGTCTTTCAACCAGCTGATGAAAGGTCTGGGACAAA
AACCTCTTTACACATACCTCATTGCAGGGGGTGACAGGTCTGTTGTAGCCTCTCGGGAACGGAC
AGAAGATAGCGCCCTACACGGAATCGAGGAGCTGAAGAAGGTGGCTGCTGGGAAAAAGAGAGTG
GTCGTTATAGGCATTTCCGTGGGACTCTCTGCGCCCTTTGTGGCAGGCCAGATGGACTACTGCA
TGGATAACACAGCTGTCTTCTTGCCGGTCCTGGTTGGCTTCAATCCGGTGAGCATGGCCAGAAA
TGATCCCATTGAAGACTGGAGATCGACATTCCGACAAGTGGCAGAGCGGATGCAGAAGATGCAG
GAGAAACAGGAAGCCTTTGTGCTCAATCCTGCCATCGGGCCTGAGGGGCTCAGTGGCTCTTCCC
GAATGAAAGGTGGAAGCGCCACCAAGATTCTACTGGAAACCCTGCTACTAGCAGCCCATAAGAC
TGTGGACCAGGGTGTTGTGTCCTCTCAAAGATGCCTTCTGGAAATCCTGAGGACATTTGAGCGG
GCTCATCAGGTAACCTACAGTCAAAGTTCCAAAATTGCCACTCTGACGAAGCAAGTTGGCATCA
GCCTGGAGAAAAAAGGCCACGTGCACTTGGTTGGCTGGCAGACCCTCGGTATCATCGCCATTAT
GGATGGGGTAGAGTGTATCCACACTTTTGGTGCTGATTTCCGAGATATCCGTGGCTTTCTTATT
GGTGACCACAATGACATGTTTAACCAGAAGGATGAGCTCAGCAATCAGGGTCCCCAGTTCACCT
TCTCTCAGGATGACTTCCTGACTTCTGTTCTGCCATCCCTTACGGAAATTGACACTGTGGTCTT
CATTTTTACCCTGGATGATAACCTCGCAGAAGTACAGGCCCTGGCAGAAAGGGTGAGGGAGAAG
AGTTGGAACATCCAGGCCCTGGTGCACAGCACAGTGGGGCAGTCCTTGCCAGCTCCTCTAAAGA
AGCTCTTTCCCTCGCTCATCAGCATCACATGGCCACTTCTTTTCTTCGATTATGAAGGGAGCTA
CGTTCAGAAGTTCCAGCGTGAGTTAAGCACCAAGTGGGTGTTGAATACAAGGTTCTCAGGACAG
TCCAAGGCTCGCTGCATTGAGAGTCTTCTTCAAGTGATACATTTCCCTCAACCGCTGTCGAATG
ATGTCCGCGCGGCCCCCATCTCCTGCCATGTCCAGGTTGCCCACGAGAAGGAAAAGGTGATCCC
CACAGCCTTGCTGAGTCTCCTACTCAGGTGCTCCATCACTGAGGCTAAGGAACGCCTGGCTGCA
GCTTCTTCAGTCTGTGAGGTTGTTAGGAGCGCCCTCTCTGGGCCAGGTCAGAAACGCAGCATCC
AAGCCTTTGGAGACCCTGTGGTGCCCTGAATTGATGTTTCTGTGACCATTGAAAAGTCTCCATC
CACTTCTGAGGGGACTTGTGCCAGTAATACACGTTGCAGGACAGACTCAGTTCCGGTGGGTGGG
GCACTAACAGCCCAGAATTGAGGAAGAGTCCTGTTCTCAGCTGGATCATTTCCATTTTTACTGG
CATCTTCTGATCTTAGGAATAAAACTAAATGTCTTGTTTTGAACCCAA

hide sequence

RefSeq Acc Id:

XM_006503882 ⟹ XP_006503945

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,454,594 - 31,484,646 (+)	NCBI
GRCm38	5	31,297,266 - 31,327,302 (+)	NCBI

Sequence:

show sequence

ACTGACCCTGATCTCTGGCCTTTGGAGGCATTTGGGCCACAGATTTGTTCAGGGATTCTTTCTG
ACCTGGGTGTTCTGCAAGGGCAAAAGCAAAGAACGTCTGGTCCTCTTCTCCAAGGGCAGAGGCT
GGCAAGCCAGAGTATACGCAAAGAGGACCCTCAGGAGCTCCTGTGAGGGCTGGAAGCCCCGGCG
ACAGGAACGGGTGTTGAAGAGAGGGGCGTAGGGGGTGGTGTTTTGAGAGGCAGGGTTCTTAGGT
TAATCATCTCCATGGCTCAGATAAGACCCTGCCAACTGGAAGCAAATTATTGGGGCCAGAACAG
ATTGCGTGAGTGCAGAGGCAGGCGGGTTGGAGAGTCTGCAGTGTGGGACCATGCCAAGCACCAA
GCGGTATCAGCATGTGATCGAGACCCCTGAGCCTGGGGAATGGGAGTTGTCAGGGTATGAAGCA
GCTGTGCCAATCACAGAGAAGTCCAACCCACTGACCCGGAACTTGGACAAAGCAGATGCAGAGA
AAATTGTTCAACTGCTGGGGCAGTGTGATGCTGAGATATTCCAGGAGGAGGGGCAAATCATGCC
CACCTACCAGCGACTGTACAGTGAGTCAGTTCTGACCACCATGTTGCAAGTGGCTGGCAAGGTC
CAGGAAGTGCTGAAGGAGCCAGATGGGGGCCTGGTGGTGCTGAGTGGAGGGGGCACCTCTGGTC
GTATGGCATTCCTTATGTCTGTGTCTTTCAACCAGCTGATGAAAGGTCTGGGACAAAAACCTCT
TTACACATACCTCATTGCAGGGGGTGACAGGTCTGTTGTAGCCTCTCGGGAACGGACAGAAGAT
AGCGCCCTACACGGAATCGAGGAGCTGAAGAAGGCGCCCTTTGTGGCAGGCCAGATGGACTACT
GCATGGATAACACAGCTGTCTTCTTGCCGGTCCTGGTTGGCTTCAATCCGGTGAGCATGGCCAG
AAATGATCCCATTGAAGACTGGAGATCGACATTCCGACAAGTGGCAGAGCGGATGCAGAAGATG
CAGGAGAAACAGGAAGCCTTTGTGCTCAATCCTGCCATCGGGCCTGAGGGGCTCAGTGGCTCTT
CCCGAATGAAAGGTGGAAGCGCCACCAAGATTCTACTGGAAACCCTGCTACTAGCAGCCCATAA
GACTGTGGACCAGGGTGTTGTGTCCTCTCAAAGATGCCTTCTGGAAATCCTGAGGACATTTGAG
CGGGCTCATCAGGTAACCTACAGTCAAAGTTCCAAAATTGCCACTCTGACGAAGCAAGTTGGCA
TCAGCCTGGAGAAAAAAGGCCACGTGCACTTGGTTGGCTGGCAGACCCTCGGTATCATCGCCAT
TATGGATGGGGTAGAGTGTATCCACACTTTTGGTGCTGATTTCCGAGATATCCGTGGCTTTCTT
ATTGGTGACCACAATGACATGTTTAACCAGAAGGATGAGCTCAGCAATCAGGGTCCCCAGTTCA
CCTTCTCTCAGGATGACTTCCTGACTTCTGTTCTGCCATCCCTTACGGAAATTGACACTGTGGT
CTTCATTTTTACCCTGGATGATAACCTCGCAGAAGTACAGGCCCTGGCAGAAAGGGTGAGGGAG
AAGAGTTGGAACATCCAGGCCCTGGTGCACAGCACAGTGGGGCAGTCCTTGCCAGCTCCTCTAA
AGAAGCTCTTTCCCTCGCTCATCAGCATCACATGGCCACTTCTTTTCTTCGATTATGAAGGGAG
CTACGTTCAGAAGTTCCAGCGTGAGTTAAGCACCAAGTGGGTGTTGAATACAGTGAGTACTGGG
GCCCATGTGCTGCTGGGGAAGATCCTACAGAACCACATGCTGGACCTCCGCATCGCCAACTCCA
AACTCTTCTGGAGGGCACTGGCCATGTTGCAGAGGTTCTCAGGACAGTCCAAGGCTCGCTGCAT
TGAGAGTCTTCTTCAAGTGATACATTTCCCTCAACCGCTGTCGAATGATGTCCGCGCGGCCCCC
ATCTCCTGCCATGTCCAGGTTGCCCACGAGAAGGAAAAGGTGATCCCCACAGCCTTGCTGAGTC
TCCTACTCAGGTGCTCCATCACTGAGGCTAAGGAACGCCTGGCTGCAGCTTCTTCAGTCTGTGA
GGTTGTTAGGAGCGCCCTCTCTGGGCCAGGTCAGAAACGCAGCATCCAAGCCTTTGGAGACCCT
GTGGTGCCCTGAATTGATGTTTCTGTGACCATTGAAAAGTCTCCATCCACTTCTGAGGGGACTT
GTGCCAGTAATACACGTTGCAGGACAGACTCAGTTCCGGTGGGTGGGGCACTAACAGCCCAGAA
TTGAGGAAGAGTCCTGTTCTCAGCTGGATCATTTCCATTTTTACTGGCATCTTCTGATCTTAGG
AATAAAACTAAATGTCTTGTTTTGAACCCAA

hide sequence

RefSeq Acc Id:

XM_006503883 ⟹ XP_006503946

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	31,454,596 - 31,484,646 (+)	NCBI
GRCm38	5	31,297,266 - 31,327,302 (+)	NCBI

Sequence:

show sequence

TGACCCTGATCTCTGGCCTTTGGAGGCATTTGGGCCACAGATTTGTTCAGGGATTCTTTCTGAC
CTGGGTGTTCTGCAAGGGCAAAAGCAAAGAACGTCTGGTCCTCTTCTCCAAGGGCAGAGGCTGG
CAAGCCAGAGTATACGCAAAGAGGACCCTCAGGAGCTCCTGTGAGGGCTGGAAGCCCCGGCGAC
AGGAACGGGTGTTGAAGAGAGGGGCGTAGGGGGTGGTGTTTTGAGAGGCAGGGTTCTTAGGTTA
ATCATCTCCATGGCTCAGATAAGACCCTGCCAACTGGAAGCAAATTATTGGGGCCAGAACAGAT
TGCGTGAGTGCAGAGGCAGGCGGGTTGGAGAGTCTGCAGTGTGGGACCATGCCAAGCACCAAGC
GGTATCAGCATGTGATCGAGACCCCTGAGCCTGGGGAATGGGAGCGACTGTACAGTGAGTCAGT
TCTGACCACCATGTTGCAAGTGGCTGGCAAGGTCCAGGAAGTGCTGAAGGAGCCAGATGGGGGC
CTGGTGGTGCTGAGTGGAGGGGGCACCTCTGGTCGTATGGCATTCCTTATGTCTGTGTCTTTCA
ACCAGCTGATGAAAGGTCTGGGACAAAAACCTCTTTACACATACCTCATTGCAGGGGGTGACAG
GTCTGTTGTAGCCTCTCGGGAACGGACAGAAGATAGCGCCCTACACGGAATCGAGGAGCTGAAG
AAGGTGGCTGCTGGGAAAAAGAGAGTGGTCGTTATAGGCATTTCCGTGGGACTCTCTGCGCCCT
TTGTGGCAGGCCAGATGGACTACTGCATGGATAACACAGCTGTCTTCTTGCCGGTCCTGGTTGG
CTTCAATCCGGTGAGCATGGCCAGAAATGATCCCATTGAAGACTGGAGATCGACATTCCGACAA
GTGGCAGAGCGGATGCAGAAGATGCAGGAGAAACAGGAAGCCTTTGTGCTCAATCCTGCCATCG
GGCCTGAGGGGCTCAGTGGCTCTTCCCGAATGAAAGGTGGAAGCGCCACCAAGATTCTACTGGA
AACCCTGCTACTAGCAGCCCATAAGACTGTGGACCAGGGTGTTGTGTCCTCTCAAAGATGCCTT
CTGGAAATCCTGAGGACATTTGAGCGGGCTCATCAGGTAACCTACAGTCAAAGTTCCAAAATTG
CCACTCTGACGAAGCAAGTTGGCATCAGCCTGGAGAAAAAAGGCCACGTGCACTTGGTTGGCTG
GCAGACCCTCGGTATCATCGCCATTATGGATGGGGTAGAGTGTATCCACACTTTTGGTGCTGAT
TTCCGAGATATCCGTGGCTTTCTTATTGGTGACCACAATGACATGTTTAACCAGAAGGATGAGC
TCAGCAATCAGGGTCCCCAGTTCACCTTCTCTCAGGATGACTTCCTGACTTCTGTTCTGCCATC
CCTTACGGAAATTGACACTGTGGTCTTCATTTTTACCCTGGATGATAACCTCGCAGAAGTACAG
GCCCTGGCAGAAAGGGTGAGGGAGAAGAGTTGGAACATCCAGGCCCTGGTGCACAGCACAGTGG
GGCAGTCCTTGCCAGCTCCTCTAAAGAAGCTCTTTCCCTCGCTCATCAGCATCACATGGCCACT
TCTTTTCTTCGATTATGAAGGGAGCTACGTTCAGAAGTTCCAGCGTGAGTTAAGCACCAAGTGG
GTGTTGAATACAGTGAGTACTGGGGCCCATGTGCTGCTGGGGAAGATCCTACAGAACCACATGC
TGGACCTCCGCATCGCCAACTCCAAACTCTTCTGGAGGGCACTGGCCATGTTGCAGAGGTTCTC
AGGACAGTCCAAGGCTCGCTGCATTGAGAGTCTTCTTCAAGTGATACATTTCCCTCAACCGCTG
TCGAATGATGTCCGCGCGGCCCCCATCTCCTGCCATGTCCAGGTTGCCCACGAGAAGGAAAAGG
TGATCCCCACAGCCTTGCTGAGTCTCCTACTCAGGTGCTCCATCACTGAGGCTAAGGAACGCCT
GGCTGCAGCTTCTTCAGTCTGTGAGGTTGTTAGGAGCGCCCTCTCTGGGCCAGGTCAGAAACGC
AGCATCCAAGCCTTTGGAGACCCTGTGGTGCCCTGAATTGATGTTTCTGTGACCATTGAAAAGT
CTCCATCCACTTCTGAGGGGACTTGTGCCAGTAATACACGTTGCAGGACAGACTCAGTTCCGGT
GGGTGGGGCACTAACAGCCCAGAATTGAGGAAGAGTCCTGTTCTCAGCTGGATCATTTCCATTT
TTACTGGCATCTTCTGATCTTAGGAATAAAACTAAATGTCTTGTTTTGAACCCAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001361670	(Get FASTA)	NCBI Sequence Viewer
	NP_659158	(Get FASTA)	NCBI Sequence Viewer
	XP_006503945	(Get FASTA)	NCBI Sequence Viewer
	XP_006503946	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH12412	(Get FASTA)	NCBI Sequence Viewer
	EDL37365	(Get FASTA)	NCBI Sequence Viewer
	EDL37366	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000072084
	ENSMUSP00000072084.6
	ENSMUSP00000144202
	ENSMUSP00000144202.2
GenBank Protein	Q91X44	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_659158 ⟸ NM_144909
- Peptide Label:	isoform 2
- UniProtKB:	Q91X44 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MPSTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVQLLGQCDAEIFQEE GQIMPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGL GQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMD YCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSG SSRMKGGSATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLTKQV GISLEKKGHVHLVGWQTLGIIAIMDGVECIHTFGADFRDIRGFLIGDHNDMFNQKDELSNQGPQ FTFSQDDFLTSVLPSLTEIDTVVFIFTLDDNLAEVQALAERVREKSWNIQALVHSTVGQSLPAP LKKLFPSLISITWPLLFFDYEGSYVQKFQRELSTKWVLNTRFSGQSKARCIESLLQVIHFPQPL SNDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSITEAKERLAAASSVCEVVRSALSGPGQKR SIQAFGDPVVP hide sequence

RefSeq Acc Id:

XP_006503945 ⟸ XM_006503882

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPSTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVQLLGQCDAEIFQEE
GQIMPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGL
GQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKAPFVAGQMDYCMDNTAVFLPVLVGFNP
VSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGSATKILLETLL
LAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLTKQVGISLEKKGHVHLVGWQTL
GIIAIMDGVECIHTFGADFRDIRGFLIGDHNDMFNQKDELSNQGPQFTFSQDDFLTSVLPSLTE
IDTVVFIFTLDDNLAEVQALAERVREKSWNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFF
DYEGSYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQS
KARCIESLLQVIHFPQPLSNDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSITEAKERLAAA
SSVCEVVRSALSGPGQKRSIQAFGDPVVP

hide sequence

RefSeq Acc Id:

XP_006503946 ⟸ XM_006503883

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPSTKRYQHVIETPEPGEWERLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFL
MSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKVAAGKKRVVVIGISV
GLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFV
LNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYS
QSSKIATLTKQVGISLEKKGHVHLVGWQTLGIIAIMDGVECIHTFGADFRDIRGFLIGDHNDMF
NQKDELSNQGPQFTFSQDDFLTSVLPSLTEIDTVVFIFTLDDNLAEVQALAERVREKSWNIQAL
VHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGSYVQKFQRELSTKWVLNTVSTGAHVLLGKI
LQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQVIHFPQPLSNDVRAAPISCHVQVA
HEKEKVIPTALLSLLLRCSITEAKERLAAASSVCEVVRSALSGPGQKRSIQAFGDPVVP

hide sequence

RefSeq Acc Id:	NP_001361670 ⟸ NM_001374741
- Peptide Label:	isoform 1
- UniProtKB:	Q91X44 (UniProtKB/Swiss-Prot), A0A0J9YUI8 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSMUSP00000072084 ⟸ ENSMUST00000072228

Ensembl Acc Id:

ENSMUSP00000144202 ⟸ ENSMUST00000201166

Ensembl Acc Id:

ENSMUSP00000144568 ⟸ ENSMUST00000201675

Protein Domains

SIS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q91X44-F1-model_v2	AlphaFold	Q91X44	1-587	view protein structure

Promoters

RGD ID:

6886366

Promoter ID:

EPDNEW_M6634

Type:

initiation region

Name:

Gckr_1

Description:

Mus musculus glucokinase regulatory protein , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	31,297,563 - 31,297,623	EPDNEW

RGD ID:

6837566

Promoter ID:

MM_KWN:41838

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Liver

Transcripts:

NM_144909

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	31,599,401 - 31,599,901 (+)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1096345	AgrOrtholog
Ensembl Genes	ENSMUSG00000059434	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000072228	ENTREZGENE
	ENSMUST00000072228.9	UniProtKB/Swiss-Prot
	ENSMUST00000201166	ENTREZGENE
	ENSMUST00000201166.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.8.1080	UniProtKB/Swiss-Prot
	3.40.50.12620	UniProtKB/Swiss-Prot
	Glucose-6-phosphate isomerase like protein, domain 1	UniProtKB/Swiss-Prot
InterPro	GKRP_SIS_2	UniProtKB/Swiss-Prot
	Glucokinase_regulatory_CS	UniProtKB/Swiss-Prot
	MURQ/GCKR	UniProtKB/Swiss-Prot
	SIS	UniProtKB/Swiss-Prot
	SIS_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	mmu:231103	UniProtKB/Swiss-Prot
MGD	MGI:1096345	ENTREZGENE
NCBI Gene	Gckr	ENTREZGENE
PANTHER	GLUCOKINASE REGULATORY PROTEIN	UniProtKB/Swiss-Prot
	PTHR10088	UniProtKB/Swiss-Prot
Pfam	GKRP-like_C	UniProtKB/Swiss-Prot
	GKRP_SIS_2	UniProtKB/Swiss-Prot
	GKRP_SIS_N	UniProtKB/Swiss-Prot
PharmGKB	GCKR	RGD
PhenoGen	Gckr	PhenoGen
PROSITE	GCKR	UniProtKB/Swiss-Prot
	SIS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53697	UniProtKB/Swiss-Prot
UniProt	A0A0J9YUI8	ENTREZGENE
	A0A0J9YVA3_MOUSE	UniProtKB/TrEMBL
	GCKR_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A0J9YUI8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Mammalian Phenotype