Gckr (glucokinase regulatory protein) - Rat Genome Database

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Gene: Gckr (glucokinase regulatory protein) Mus musculus
Analyze
Symbol: Gckr
Name: glucokinase regulatory protein
RGD ID: 69131
MGI Page MGI
Description: Predicted to enable several functions, including fructose-6-phosphate binding activity; glucose sensor activity; and kinase inhibitor activity. Acts upstream of or within intracellular glucose homeostasis and protein import into nucleus. Located in nucleus. Is expressed in diencephalon lateral wall mantle layer; liver left lobe; liver right lobe; midbrain mantle layer; and retina. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GK; GKRP; glucokinase regulator; MGC19300
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,454,594 - 31,484,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,454,787 - 31,484,658 (+)EnsemblGRCm39 Ensembl
GRCm38531,297,266 - 31,327,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,297,443 - 31,327,314 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,599,954 - 31,629,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,574,162 - 31,603,883 (+)NCBIMGSCv36mm8
Celera528,776,863 - 28,806,281 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
alloxan  (EXP)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
clofibric acid  (ISO)
clomipramine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
endosulfan  (ISO)
ethylparaben  (ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
fructose  (ISO)
furan  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
imipramine  (ISO)
ketoconazole  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
Muraglitazar  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
p-toluidine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propanal  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (ISO)
tauroursodeoxycholic acid  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vanillic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA,ISO)
mitochondrion  (IEA)
nucleoplasm  (IBA,ISO)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. Boger CA, etal., PLoS Genet. 2011 Sep;7(9):e1002292. doi: 10.1371/journal.pgen.1002292. Epub 2011 Sep 29.
2. Variants of GCKR affect both beta-cell and kidney function in patients with newly diagnosed type 2 diabetes: the Verona newly diagnosed type 2 diabetes study 2. Bonetti S, etal., Diabetes Care. 2011 May;34(5):1205-10. doi: 10.2337/dc10-2218. Epub 2011 Mar 16.
3. Differences in regulatory properties between human and rat glucokinase regulatory protein. Brocklehurst KJ, etal., Biochem J. 2004 Mar 1;378(Pt 2):693-7.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Qi Q, etal., Diabetologia. 2009 May;52(5):834-43. Epub 2009 Feb 25.
9. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein. Slosberg ED, etal., Diabetes. 2001 Aug;50(8):1813-20.
14. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. van der Harst P, etal., Hum Mol Genet. 2010 Jan 15;19(2):387-95. doi: 10.1093/hmg/ddp489. Epub 2009 Oct 27.
15. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Vaxillaire M, etal., Diabetes. 2008 Aug;57(8):2253-7. Epub 2008 Jun 12.
16. Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians. Veiga-da-Cunha M, etal., Diabetologia. 2003 May;46(5):704-11. Epub 2003 May 9.
17. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
Additional References at PubMed
PMID:9271679   PMID:10349636   PMID:10588736   PMID:10614646   PMID:10713097   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:23341629   PMID:24333860   PMID:24879641   PMID:26620281   PMID:27146480   PMID:29296001   PMID:29925374   PMID:37031802  


Genomics

Comparative Map Data
Gckr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,454,594 - 31,484,646 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,454,787 - 31,484,658 (+)EnsemblGRCm39 Ensembl
GRCm38531,297,266 - 31,327,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,297,443 - 31,327,314 (+)EnsemblGRCm38mm10GRCm38
MGSCv37531,599,954 - 31,629,675 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,574,162 - 31,603,883 (+)NCBIMGSCv36mm8
Celera528,776,863 - 28,806,281 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
GCKR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,496,839 - 27,523,684 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,496,839 - 27,523,684 (+)EnsemblGRCh38hg38GRCh38
GRCh37227,719,706 - 27,746,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,573,210 - 27,600,055 (+)NCBINCBI36Build 36hg18NCBI36
Build 34227,631,356 - 27,658,199NCBI
Celera227,565,881 - 27,592,728 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,461,595 - 27,488,434 (+)NCBIHuRef
CHM1_1227,649,617 - 27,676,462 (+)NCBICHM1_1
T2T-CHM13v2.0227,539,204 - 27,566,046 (+)NCBIT2T-CHM13v2.0
Gckr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,765,071 - 30,795,627 (-)NCBIGRCr8
mRatBN7.2625,044,592 - 25,075,834 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,045,100 - 25,075,654 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,345,943 - 25,376,501 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,661,829 - 25,692,391 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,141,212 - 25,171,764 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,355,296 - 26,385,761 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,355,296 - 26,385,761 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,175,967 - 36,205,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera624,538,242 - 24,568,355 (-)NCBICelera
RH 3.4 Map693.5RGD
Cytogenetic Map6q14NCBI
Gckr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,461,848 - 9,484,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,461,541 - 9,485,034 (+)NCBIChiLan1.0ChiLan1.0
GCKR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21298,988,257 - 99,016,423 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A98,991,561 - 99,020,392 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,497,938 - 27,530,650 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,587,077 - 27,613,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,587,077 - 27,613,927 (+)Ensemblpanpan1.1panPan2
GCKR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,431,113 - 21,460,143 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,434,200 - 21,459,935 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,325,464 - 21,351,412 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,748,359 - 21,780,870 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,755,097 - 21,780,825 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,441,647 - 21,467,181 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,451,118 - 21,476,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,499,397 - 21,525,150 (+)NCBIUU_Cfam_GSD_1.0
Gckr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,735,931 - 65,759,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,080,559 - 5,101,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,080,517 - 5,101,892 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCKR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,649,539 - 111,676,772 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,649,557 - 111,683,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,789,323 - 118,823,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCKR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,069,662 - 80,124,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,100,436 - 80,123,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,031,883 - 32,058,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gckr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,552,386 - 9,574,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,552,260 - 9,574,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gckr
860 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:91
Interacting mature miRNAs:93
Transcripts:ENSMUST00000072228
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401122Pgia41_mproteoglycan induced arthritis 41 (mouse)Not determined582314434823280Mouse
15039371Nmrs21_mNAFLD-associated magnetic resonance shift 21 (mouse)5350482337504823Mouse
1301806Actd2_mactivity-distance traveled 2 (mouse)Not determined5538452039384652Mouse
4141207Imrfq1_mimmune response to Factor IX QTL 1 (mouse)Not determined5812411742124239Mouse
7394748Mom5_mmodifier of Min 5 (mouse)Not determined5884767233475637Mouse
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
1357478Kdnw1_mkidney weight 1 (mouse)Not determined5891594940529869Mouse
14696730Kidlq1_mkidney weight, left QTL 1 (mouse)51356315247563152Mouse
1301685Estq2_mestradiol regulated response QTL 2 (mouse)Not determined51563408449634190Mouse
1300719Iba5_minduction of brown adipocytes 5 (mouse)Not determined52068699354687134Mouse
1301776Skts3_mskin tumor susceptibility 3 (mouse)Not determined52166729555667403Mouse
11537368Hmtb10_mhemostasis and thrombosis 10 (mouse)52210082354500318Mouse
11537367Hmtb11_mhemostasis and thrombosis 11 (mouse)52210082364806579Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
1300701Cd8ts1_mCD8 T cell subset 1 (mouse)Not determined52721534861215451Mouse
1301555Alcp10_malcohol preference locus 10 (mouse)Not determined53102427565024480Mouse
1301403Alcp9_malcohol preference locus 9 (mouse)Not determined53102427565024480Mouse

Markers in Region
26.mHAa8b2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,327,459 - 31,327,612UniSTSGRCm38
MGSCv37531,629,832 - 31,629,985UniSTSGRCm37
Celera528,806,438 - 28,806,591UniSTS
Cytogenetic Map5B1UniSTS
cM Map518.1UniSTS
Whitehead_YAC12 UniSTS
Gckr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38531,302,045 - 31,302,243UniSTSGRCm38
MGSCv37531,604,418 - 31,604,616UniSTSGRCm37
Celera528,781,146 - 28,781,344UniSTS
Cytogenetic Map5B1UniSTS
cM Map518.1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000072228   ⟹   ENSMUSP00000072084
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,454,925 - 31,484,646 (+)Ensembl
GRCm38.p6 Ensembl531,297,581 - 31,327,302 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201166   ⟹   ENSMUSP00000144202
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,454,787 - 31,484,658 (+)Ensembl
GRCm38.p6 Ensembl531,297,443 - 31,327,314 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201675   ⟹   ENSMUSP00000144568
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,454,956 - 31,457,927 (+)Ensembl
GRCm38.p6 Ensembl531,297,612 - 31,300,583 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202242
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,483,575 - 31,484,641 (+)Ensembl
GRCm38.p6 Ensembl531,326,231 - 31,327,297 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202312
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,456,045 - 31,463,942 (+)Ensembl
GRCm38.p6 Ensembl531,298,701 - 31,306,598 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,456,850 - 31,462,848 (+)Ensembl
GRCm38.p6 Ensembl531,299,506 - 31,305,504 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl531,454,898 - 31,484,639 (+)Ensembl
GRCm38.p6 Ensembl531,297,554 - 31,327,295 (+)Ensembl
RefSeq Acc Id: NM_001374741   ⟹   NP_001361670
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,454,907 - 31,484,646 (+)NCBI
GRCm38531,297,563 - 31,327,302 (+)NCBI
Sequence:
RefSeq Acc Id: NM_144909   ⟹   NP_659158
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,454,907 - 31,484,646 (+)NCBI
GRCm38531,297,563 - 31,327,302 (+)NCBI
MGSCv37531,599,954 - 31,629,675 (+)RGD
Celera528,776,863 - 28,806,281 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503882   ⟹   XP_006503945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,454,594 - 31,484,646 (+)NCBI
GRCm38531,297,266 - 31,327,302 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006503883   ⟹   XP_006503946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39531,454,596 - 31,484,646 (+)NCBI
GRCm38531,297,266 - 31,327,302 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_659158   ⟸   NM_144909
- Peptide Label: isoform 2
- UniProtKB: Q91X44 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006503945   ⟸   XM_006503882
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006503946   ⟸   XM_006503883
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001361670   ⟸   NM_001374741
- Peptide Label: isoform 1
- UniProtKB: Q91X44 (UniProtKB/Swiss-Prot),   A0A0J9YUI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000072084   ⟸   ENSMUST00000072228
RefSeq Acc Id: ENSMUSP00000144202   ⟸   ENSMUST00000201166
RefSeq Acc Id: ENSMUSP00000144568   ⟸   ENSMUST00000201675
Protein Domains
SIS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91X44-F1-model_v2 AlphaFold Q91X44 1-587 view protein structure

Promoters
RGD ID:6886366
Promoter ID:EPDNEW_M6634
Type:initiation region
Name:Gckr_1
Description:Mus musculus glucokinase regulatory protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38531,297,563 - 31,297,623EPDNEW
RGD ID:6837566
Promoter ID:MM_KWN:41838
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_144909
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36531,599,401 - 31,599,901 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096345 AgrOrtholog
Ensembl Genes ENSMUSG00000059434 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072228 ENTREZGENE
  ENSMUST00000072228.9 UniProtKB/Swiss-Prot
  ENSMUST00000201166 ENTREZGENE
  ENSMUST00000201166.4 UniProtKB/Swiss-Prot
  ENSMUST00000201675.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.1080 UniProtKB/Swiss-Prot
  3.40.50.12620 UniProtKB/Swiss-Prot
InterPro Glucokinase_regulatory_CS UniProtKB/Swiss-Prot
  MURQ/GCKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIS UniProtKB/Swiss-Prot
  SIS_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:231103 UniProtKB/Swiss-Prot
MGD MGI:1096345 ENTREZGENE
NCBI Gene 231103 ENTREZGENE
PANTHER GLUCOKINASE REGULATORY PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10088 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GKRP-like_C UniProtKB/Swiss-Prot
PharmGKB GCKR RGD
PhenoGen Gckr PhenoGen
PROSITE GCKR UniProtKB/Swiss-Prot
  SIS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53697 UniProtKB/Swiss-Prot
UniProt A0A0J9YUI8 ENTREZGENE
  A0A0J9YVA3_MOUSE UniProtKB/TrEMBL
  GCKR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0J9YUI8 UniProtKB/Swiss-Prot