Cobl (cordon-bleu WH2 repeat protein) - Rat Genome Database
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Gene: Cobl (cordon-bleu WH2 repeat protein) Rattus norvegicus
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Symbol: Cobl
Name: cordon-bleu WH2 repeat protein
RGD ID: 1312002
Description: Predicted to have actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; chordate embryonic development; and positive regulation of cell projection organization. Localizes to cell cortex and plasma membrane. Predicted to colocalize with actin filament. Orthologous to human COBL (cordon-bleu WH2 repeat protein); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cordon-bleu ; cordon-bleu homolog; cordon-bleu homolog (mouse); LOC305497; protein cordon-bleu
Orthologs:
Homo sapiens (human) : COBL (cordon-bleu WH2 repeat protein)  HGNC  Alliance
Mus musculus (house mouse) : Cobl (cordon-bleu WH2 repeat)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : COBL (cordon-bleu WH2 repeat protein)
Canis lupus familiaris (dog) : COBL (cordon-bleu WH2 repeat protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cobl (cordon-bleu WH2 repeat protein)
Sus scrofa (pig) : COBL (cordon-bleu WH2 repeat protein)
Chlorocebus sabaeus (African green monkey) : COBL (cordon-bleu WH2 repeat protein)
Heterocephalus glaber (naked mole-rat) : Cobl (cordon-bleu WH2 repeat protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01492,341,949 - 92,497,169 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01492,142,186 - 92,321,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41493,154,637 - 93,309,406 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11492,994,412 - 93,340,571 (-)NCBI
Celera1485,826,388 - 85,975,943 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (IBA,IEA,ISO)
axon  (ISO)
axonal growth cone  (IBA,IEA,ISO)
cell cortex  (IDA,IEA,ISO)
cytosol  (IEA)
dendrite  (ISO)
dendritic growth cone  (IBA,IEA,ISO)
membrane  (IEA,ISO)
neuronal cell body  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IBA,IEA,ISO)
plasma membrane  (IBA,IDA)
ruffle  (IBA,IEA,ISO)
terminal web  (IBA,ISO)

Molecular Function
actin monomer binding  (IBA,IEA,ISO)
protein binding  (IPI,ISO)

References

Additional References at PubMed
PMID:7586755   PMID:14512015   PMID:17956734   PMID:22114352   PMID:29891944  


Genomics

Comparative Map Data
Cobl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01492,341,949 - 92,497,169 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01492,142,186 - 92,321,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41493,154,637 - 93,309,406 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11492,994,412 - 93,340,571 (-)NCBI
Celera1485,826,388 - 85,975,943 (-)NCBICelera
Cytogenetic Map14q21NCBI
COBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl751,016,212 - 51,316,818 (-)EnsemblGRCh38hg38GRCh38
GRCh38751,016,212 - 51,316,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37751,083,909 - 51,384,515 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36751,051,404 - 51,351,990 (-)NCBINCBI36hg18NCBI36
Build 34750,858,118 - 51,158,705NCBI
Celera751,148,737 - 51,449,348 (-)NCBI
Cytogenetic Map7p12.1NCBI
HuRef750,933,696 - 51,137,285 (-)NCBIHuRef
CHM1_1751,086,207 - 51,386,564 (-)NCBICHM1_1
CRA_TCAGchr7v2751,089,893 - 51,390,521 (-)NCBI
Cobl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391112,186,676 - 12,415,022 (-)NCBI
GRCm381112,236,676 - 12,465,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1112,236,608 - 12,464,960 (-)EnsemblGRCm38mm10GRCm38
MGSCv371112,136,679 - 12,364,963 (-)NCBIGRCm37mm9NCBIm37
MGSCv361112,136,681 - 12,364,803 (-)NCBImm8
Celera1112,678,618 - 12,909,422 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.3NCBI
COBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1751,894,468 - 52,114,849 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,895,807 - 52,097,841 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0751,652,318 - 51,952,256 (-)NCBIMhudiblu_PPA_v0panPan3
COBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl182,208,260 - 2,459,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1182,206,957 - 2,386,333 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cobl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936686621,502 - 872,824 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.19136,850,521 - 137,055,249 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,659,325 - 150,667,343 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COBL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl217,598,126 - 7,803,177 (+)Ensembl
ChlSab1.1217,501,647 - 7,803,175 (+)NCBI
Cobl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247403,332,977 - 3,399,915 (+)NCBI

Position Markers
RH130337  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01492,343,002 - 92,343,182NCBIRnor6.0
Rnor_5.01492,142,192 - 92,142,372UniSTSRnor5.0
RGSC_v3.41493,154,641 - 93,154,821UniSTSRGSC3.4
Celera1485,826,392 - 85,826,572UniSTS
Cytogenetic Map14q21UniSTS
RH 3.4 Map14651.1UniSTS
BE120256  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01492,483,656 - 92,483,811NCBIRnor6.0
Rnor_5.01492,280,451 - 92,280,606UniSTSRnor5.0
RGSC_v3.41493,297,149 - 93,297,304UniSTSRGSC3.4
Celera1485,963,686 - 85,963,841UniSTS
Cytogenetic Map14q21UniSTS
RH 3.4 Map14641.1UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1485307663106641756Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)1487458772106641756Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:149
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000064483
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 18 18 18 2 47 20 11 11
Low 1 35 33 23 12 23 8 9 27 15 30 8
Below cutoff 6 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07016042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07016043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01081187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000064483   ⟹   ENSRNOP00000063258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1492,342,998 - 92,495,894 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086154   ⟹   ENSRNOP00000072330
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1492,342,957 - 92,577,936 (-)Ensembl
RefSeq Acc Id: NM_001107236   ⟹   NP_001100706
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,342,998 - 92,495,894 (-)NCBI
Rnor_5.01492,142,186 - 92,321,314 (-)NCBI
RGSC_v3.41493,154,637 - 93,309,406 (-)RGD
Celera1485,826,388 - 85,975,943 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599225   ⟹   XP_017454714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,341,949 - 92,497,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599226   ⟹   XP_017454715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,341,949 - 92,497,168 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599227   ⟹   XP_017454716
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,341,949 - 92,497,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599228   ⟹   XP_017454717
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01492,341,949 - 92,497,168 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001100706   ⟸   NM_001107236
- UniProtKB: D3ZUI5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454716   ⟸   XM_017599227
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017454714   ⟸   XM_017599225
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K2Q1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454715   ⟸   XM_017599226
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017454717   ⟸   XM_017599228
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000072330   ⟸   ENSRNOT00000086154
RefSeq Acc Id: ENSRNOP00000063258   ⟸   ENSRNOT00000064483
Protein Domains
WH2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1312002 AgrOrtholog
Ensembl Genes ENSRNOG00000004281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000063258 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072330 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064483 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086154 ENTREZGENE, UniProtKB/TrEMBL
InterPro COBL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cordon-bleu_ubiquitin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305497 UniProtKB/Swiss-Prot
NCBI Gene 305497 ENTREZGENE
PANTHER PTHR47008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cobl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cobl PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.114948 ENTREZGENE
UniProt A0A0G2K2Q1 ENTREZGENE, UniProtKB/TrEMBL
  COBL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Cobl  cordon-bleu WH2 repeat protein  Cobl  cordon-bleu homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Cobl  cordon-bleu homolog (mouse)  Cobl  cordon-bleu   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cobl  cordon-bleu   Cobl_predicted  cordon-bleu (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cobl_predicted  cordon-bleu (predicted)      Symbol and Name status set to approved 70820 APPROVED