Vstm2a (V-set and transmembrane domain containing 2A) - Rat Genome Database

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Pathways
Gene: Vstm2a (V-set and transmembrane domain containing 2A) Rattus norvegicus
Analyze
Symbol: Vstm2a
Name: V-set and transmembrane domain containing 2A
RGD ID: 1596197
Description: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including cellular response to BMP stimulus; positive regulation of brown fat cell differentiation; and positive regulation of white fat cell proliferation. Predicted to be located in extracellular region. Orthologous to human VSTM2A (V-set and transmembrane domain containing 2A); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC689106; LOC102546914; LOC364204; LOC689106; V-set and transmembrane domain-containing protein 2A; V-set and transmembrane domain-containing protein 2A-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21490,660,012 - 90,897,561 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1490,660,004 - 90,685,656 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01499,528,996 - 99,558,304 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,529,284 - 99,554,479 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01499,292,180 - 99,317,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,074,759 - 97,100,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1489,755,785 - 89,785,082 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:28052263  


Genomics

Comparative Map Data
Vstm2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21490,660,012 - 90,897,561 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1490,660,004 - 90,685,656 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01499,528,996 - 99,558,304 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,529,284 - 99,554,479 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01499,292,180 - 99,317,627 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,074,759 - 97,100,169 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1489,755,785 - 89,785,082 (+)NCBICelera
Cytogenetic Map14q22NCBI
VSTM2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38754,542,375 - 54,571,067 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl754,542,325 - 54,571,080 (+)EnsemblGRCh38hg38GRCh38
GRCh37754,610,068 - 54,638,760 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36754,577,513 - 54,604,442 (+)NCBINCBI36Build 36hg18NCBI36
Celera754,714,731 - 54,741,659 (+)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef754,447,719 - 54,473,944 (+)NCBIHuRef
CHM1_1754,612,543 - 54,639,436 (+)NCBICHM1_1
T2T-CHM13v2.0754,702,348 - 54,731,660 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2754,615,835 - 54,642,765 (+)NCBI
Vstm2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,207,742 - 16,234,551 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1116,207,724 - 16,377,310 (+)EnsemblGRCm39 Ensembl
GRCm381116,257,742 - 16,284,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,257,724 - 16,427,310 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,157,727 - 16,184,554 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361116,157,775 - 16,184,189 (+)NCBIMGSCv36mm8
Celera1116,651,091 - 16,678,297 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map118.89NCBI
Vstm2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955456767,303 - 794,635 (-)NCBIChiLan1.0ChiLan1.0
VSTM2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan17107,700,323 - 107,729,191 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,136,669 - 55,168,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1755,447,878 - 55,477,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl755,447,878 - 55,477,148 (+)Ensemblpanpan1.1panPan2
VSTM2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,344,966 - 5,373,486 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,345,261 - 5,371,332 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,199,044 - 5,395,038 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,401,270 - 5,591,014 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,400,982 - 5,495,682 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,392,587 - 5,582,022 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,366,130 - 5,556,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,469,372 - 5,660,933 (+)NCBIUU_Cfam_GSD_1.0
Vstm2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118108,918,690 - 108,997,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678945,791 - 971,219 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936678932,663 - 970,905 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VSTM2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9138,990,480 - 138,997,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19138,990,480 - 139,017,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29153,209,795 - 153,236,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VSTM2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,300,584 - 4,330,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,298,700 - 4,330,543 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606218,165,655 - 18,195,538 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vstm2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740999,851 - 1,023,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740997,516 - 1,023,489 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vstm2a
1722 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:46
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000006897, ENSRNOT00000067134
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

Markers in Region
RH132214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21490,666,175 - 90,666,361 (+)MAPPERmRatBN7.2
Rnor_6.01499,535,184 - 99,535,369NCBIRnor6.0
Rnor_5.01499,313,991 - 99,314,176UniSTSRnor5.0
RGSC_v3.41497,081,168 - 97,081,353UniSTSRGSC3.4
Celera1489,761,956 - 89,762,141UniSTS
RH 3.4 Map14678.4UniSTS
Cytogenetic Map14q22UniSTS
RH138403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21490,665,462 - 90,665,617 (+)MAPPERmRatBN7.2
Rnor_6.01499,534,471 - 99,534,625NCBIRnor6.0
Rnor_5.01499,314,735 - 99,314,889UniSTSRnor5.0
RGSC_v3.41497,080,455 - 97,080,609UniSTSRGSC3.4
Celera1489,761,243 - 89,761,397UniSTS
RH 3.4 Map14679.1UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58 14 22
Low 3 14 3 3 14 21 13 3
Below cutoff 16 24 10 10 10 4 5 2 3 7 4

Sequence


RefSeq Acc Id: ENSRNOT00000006897   ⟹   ENSRNOP00000006897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1490,660,004 - 90,685,656 (+)Ensembl
Rnor_6.0 Ensembl1499,529,284 - 99,554,309 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067134   ⟹   ENSRNOP00000063877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1499,529,284 - 99,554,479 (+)Ensembl
RefSeq Acc Id: XM_039092861   ⟹   XP_038948789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,660,014 - 90,690,446 (+)NCBI
RefSeq Acc Id: XM_039092862   ⟹   XP_038948790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,660,012 - 90,897,561 (+)NCBI
RefSeq Acc Id: XM_039092863   ⟹   XP_038948791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,660,014 - 90,690,446 (+)NCBI
RefSeq Acc Id: XM_039092865   ⟹   XP_038948793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,660,014 - 90,685,234 (+)NCBI
RefSeq Acc Id: XM_039092866   ⟹   XP_038948794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,660,014 - 90,670,714 (+)NCBI
RefSeq Acc Id: XM_039092867   ⟹   XP_038948795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21490,662,587 - 90,690,984 (+)NCBI
RefSeq Acc Id: ENSRNOP00000063877   ⟸   ENSRNOT00000067134
RefSeq Acc Id: ENSRNOP00000006897   ⟸   ENSRNOT00000006897
RefSeq Acc Id: XP_038948790   ⟸   XM_039092862
- Peptide Label: isoform X2
- UniProtKB: A6JPX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948791   ⟸   XM_039092863
- Peptide Label: isoform X3
- UniProtKB: D3ZM70 (UniProtKB/TrEMBL),   A6JPX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948789   ⟸   XM_039092861
- Peptide Label: isoform X1
- UniProtKB: A6JPX3 (UniProtKB/TrEMBL),   A6JPX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948793   ⟸   XM_039092865
- Peptide Label: isoform X4
- UniProtKB: A6JPX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948794   ⟸   XM_039092866
- Peptide Label: isoform X5
- UniProtKB: A6JPX2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948795   ⟸   XM_039092867
- Peptide Label: isoform X6
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWD0-F1-model_v2 AlphaFold D3ZWD0 1-250 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596197 AgrOrtholog
BioCyc Gene G2FUF-14946 BioCyc
Ensembl Genes ENSRNOG00000005180 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006897 ENTREZGENE
  ENSRNOP00000006897.7 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006897 ENTREZGENE
  ENSRNOT00000006897.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
NCBI Gene 689106 ENTREZGENE
PANTHER V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2A UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Vstm2a PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6JPX2 ENTREZGENE, UniProtKB/TrEMBL
  A6JPX3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZM70 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Vstm2a  V-set and transmembrane domain containing 2A  LOC102546914  V-set and transmembrane domain-containing protein 2A-like  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102546914  V-set and transmembrane domain-containing protein 2A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Vstm2a  V-set and transmembrane domain containing 2A  LOC689106  hypothetical protein LOC689106  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689106  hypothetical protein LOC689106  RGD1308957_predicted  similar to cDNA sequence BC027127; 9330184N17Rik (predicted)  Data Merged 1643240 APPROVED
2006-11-20 LOC689106  hypothetical protein LOC689106      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1308957_predicted  similar to cDNA sequence BC027127; 9330184N17Rik (predicted)  LOC364204_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364204_predicted  similar to cDNA sequence BC027127; 9330184N17Rik (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL