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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:731837 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:731837 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Striatal neurochemical changes in transgenic models of Huntington's disease. | Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29. |
2. | DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families. | Bakker SC, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):50-2. |
3. | Increased expression of dopamine receptors on lymphocytes in Parkinson's disease. | Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71. |
4. | Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor. | Barr CL, etal., Mol Psychiatry. 2000 Sep;5(5):548-51. |
5. | The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8. |
6. | Dopamine receptors - IUPHAR Review 13. | Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23. |
7. | Dopamine D5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release. | Berlanga ML, etal., J Comp Neurol. 2005 Nov 7;492(1):34-49. |
8. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
9. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
10. | Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. | Hollon TR, etal., J Neurosci. 2002 Dec 15;22(24):10801-10. |
11. | Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. | Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19. |
12. | Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. | Kustanovich V, etal., Mol Psychiatry 2004 Jul;9(7):711-7. |
13. | Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. | Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9. |
14. | The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. | Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1. |
15. | Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus. | Medin T, etal., Neuroscience. 2011 Sep 29;192:164-71. Epub 2011 Jun 25. |
16. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
17. | A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. | Misbahuddin A, etal., Neurology 2002 Jan 8;58(1):124-6. |
18. | Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus. | Mockett BG, etal., Brain Res. 2004 Sep 17;1021(1):92-100. |
19. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
20. | Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. | O'Carroll CM, etal., Learn Mem. 2006 Nov-Dec;13(6):760-9. |
21. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
22. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
23. | Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. | Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22. |
24. | GOA pipeline | RGD automated data pipeline |
25. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
26. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
27. | Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. | Schilström B, etal., J Neurosci. 2006 Aug 16;26(33):8549-58. doi: 10.1523/JNEUROSCI.5179-05.2006. |
28. | Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. | Taurines R, etal., World J Biol Psychiatry. 2011 Sep;12 Suppl 1:104-8. |
29. | Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. | Tiberi M, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7491-5. |
30. | The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors. | Tome M, etal., Cell Tissue Res. 2004 Jul;317(1):65-77. Epub 2004 Jun 9. |
31. | Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors. | Yasunari K, etal., J Cardiovasc Pharmacol. 2003 Jan;41 Suppl 1:S33-8. |
32. | Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron. | Zheng S, etal., Hypertension 2003 Mar;41(3):604-10. |
PMID:1826762 | PMID:9603210 | PMID:10531415 | PMID:11500503 | PMID:11595429 | PMID:11823893 | PMID:12768268 | PMID:12867509 | PMID:13679419 | PMID:15598876 | PMID:15696326 | PMID:16352863 |
PMID:16962565 | PMID:17293055 | PMID:18403039 | PMID:19669160 | PMID:19690230 | PMID:19723560 | PMID:20226768 | PMID:20531939 | PMID:20646048 | PMID:21768371 | PMID:22038910 | PMID:22707255 |
PMID:23541742 | PMID:23626827 | PMID:23672849 | PMID:23977170 | PMID:25775606 | PMID:27652590 | PMID:28154160 | PMID:28259782 | PMID:28336436 | PMID:29537707 | PMID:34064454 | PMID:34881789 |
PMID:35478421 |
Drd5 (Rattus norvegicus - Norway rat) |
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DRD5 (Homo sapiens - human) |
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Drd5 (Mus musculus - house mouse) |
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Drd5 (Chinchilla lanigera - long-tailed chinchilla) |
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DRD5 (Pan paniscus - bonobo/pygmy chimpanzee) |
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DRD5 (Canis lupus familiaris - dog) |
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Drd5 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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DRD5 (Sus scrofa - pig) |
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DRD5 (Chlorocebus sabaeus - green monkey) |
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Drd5 (Heterocephalus glaber - naked mole-rat) |
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Variants in Drd5
3 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
D14Mgh8 |
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D14Arb11 |
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D14Uia1 |
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D14Mco3 |
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D14Mco14 |
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D14Wox23 |
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UniSTS:166211 |
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UniSTS:495985 |
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nervous system | reproductive system | |
High | ||
Medium | ||
Low | 41 | 2 |
Below cutoff | 21 | 5 |
RefSeq Transcripts | NM_012768 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | CH473963 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
JACYVU010000254 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M69118 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000007074 ⟹ ENSRNOP00000007074 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_012768 ⟹ NP_036900 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_036900 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAA41072 | (Get FASTA) | NCBI Sequence Viewer |
EDL99998 | (Get FASTA) | NCBI Sequence Viewer | |
P25115 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036900 ⟸ NM_012768 |
- UniProtKB: | G3V6N6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000007074 ⟸ ENSRNOT00000007074 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P25115-F1-model_v2 | AlphaFold | P25115 | 1-475 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:2523 | AgrOrtholog |
BioCyc Gene | G2FUF-15387 | BioCyc |
Ensembl Genes | ENSRNOG00000005338 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000007074 | ENTREZGENE |
ENSRNOP00000007074.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000007074 | ENTREZGENE |
ENSRNOT00000007074.3 | UniProtKB/TrEMBL | |
Gene3D-CATH | Rhodopsin 7-helix transmembrane proteins | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Dopamine_D5_rcpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Dopamine_rcpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_Rhodpsn | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCR_Rhodpsn_7TM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:25195 | UniProtKB/Swiss-Prot |
NCBI Gene | 25195 | ENTREZGENE |
PANTHER | ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
D(1B) DOPAMINE RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | 7tm_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PharmGKB | DRD5 | RGD |
PhenoGen | Drd5 | PhenoGen |
PRINTS | DOPAMINED1BR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
DOPAMINER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GPCRRHODOPSN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | 7TM_GPCR_Srsx | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | Family A G protein-coupled receptor-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | DRD5_RAT | UniProtKB/Swiss-Prot |
G3V6N6 | ENTREZGENE, UniProtKB/TrEMBL | |
P25115 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2006-03-30 | Drd5 | dopamine receptor D5 | dopamine receptor 5 | Name updated | 1299863 | APPROVED | |
2002-06-10 | Drd5 | Dopamine receptor D5 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_expression | present in hippocampus, mammillary nuclei, and anterior pretectal nuclei | 728422 |
gene_protein | 475 amino acids; 52.8 kDa | 728422 |