Drd5 (dopamine receptor D5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Drd5 (dopamine receptor D5) Rattus norvegicus
Analyze
Symbol: Drd5
Name: dopamine receptor D5
RGD ID: 2523
Description: Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating dopamine receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (dopamine receptor D5); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: d(1B) dopamine receptor; d(5) dopamine receptor; D1B; dopamine D5 receptor; dopamine receptor 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,700,244 - 76,703,344 (-)NCBIGRCr8
mRatBN7.21472,487,950 - 72,491,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1472,489,347 - 72,490,774 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1476,931,000 - 76,932,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,171,890 - 78,173,317 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,611,945 - 74,613,372 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,220,579 - 77,222,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,220,579 - 77,222,006 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,202,167 - 77,203,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,768,060 - 77,769,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11477,770,450 - 77,771,878 (-)NCBI
Celera1471,440,495 - 71,441,922 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Striatal neurochemical changes in transgenic models of Huntington's disease. Ariano MA, etal., J Neurosci Res. 2002 Jun 15;68(6):716-29.
2. DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families. Bakker SC, etal., Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):50-2.
3. Increased expression of dopamine receptors on lymphocytes in Parkinson's disease. Barbanti P, etal., Mov Disord. 1999 Sep;14(5):764-71.
4. Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor. Barr CL, etal., Mol Psychiatry. 2000 Sep;5(5):548-51.
5. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
6. Dopamine receptors - IUPHAR Review 13. Beaulieu JM, etal., Br J Pharmacol. 2015 Jan;172(1):1-23.
7. Dopamine D5 receptor localization on cholinergic neurons of the rat forebrain and diencephalon: a potential neuroanatomical substrate involved in mediating dopaminergic influences on acetylcholine release. Berlanga ML, etal., J Comp Neurol. 2005 Nov 7;492(1):34-49.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive. Hollon TR, etal., J Neurosci. 2002 Dec 15;22(24):10801-10.
11. Immunohistochemical localization of dopamine receptor subtypes (D1R-D5R) in Alzheimer's disease brain. Kumar U and Patel SC, Brain Res. 2007 Feb 2;1131(1):187-96. Epub 2006 Dec 19.
12. Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5. Kustanovich V, etal., Mol Psychiatry 2004 Jul;9(7):711-7.
13. Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. Lemon N and Manahan-Vaughan D, J Neurosci. 2006 Jul 19;26(29):7723-9.
14. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Li Q, etal., Neurochem Int. 2007 May;50(6):848-57. Epub 2007 Mar 1.
15. Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus. Medin T, etal., Neuroscience. 2011 Sep 29;192:164-71. Epub 2011 Jun 25.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Misbahuddin A, etal., Neurology 2002 Jan 8;58(1):124-6.
18. Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus. Mockett BG, etal., Brain Res. 2004 Sep 17;1021(1):92-100.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. O'Carroll CM, etal., Learn Mem. 2006 Nov-Dec;13(6):760-9.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Colocalization of dopamine receptor subtypes with dopamine and cAMP-regulated phosphoprotein (DARPP-32) in rat brain. Rajput PS, etal., Neurosci Res. 2009 Sep;65(1):53-63. Epub 2009 May 22.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Cocaine enhances NMDA receptor-mediated currents in ventral tegmental area cells via dopamine D5 receptor-dependent redistribution of NMDA receptors. Schilström B, etal., J Neurosci. 2006 Aug 16;26(33):8549-58. doi: 10.1523/JNEUROSCI.5179-05.2006.
28. Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder. Taurines R, etal., World J Biol Psychiatry. 2011 Sep;12 Suppl 1:104-8.
29. Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Tiberi M, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7491-5.
30. The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors. Tome M, etal., Cell Tissue Res. 2004 Jul;317(1):65-77. Epub 2004 Jun 9.
31. Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors. Yasunari K, etal., J Cardiovasc Pharmacol. 2003 Jan;41 Suppl 1:S33-8.
32. Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron. Zheng S, etal., Hypertension 2003 Mar;41(3):604-10.
Additional References at PubMed
PMID:1826762   PMID:9603210   PMID:10531415   PMID:11500503   PMID:11595429   PMID:11823893   PMID:12768268   PMID:12867509   PMID:13679419   PMID:15598876   PMID:15696326   PMID:16352863  
PMID:16962565   PMID:17293055   PMID:18403039   PMID:19669160   PMID:19690230   PMID:19723560   PMID:20226768   PMID:20531939   PMID:20646048   PMID:21768371   PMID:22038910   PMID:22707255  
PMID:23541742   PMID:23626827   PMID:23672849   PMID:23977170   PMID:25775606   PMID:27652590   PMID:28154160   PMID:28259782   PMID:28336436   PMID:29537707   PMID:34064454   PMID:34881789  
PMID:35478421  


Genomics

Comparative Map Data
Drd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,700,244 - 76,703,344 (-)NCBIGRCr8
mRatBN7.21472,487,950 - 72,491,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1472,489,347 - 72,490,774 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1476,931,000 - 76,932,427 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,171,890 - 78,173,317 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,611,945 - 74,613,372 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,220,579 - 77,222,006 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,220,579 - 77,222,006 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,202,167 - 77,203,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,768,060 - 77,769,487 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11477,770,450 - 77,771,878 (-)NCBI
Celera1471,440,495 - 71,441,922 (-)NCBICelera
Cytogenetic Map14q21NCBI
DRD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3849,781,634 - 9,784,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl49,781,634 - 9,784,009 (+)EnsemblGRCh38hg38GRCh38
GRCh3749,783,258 - 9,785,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3649,392,701 - 9,394,731 (+)NCBINCBI36Build 36hg18NCBI36
Build 3449,459,871 - 9,461,901NCBI
Celera410,266,117 - 10,268,492 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef49,117,663 - 9,120,038 (+)NCBIHuRef
CHM1_149,781,174 - 9,783,549 (+)NCBICHM1_1
T2T-CHM13v2.049,781,407 - 9,783,782 (+)NCBIT2T-CHM13v2.0
Drd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39538,476,742 - 38,479,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl538,476,710 - 38,479,861 (+)EnsemblGRCm39 Ensembl
GRCm38538,319,509 - 38,322,523 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl538,319,367 - 38,322,518 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,710,748 - 38,713,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,607,758 - 38,610,559 (+)NCBIMGSCv36mm8
Celera535,773,146 - 35,775,947 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.4NCBI
Drd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555145,450,495 - 5,452,282 (+)NCBIChiLan1.0ChiLan1.0
DRD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2310,026,932 - 10,030,293 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1410,235,569 - 10,237,977 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v044,189,536 - 4,193,144 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.149,508,711 - 9,511,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl49,509,094 - 9,510,527 (+)Ensemblpanpan1.1panPan2
DRD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,621,187 - 69,623,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,621,734 - 69,623,893 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,173,244 - 72,175,212 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0370,378,089 - 70,380,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl370,378,633 - 70,380,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1369,652,224 - 69,654,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,817,637 - 69,819,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,198,942 - 70,200,910 (-)NCBIUU_Cfam_GSD_1.0
Drd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,158,693 - 63,162,200 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647716,861,773 - 16,863,215 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647716,860,222 - 16,863,505 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DRD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl86,180,221 - 6,181,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.186,180,221 - 6,182,575 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.285,694,230 - 5,696,186 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DRD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12740,267,681 - 40,270,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2740,268,235 - 40,269,671 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604787,064,155 - 87,066,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Drd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475521,358,586 - 21,361,410 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Drd5
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:53
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000007074
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
D14Mgh8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21472,489,207 - 72,489,324 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,440 - 77,220,556NCBIRnor6.0
Rnor_5.01477,202,028 - 77,202,144UniSTSRnor5.0
RGSC_v3.41477,767,919 - 77,768,037RGDRGSC3.4
RGSC_v3.41477,767,921 - 77,768,037UniSTSRGSC3.4
RGSC_v3.11477,770,310 - 77,770,428RGD
Celera1471,440,356 - 71,440,472UniSTS
Cytogenetic Map14q21UniSTS
D14Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81476,701,498 - 76,701,771 (+)Marker Load Pipeline
mRatBN7.21472,489,205 - 72,489,477 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,438 - 77,220,709NCBIRnor6.0
Rnor_5.01477,202,026 - 77,202,297UniSTSRnor5.0
RGSC_v3.41477,767,919 - 77,768,190UniSTSRGSC3.4
RGSC_v3.11477,770,308 - 77,770,581RGD
Celera1471,440,354 - 71,440,625UniSTS
FHH x ACI Map1455.78RGD
FHH x ACI Map1455.78UniSTS
Cytogenetic Map14q21UniSTS
D14Uia1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81476,701,498 - 76,701,598 (+)Marker Load Pipeline
mRatBN7.21472,489,204 - 72,489,304 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,437 - 77,220,536NCBIRnor6.0
Rnor_5.01477,202,025 - 77,202,124UniSTSRnor5.0
RGSC_v3.41477,767,917 - 77,768,017RGDRGSC3.4
RGSC_v3.41477,767,918 - 77,768,017UniSTSRGSC3.4
RGSC_v3.11477,770,308 - 77,770,408RGD
Celera1471,440,353 - 71,440,452UniSTS
Cytogenetic Map14q21UniSTS
D14Mco3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01477,202,026 - 77,202,220UniSTSRnor5.0
Celera1471,440,354 - 71,440,548UniSTS
Cytogenetic Map14q21UniSTS
D14Mco14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81476,701,498 - 76,701,694 (+)Marker Load Pipeline
mRatBN7.21472,489,205 - 72,489,400 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,438 - 77,220,632NCBIRnor6.0
Rnor_5.01477,202,026 - 77,202,220UniSTSRnor5.0
RGSC_v3.41477,767,919 - 77,768,113UniSTSRGSC3.4
Celera1471,440,354 - 71,440,548UniSTS
Cytogenetic Map14q21UniSTS
D14Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21472,489,208 - 72,489,385 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,441 - 77,220,617NCBIRnor6.0
Rnor_5.01477,202,029 - 77,202,205UniSTSRnor5.0
RGSC_v3.41477,767,922 - 77,768,098UniSTSRGSC3.4
Celera1471,440,357 - 71,440,533UniSTS
Cytogenetic Map14q21UniSTS
UniSTS:166211  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21472,489,425 - 72,489,600 (+)MAPPERmRatBN7.2
Rnor_6.01477,220,658 - 77,220,832NCBIRnor6.0
Rnor_5.01477,202,246 - 77,202,420UniSTSRnor5.0
RGSC_v3.41477,768,139 - 77,768,313UniSTSRGSC3.4
Celera1471,440,574 - 71,440,748UniSTS
Cytogenetic Map14q21UniSTS
UniSTS:495985  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21472,489,987 - 72,490,057 (+)MAPPERmRatBN7.2
Rnor_6.01477,221,220 - 77,221,289NCBIRnor6.0
Rnor_5.01477,202,808 - 77,202,877UniSTSRnor5.0
RGSC_v3.41477,768,701 - 77,768,770UniSTSRGSC3.4
Celera1471,441,136 - 71,441,205UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
nervous system
renal system
reproductive system
77 2 1 1 1 2 77 1 18

Sequence


Ensembl Acc Id: ENSRNOT00000007074   ⟹   ENSRNOP00000007074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1472,489,347 - 72,490,774 (-)Ensembl
Rnor_6.0 Ensembl1477,220,579 - 77,222,006 (-)Ensembl
RefSeq Acc Id: NM_012768   ⟹   NP_036900
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81476,700,244 - 76,703,344 (-)NCBI
mRatBN7.21472,487,950 - 72,491,050 (-)NCBI
Rnor_6.01477,220,579 - 77,222,006 (-)NCBI
Rnor_5.01477,202,167 - 77,203,594 (-)NCBI
RGSC_v3.41477,768,060 - 77,769,487 (-)RGD
Celera1471,440,495 - 71,441,922 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036900 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41072 (Get FASTA)   NCBI Sequence Viewer  
  EDL99998 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007074
GenBank Protein P25115 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036900   ⟸   NM_012768
- UniProtKB: P25115 (UniProtKB/Swiss-Prot),   G3V6N6 (UniProtKB/TrEMBL),   A6IJT5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007074   ⟸   ENSRNOT00000007074
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25115-F1-model_v2 AlphaFold P25115 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2523 AgrOrtholog
BioCyc Gene G2FUF-15387 BioCyc
Ensembl Genes ENSRNOG00000005338 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007074 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Dopamine_D5_rcpt UniProtKB/Swiss-Prot
  Dopamine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25195 UniProtKB/Swiss-Prot
NCBI Gene 25195 ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  D(1B) DOPAMINE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB DRD5 RGD
PhenoGen Drd5 PhenoGen
PRINTS DOPAMINED1BR UniProtKB/Swiss-Prot
  DOPAMINER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005338 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6IJT5 ENTREZGENE, UniProtKB/TrEMBL
  DRD5_RAT UniProtKB/Swiss-Prot
  G3V6N6 ENTREZGENE, UniProtKB/TrEMBL
  P25115 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Drd5  dopamine receptor D5    dopamine receptor 5  Name updated 1299863 APPROVED
2002-06-10 Drd5  Dopamine receptor D5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression present in hippocampus, mammillary nuclei, and anterior pretectal nuclei 728422
gene_protein 475 amino acids; 52.8 kDa 728422