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Gene: Nefh (neurofilament heavy) Rattus norvegicus
Symbol: Nefh
Name: neurofilament heavy
RGD ID: 3159
Description: Exhibits protein-macromolecule adaptor activity and toxic substance binding activity. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and ovarian follicle atresia. Localizes to several cellular components, including dendrite; intermediate filament; and perikaryon. Used to study congenital hypothyroidism. Biomarker of glaucoma; hypothyroidism; phenylketonuria; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH (+)-alpha-tocopherol; (R)-adrenaline; 1,2-dichlorobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 200 kDa neurofilament protein; neurofilament heavy polypeptide; neurofilament triplet H protein; neurofilament, heavy polypeptide; NF-H; Nfh
Homo sapiens (human) : NEFH (neurofilament heavy)  HGNC  Alliance
Mus musculus (house mouse) : Nefh (neurofilament, heavy polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefh (neurofilament heavy)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFH (neurofilament heavy)
Canis lupus familiaris (dog) : NEFH (neurofilament heavy)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefh (neurofilament heavy)
Sus scrofa (pig) : NEFH (neurofilament heavy)
Chlorocebus sabaeus (African green monkey) : NEFH (neurofilament heavy)
Heterocephalus glaber (naked mole-rat) : Nefh (neurofilament heavy)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01485,181,572 - 85,191,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,181,572 - 85,191,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,859,193 - 85,869,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,594,789 - 85,604,774 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11485,614,415 - 85,623,919 (-)NCBI
Celera1478,720,827 - 78,730,812 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nefh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3159
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.