RGD Reference Report - The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies. - Rat Genome Database

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The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies.

Authors: Petzold, Axel  Plant, Gordon T 
Citation: Petzold A and Plant GT, Mult Scler Int. 2012;2012:217802. doi: 10.1155/2012/217802. Epub 2012 Dec 17.
RGD ID: 27226805
Pubmed: PMID:23316360   (View Abstract at PubMed)
PMCID: PMC3534363   (View Article at PubMed Central)
DOI: DOI:10.1155/2012/217802   (Journal Full-text)

Background. Loss of visual function differs between immune-mediated optic neuropathies and is related to axonal loss in the optic nerve. This study investigated the diagnostic and prognostic value of a biomarker for neurodegeneration, the neurofilament heavy chain (NfH) in three immune-mediated optic neuropathies. Methods. A prospective, longitudinal study including patients with optic neuritis due to multiple sclerosis (MSON, n = 20), chronic relapsing inflammatory optic neuritis (CRION, n = 19), neuromyelitis optica (NMO, n = 9), and healthy controls (n = 28). Serum NfH-SMI35 levels were quantified by ELISA. Findings. Serum NfH-SMI35 levels were highest in patients with NMO (mean 0.79 ± 1.51 ng/mL) compared to patients with CRION (0.13 ± 0.16 ng/mL, P = 0.007), MSON (0.09 ± 0.09, P = 0.008), and healthy controls (0.01 ± 0.02 ng/mL, P = 0.001). High serum NfH-SMI35 levels were related to poor visual outcome. Conclusions. Blood NfH-SMI35 levels are of moderate diagnostic and more important prognostic value in immune-mediated optic neuropathies. We speculate that longitudinal blood NfH levels may help to identify particular disabling events in relapsing conditions.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NEFHHumanautoimmune optic neuritis severityIEP  RGD 
NefhRatautoimmune optic neuritis severityISONEFH (Homo sapiens) RGD 
NefhMouseautoimmune optic neuritis severityISONEFH (Homo sapiens) RGD 
NEFHHumanneuromyelitis optica  IEP protein:increased expression:serum:RGD 
NefhRatneuromyelitis optica  ISONEFH (Homo sapiens)protein:increased expression:serum:RGD 
NefhMouseneuromyelitis optica  ISONEFH (Homo sapiens)protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nefh  (neurofilament heavy chain)

Genes (Mus musculus)
Nefh  (neurofilament, heavy polypeptide)

Genes (Homo sapiens)
NEFH  (neurofilament heavy chain)


Additional Information