Nefh (neurofilament, heavy polypeptide) - Rat Genome Database

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Gene: Nefh (neurofilament, heavy polypeptide) Mus musculus
Analyze
Symbol: Nefh
Name: neurofilament, heavy polypeptide
RGD ID: 10969
MGI Page MGI
Description: A structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in axon development and postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within cellular response to leukemia inhibitory factor; cytoskeleton organization; and peripheral nervous system neuron axonogenesis. Located in axon; neurofilament; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and postsynaptic intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 200 kDa neurofilament protein; mKIAA0845; NEF; neurofilament 200kDa; neurofilament heavy polypeptide; neurofilament triplet H protein; NF-; NF-H; NF20; NF200; Nfh
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,888,754 - 4,898,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,888,754 - 4,898,064 (-)EnsemblGRCm39 Ensembl
GRCm38114,938,754 - 4,948,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,938,754 - 4,948,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,838,757 - 4,848,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,838,761 - 4,851,268 (-)NCBIMGSCv36mm8
Celera115,436,254 - 5,444,974 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(R)-adrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichlorobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,5-hexanedione  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyladenine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetonitrile  (ISO)
actinomycin D  (ISO)
aldicarb  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-amanitin  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
Ampullosporin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
atropine  (ISO)
benzo[a]pyrene  (ISO)
benzyl benzoate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon disulfide  (ISO)
carbonyl sulfide  (ISO)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cypermethrin  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
deguelin  (ISO)
diazepam  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorvos  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxycycline  (ISO)
emetine  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethylene glycol  (ISO)
fenvalerate  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glufosinate  (ISO)
glycerol  (ISO)
graphite  (ISO)
hydroquinone  (ISO)
ketamine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lithium sulfate  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP)
mercury dibromide  (ISO)
methanol  (ISO)
methylmercury chloride  (ISO)
Mipafox  (ISO)
mitoxantrone  (ISO)
morphine  (ISO)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (ISO)
ochratoxin A  (ISO)
octanoic acid  (ISO)
octyl gallate  (ISO)
orphenadrine  (ISO)
ozone  (EXP)
paraoxon  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP,ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium citrate monohydrate  (ISO)
potassium sulfate  (ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propranolol  (ISO)
puromycin  (ISO)
resveratrol  (ISO)
Riluzole  (ISO)
rotenone  (ISO)
sarin  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichlorfon  (ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
Tryptanthrine  (ISO)
tunicamycin  (ISO)
urea  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
Withanone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Al-Chalabi A, etal., Hum Mol Genet 1999 Feb;8(2):157-64.
2. Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma. Bordone MP, etal., J Neurochem. 2017 Jul;142(2):323-337. doi: 10.1111/jnc.14070. Epub 2017 Jun 9.
3. Effects of brain ischemia on intermediate filaments of rat hippocampus. Camargo-De-Morais M, etal., Neurochem Res. 1996 May;21(5):595-602.
4. The prognostic value of neurofilament levels in patients with sepsis-associated encephalopathy - A prospective, pilot observational study. Ehler J, etal., PLoS One. 2019 Jan 24;14(1):e0211184. doi: 10.1371/journal.pone.0211184. eCollection 2019.
5. Regulation of neurofilament gene expression by thyroid hormone in the developing rat brain. Ghosh S, etal., Neuroreport. 1999 Aug 2;10(11):2361-5.
6. mRNA levels of all three neurofilament proteins decline following nerve transection. Goldstein ME, etal., Brain Res. 1988 Jun;427(3):287-91.
7. Overexpression of neurofilament subunit NF-L and NF-H extends survival of a mouse model for amyotrophic lateral sclerosis. Kong J and Xu Z, Neurosci Lett. 2000 Mar 3;281(1):72-4.
8. Cerebrospinal fluid light and heavy neurofilament level increased in anti-N-methyl-d-aspartate receptor encephalitis. Li J, etal., Brain Behav. 2019 Aug;9(8):e01354. doi: 10.1002/brb3.1354. Epub 2019 Jul 17.
9. Vascular Endothelial Growth Factor-Transfected Bone Marrow Mesenchymal Stem Cells Improve the Recovery of Motor and Sensory Functions of Rats With Spinal Cord Injury. Liu X, etal., Spine (Phila Pa 1976). 2020 Apr 1;45(7):E364-E372. doi: 10.1097/BRS.0000000000003333.
10. Longitudinal Assessment of Transorbital Sonography, Visual Acuity, and Biomarkers for Inflammation and Axonal Injury in Optic Neuritis. Lochner P, etal., Dis Markers. 2017;2017:5434310. doi: 10.1155/2017/5434310. Epub 2017 Sep 11.
11. Impaired Neurofilament Integrity and Neuronal Morphology in Different Models of Focal Cerebral Ischemia and Human Stroke Tissue. Mages B, etal., Front Cell Neurosci. 2018 Jun 18;12:161. doi: 10.3389/fncel.2018.00161. eCollection 2018.
12. Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: multi-parametric assessment and direct evidence. Meyer L, etal., Pain. 2011 Jan;152(1):170-81. doi: 10.1016/j.pain.2010.10.015. Epub 2010 Nov 10.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. Overexpression of MAP2 and NF-H Associated with Dendritic Pathology in the Spinal Cord of Mice Infected with Rabies Virus. Monroy-Gómez J, etal., Viruses. 2018 Mar 6;10(3). pii: v10030112. doi: 10.3390/v10030112.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Neurofilament heavy chain expression and neuroplasticity in rat auditory cortex after unilateral and bilateral deafness. Park MH, etal., Hear Res. 2016 Sep;339:155-60. doi: 10.1016/j.heares.2016.07.010. Epub 2016 Jul 22.
18. The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies. Petzold A and Plant GT, Mult Scler Int. 2012;2012:217802. doi: 10.1155/2012/217802. Epub 2012 Dec 17.
19. Quantification of neurodegeneration by measurement of brain-specific proteins. Petzold A, etal., J Neuroimmunol. 2003 May;138(1-2):45-8. doi: 10.1016/s0165-5728(03)00092-4.
20. Axonal degeneration and inflammation in acute optic neuritis. Petzold A, etal., J Neurol Neurosurg Psychiatry. 2004 Aug;75(8):1178-80. doi: 10.1136/jnnp.2003.017236.
21. Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis. Petzold A, etal., Mult Scler. 2004 Jun;10(3):281-3. doi: 10.1191/1352458504ms1021sr.
22. The new global multiple sclerosis severity score (MSSS) correlates with axonal but not glial biomarkers. Petzold A, etal., Mult Scler. 2006 Jun;12(3):325-8. doi: 10.1191/135248505ms1277oa.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. Retarded development of neurons and oligodendroglia in rat forebrain produced by hyperphenylalaninemia results in permanent deficits in myelin despite long recovery periods. Reynolds R, etal., Exp Neurol. 1993 Dec;124(2):357-67.
25. Mouse MP Annotation Import Pipeline RGD automated import pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic rats. Sayers NM, etal., Diabetes. 2003 Sep;52(9):2372-80.
29. Thyroid hormones stimulate expression and modification of cytoskeletal protein during rat sciatic nerve regeneration. Schenker M, etal., Brain Res. 2002 Dec 13;957(2):259-70.
30. [Tetramethylpyrazine accelerated spinal cord repair through regulation of caspase-3 and neurofilament protein expression: an acute spinal cord injury model in rats]. Shen ZX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Aug;33(8):693-9.
31. Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease. Steinacker P, etal., Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737.
32. Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. Stubbs EB Jr, etal., Acta Neuropathol. 2003 Feb;105(2):109-16. Epub 2002 Sep 13.
33. Selective solubilization of high-molecular-mass neurofilament subunit during nerve regeneration. Tsuda M, etal., J Neurochem. 2000 Feb;74(2):860-8.
34. Artemin induced functional recovery and reinnervation after partial nerve injury. Wang R, etal., Pain. 2014 Mar;155(3):476-84. doi: 10.1016/j.pain.2013.11.007. Epub 2013 Nov 21.
35. Congenital hypothyroidism is associated with intermediate filament misregulation, glutamate transporters down-regulation and MAPK activation in developing rat brain. Zamoner A, etal., Neurotoxicology. 2008 Nov;29(6):1092-9. doi: 10.1016/j.neuro.2008.09.004. Epub 2008 Sep 18.
Additional References at PubMed
PMID:1315909   PMID:1349581   PMID:2292721   PMID:3103856   PMID:3138108   PMID:3145094   PMID:3220257   PMID:7526952   PMID:7533563   PMID:7536898   PMID:7561023   PMID:7563228  
PMID:7566355   PMID:7698769   PMID:7720210   PMID:7790359   PMID:7849698   PMID:7889564   PMID:7895274   PMID:8103600   PMID:8110465   PMID:8139657   PMID:8175776   PMID:8199405  
PMID:8401507   PMID:8416841   PMID:8462093   PMID:8462101   PMID:8510499   PMID:8555108   PMID:8575331   PMID:8622765   PMID:8632990   PMID:8653788   PMID:8790740   PMID:8793115  
PMID:8821035   PMID:8889548   PMID:8909545   PMID:8951795   PMID:8994061   PMID:9144923   PMID:9231734   PMID:9242412   PMID:9624616   PMID:9661659   PMID:9689131   PMID:9763429  
PMID:9763430   PMID:9763431   PMID:9804382   PMID:9819140   PMID:9865699   PMID:9971739   PMID:10221457   PMID:10331972   PMID:10349636   PMID:10360575   PMID:10369145   PMID:10397632  
PMID:10398046   PMID:10402469   PMID:10421573   PMID:10461886   PMID:10482239   PMID:10719886   PMID:10846156   PMID:10864954   PMID:11018052   PMID:11018158   PMID:11042159   PMID:11050249  
PMID:11076861   PMID:11090858   PMID:11135306   PMID:11156601   PMID:11163269   PMID:11217851   PMID:11241389   PMID:11343650   PMID:11487626   PMID:11493023   PMID:11493566   PMID:11516395  
PMID:11517264   PMID:11733539   PMID:11802174   PMID:11804570   PMID:11804571   PMID:11807832   PMID:11823413   PMID:11861467   PMID:11889045   PMID:12117822   PMID:12186852   PMID:12351730  
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PMID:15647317   PMID:15944387   PMID:16002469   PMID:16026466   PMID:16039563   PMID:16141072   PMID:16141073   PMID:16216006   PMID:16223892   PMID:16246456   PMID:16266786   PMID:16284245  
PMID:16330480   PMID:16481432   PMID:16514356   PMID:16540585   PMID:16602821   PMID:16678988   PMID:16794080   PMID:16817202   PMID:16854970   PMID:16978876   PMID:16981854   PMID:17005864  
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PMID:17875933   PMID:17913789   PMID:17961552   PMID:18090917   PMID:18179891   PMID:18305247   PMID:18371380   PMID:18385319   PMID:18430798   PMID:18434421   PMID:18455884   PMID:18455988  
PMID:18498732   PMID:18498735   PMID:18524893   PMID:18558633   PMID:18650339   PMID:18665422   PMID:18675571   PMID:18709652   PMID:18787067   PMID:18794345   PMID:18830272   PMID:18839409  
PMID:18940588   PMID:19423573   PMID:19457133   PMID:19541997   PMID:19554387   PMID:19571125   PMID:19717447   PMID:19726663   PMID:19783990   PMID:19786578   PMID:19838178   PMID:19850157  
PMID:19935654   PMID:19945391   PMID:19954489   PMID:20064392   PMID:20071536   PMID:20127431   PMID:20152827   PMID:20170731   PMID:20176735   PMID:20235171   PMID:20306637   PMID:20353824  
PMID:20394048   PMID:20439489   PMID:20534675   PMID:20616011   PMID:20619750   PMID:20633607   PMID:20706633   PMID:20830809   PMID:21119615   PMID:21210220   PMID:21220101   PMID:21228161  
PMID:21300867   PMID:21315259   PMID:21471385   PMID:21486449   PMID:21533046   PMID:21593306   PMID:21733846   PMID:21752988   PMID:21827743   PMID:21832185   PMID:21844226   PMID:21873635  
PMID:21884692   PMID:21945863   PMID:22028026   PMID:22048169   PMID:22048787   PMID:22090513   PMID:22103411   PMID:22241839   PMID:22243746   PMID:22345400   PMID:22353733   PMID:22427743  
PMID:22514301   PMID:22586713   PMID:22627288   PMID:22767514   PMID:22794259   PMID:22815892   PMID:22879516   PMID:22982106   PMID:23028520   PMID:23045641   PMID:23136128   PMID:23259946  
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PMID:38351062   PMID:38355793   PMID:38386003   PMID:38639409  


Genomics

Comparative Map Data
Nefh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,888,754 - 4,898,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,888,754 - 4,898,064 (-)EnsemblGRCm39 Ensembl
GRCm38114,938,754 - 4,948,064 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,938,754 - 4,948,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv37114,838,757 - 4,848,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,838,761 - 4,851,268 (-)NCBIMGSCv36mm8
Celera115,436,254 - 5,444,974 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.12NCBI
NEFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,480,218 - 29,491,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,480,218 - 29,491,390 (+)EnsemblGRCh38hg38GRCh38
GRCh372229,876,207 - 29,887,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,206,219 - 28,217,279 (+)NCBINCBI36Build 36hg18NCBI36
Build 342228,200,772 - 28,211,829NCBI
Celera2213,676,024 - 13,687,118 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,839,995 - 12,851,105 (+)NCBIHuRef
CHM1_12229,835,584 - 29,846,662 (+)NCBICHM1_1
T2T-CHM13v2.02229,943,567 - 29,954,761 (+)NCBIT2T-CHM13v2.0
Nefh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,044,428 - 84,054,413 (-)NCBIGRCr8
mRatBN7.21479,830,362 - 79,840,347 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,830,362 - 79,840,351 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1484,232,750 - 84,242,741 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,472,824 - 85,482,815 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,922,138 - 81,932,117 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,181,572 - 85,191,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,181,572 - 85,191,557 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,859,193 - 85,869,187 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,594,789 - 85,604,774 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11485,614,415 - 85,623,919 (-)NCBI
Celera1478,720,827 - 78,730,812 (-)NCBICelera
Cytogenetic Map14q21NCBI
Nefh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,735,410 - 3,744,107 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554553,735,330 - 3,744,714 (+)NCBIChiLan1.0ChiLan1.0
NEFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,453,989 - 39,465,030 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,155,232 - 42,166,273 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,525,738 - 10,536,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,331,778 - 28,341,874 (+)NCBIpanpan1.1PanPan1.1panPan2
NEFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,726,523 - 22,735,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,726,526 - 22,735,125 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,598,106 - 22,606,671 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,100,617 - 23,109,200 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,100,626 - 23,109,200 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,810,029 - 22,818,553 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,073,295 - 23,081,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,138,184 - 23,146,781 (+)NCBIUU_Cfam_GSD_1.0
Nefh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,417,611 - 112,427,289 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,443,485 - 3,453,133 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,443,406 - 3,453,096 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,559,860 - 46,568,088 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,559,698 - 46,568,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,572,997 - 49,583,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,357,982 - 12,375,449 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045113,778,644 - 113,789,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nefh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,806,645 - 5,815,554 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247475,806,576 - 5,816,158 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nefh
265 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:207
Count of miRNA genes:167
Interacting mature miRNAs:182
Transcripts:ENSMUST00000093369
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
42.MMHAP9FLF6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,941,225 - 4,941,378UniSTSGRCm38
MGSCv37114,841,228 - 4,841,381UniSTSGRCm37
Celera115,438,671 - 5,438,824UniSTS
Cytogenetic Map11A1-A5UniSTS
Whitehead_YAC11 UniSTS
M24496  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,939,072 - 4,939,238UniSTSGRCm38
MGSCv37114,839,075 - 4,839,241UniSTSGRCm37
Celera115,436,572 - 5,436,738UniSTS
Cytogenetic Map11A1-A5UniSTS
Whitehead_YAC11 UniSTS
Nefh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,939,069 - 4,939,520UniSTSGRCm38
MGSCv37114,839,072 - 4,839,523UniSTSGRCm37
Celera115,436,569 - 5,437,020UniSTS
Cytogenetic Map11A1-A5UniSTS
Nfh  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38114,938,866 - 4,939,056UniSTSGRCm38
MGSCv37114,838,869 - 4,839,059UniSTSGRCm37
Celera115,436,366 - 5,436,556UniSTS
Cytogenetic Map11A1-A5UniSTS
cM Map115.0UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000093369   ⟹   ENSMUSP00000091061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl114,888,754 - 4,898,064 (-)Ensembl
GRCm38.p6 Ensembl114,938,754 - 4,948,064 (-)Ensembl
RefSeq Acc Id: NM_010904   ⟹   NP_035034
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39114,888,754 - 4,898,064 (-)NCBI
GRCm38114,938,754 - 4,948,064 (-)ENTREZGENE
MGSCv37114,838,757 - 4,848,067 (-)RGD
Celera115,436,254 - 5,444,974 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035034   ⟸   NM_010904
- UniProtKB: Q61959 (UniProtKB/Swiss-Prot),   Q5SVF6 (UniProtKB/Swiss-Prot),   P19246 (UniProtKB/Swiss-Prot),   A1E2H9 (UniProtKB/Swiss-Prot),   Q80TQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000091061   ⟸   ENSMUST00000093369
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19246-F1-model_v2 AlphaFold P19246 1-1090 view protein structure

Promoters
RGD ID:6821408
Promoter ID:MM_KWN:6261
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Lung
Transcripts:ENSMUST00000020667,   OTTMUST00000011325
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36114,847,251 - 4,847,912 (-)MPROMDB
RGD ID:8673818
Promoter ID:EPDNEW_M14940
Type:single initiation site
Name:Nefh_1
Description:Mus musculus neurofilament, heavy polypeptide , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38114,947,998 - 4,948,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97309 AgrOrtholog
Ensembl Genes ENSMUSG00000020396 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000093369 ENTREZGENE
  ENSMUST00000093369.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DUF1388 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NF-H UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:380684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97309 ENTREZGENE
NCBI Gene Nefh ENTREZGENE
PANTHER NEUROFILAMENT HEAVY POLYPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23214 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF1388 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nefh PhenoGen
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1E2H9 ENTREZGENE
  NFH_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q5SVF6 ENTREZGENE
  Q61959 ENTREZGENE
  Q80TQ3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A1E2H9 UniProtKB/Swiss-Prot
  Q5SVF6 UniProtKB/Swiss-Prot
  Q61959 UniProtKB/Swiss-Prot