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Gene: Man2b2 (mannosidase, alpha, class 2B, member 2) Rattus norvegicus

Analyze

Symbol:

Man2b2 (Ensembl: Mrfap1)

Name:

mannosidase, alpha, class 2B, member 2 (Ensembl:Morf4 family associated protein 1)

RGD ID:

1308840

Description:

Enables alpha-mannosidase activity. Involved in mannose metabolic process. Orthologous to human MAN2B2 (mannosidase alpha class 2B member 2); INTERACTS WITH acrylamide; aflatoxin B1; atrazine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ab2-450; epididymis-specific alpha-mannosidase; LOC360955; mannosidase 2, alpha B2; MGC188563

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	78,193,797 - 78,218,802 (+)	NCBI		GRCr8
mRatBN7.2	14	73,969,079 - 73,994,089 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	73,969,003 - 74,004,281 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	78,410,461 - 78,435,475 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	79,651,326 - 79,676,319 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	76,096,283 - 76,121,290 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	78,939,959 - 78,964,961 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	78,939,903 - 78,964,961 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	87,135,572 - 87,160,118 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,553,600 - 79,578,877 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	79,555,992 - 79,590,191 (+)	NCBI
Celera	14	72,913,859 - 72,938,768 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

combined immunodeficiency (ISO)

congenital disorder of glycosylation (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclophosphamide (EXP)

dexamethasone (ISO)

diquat (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenamidone (ISO)

folic acid (ISO)

indometacin (ISO)

lidocaine (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulindac sulfide (ISO)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mannose metabolic process (IDA)

oligosaccharide catabolic process (ISO)

Molecular Function

alpha-mannosidase activity (IDA)

carbohydrate binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The core-specific lysosomal alpha(1-6)-mannosidase activity depends on aspartamidohydrolase activity.	Haeuw JF, etal., Biochem J. 1994 Feb 1;297 ( Pt 3):463-6.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15632090	PMID:23376485	PMID:23533145	PMID:24006456

Genomics

Comparative Map Data

Man2b2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	78,193,797 - 78,218,802 (+)	NCBI		GRCr8
mRatBN7.2	14	73,969,079 - 73,994,089 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	73,969,003 - 74,004,281 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	78,410,461 - 78,435,475 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	79,651,326 - 79,676,319 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	76,096,283 - 76,121,290 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	78,939,959 - 78,964,961 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	78,939,903 - 78,964,961 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	87,135,572 - 87,160,118 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,553,600 - 79,578,877 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	79,555,992 - 79,590,191 (+)	NCBI
Celera	14	72,913,859 - 72,938,768 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

MAN2B2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	6,575,189 - 6,623,362 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	6,575,189 - 6,623,362 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	6,576,916 - 6,625,089 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	6,627,803 - 6,675,089 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	6,694,973 - 6,742,260	NCBI
Celera	4	6,478,589 - 6,525,854 (+)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	6,509,194 - 6,555,738 (+)	NCBI		HuRef
CHM1_1	4	6,575,420 - 6,622,573 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	6,551,558 - 6,599,721 (+)	NCBI		T2T-CHM13v2.0

Man2b2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	36,963,913 - 36,987,973 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	36,964,265 - 36,987,997 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	36,806,813 - 36,830,649 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	36,806,921 - 36,830,653 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	37,198,052 - 37,221,888 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	37,095,170 - 37,118,876 (-)	NCBI		MGSCv36	mm8
Celera	5	34,258,072 - 34,281,974 (-)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	19.26	NCBI

Man2b2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	3,743,417 - 3,771,970 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	3,743,265 - 3,771,970 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAN2B2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	6,845,904 - 6,893,488 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	6,774,830 - 6,821,475 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	6,649,129 - 6,695,987 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	6,649,076 - 6,696,407 (+)	Ensembl	panpan1.1		panPan2

MAN2B2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	58,669,585 - 58,702,555 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	61,361,449 - 61,391,992 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	59,136,943 - 59,169,791 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	3	58,639,626 - 58,672,446 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	58,841,614 - 58,874,421 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	59,190,524 - 59,223,346 (+)	NCBI		UU_Cfam_GSD_1.0

Man2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	64,841,834 - 64,869,320 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	18,543,484 - 18,571,014 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	18,543,541 - 18,571,002 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAN2B2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	4,137,035 - 4,181,195 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	4,123,151 - 4,181,196 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	3,060,886 - 3,103,162 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAN2B2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	42,702,723 - 42,748,256 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	42,703,608 - 42,751,212 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	89,501,287 - 89,547,289 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Man2b2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	22,971,217 - 22,994,389 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	22,971,205 - 22,996,052 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	129
Count of miRNA genes:	111
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000064548
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	77914838	104348525	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	72970210	87582095	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	77640071	96755654	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	100078267	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	77640071	96755654	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	65920283	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

AU048890

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	73,999,384 - 73,999,683 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	78,970,257 - 78,970,555	NCBI	Rnor6.0
Rnor_5.0	14	87,165,415 - 87,165,713	UniSTS	Rnor5.0
RGSC_v3.4	14	79,584,174 - 79,584,472	UniSTS	RGSC3.4
Celera	14	72,944,024 - 72,945,207	UniSTS
Cytogenetic Map	14	q21	UniSTS

RH136865

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	74,004,017 - 74,004,219 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	78,974,890 - 78,975,091	NCBI	Rnor6.0
Rnor_5.0	14	87,170,048 - 87,170,249	UniSTS	Rnor5.0
RGSC_v3.4	14	79,588,807 - 79,589,008	UniSTS	RGSC3.4
Celera	14	72,949,542 - 72,949,743	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078562 ⟹ ENSRNOP00000074589

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	78,939,903 - 78,964,961 (+)	Ensembl

RefSeq Acc Id:

NM_001134971 ⟹ NP_001128443

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	78,193,797 - 78,218,802 (+)	NCBI
mRatBN7.2	14	73,969,079 - 73,994,089 (+)	NCBI
Rnor_6.0	14	78,939,959 - 78,964,961 (+)	NCBI
Rnor_5.0	14	87,135,572 - 87,160,118 (+)	NCBI
RGSC_v3.4	14	79,553,600 - 79,578,877 (+)	RGD
Celera	14	72,913,859 - 72,938,768 (+)	NCBI

Sequence:

show sequence

CAATGGGGCCGCTGCGCTGGCTGCCGCTGCTCGGCCAGCTATTGCTGCTGTGGCCGCTGGCGGC
CCGGCCCGCCAGCCCCATCCGGGCCTTTGTGGTGCCCCACAGTCACATGGACGTGGGCTGGGTC
TACACGGTCCAGGAAAGCATGCGGGCCTATGCAGCCAATGTCTACACCACCGTGGTGGAGGAAC
TGGTCCGAGGCAGGCAGCGCCGCTTCATCGCTGTGGAGCAGGAGTTCTTCCGGCTGTGGTGGGA
TGGTGTAGCCTCTGAGCAGCAGAAACAGCAGGTCCGCCAGCTCCTGGATGAAGGATGCCTGGAG
TTCGTTCTTGGAGGCCAGGTCATGCATGACGAGGCTGTGACCCACCTGGATGACCAGATCCTAC
AGCTCACAGAAGGACATGGCTTTCTCTACGAAACGTTTGGAATCCGGCCACAGTTCTCCTGGCA
CGTGGACCCCTTTGGTGCATCAGCGACGACCCCTACCCTATTTTCCCTGGCCGGCTTCAATGCC
CACCTCATCTCCCGGATTGACTACGACCTCAAGGATGCCATGCAGGAAGCTCAGGGGCTACAGT
TCGTGTGGCACGGGTCCCCATCTCTGTCAGAGCAGCAGGAGATCTACACCCACGTCATGGACCT
TTATAGCTACTGCACCCCCTCACACATCCCTTTCTCTAACAGGTCTGGATTTTACTGGAATGGT
GTGGCCGTCTTCCCAGAGCCACCCCCAGATGGCGTGTATCCTAACATGAGTGAACCTGTCACCG
TAGACAACATCCACCTCTACGCTGAGGCTCTGGTGGCCAACATTAAACAGAGGGCCGCATGGTT
CCGGACTCCCCACGTCCTCTGGCCCTGGGGATGTGACAAGCAGTTCTTCAACGCCTCGGTGCAG
TTTGACAACATGGACCCCCTGCTGGAGTACATTAACAACCGCTCTGCCCAGTTTGGCATCTCAG
TGCAGTACGCCACACTGAATGATTACTTCCAGGCCCTGCACGACTTCAACGTGACCTGGGACAT
CCGAGACCACCATGACTTCCTACCCTATTCTTCAGAGCCACAGCAGGCCTGGACCGGATTCTAC
ACATCCCGGAGCACTCTCAAGGGTCTAGCGAGACAAGCCAGTGCCTTGCTATATGCTGGGGAGT
CCATGTTCACACGCTATATGTGGCCACACCCCCGTGGAACTCTGGACCCTACCTGGGCCCTGCA
GCAGCTCCAACAGCTTCGCTGGGCCGTGTCTGAGGTCCAGCACCACGATGCCATCACAGGCACT
GAATCCCCCAAGGTGAAAAACATGTACATGGAACATCTCAGCATGGGGATGCGAGGTGTACATA
AGCTGATGGCCTCCATTGCCCTGGACAGGTCCCCAGGGTCTGGCACAGACACGAGGCCTGTGGG
ATACTCTGCCTCTGTGTACAACCCGCTAGCCTGGAAGATCACTACCATTATCACCCTGACTGTC
GCTTTCCCCAGTGTCAGCGTCACAGATGAGTTGGGCCGTCCAGTGTCAGCACAGATTCAGAACT
CGACAAAGGACCCTTCTGCGTATGACCTGCTCATCCTGACCACCATCCCAGGCCTCAGCTACCG
GTACTACAAAGTCAGGCGCATACTCGGGGACCAGGCAGGCACCAGAGAGCTGGTCACCCCCAGG
GCCAACACCCTCAAGTTTAGTCGCAAACTGAGGAACCAGACCAGCCAGGAAGGCAAGCTCCTGG
TGCCTGTAATGAATGACTGCTACACTTTGCTGTTCGACCAGGACACCAACATGTTACATAGCAT
TCAGGACAGACAGAGTAACCGCACAGTGCACATGACCCAAGAGTTCCTGGAGTATCGAGCCAAC
GGGGACGTGAAGCAGGGCCCCATTTCTGACAACTACCTCTTTGCATCCAACGATACCGCTGAGC
CTTCCTGGGAAGCGGTGGGGATGGAGATGGTGGTGGGCACGCTGGCCACGGACGTAAGGCAGTA
TTTCTACAGGAACATAACAGACCAGGGTTACATCTATTCGATCCACACTCGTCTGGCCCATGTG
CATCCGAGCCTTGCTGGGGAACTGCTCTGCCGACGGATAGAGCAGCAGTACCAAGTGGGCCCCC
TGGACCTAAACCGTGAGGCCATCCTGAGGACCAGCAGTGACCTAAACAGCCAACAAGTCCTCTA
CTCTGACAACAATGGCTACCAGATGCAGCGGAGGCCCTACAAGGCTTTCAAGAGCAATCCCATC
CCCCGGAATTACTACCCCATGGTACAGTCGGCCTTCATCGAGGATGACAAGAGCAGGCTGGTGC
TGCTGGCAGAGCGACCGCATGGTGTCTCCAGCCAAGAGAATGGGCAGGTGGAGGTAATGCTCCA
TCGGCGGCTGTGGAACAACCTGGTCTGGGACCTGAACTACAACCTCACACTGAATGACACCTCT
GTCGTCCACCCAGTGCTCTGGCTTCTGCTGGGGCCCAAGTCCACCACAACTGCCCTGCGCCCGA
GGAGTGGGGTGGCCCTCCAGCACAGGCCTGTCGTGTTGTTAAAAGAGCTAACTGATGAAGAAGA
GACAGCCATTCACAGACCCCATCACCCCTGGCCTGTGACATTGCCCCCAAGCCTGCACCTGCAG
GTCCTCAGCTTACGTGGCTGGCAGTACAGCAGGAACCATGCCCAGCACCTGAAGAACCTTCAGA
GAGGCCACCCAGAGAAACCACAGGTCAACCTACAACGTGTGCTGCTGCGCCTGCACCACCTGTA
TGAAGCAGGGGAGGACCCGGTACTGTCTCGGCCTGCTACAGTGGATCTCAAGATTGCACTTCGA
GGACTAGGGTCTGTAGTGGCCGTGGAGGAACGCTCACTCACAGGGACCTGGGATGTGCAGACGC
TGCAGCGCTGGCACTGGAGGACAAAGATTGGCCAGCTAAAAGGGCACCCTACCTCTCCACCAAG
GTCACCAGGAGGCTCCATCATCACTGTGTACCCCAAGGAAATCCGGACCTTCTTCATTTACCTC
CAGCAGTGACATCAGTGCACTTGGCCCCAGGGACATGGAACTGGAACCACTCCCCCCCCCCCCC
GCGCAAAAAAAAAAAAAAAAAAAAAAAAACAACGAAGCTGGCCCCAGAGGGAGGAGCAAGCTGC
TCATCTGACAGCTCTCCATCTGACAGAAGTGGCCATGTGGGGAGAGGAATAGCTCTGATTTTTT
TTAATAAAAAATTAACATCTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001128443	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68692	(Get FASTA)	NCBI Sequence Viewer
	EDM00034	(Get FASTA)	NCBI Sequence Viewer
	EDM00035	(Get FASTA)	NCBI Sequence Viewer
	EDM00036	(Get FASTA)	NCBI Sequence Viewer
	EDM00037	(Get FASTA)	NCBI Sequence Viewer
	EDM00038	(Get FASTA)	NCBI Sequence Viewer
	EDM00039	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071505.2
	ENSRNOP00000074589.2
	ENSRNOP00000075327.1
	ENSRNOP00000095138.1

RefSeq Acc Id:	NP_001128443 ⟸ NM_001134971
- Peptide Label:	precursor
- UniProtKB:	B5DEJ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGPLRWLPLLGQLLLLWPLAARPASPIRAFVVPHSHMDVGWVYTVQESMRAYAANVYTTVVEEL VRGRQRRFIAVEQEFFRLWWDGVASEQQKQQVRQLLDEGCLEFVLGGQVMHDEAVTHLDDQILQ LTEGHGFLYETFGIRPQFSWHVDPFGASATTPTLFSLAGFNAHLISRIDYDLKDAMQEAQGLQF VWHGSPSLSEQQEIYTHVMDLYSYCTPSHIPFSNRSGFYWNGVAVFPEPPPDGVYPNMSEPVTV DNIHLYAEALVANIKQRAAWFRTPHVLWPWGCDKQFFNASVQFDNMDPLLEYINNRSAQFGISV QYATLNDYFQALHDFNVTWDIRDHHDFLPYSSEPQQAWTGFYTSRSTLKGLARQASALLYAGES MFTRYMWPHPRGTLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVKNMYMEHLSMGMRGVHK LMASIALDRSPGSGTDTRPVGYSASVYNPLAWKITTIITLTVAFPSVSVTDELGRPVSAQIQNS TKDPSAYDLLILTTIPGLSYRYYKVRRILGDQAGTRELVTPRANTLKFSRKLRNQTSQEGKLLV PVMNDCYTLLFDQDTNMLHSIQDRQSNRTVHMTQEFLEYRANGDVKQGPISDNYLFASNDTAEP SWEAVGMEMVVGTLATDVRQYFYRNITDQGYIYSIHTRLAHVHPSLAGELLCRRIEQQYQVGPL DLNREAILRTSSDLNSQQVLYSDNNGYQMQRRPYKAFKSNPIPRNYYPMVQSAFIEDDKSRLVL LAERPHGVSSQENGQVEVMLHRRLWNNLVWDLNYNLTLNDTSVVHPVLWLLLGPKSTTTALRPR SGVALQHRPVVLLKELTDEEETAIHRPHHPWPVTLPPSLHLQVLSLRGWQYSRNHAQHLKNLQR GHPEKPQVNLQRVLLRLHHLYEAGEDPVLSRPATVDLKIALRGLGSVVAVEERSLTGTWDVQTL QRWHWRTKIGQLKGHPTSPPRSPGGSIITVYPKEIRTFFIYLQQ hide sequence

Ensembl Acc Id:

ENSRNOP00000074589 ⟸ ENSRNOT00000078562

Protein Domains

Glycoside hydrolase family 38 central

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K8F6-F1-model_v2	AlphaFold	A0A0G2K8F6	1-1004	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699376

Promoter ID:

EPDNEW_R9901

Type:

initiation region

Name:

Man2b2_1

Description:

mannosidase, alpha, class 2B, member 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	78,939,941 - 78,940,001	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308840	AgrOrtholog
BioCyc Gene	G2FUF-15345	BioCyc
Ensembl Genes	ENSRNOG00000056162	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000061779	Ensembl
Ensembl Transcript	ENSRNOT00000078562.2	UniProtKB/TrEMBL
	ENSRNOT00000088221.2	UniProtKB/TrEMBL
	ENSRNOT00000089759.2	UniProtKB/TrEMBL
	ENSRNOT00000097552.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.50	UniProtKB/TrEMBL
	2.60.40.1180	UniProtKB/TrEMBL
	2.60.40.1360	UniProtKB/TrEMBL
	3.20.110.10	UniProtKB/TrEMBL
InterPro	Glyco_hydro-type_carb-bd	UniProtKB/TrEMBL
	Glyco_hydro/deAcase_b/a-brl	UniProtKB/TrEMBL
	Glyco_hydro_38/57_N	UniProtKB/TrEMBL
	Glyco_hydro_38_C	UniProtKB/TrEMBL
	Glyco_hydro_38_cen_dom	UniProtKB/TrEMBL
	Glyco_hydro_38_cen_sf	UniProtKB/TrEMBL
	Glyco_hydro_38_core	UniProtKB/TrEMBL
	Glyco_hydro_57/38_cen	UniProtKB/TrEMBL
	Glyco_hydro_b	UniProtKB/TrEMBL
	Glycosyl_Hydrlase_38	UniProtKB/TrEMBL
	MRFAP1	UniProtKB/TrEMBL
KEGG Report	rno:360955	UniProtKB/TrEMBL
NCBI Gene	360955	ENTREZGENE
PANTHER	ALPHA-MANNOSIDASE	UniProtKB/TrEMBL
	EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE	UniProtKB/TrEMBL
	MORF4 FAMILY-ASSOCIATED PROTEIN 1	UniProtKB/TrEMBL
	PTHR31324	UniProtKB/TrEMBL
Pfam	Alpha-mann_mid	UniProtKB/TrEMBL
	Glyco_hydro_38	UniProtKB/TrEMBL
	Glyco_hydro_38C	UniProtKB/TrEMBL
	MRFAP1	UniProtKB/TrEMBL
PharmGKB	MAN2B2	RGD
PhenoGen	Man2b2	PhenoGen
RatGTEx	ENSRNOG00000056162	RatGTEx
	ENSRNOG00000061779	RatGTEx
SMART	Alpha-mann_mid	UniProtKB/TrEMBL
Superfamily-SCOP	Gal_mut_like	UniProtKB/TrEMBL
	Glyco_hydro/deAcase_b/a-brl	UniProtKB/TrEMBL
	SSF88688	UniProtKB/TrEMBL
UniProt	A0A0G2K8F6_RAT	UniProtKB/TrEMBL
	A0A8I6AJ32_RAT	UniProtKB/TrEMBL
	A0A8L2R539_RAT	UniProtKB/TrEMBL
	B5DEJ3	ENTREZGENE, UniProtKB/TrEMBL
	Q7TP34_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2010-04-23	Man2b2	mannosidase, alpha, class 2B, member 2	Man2b2	mannosidase 2, alpha B2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Man2b2	mannosidase 2, alpha B2	Man2b2_predicted	mannosidase 2, alpha B2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Man2b2_predicted	mannosidase 2, alpha B2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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