Man2b2 (mannosidase alpha class 2B member 2) - Rat Genome Database

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Gene: Man2b2 (mannosidase alpha class 2B member 2) Ictidomys tridecemlineatus
Analyze
Symbol: Man2b2
Name: mannosidase alpha class 2B member 2
RGD ID: 12509668
Description: ENCODES a protein that exhibits alpha-mannosidase activity (ortholog); INVOLVED IN mannose metabolic process (ortholog); ASSOCIATED WITH combined immunodeficiency (ortholog); congenital disorder of glycosylation (ortholog); FOUND IN lysosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epididymis-specific alpha-mannosidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528564,841,834 - 64,869,320 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,543,484 - 18,571,014 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,543,541 - 18,571,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Man2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528564,841,834 - 64,869,320 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,543,484 - 18,571,014 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,543,541 - 18,571,002 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAN2B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3846,575,189 - 6,623,362 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl46,575,189 - 6,623,362 (+)EnsemblGRCh38hg38GRCh38
GRCh3746,576,916 - 6,625,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3646,627,803 - 6,675,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 3446,694,973 - 6,742,260NCBI
Celera46,478,589 - 6,525,854 (+)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef46,509,194 - 6,555,738 (+)NCBIHuRef
CHM1_146,575,420 - 6,622,573 (+)NCBICHM1_1
T2T-CHM13v2.046,551,558 - 6,599,721 (+)NCBIT2T-CHM13v2.0
Man2b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,963,913 - 36,987,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,964,265 - 36,987,997 (-)EnsemblGRCm39 Ensembl
GRCm38536,806,813 - 36,830,649 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,806,921 - 36,830,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,198,052 - 37,221,888 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36537,095,170 - 37,118,876 (-)NCBIMGSCv36mm8
Celera534,258,072 - 34,281,974 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.26NCBI
Man2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,193,797 - 78,218,802 (+)NCBIGRCr8
mRatBN7.21473,969,079 - 73,994,089 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,969,003 - 74,004,281 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1478,410,461 - 78,435,475 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,651,326 - 79,676,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,096,283 - 76,121,290 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01478,939,959 - 78,964,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1478,939,903 - 78,964,961 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01487,135,572 - 87,160,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,553,600 - 79,578,877 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11479,555,992 - 79,590,191 (+)NCBI
Celera1472,913,859 - 72,938,768 (+)NCBICelera
Cytogenetic Map14q21NCBI
Man2b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,743,417 - 3,771,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555143,743,265 - 3,771,970 (-)NCBIChiLan1.0ChiLan1.0
MAN2B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v236,845,904 - 6,893,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan146,774,830 - 6,821,475 (+)NCBINHGRI_mPanPan1
PanPan1.146,649,129 - 6,695,987 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl46,649,076 - 6,696,407 (+)Ensemblpanpan1.1panPan2
MAN2B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1358,669,585 - 58,702,555 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha361,361,449 - 61,391,992 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0359,136,943 - 59,169,791 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1358,639,626 - 58,672,446 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,841,614 - 58,874,421 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0359,190,524 - 59,223,346 (+)NCBIUU_Cfam_GSD_1.0
MAN2B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl84,137,035 - 4,181,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.184,123,151 - 4,181,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.283,060,886 - 3,103,162 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAN2B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12742,702,723 - 42,748,256 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2742,703,608 - 42,751,212 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604789,501,287 - 89,547,289 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Man2b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475522,971,217 - 22,994,389 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475522,971,205 - 22,996,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013355838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000003902   ⟹   ENSSTOP00000003498
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647718,543,484 - 18,571,014 (+)Ensembl
Ensembl Acc Id: ENSSTOT00000042619   ⟹   ENSSTOP00000026584
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647718,543,484 - 18,571,014 (+)Ensembl
RefSeq Acc Id: XM_013355838   ⟹   XP_013211292
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528564,841,834 - 64,869,320 (+)NCBI
SpeTri2.0NW_00493647718,543,541 - 18,571,002 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013211292 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000003498.3
  ENSSTOP00000026584.1
GenBank Protein KAG3276937 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_013211292   ⟸   XM_013355838
- UniProtKB: I3M384 (UniProtKB/TrEMBL),   A0A287CZA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000003498   ⟸   ENSSTOT00000003902
Ensembl Acc Id: ENSSTOP00000026584   ⟸   ENSSTOT00000042619

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003905 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003902.3 UniProtKB/TrEMBL
  ENSSTOT00000042619.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.50 UniProtKB/TrEMBL
  2.60.40.1180 UniProtKB/TrEMBL
  2.60.40.1360 UniProtKB/TrEMBL
  3.20.110.10 UniProtKB/TrEMBL
InterPro Gal_mutarotase_sf_dom UniProtKB/TrEMBL
  Glyco_hydro/deAcase_b/a-brl UniProtKB/TrEMBL
  Glyco_hydro_38_C UniProtKB/TrEMBL
  Glyco_hydro_38_cen UniProtKB/TrEMBL
  Glyco_hydro_38_cen_sf UniProtKB/TrEMBL
  Glyco_hydro_38_N UniProtKB/TrEMBL
  Glyco_hydro_38_N_sf UniProtKB/TrEMBL
  Glyco_hydro_57/38_cen_sf UniProtKB/TrEMBL
  Glyco_hydro_b UniProtKB/TrEMBL
  Glycosyl_Hydrlase_38 UniProtKB/TrEMBL
NCBI Gene Man2b2 ENTREZGENE
PANTHER ALPHA-MANNOSIDASE UniProtKB/TrEMBL
  EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE UniProtKB/TrEMBL
Pfam Alpha-mann_mid UniProtKB/TrEMBL
  Glyco_hydro_38C UniProtKB/TrEMBL
  Glyco_hydro_38N UniProtKB/TrEMBL
SMART Alpha-mann_mid UniProtKB/TrEMBL
Superfamily-SCOP SSF74650 UniProtKB/TrEMBL
  SSF88688 UniProtKB/TrEMBL
  SSF88713 UniProtKB/TrEMBL
UniProt A0A287CZA4 ENTREZGENE, UniProtKB/TrEMBL
  I3M384 ENTREZGENE, UniProtKB/TrEMBL