Gene: Ddc (dopa decarboxylase) Rattus norvegicus
Analyze
Symbol:
Ddc
Name:
dopa decarboxylase
RGD ID:
2494
Description:
Exhibits anion binding activity; aromatic-L-amino-acid decarboxylase activity; and protein domain specific binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; phenol-containing compound biosynthetic process; and response to pyrethroid. Localizes to axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); L-Dopa decarboxylase; MGC93628
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
DDC (dopa decarboxylase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ddc (dopa decarboxylase) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ddc (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
DDC (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
DDC (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ddc (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
DDC (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
DDC (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ddc (dopa decarboxylase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
HDC (histidine decarboxylase) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Ddc (dopa decarboxylase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
DDC (dopa decarboxylase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
ddc (dopa decarboxylase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
Ddc
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
amd
Alliance
DIOPT (OMA|OrthoFinder|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
tdc-1
Alliance
DIOPT (InParanoid|OMA|OrthoInspector)
Caenorhabditis elegans (roundworm):
bas-1
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER|TreeFam)
Caenorhabditis elegans (roundworm):
basl-1
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|PANTHER|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 14 91,905,919 - 91,996,816 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 91,905,919 - 91,996,774 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 91,689,894 - 91,793,700 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 92,698,636 - 92,788,635 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 14 92,714,598 - 92,790,197 (-) NCBI Celera 14 85,380,254 - 85,470,515 (-) NCBI Celera Cytogenetic Map 14 q21 NCBI RH 3.4 Map 14 636.18 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:31104889 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:22143761 , PMID:24865461 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:28492532 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:15079002 more ... aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:17533144 more ... aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:15079002 more ... aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:20505134 , PMID:28492532 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:1357595 more ... aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:25741868 , PMID:28492532 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:17533144 , PMID:24865461 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:23430870 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:25741868 aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 8554872 ClinVar Annotator: match by term: Deficiency of aromatic-L-amino-acid decarboxylase ClinVar PMID:20505134 Muscle Hypotonia ISO RGD:734177 8554872 ClinVar Annotator: match by term: Neonatal hypotonia ClinVar PMID:30311386 pleomorphic xanthoastrocytoma ISO RGD:734177 8554872 ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma ClinVar PMID:28299358
Imported Annotations - CTD
disease of mental health ISO RGD:734177 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:2969953 Experimental Liver Cirrhosis ISO RGD:734177 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 Nerve Degeneration ISO RGD:734177 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19522546 Parkinson's disease ISO RGD:734177 11554173 CTD Direct Evidence: therapeutic CTD PMID:2969953 , PMID:11445284 Parkinsonian Disorders ISO RGD:734177 11554173 CTD Direct Evidence: therapeutic CTD PMID:16269145 pheochromocytoma ISO RGD:734177 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22569243 Imported Annotations - OMIM
aromatic L-amino acid decarboxylase deficiency ISO RGD:734177 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DDC mRNA] CTD PMID:31150632 (2,4,5-trichlorophenoxy)acetic acid increases expression ISO RGD:10469 6480464 2 more ... CTD PMID:18579281 1,2-dimethylhydrazine affects expression ISO RGD:10469 6480464 1, 2-Dimethylhydrazine affects the expression of DDC mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:10469 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DDC mRNA CTD PMID:22206623 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of DDC mRNA CTD PMID:25380136 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of DDC mRNA CTD PMID:30723492 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of DDC mRNA CTD PMID:15834898 , PMID:15901920 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of DDC mRNA CTD PMID:20068009 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10469 6480464 Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA CTD PMID:19770486 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10469 6480464 Tetrachlorodibenzodioxin affects the expression of DDC mRNA CTD PMID:21570461 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10469 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of DDC mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DDC gene] CTD PMID:25975270 , PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA CTD PMID:19490992 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:734177 6480464 Tetrachlorodibenzodioxin results in decreased expression of DDC mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of DDC mRNA CTD PMID:22298810 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of DDC mRNA CTD PMID:21346803 2-Amino-3-methyl-9H-pyrido[2,3-b]indole decreases activity ISO RGD:734177 6480464 2-amino-3-methyl-9H-pyrido(2, 3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases activity EXP 6480464 Puromycin Aminonucleoside results in decreased activity of DDC protein CTD PMID:16204272 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:20959002 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:10469 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of DDC mRNA CTD PMID:20188158 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity ISO RGD:734177 6480464 3-amino-1-methyl-5H-pyrido(4, 3-b)indole results in decreased activity of DDC protein CTD PMID:2243617 3-Amino-1-methyl-5H-pyrido[4,3-b]indole decreases activity EXP 6480464 3-amino-1-methyl-5H-pyrido(4, 3-b)indole results in decreased activity of DDC protein CTD PMID:2904812 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of DDC mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol increases expression ISO RGD:10469 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of DDC mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:10469 6480464 Fenretinide results in increased expression of DDC mRNA CTD PMID:28973697 5-hydroxytryptophan multiple interactions EXP 6480464 [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 aflatoxin B1 affects expression ISO RGD:734177 6480464 Aflatoxin B1 affects the expression of DDC protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:734177 6480464 Aflatoxin B1 results in decreased methylation of DDC gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:734177 6480464 Aflatoxin B1 results in decreased expression of DDC mRNA CTD PMID:21632981 more ... aflatoxin B1 increases expression ISO RGD:10469 6480464 Aflatoxin B1 results in increased expression of DDC mRNA CTD PMID:19770486 aldrin increases expression ISO RGD:10469 6480464 Aldrin results in increased expression of DDC mRNA CTD PMID:18579281 all-trans-retinoic acid increases expression ISO RGD:10469 6480464 Tretinoin results in increased expression of DDC mRNA CTD PMID:16604517 all-trans-retinoic acid decreases expression ISO RGD:734177 6480464 Tretinoin results in decreased expression of DDC mRNA CTD PMID:23724009 all-trans-retinoic acid increases expression ISO RGD:734177 6480464 Tretinoin results in increased expression of DDC mRNA CTD PMID:21934132 amiodarone increases expression ISO RGD:10469 6480464 Amiodarone results in increased expression of DDC mRNA CTD PMID:24489787 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of DDC protein CTD PMID:16483693 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of DDC mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of DDC mRNA CTD PMID:8717341 andrographolide increases expression ISO RGD:10469 6480464 andrographolide results in increased expression of DDC mRNA CTD PMID:19737545 andrographolide multiple interactions ISO RGD:10469 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA CTD PMID:19737545 atrazine decreases expression ISO RGD:734177 6480464 Atrazine results in decreased expression of DDC mRNA CTD PMID:22378314 azathioprine decreases expression ISO RGD:734177 6480464 Azathioprine results in decreased expression of DDC mRNA CTD PMID:22623647 belinostat decreases expression ISO RGD:734177 6480464 belinostat results in decreased expression of DDC mRNA CTD PMID:27188386 benzo[a]pyrene increases expression ISO RGD:734177 6480464 Benzo(a)pyrene results in increased expression of DDC mRNA CTD PMID:17879257 benzo[a]pyrene affects methylation ISO RGD:734177 6480464 Benzo(a)pyrene affects the methylation of DDC 5' UTR, Benzo(a)pyrene affects the methylation of DDC promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:10469 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA CTD PMID:27858113 benzo[a]pyrene decreases expression ISO RGD:734177 6480464 Benzo(a)pyrene results in decreased expression of DDC mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO RGD:10469 6480464 Benzo(a)pyrene results in increased expression of DDC mRNA CTD PMID:19770486 , PMID:22610609 benzo[b]fluoranthene multiple interactions ISO RGD:10469 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA CTD PMID:27858113 beta-naphthoflavone multiple interactions ISO RGD:10469 6480464 [andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA CTD PMID:19737545 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 bisphenol A decreases expression ISO RGD:10469 6480464 bisphenol A results in decreased expression of DDC mRNA CTD PMID:25270620 bisphenol A increases expression ISO RGD:10469 6480464 bisphenol A results in increased expression of DDC mRNA CTD PMID:30951980 bisphenol A affects expression ISO RGD:734177 6480464 bisphenol A affects the expression of DDC mRNA CTD PMID:30903817 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DDC mRNA CTD PMID:25181051 more ... bisphenol F decreases expression EXP 6480464 4, 4'-bisphenol F results in decreased expression of DDC mRNA CTD PMID:26186136 bisphenol F increases expression ISO RGD:10469 6480464 bisphenol F results in increased expression of DDC mRNA CTD PMID:30951980 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of DDC mRNA CTD PMID:24136188 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 cadmium dichloride affects expression EXP 6480464 Cadmium Chloride affects the expression of DDC mRNA CTD PMID:22110744 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of DDC mRNA CTD PMID:25993096 cadmium sulfate increases expression ISO RGD:10469 6480464 cadmium sulfate results in increased expression of DDC mRNA CTD PMID:16221973 carbon nanotube decreases expression ISO RGD:10469 6480464 Nanotubes, Carbon analog results in decreased expression of DDC mRNA, Nanotubes, Carbon results in decreased expression of DDC mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube increases expression ISO RGD:10469 6480464 Nanotubes, Carbon results in increased expression of DDC mRNA CTD PMID:25620056 carbonyl sulfide decreases expression EXP 6480464 carbonyl sulfide results in decreased expression of DDC mRNA CTD PMID:19395590 cefaloridine decreases expression EXP 6480464 Cephaloridine results in decreased expression of DDC mRNA CTD PMID:18500788 chrysene multiple interactions ISO RGD:10469 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA CTD PMID:27858113 clozapine multiple interactions ISO RGD:10469 6480464 Clozapine results in increased expression of and results in increased activity of DDC protein CTD PMID:16415089 clozapine increases expression ISO RGD:10469 6480464 Clozapine results in increased expression of DDC mRNA CTD PMID:16415089 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of DDC mRNA CTD PMID:24386269 copper atom multiple interactions ISO RGD:734177 6480464 [NSC 689534 binds to Copper] which results in increased expression of DDC mRNA CTD PMID:20971185 copper atom decreases expression EXP 6480464 Copper results in decreased expression of DDC mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:734177 6480464 [NSC 689534 binds to Copper] which results in increased expression of DDC mRNA CTD PMID:20971185 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of DDC mRNA CTD PMID:22465980 copper(II) sulfate decreases expression ISO RGD:734177 6480464 Copper Sulfate results in decreased expression of DDC mRNA CTD PMID:19549813 copper(II) sulfate increases expression ISO RGD:10469 6480464 Copper Sulfate results in increased expression of DDC mRNA CTD PMID:18579281 cyclosporin A decreases expression ISO RGD:734177 6480464 Cyclosporine results in decreased expression of DDC mRNA CTD PMID:20106945 more ... cyclosporin A increases expression ISO RGD:734177 6480464 Cyclosporine results in increased expression of DDC mRNA CTD PMID:27989131 dexamethasone increases expression ISO RGD:10469 6480464 Dexamethasone results in increased expression of DDC mRNA CTD PMID:22733784 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of DDC mRNA, Dibutyl Phthalate results in decreased expression of DDC protein CTD PMID:15728792 more ... dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of DDC mRNA CTD PMID:18636392 dichlorine decreases expression EXP 6480464 Chlorine results in decreased expression of DDC mRNA CTD PMID:18636392 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 diisobutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 diisononyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of DDC mRNA CTD PMID:31199487 dioxygen decreases expression ISO RGD:734177 6480464 Oxygen deficiency results in decreased expression of DDC mRNA CTD PMID:19695866 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of DDC mRNA CTD PMID:29391264 entinostat decreases expression ISO RGD:734177 6480464 entinostat results in decreased expression of DDC mRNA CTD PMID:27188386 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of DDC mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:10469 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DDC mRNA CTD PMID:22206623 furan decreases expression EXP 6480464 furan results in decreased expression of DDC mRNA CTD PMID:26194646 genistein increases expression ISO RGD:734177 6480464 Genistein results in increased expression of DDC mRNA CTD PMID:15378649 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of DDC mRNA CTD PMID:24136188 gold atom multiple interactions ISO RGD:10469 6480464 [Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA CTD PMID:19695318 gold(0) multiple interactions ISO RGD:10469 6480464 [Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA CTD PMID:19695318 homocysteine multiple interactions ISO RGD:734177 6480464 [Levodopa co-treated with DDC] results in decreased abundance of Homocysteine CTD PMID:11445284 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of DDC mRNA CTD PMID:21396975 isotretinoin decreases expression ISO RGD:734177 6480464 Isotretinoin results in decreased expression of DDC mRNA CTD PMID:20436886 ketanserin increases activity ISO RGD:10469 6480464 Ketanserin results in increased activity of DDC protein CTD PMID:16415089 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of DDC mRNA CTD PMID:22641619 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of DDC mRNA CTD PMID:24136188 levofloxacin decreases expression EXP 6480464 Levofloxacin results in decreased expression of DDC mRNA CTD PMID:24136188 menadione affects expression ISO RGD:734177 6480464 Vitamin K 3 affects the expression of DDC mRNA CTD PMID:20044591 metergoline increases activity ISO RGD:10469 6480464 Metergoline results in increased activity of DDC protein CTD PMID:16415089 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide multiple interactions ISO RGD:10469 6480464 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased activity of DDC protein CTD PMID:16415089 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:10469 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of DDC mRNA CTD PMID:25566086 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of DDC mRNA CTD PMID:16026605 N-methyl-4-phenylpyridinium decreases expression ISO RGD:10469 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of DDC mRNA CTD PMID:26558463 N-nitrosodiethylamine decreases expression ISO RGD:734177 6480464 Diethylnitrosamine results in decreased expression of DDC mRNA CTD PMID:21527772 N-Nitrosopyrrolidine decreases expression ISO RGD:734177 6480464 N-Nitrosopyrrolidine results in decreased expression of DDC mRNA CTD PMID:32234424 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of DDC mRNA CTD PMID:24136188 nimesulide decreases expression EXP 6480464 nimesulide results in decreased expression of DDC mRNA CTD PMID:24136188 nitric oxide increases activity EXP 6480464 Nitric Oxide deficiency results in increased activity of DDC protein CTD PMID:7541690 O-methyleugenol decreases expression ISO RGD:734177 6480464 methyleugenol results in decreased expression of DDC mRNA CTD PMID:32234424 oxidopamine decreases expression EXP 6480464 Oxidopamine results in decreased expression of DDC protein CTD PMID:20232137 oxidopamine multiple interactions EXP 6480464 Levodopa inhibits the reaction [Oxidopamine results in decreased expression of DDC protein] CTD PMID:20232137 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] affects the expression of DDC mRNA CTD PMID:18636392 ozone multiple interactions ISO RGD:10469 6480464 [NOTCH3 gene mutant form affects the susceptibility to Ozone] which results in decreased expression of DDC mRNA, [NOTCH4 gene mutant form affects the susceptibility to Ozone] which affects the expression of DDC mRNA CTD PMID:25658374 paracetamol affects expression ISO RGD:10469 6480464 Acetaminophen affects the expression of DDC mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:734177 6480464 Acetaminophen results in decreased expression of DDC mRNA CTD PMID:29067470 paraquat decreases expression ISO RGD:10469 6480464 Paraquat results in decreased expression of DDC mRNA CTD PMID:21371552 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of DDC mRNA CTD PMID:18692542 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of DDC mRNA CTD PMID:19162173 permethrin decreases expression EXP 6480464 Permethrin results in decreased expression of DDC mRNA CTD PMID:19017407 phenobarbital decreases expression ISO RGD:10469 6480464 Phenobarbital results in decreased expression of DDC mRNA CTD PMID:19270015 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of DDC mRNA CTD PMID:19162173 PhIP decreases activity ISO RGD:734177 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased activity of DDC protein CTD PMID:2243617 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of DDC mRNA CTD PMID:19162173 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:10469 6480464 Pregnenolone Carbonitrile results in decreased expression of DDC mRNA CTD PMID:28903501 propanal decreases expression ISO RGD:734177 6480464 propionaldehyde results in decreased expression of DDC mRNA CTD PMID:26079696 quercetin decreases expression ISO RGD:734177 6480464 Quercetin results in decreased expression of DDC mRNA CTD PMID:21632981 reserpine increases expression EXP 6480464 Reserpine results in increased expression of DDC mRNA CTD PMID:1359376 resveratrol increases expression ISO RGD:734177 6480464 resveratrol results in increased expression of DDC mRNA CTD PMID:18586690 rotenone affects expression EXP 6480464 Rotenone affects the expression of DDC mRNA CTD PMID:28374803 S-adenosyl-L-methioninate multiple interactions ISO RGD:734177 6480464 [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 S-adenosyl-L-methionine multiple interactions ISO RGD:734177 6480464 [Levodopa co-treated with DDC] results in increased abundance of S-Adenosylmethionine CTD PMID:11445284 sarin decreases expression ISO RGD:734177 6480464 Sarin results in decreased expression of DDC mRNA, Sarin results in decreased expression of DDC protein CTD PMID:19522546 scopolamine decreases expression EXP 6480464 Scopolamine results in decreased expression of DDC mRNA CTD PMID:17540011 Securinine decreases expression ISO RGD:734177 6480464 securinine results in decreased expression of DDC mRNA CTD PMID:32662633 serotonin multiple interactions EXP 6480464 [DDC protein results in decreased carboxylation of 5-Hydroxytryptophan] which results in increased chemical synthesis of Serotonin CTD PMID:32243540 silicon dioxide decreases expression ISO RGD:734177 6480464 Silicon Dioxide analog results in decreased expression of DDC mRNA CTD PMID:25895662 silicon dioxide decreases expression ISO RGD:10469 6480464 Silicon Dioxide results in decreased expression of DDC mRNA CTD PMID:23221170 , PMID:29341224 simazine affects expression ISO RGD:10469 6480464 Simazine affects the expression of DDC mRNA, Simazine affects the expression of DDC protein CTD PMID:29137186 simazine decreases expression EXP 6480464 Simazine results in decreased expression of DDC mRNA, Simazine results in decreased expression of DDC protein CTD PMID:29115391 sodium arsenite multiple interactions ISO RGD:10469 6480464 [sodium arsenite affects the localization of NR4A2 protein] inhibits the reaction [NR4A2 protein results in increased expression of DDC mRNA] CTD PMID:23283970 sodium arsenite decreases expression ISO RGD:10469 6480464 sodium arsenite results in decreased expression of DDC mRNA CTD PMID:23283970 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of DDC mRNA CTD PMID:22110744 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of DDC mRNA CTD PMID:25993096 Soman decreases expression EXP 6480464 Soman results in decreased expression of DDC mRNA CTD PMID:19281266 tamoxifen affects expression ISO RGD:10469 6480464 Tamoxifen affects the expression of DDC mRNA CTD PMID:20937368 testosterone increases expression ISO RGD:10469 6480464 Testosterone results in increased expression of DDC mRNA CTD PMID:19693291 tetrachloromethane decreases expression ISO RGD:10469 6480464 Carbon Tetrachloride results in decreased expression of DDC mRNA CTD PMID:27339419 , PMID:31919559 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of DDC mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of DDC mRNA CTD PMID:31150632 tetracycline decreases expression ISO RGD:10469 6480464 Tetracycline results in decreased expression of DDC mRNA CTD PMID:24489787 tetraphene multiple interactions ISO RGD:10469 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of DDC mRNA CTD PMID:27858113 thapsigargin decreases expression ISO RGD:734177 6480464 Thapsigargin results in decreased expression of DDC mRNA CTD PMID:22378314 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of DDC mRNA CTD PMID:23411599 titanium dioxide decreases expression ISO RGD:10469 6480464 titanium dioxide results in decreased expression of DDC mRNA CTD PMID:27760801 trichloroethene decreases expression ISO RGD:10469 6480464 Trichloroethylene results in decreased expression of DDC mRNA CTD PMID:25549359 triphenyl phosphate multiple interactions EXP 6480464 [triphenyl phosphate co-treated with Flame Retardants] results in decreased expression of DDC mRNA CTD PMID:32243540 tunicamycin decreases expression ISO RGD:734177 6480464 Tunicamycin results in decreased expression of DDC mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:734177 6480464 Urethane results in decreased expression of DDC mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:734177 6480464 Valproic Acid affects the expression of DDC mRNA CTD PMID:25979313 vancomycin increases expression ISO RGD:10469 6480464 Vancomycin results in increased expression of DDC mRNA CTD PMID:18930951 vigabatrin decreases expression EXP 6480464 Vigabatrin results in decreased expression of DDC mRNA CTD PMID:8717341 vorinostat decreases expression ISO RGD:734177 6480464 vorinostat results in decreased expression of DDC mRNA CTD PMID:27188386 zearalenone decreases expression ISO RGD:734177 6480464 Zearalenone results in decreased expression of DDC mRNA CTD PMID:24412706
Gene-Chemical Interaction Annotations
