Ddc (dopa decarboxylase) - Rat Genome Database

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Gene: Ddc (dopa decarboxylase) Rattus norvegicus
Analyze
Symbol: Ddc
Name: dopa decarboxylase
RGD ID: 2494
Description: Enables anion binding activity; aromatic-L-amino-acid decarboxylase activity; and protein domain specific binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; phenol-containing compound biosynthetic process; and response to pyrethroid. Located in axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); L-Dopa decarboxylase; MGC93628
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21486,378,685 - 86,469,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,378,685 - 86,469,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,784,649 - 90,875,109 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,028,980 - 92,119,440 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,496,613 - 88,587,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,905,919 - 91,996,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,905,919 - 91,996,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,689,894 - 91,793,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,698,636 - 92,788,635 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11492,714,598 - 92,790,197 (-)NCBI
Celera1485,380,254 - 85,470,515 (-)NCBICelera
RH 3.4 Map14636.18RGD
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-hydroxytryptophan  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
belinostat  (ISO)
benserazide  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
carbidopa  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
cefaloridine  (EXP)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
homocysteine  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
ketanserin  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP)
levofloxacin  (EXP)
malathion  (ISO)
menadione  (ISO)
metergoline  (ISO)
Mipafox  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP)
O-methyleugenol  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
pyridoxal 5'-phosphate  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
sarin  (ISO)
sarpogrelate  (ISO)
scopolamine  (EXP)
Securinine  (ISO)
serotonin  (EXP)
silicon dioxide  (EXP,ISO)
simazine  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP,ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vigabatrin  (EXP)
vorinostat  (ISO)
VX nerve agent  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IBA,IEA,ISO)
neuronal cell body  (IDA)
synaptic vesicle  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Mutations in the human aromatic L-amino acid decarboxylase gene J. Inherit. Metab. Dis. 21: 4 only, 1998.
2. Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Borglum AD, etal., Am J Med Genet B Neuropsychiatr Genet 2003 Feb;117(1):18-22.
3. Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. Brown ST, etal., J Neurochem. 2009 Jul;110(2):622-30. Epub 2009 May 8.
4. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Brun L, etal., Neurology. 2010 Jul 6;75(1):64-71. Epub 2010 May 26.
5. A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. Cartier EA, etal., J Biol Chem. 2010 Jan 15;285(3):1957-66. Epub 2009 Nov 10.
6. Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis. Chiou SH, etal., Anal Biochem. 2007 Apr 1;363(1):46-57. Epub 2007 Jan 17.
7. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. Coll M, etal., J Hepatol. 2008 Jul;49(1):43-51. Epub 2008 Apr 18.
8. Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments. Cruz-Muros I, etal., Exp Neurol. 2007 Mar;204(1):147-61. Epub 2006 Nov 16.
9. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. DasBanerjee T, etal., Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1554-63.
10. Congenital hyperinsulinism: pancreatic fluoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion. de Lonlay P, etal., J Clin Endocrinol Metab. 2006 Mar;91(3):933-40. Epub 2006 Jan 10.
11. Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats. Ershov PV, etal., J Chem Neuroanat. 2005 Jul;30(1):27-33.
12. Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate adeno-associated virus vectors. Fan DS, etal., Hum Gene Ther. 1998 Nov 20;9(17):2527-35.
13. The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study. Foster SB, etal., Chem Res Toxicol. 2003 Oct;16(10):1372-84.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. The roles of striatal serotonin and L -amino-acid decarboxylase on L-DOPA-induced Dyskinesia in a Hemiparkinsonian rat model. Gil S, etal., Cell Mol Neurobiol. 2010 Aug;30(6):817-25. Epub 2010 Mar 16.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin. Harrill JA, etal., BMC Genomics. 2008 Nov 18;9:546.
18. Rat liver aromatic L-amino acid decarboxylase: spectroscopic and kinetic analysis of the coenzyme and reaction intermediates. Hayashi H, etal., Biochemistry. 1993 Jan 26;32(3):812-8.
19. Acid-base chemistry of the reaction of aromatic L-amino acid decarboxylase and dopa analyzed by transient and steady-state kinetics: preferential binding of the substrate with its amino group unprotonated. Hayashi H, etal., Biochemistry. 1999 Nov 23;38(47):15615-22.
20. Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells. Ishida Y, etal., Genes Cells 2002 May;7(5):447-59.
21. Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP. Jin CM, etal., Eur J Pharmacol. 2008 Sep 4;591(1-3):88-95. Epub 2008 Jun 19.
22. Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells. Jin CM, etal., J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):747-55.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Aromatic L-amino acid decarboxylase-immunoreactive structures in human midbrain, pons, and medulla. Kitahama K, etal., J Chem Neuroanat. 2009 Oct;38(2):130-40. Epub 2009 Jul 7.
25. Catecholaminergic systems in stress: structural and molecular genetic approaches. Kvetnansky R, etal., Physiol Rev. 2009 Apr;89(2):535-606.
26. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
27. Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Lee JJ, etal., Molecules. 2008 Feb 27;13(2):475-87.
28. Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. Moreira-Rodrigues M, etal., Life Sci. 2009 Mar 27;84(13-14):409-14. Epub 2009 Jan 8.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Rorsman F, etal., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8626-9.
37. Blunted renal dopaminergic system activity in puromycin aminonucleoside-induced nephrotic syndrome. Sampaio-Maia B, etal., Nephrol Dial Transplant. 2006 Feb;21(2):314-23. Epub 2005 Oct 4.
38. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Shen H, etal., Tohoku J Exp Med. 2003 Mar;199(3):149-59.
39. Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: partial amino acid homologies with other enzymes synthesizing catecholamines. Tanaka T, etal., Proc Natl Acad Sci U S A 1989 Oct;86(20):8142-6.
40. Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. Tehranian R, etal., J Neurochem. 2006 Nov;99(4):1188-96. Epub 2006 Sep 18.
41. Caco-2 cells in culture synthesize and degrade dopamine and 5-hydroxytryptamine: a comparison with rat jejunal epithelial cells. Vieira-Coelho MA, etal., Life Sci. 1999;64(1):69-81.
42. Activities of aromatic L-amino acid decarboxylase with L-dopa as substrate in brush-border- and basolateral membranes and cytoplasm obtained from rat renal cortex. Yamazaki N and Sudo J, Jpn J Pharmacol. 1988 Feb;46(2):193-6.
43. Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Yang YJ, etal., J Neurosci Res. 2009 Jun;87(8):1929-37.
Additional References at PubMed
PMID:1465439   PMID:7904615   PMID:8889823   PMID:12477932   PMID:15489334   PMID:16338639   PMID:19056867   PMID:19703902   PMID:22829864   PMID:23010799   PMID:23376485   PMID:23863468  
PMID:36768816  


Genomics

Comparative Map Data
Ddc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21486,378,685 - 86,469,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,378,685 - 86,469,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,784,649 - 90,875,109 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,028,980 - 92,119,440 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,496,613 - 88,587,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,905,919 - 91,996,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,905,919 - 91,996,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,689,894 - 91,793,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,698,636 - 92,788,635 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11492,714,598 - 92,790,197 (-)NCBI
Celera1485,380,254 - 85,470,515 (-)NCBICelera
RH 3.4 Map14636.18RGD
Cytogenetic Map14q21NCBI
DDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38750,458,442 - 50,565,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl750,458,436 - 50,565,405 (-)EnsemblGRCh38hg38GRCh38
GRCh37750,526,140 - 50,633,102 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,493,628 - 50,600,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34750,300,344 - 50,402,960NCBI
Celera750,591,055 - 50,698,048 (-)NCBICelera
Cytogenetic Map7p12.2-p12.1NCBI
HuRef750,376,100 - 50,483,099 (-)NCBIHuRef
CHM1_1750,528,427 - 50,635,428 (-)NCBICHM1_1
T2T-CHM13v2.0750,619,658 - 50,726,621 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2750,532,205 - 50,639,203 (-)NCBI
Ddc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,764,101 - 11,848,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,764,101 - 11,848,144 (-)EnsemblGRCm39 Ensembl
GRCm381111,814,101 - 11,898,144 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,814,101 - 11,898,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,714,104 - 11,798,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,714,445 - 11,780,657 (-)NCBIMGSCv36mm8
Celera1112,273,377 - 12,350,184 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.09NCBI
Ddc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,513,042 - 3,582,911 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,513,779 - 3,582,851 (+)NCBIChiLan1.0ChiLan1.0
DDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan17103,662,348 - 103,762,697 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,101,169 - 51,206,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,345,228 - 51,449,710 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,345,228 - 51,449,710 (-)Ensemblpanpan1.1panPan2
DDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,802,239 - 1,876,714 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,803,273 - 1,867,616 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,793,310 - 1,867,692 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,860,735 - 1,935,186 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,860,735 - 1,933,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,833,628 - 1,907,793 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,830,057 - 1,904,284 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,966,951 - 2,041,333 (-)NCBIUU_Cfam_GSD_1.0
Ddc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,117,869 - 105,222,691 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,301,207 - 1,405,384 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,322,153 - 1,405,434 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,496,365 - 136,571,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,496,364 - 136,571,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,076,907 - 150,157,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,235,396 - 8,343,086 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,235,343 - 8,343,361 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606213,938,028 - 14,045,297 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247403,674,609 - 3,732,676 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247403,674,727 - 3,732,058 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ddc
273 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1020
Count of miRNA genes:336
Interacting mature miRNAs:460
Transcripts:ENSRNOT00000005851, ENSRNOT00000057051, ENSRNOT00000073892
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

Markers in Region
RH130833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,381,993 - 86,382,203 (+)MAPPERmRatBN7.2
Rnor_6.01491,909,228 - 91,909,437NCBIRnor6.0
Rnor_5.01491,693,203 - 91,693,412UniSTSRnor5.0
RGSC_v3.41492,698,762 - 92,698,971UniSTSRGSC3.4
Celera1485,383,563 - 85,383,772UniSTS
RH 3.4 Map14635.59UniSTS
Cytogenetic Map14q21UniSTS
RH143134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,378,764 - 86,378,934 (+)MAPPERmRatBN7.2
Rnor_6.01491,905,999 - 91,906,168NCBIRnor6.0
Rnor_5.01491,689,974 - 91,690,143UniSTSRnor5.0
RGSC_v3.41492,695,533 - 92,695,702UniSTSRGSC3.4
Celera1485,380,334 - 85,380,503UniSTS
RH 3.4 Map14636.59UniSTS
Cytogenetic Map14q21UniSTS
RH94401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,381,868 - 86,382,056 (+)MAPPERmRatBN7.2
Rnor_6.01491,909,103 - 91,909,290NCBIRnor6.0
Rnor_5.01491,693,078 - 91,693,265UniSTSRnor5.0
RGSC_v3.41492,698,637 - 92,698,824UniSTSRGSC3.4
Celera1485,383,438 - 85,383,625UniSTS
RH 3.4 Map14636.18UniSTS
Cytogenetic Map14q21UniSTS
BF408245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21486,379,946 - 86,380,092 (+)MAPPERmRatBN7.2
Rnor_6.01491,907,181 - 91,907,326NCBIRnor6.0
Rnor_5.01491,691,156 - 91,691,301UniSTSRnor5.0
RGSC_v3.41492,696,715 - 92,696,860UniSTSRGSC3.4
Celera1485,381,516 - 85,381,661UniSTS
RH 3.4 Map14635.99UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 37 25 21 21 13 19 9 1
Low 1 6 25 20 2 20 8 11 61 16 29 10 8
Below cutoff 7 17 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF273828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005851   ⟹   ENSRNOP00000005851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,378,685 - 86,469,208 (-)Ensembl
Rnor_6.0 Ensembl1491,905,919 - 91,996,774 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057051   ⟹   ENSRNOP00000053885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,378,685 - 86,462,016 (-)Ensembl
Rnor_6.0 Ensembl1491,905,919 - 91,989,307 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073892   ⟹   ENSRNOP00000064520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,378,685 - 86,469,175 (-)Ensembl
Rnor_6.0 Ensembl1491,905,919 - 91,979,500 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093904   ⟹   ENSRNOP00000085523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,378,685 - 86,469,208 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103628   ⟹   ENSRNOP00000082788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1486,378,685 - 86,452,371 (-)Ensembl
RefSeq Acc Id: NM_001270852   ⟹   NP_001257781
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,378,685 - 86,452,210 (-)NCBI
Rnor_6.01491,905,919 - 91,979,500 (-)NCBI
Rnor_5.01491,689,894 - 91,793,700 (-)NCBI
Celera1485,380,254 - 85,453,633 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270853   ⟹   NP_001257782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,378,685 - 86,462,016 (-)NCBI
Rnor_6.01491,905,919 - 91,989,307 (-)NCBI
Rnor_5.01491,689,894 - 91,793,700 (-)NCBI
Celera1485,380,254 - 85,463,439 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012545   ⟹   NP_036677
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,378,685 - 86,469,175 (-)NCBI
Rnor_6.01491,905,919 - 91,996,774 (-)NCBI
Rnor_5.01491,689,894 - 91,793,700 (-)NCBI
RGSC_v3.41492,698,636 - 92,788,635 (-)RGD
Celera1485,380,254 - 85,470,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770253   ⟹   XP_008768475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,381,866 - 86,469,183 (-)NCBI
Rnor_6.01491,909,100 - 91,996,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770254   ⟹   XP_008768476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,392,275 - 86,469,183 (-)NCBI
Rnor_6.01491,917,320 - 91,996,816 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091617   ⟹   XP_038947545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21486,390,147 - 86,469,189 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036677   ⟸   NM_012545
- Peptide Label: isoform a
- UniProtKB: Q6LEG4 (UniProtKB/Swiss-Prot),   P14173 (UniProtKB/Swiss-Prot),   A6KJB5 (UniProtKB/TrEMBL),   A0A8L2QX98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257782   ⟸   NM_001270853
- Peptide Label: isoform b
- UniProtKB: D3ZMA5 (UniProtKB/TrEMBL),   A0A8J8YSU9 (UniProtKB/TrEMBL),   F8TLS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257781   ⟸   NM_001270852
- Peptide Label: isoform a
- UniProtKB: Q6LEG4 (UniProtKB/Swiss-Prot),   P14173 (UniProtKB/Swiss-Prot),   A6KJB5 (UniProtKB/TrEMBL),   A0A8L2QX98 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768475   ⟸   XM_008770253
- Peptide Label: isoform X1
- UniProtKB: A0A8J8YSU9 (UniProtKB/TrEMBL),   D3ZMA5 (UniProtKB/TrEMBL),   F8TLS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768476   ⟸   XM_008770254
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000053885   ⟸   ENSRNOT00000057051
RefSeq Acc Id: ENSRNOP00000064520   ⟸   ENSRNOT00000073892
RefSeq Acc Id: ENSRNOP00000005851   ⟸   ENSRNOT00000005851
RefSeq Acc Id: XP_038947545   ⟸   XM_039091617
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000082788   ⟸   ENSRNOT00000103628
RefSeq Acc Id: ENSRNOP00000085523   ⟸   ENSRNOT00000093904

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14173-F1-model_v2 AlphaFold P14173 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699496
Promoter ID:EPDNEW_R10018
Type:multiple initiation site
Name:Ddc_1
Description:dopa decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01491,996,774 - 91,996,834EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2494 AgrOrtholog
BioCyc Gene G2FUF-14989 BioCyc
Ensembl Genes ENSRNOG00000004327 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005851 ENTREZGENE
  ENSRNOT00000005851.7 UniProtKB/TrEMBL
  ENSRNOT00000057051 ENTREZGENE
  ENSRNOT00000057051.5 UniProtKB/TrEMBL
  ENSRNOT00000073892.4 UniProtKB/TrEMBL
  ENSRNOT00000093904 ENTREZGENE
  ENSRNOT00000093904.1 UniProtKB/TrEMBL
  ENSRNOT00000103628 ENTREZGENE
  ENSRNOT00000103628.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  dopa decarboxylase, N-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098083 IMAGE-MGC_LOAD
InterPro Aromatic_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_de-COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyridoxal-P_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24311 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93628 IMAGE-MGC_LOAD
NCBI Gene 24311 ENTREZGENE
PANTHER AROMATIC-L-AMINO-ACID DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyridoxal_deC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB DDC RGD
PhenoGen Ddc PhenoGen
PRINTS YHDCRBOXLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DDC_GAD_HDC_YDC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004327 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZV89_RAT UniProtKB/TrEMBL
  A0A8I5ZZE6_RAT UniProtKB/TrEMBL
  A0A8J8YSU9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q249_RAT UniProtKB/TrEMBL
  A0A8L2QX98 ENTREZGENE, UniProtKB/TrEMBL
  A6KJB3_RAT UniProtKB/TrEMBL
  A6KJB5 ENTREZGENE, UniProtKB/TrEMBL
  A6KJB6_RAT UniProtKB/TrEMBL
  D3ZMA5 ENTREZGENE, UniProtKB/TrEMBL
  DDC_RAT UniProtKB/Swiss-Prot
  F8TLS6 ENTREZGENE
  P14173 ENTREZGENE
  Q6LEG4 ENTREZGENE
UniProt Secondary F8TLS6 UniProtKB/TrEMBL
  Q6LEG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Ddc  dopa decarboxylase  Ddc  dopa decarboxylase (aromatic L-amino acid decarboxylase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ddc  dopa decarboxylase (aromatic L-amino acid decarboxylase)  Ddc  dopa decarboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Ddc  dopa decarboxylase    Dopa decarboxylase (aromatic L-amino acid decarboxylase)  Name updated 625702 APPROVED
2002-06-10 Ddc  Dopa decarboxylase (aromatic L-amino acid decarboxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease an autoantigen in autoimmune polyendocrine syndrome type I 727686
gene_other pyrodoxal phosphate is a cofactor for enzyme activity 727686