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Gene: Ddc (dopa decarboxylase) Rattus norvegicus
Symbol: Ddc
Name: dopa decarboxylase
RGD ID: 2494
Description: Exhibits anion binding activity; aromatic-L-amino-acid decarboxylase activity; and protein domain specific binding activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; phenol-containing compound biosynthetic process; and response to pyrethroid. Localizes to axon; neuronal cell body; and synaptic vesicle. Used to study Parkinson's disease. Biomarker of Parkinson's disease; end stage renal disease; nephrotic syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); L-Dopa decarboxylase; MGC93628
Homo sapiens (human) : DDC (dopa decarboxylase)  HGNC  Alliance
Mus musculus (house mouse) : Ddc (dopa decarboxylase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddc (dopa decarboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : DDC (dopa decarboxylase)
Canis lupus familiaris (dog) : DDC (dopa decarboxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddc (dopa decarboxylase)
Sus scrofa (pig) : DDC (dopa decarboxylase)
Chlorocebus sabaeus (African green monkey) : DDC (dopa decarboxylase)
Heterocephalus glaber (naked mole-rat) : Ddc (dopa decarboxylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01491,905,919 - 91,996,816 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,905,919 - 91,996,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,689,894 - 91,793,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,698,636 - 92,788,635 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11492,714,598 - 92,790,197 (-)NCBI
Celera1485,380,254 - 85,470,515 (-)NCBICelera
Cytogenetic Map14q21NCBI
RH 3.4 Map14636.18RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ddc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2494
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.