Gene: Msx1 (msh homeobox 1) Rattus norvegicus
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Symbol:
Msx1
Name:
msh homeobox 1
Description:
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding activity; and transcription regulatory region DNA binding activity. Involved in cartilage development; cellular response to nicotine; and pituitary gland development. Predicted to localize to the nucleoplasm and transcription factor complex. Biomarker of cryptorchidism. Human ortholog(s) of this gene implicated in cleft lip; cleft palate; orofacial cleft 5; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1); INTERACTS WITH (S)-nicotine; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
homeo box, msh-like 1; homeobox protein MSX-1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MSX1 (msh homeobox 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Msx1 (msh homeobox 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Msx1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MSX1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MSX1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Msx1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MSX1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
MSX1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Msx1 (msh homeobox 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
MSX2 (msh homeobox 2) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
MSX1 (msh homeobox 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, OMA, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Msx1 (msh homeobox 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
msx1a (muscle segment homeobox 1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Dr
Alliance
DIOPT (Ensembl Compara, Hieranoid, PANTHER, TreeFam)
Caenorhabditis elegans (roundworm):
vab-15
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 14 77,712,262 - 77,716,061 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 77,712,240 - 77,716,059 (+) Ensembl Rnor_5.0 14 77,690,990 - 77,694,789 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 78,257,345 - 78,261,144 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 14 78,259,735 - 78,263,533 (+) NCBI Celera 14 71,923,586 - 71,927,385 (+) NCBI Celera Cytogenetic Map 14 q21 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Partial congenital absence of teeth ClinVar PMID:16498076 anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Partial congenital absence of teeth ClinVar PMID:24914010 , PMID:8696335 anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Partial congenital absence of teeth ClinVar PMID:12097313 anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Partial congenital absence of teeth ClinVar PMID:15264286 anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Partial congenital absence of teeth ClinVar PMID:8696335 , PMID:9742121 anodontia ISO RGD:731562 8554872 ClinVar Annotator: match by term: Tooth agenesis, selective, with or without orofacial cleft ClinVar PMID:10742093 craniosynostosis ISO RGD:731562 8554872 ClinVar Annotator: match by term: Craniosynostosis ClinVar PMID:25741868 , PMID:31837199 orofacial cleft 5 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Orofacial cleft 5 ClinVar PMID:12807959 more ... orofacial cleft 5 ISO RGD:731562 8554872 ClinVar Annotator: match by OMIM:608874 ClinVar PMID:15354328 more ... orofacial cleft 5 ISO RGD:731562 8554872 ClinVar Annotator: match by OMIM:608874 ClinVar PMID:12807959 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:15264286 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:8696335 , PMID:9742121 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:16498076 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:24914010 , PMID:8696335 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:12097313 Selective Tooth Agenesis 1 ISO RGD:731562 8554872 ClinVar Annotator: match by term: Selective tooth agenesis 1 ClinVar PMID:10742093 tooth and nail syndrome ISO RGD:731562 8554872 ClinVar Annotator: match by term: Tooth-and-Nail Syndrome ClinVar PMID:28492532 tooth and nail syndrome ISO RGD:731562 8554872 ClinVar Annotator: match by term: Hypoplastic enamel-onycholysis-hypohidrosis syndrome ClinVar tooth and nail syndrome ISO RGD:731562 8554872 ClinVar Annotator: match by OMIM:189500 ClinVar PMID:11369996 , PMID:9484139
Imported Annotations - CTD
anodontia ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD cleft palate ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12163415 more ... Craniofacial Abnormalities ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12163415 more ... nonsyndromic deafness ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27356075 Stomach Neoplasms ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16367923 Tooth Abnormalities ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14630905 Wolf-Hirschhorn syndrome ISO RGD:731562 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14630905 Imported Annotations - MGI
orofacial cleft ISS RGD:731563 13592920 OMIM:119530 more ... MouseDO tooth agenesis ISS RGD:731563 13592920 OMIM:106600 more ... MouseDO Imported Annotations - OMIM
orofacial cleft 5 ISO RGD:731562 7240710 OMIM Selective Tooth Agenesis 1 ISO RGD:731562 7240710 OMIM tooth and nail syndrome ISO RGD:731562 7240710 OMIM
(S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression EXP 6480464 chlorcyclizine results in increased expression of MSX1 mRNA CTD PMID:21058326 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731563 6480464 Tetrachlorodibenzodioxin affects the expression of MSX1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:731563 6480464 Tetrachlorodibenzodioxin results in decreased expression of MSX1 mRNA CTD PMID:16922920 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731563 6480464 Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of MSX1 mRNA] CTD PMID:22749964 4,4'-sulfonyldiphenol increases expression ISO RGD:731563 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of MSX1 mRNA CTD PMID:30951980 5-aza-2'-deoxycytidine increases expression ISO RGD:731562 6480464 Decitabine results in increased expression of MSX1 mRNA CTD PMID:16367923 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of MSX1 mRNA CTD PMID:25825206 aflatoxin B1 affects expression ISO RGD:731562 6480464 Aflatoxin B1 affects the expression of MSX1 protein CTD PMID:20106945 all-trans-retinoic acid increases expression ISO RGD:731563 6480464 Tretinoin results in increased expression of MSX1 mRNA CTD PMID:16604517 all-trans-retinoic acid increases expression ISO RGD:731562 6480464 Tretinoin results in increased expression of MSX1 mRNA CTD PMID:17138961 , PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MSX1 mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:731562 6480464 Antirheumatic Agents results in increased expression of MSX1 mRNA CTD PMID:24449571 arsane increases methylation ISO RGD:731562 6480464 Arsenic results in increased methylation of MSX1 promoter CTD PMID:21291286 arsenic atom increases methylation ISO RGD:731562 6480464 Arsenic results in increased methylation of MSX1 promoter CTD PMID:21291286 arsenite(3-) increases methylation ISO RGD:731562 6480464 arsenite results in increased methylation of MSX1 promoter CTD PMID:23974009 belinostat increases expression ISO RGD:731562 6480464 belinostat results in increased expression of MSX1 mRNA CTD PMID:26272509 belinostat multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 benzo[a]pyrene decreases expression ISO RGD:731562 6480464 Benzo(a)pyrene results in decreased expression of MSX1 mRNA CTD PMID:30659931 bis(2-ethylhexyl) phthalate increases expression ISO RGD:731562 6480464 Diethylhexyl Phthalate results in increased expression of MSX1 mRNA CTD PMID:28412506 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:731562 6480464 Diethylhexyl Phthalate results in decreased expression of MSX1 mRNA CTD PMID:31163220 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MSX1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:731563 6480464 bisphenol A results in increased expression of MSX1 mRNA CTD PMID:30951980 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MSX1 mRNA CTD PMID:30816183 bisphenol A affects methylation ISO RGD:731563 6480464 bisphenol A affects the methylation of MSX1 promoter CTD PMID:27334623 bisphenol F increases expression ISO RGD:731563 6480464 bisphenol F results in increased expression of MSX1 mRNA CTD PMID:30951980 carbamazepine affects expression ISO RGD:731562 6480464 Carbamazepine affects the expression of MSX1 mRNA CTD PMID:25979313 choline multiple interactions ISO RGD:731563 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MSX1 gene CTD PMID:20938992 copper atom increases expression EXP 6480464 Copper results in increased expression of MSX1 mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of MSX1 mRNA CTD PMID:30556269 copper(II) sulfate increases expression ISO RGD:731562 6480464 Copper Sulfate results in increased expression of MSX1 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:731562 6480464 Cyclosporine results in increased expression of MSX1 mRNA CTD PMID:20106945 cyproconazole decreases expression ISO RGD:731563 6480464 cyproconazole results in decreased expression of MSX1 mRNA CTD PMID:22045034 cytarabine decreases expression ISO RGD:731562 6480464 Cytarabine results in decreased expression of MSX1 mRNA CTD PMID:21198554 DDT decreases expression EXP 6480464 DDT results in decreased expression of MSX1 mRNA CTD PMID:19797855 dimethylarsinous acid decreases expression ISO RGD:731563 6480464 dimethylarsinous acid results in decreased expression of MSX1 protein CTD PMID:26024302 diuron decreases expression EXP 6480464 Diuron results in decreased expression of MSX1 mRNA CTD PMID:25152437 dorsomorphin multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:731562 6480464 Doxorubicin results in decreased expression of MSX1 mRNA CTD PMID:29803840 entinostat increases expression ISO RGD:731562 6480464 entinostat results in increased expression of MSX1 mRNA CTD PMID:26272509 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of MSX1 mRNA CTD PMID:18035473 folic acid multiple interactions ISO RGD:731563 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MSX1 gene CTD PMID:20938992 formaldehyde increases expression ISO RGD:731562 6480464 Formaldehyde results in increased expression of MSX1 mRNA CTD PMID:20655997 furan decreases expression EXP 6480464 furan results in decreased expression of MSX1 mRNA CTD PMID:25539665 glycidol increases expression EXP 6480464 glycidol results in increased expression of MSX1 mRNA CTD PMID:24395379 hexaconazole decreases expression ISO RGD:731563 6480464 hexaconazole results in decreased expression of MSX1 mRNA CTD PMID:22045034 L-methionine multiple interactions ISO RGD:731563 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MSX1 gene CTD PMID:20938992 mercury dibromide increases expression ISO RGD:731562 6480464 mercuric bromide results in increased expression of MSX1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 nicotine increases expression EXP 6480464 Nicotine results in increased expression of MSX1 mRNA CTD PMID:20339300 p-chloromercuribenzoic acid increases expression ISO RGD:731562 6480464 p-Chloromercuribenzoic Acid results in increased expression of MSX1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 panobinostat multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 panobinostat increases expression ISO RGD:731562 6480464 panobinostat results in increased expression of MSX1 mRNA CTD PMID:26272509 paracetamol increases expression ISO RGD:731562 6480464 Acetaminophen results in increased expression of MSX1 mRNA CTD PMID:21420995 , PMID:29067470 phenobarbital affects expression ISO RGD:731562 6480464 Phenobarbital affects the expression of MSX1 mRNA CTD PMID:19159669 phenylmercury acetate increases expression ISO RGD:731562 6480464 Phenylmercuric Acetate results in increased expression of MSX1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 quercetin decreases expression ISO RGD:731562 6480464 Quercetin results in decreased expression of MSX1 mRNA CTD PMID:21632981 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of MSX1 protein CTD PMID:28431985 retinyl acetate increases expression ISO RGD:731563 6480464 retinol acetate results in increased expression of MSX1 mRNA CTD PMID:16772331 SB 431542 multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom increases expression ISO RGD:731562 6480464 Silver results in increased expression of MSX1 mRNA CTD PMID:26551752 silver atom increases expression ISO RGD:731563 6480464 Silver results in increased expression of MSX1 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:731562 6480464 Silver results in increased expression of MSX1 mRNA CTD PMID:26551752 silver(0) increases expression ISO RGD:731563 6480464 Silver results in increased expression of MSX1 mRNA CTD PMID:27131904 sodium arsenite multiple interactions ISO RGD:731562 6480464 monoisoamyl-2, 3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of MSX1 mRNA] CTD PMID:19615344 sodium arsenite decreases expression ISO RGD:731563 6480464 sodium arsenite results in decreased expression of MSX1 mRNA, sodium arsenite results in decreased expression of MSX1 protein CTD PMID:26024302 sodium arsenite decreases expression ISO RGD:731562 6480464 sodium arsenite results in decreased expression of MSX1 mRNA CTD PMID:19615344 sulindac sulfide decreases expression ISO RGD:731562 6480464 sulindac sulfide results in decreased expression of MSX1 mRNA, sulindac sulfide results in decreased expression of MSX1 protein CTD PMID:12734198 tributylstannane multiple interactions ISO RGD:731563 6480464 Tetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of MSX1 mRNA] CTD PMID:22749964 tributylstannane decreases expression ISO RGD:731563 6480464 tributyltin results in decreased expression of MSX1 mRNA CTD PMID:22749964 trichostatin A increases expression ISO RGD:731562 6480464 trichostatin A results in increased expression of MSX1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 trimellitic anhydride decreases expression ISO RGD:731563 6480464 trimellitic anhydride results in decreased expression of MSX1 mRNA CTD PMID:19042947 troglitazone increases expression ISO RGD:731562 6480464 troglitazone results in increased expression of MSX1 mRNA CTD PMID:19140230 urethane increases expression ISO RGD:731562 6480464 Urethane results in increased expression of MSX1 mRNA CTD PMID:28818685 valproic acid decreases expression ISO RGD:731563 6480464 Valproic Acid results in decreased expression of MSX1 mRNA CTD PMID:19136453 , PMID:22045034 valproic acid decreases expression ISO RGD:731562 6480464 Valproic Acid results in decreased expression of MSX1 mRNA CTD PMID:28001369 valproic acid multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:731562 6480464 Valproic Acid results in increased expression of MSX1 mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:731562 6480464 Valproic Acid affects the expression of MSX1 mRNA CTD PMID:25979313 vorinostat increases expression ISO RGD:731562 6480464 vorinostat results in increased expression of MSX1 mRNA CTD PMID:26272509 vorinostat multiple interactions ISO RGD:731562 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX1 mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:731562 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MSX1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:731562 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MSX1 mRNA CTD PMID:18593933
Biological Process activation of meiosis ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:5299937 , PMID:22071108) RGD MGI:MGI:5299937 , PMID:22071108 anterior/posterior pattern specification ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:4948979 , PMID:21465616) RGD MGI:MGI:4948979 , PMID:21465616 BMP signaling pathway ISO RGD:731563 1624291 MGI:MGI:1926386 (MGI:MGI:3720542 more ... RGD MGI:MGI:3720542 more ... BMP signaling pathway involved in heart development ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3810851 , PMID:18667074) RGD MGI:MGI:3810851 , PMID:18667074 bone morphogenesis ISO RGD:731563 1624291 MGI:MGI:1933766 more ... RGD MGI:MGI:3608570 more ... cartilage development IMP 1600462 RGD cartilage morphogenesis ISO RGD:731563 1624291 MGI:MGI:1933766 (MGI:MGI:3608570 , PMID:12489152) RGD MGI:MGI:3608570 , PMID:12489152 cell morphogenesis ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 cellular response to nicotine IEP 5132605 RGD embryonic digit morphogenesis ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:4948979 , PMID:21465616) RGD MGI:MGI:4948979 , PMID:21465616 embryonic forelimb morphogenesis ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:4948979 , PMID:21465616) RGD MGI:MGI:4948979 , PMID:21465616 embryonic hindlimb morphogenesis ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:4948979 , PMID:21465616) RGD MGI:MGI:4948979 , PMID:21465616 embryonic limb morphogenesis ISO RGD:731563 1624291 MGI:MGI:97169 more ... RGD MGI:MGI:3580732 more ... embryonic morphogenesis IBA MGI:MGI:97168 more ... 13792537 PMID:21873635 GO_Central embryonic nail plate morphogenesis ISO RGD:731562 1624291 (PMID:11369996) RGD PMID:11369996 embryonic nail plate morphogenesis ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3688967 more ... RGD MGI:MGI:3688967 more ... epithelial to mesenchymal transition ISO RGD:731563 1624291 (MGI:MGI:4418636, PMID:11023873) RGD MGI:MGI:4418636 , PMID:11023873 epithelial to mesenchymal transition involved in endocardial cushion formation ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3810851 , PMID:18667074) RGD MGI:MGI:3810851 , PMID:18667074 face morphogenesis ISO RGD:731562 1624291 (PMID:10742093), (PMID:11332647), (PMID:12651933) RGD PMID:10742093 more ... face morphogenesis ISO RGD:731563 1624291 MGI:MGI:1933766 more ... RGD MGI:MGI:3611627 more ... forebrain development ISO RGD:731563 1624291 MGI:MGI:1933766 (MGI:MGI:3046130 more ... RGD MGI:MGI:3046130 more ... heart development ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3720542 , PMID:17601530) RGD MGI:MGI:3720542 , PMID:17601530 heart morphogenesis ISO RGD:731563 1624291 MGI:MGI:1926386 (MGI:MGI:3720542 , PMID:17601530) RGD MGI:MGI:3720542 , PMID:17601530 in utero embryonic development ISO RGD:731563 1624291 MGI:MGI:1926386 (MGI:MGI:3720542 , PMID:17601530) RGD MGI:MGI:3720542 , PMID:17601530 mammary gland epithelium development ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:1355063 , PMID:10742104) RGD MGI:MGI:1355063 , PMID:10742104 mesenchymal cell proliferation ISO RGD:731563 1624291 (MGI:MGI:4418636, PMID:11023873) RGD MGI:MGI:4418636 , PMID:11023873 midbrain development ISO RGD:731563 1624291 MGI:MGI:1933766 (MGI:MGI:3046130 , PMID:15188430) RGD MGI:MGI:3046130 , PMID:15188430 middle ear morphogenesis ISO RGD:731563 1624291 MGI:MGI:1933766 (MGI:MGI:3611627 , PMID:16330189) RGD MGI:MGI:3611627 , PMID:16330189 muscle organ development ISO RGD:731563 1624291 UniProtKB:P43276 (MGI:MGI:3047475 , PMID:15192231) RGD MGI:MGI:3047475 , PMID:15192231 negative regulation of apoptotic process ISO RGD:731563 1624291 MGI:MGI:1926386 (MGI:MGI:3720542 , PMID:17601530) RGD MGI:MGI:3720542 , PMID:17601530 negative regulation of cell growth ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 negative regulation of cell population proliferation ISO RGD:731563 1624291 MGI:MGI:1926386 (MGI:MGI:3720542 , PMID:17601530) RGD MGI:MGI:3720542 , PMID:17601530 negative regulation of DNA binding ISO RGD:731563 1624291 (MGI:MGI:3697003, PMID:17030628) RGD MGI:MGI:3697003 , PMID:17030628 negative regulation of striated muscle cell differentiation ISO RGD:731563 1624291 MGI:MGI:99146 (MGI:MGI:4440723 , PMID:20004191) RGD MGI:MGI:4440723 , PMID:20004191 negative regulation of transcription by RNA polymerase II ISO RGD:731563 1624291 MGI:MGI:2137495 more ... RGD MGI:MGI:1098935 more ... negative regulation of transcription regulatory region DNA binding ISO RGD:731563 1624291 MGI:MGI:96785 (MGI:MGI:1278140 , PMID:9697309) RGD MGI:MGI:1278140 , PMID:9697309 negative regulation of transcription, DNA-templated ISO RGD:731563 1624291 (MGI:MGI:3047475, PMID:15192231) RGD MGI:MGI:3047475 , PMID:15192231 odontogenesis ISO RGD:731563 1624291 MGI:MGI:97493 (MGI:MGI:4418636 more ... RGD MGI:MGI:4418636 more ... odontogenesis of dentin-containing tooth ISO RGD:731563 1624291 (MGI:MGI:3688967, PMID:11369996) RGD MGI:MGI:3688967 , PMID:11369996 odontogenesis of dentin-containing tooth ISO RGD:731562 1624291 (PMID:10742093), (PMID:11369996), (PMID:8696335) RGD PMID:10742093 more ... pituitary gland development IEP 5132608 RGD positive regulation of BMP signaling pathway ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3810851 , PMID:18667074) RGD MGI:MGI:3810851 , PMID:18667074 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 positive regulation of mesenchymal cell apoptotic process ISO RGD:731563 1624291 MGI:MGI:97169 more ... RGD MGI:MGI:3851667 , PMID:19422820 positive regulation of transcription by RNA polymerase II ISO RGD:731563 1624291 MGI:MGI:1926386 more ... RGD MGI:MGI:1336531 more ... protein localization to nucleus ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 protein stabilization ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 regulation of odontogenesis ISO RGD:731563 1624291 MGI:MGI:97493 (MGI:MGI:4453942 , PMID:20123092) RGD MGI:MGI:4453942 , PMID:20123092 roof of mouth development ISO RGD:731563 1624291 MGI:MGI:1933766 (MGI:MGI:3611627 , PMID:16330189) RGD MGI:MGI:3611627 , PMID:16330189 signal transduction involved in regulation of gene expression ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:4948979 , PMID:21465616) RGD MGI:MGI:4948979 , PMID:21465616 stem cell differentiation ISO RGD:731563 1624291 MGI:MGI:97169 (MGI:MGI:3723565 , PMID:17693062) RGD MGI:MGI:3723565 , PMID:17693062 Cellular Component cellular_component ND 1598407 05/2011: no relevant rat data RGD nucleoplasm ISO RGD:731562 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P28360 , ensembl:ENSP000003721701600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:731562 1624291 (PMID:15705871) RGD PMID:15705871 nucleus IBA FB:FBgn0000492 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:731563 1624291 MGI:MGI:99146 (MGI:MGI:4440723 , PMID:20004191) RGD MGI:MGI:4440723 , PMID:20004191 transcription factor complex ISO RGD:731563 1624291 UniProtKB:P70326 more ... RGD MGI:MGI:4461870 , PMID:18285513 Molecular Function cis-regulatory region binding ISO RGD:731563 1624291 (MGI:MGI:5805569, PMID:27741242) RGD MGI:MGI:5805569 , PMID:27741242 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:731563 1624291 (MGI:MGI:5299937, PMID:22071108) RGD MGI:MGI:5299937 , PMID:22071108 DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:731563 1624291 (MGI:MGI:4461870, PMID:18285513) RGD MGI:MGI:4461870 , PMID:18285513 DNA-binding transcription factor activity, RNA polymerase II-specific IBA MGI:MGI:97168 more ... 13792537 PMID:21873635 GO_Central DNA-binding transcription repressor activity, RNA polymerase II-specific ISO RGD:731563 1624291 (MGI:MGI:80319, PMID:8861098) RGD MGI:MGI:80319 , PMID:8861098 molecular_function ND 1598407 05/2011: no relevant rat data RGD p53 binding ISO RGD:731562 1624291 UniProtKB:P04637 (PMID:15705871) RGD PMID:15705871 protein binding ISO RGD:731563 1624291 UniProtKB:B9EJ16 more ... RGD MGI:MGI:1278140 more ... RNA polymerase II regulatory region sequence-specific DNA binding ISO RGD:731563 1624291 (MGI:MGI:1098935 more ... RGD MGI:MGI:1098935 more ... RNA polymerase II regulatory region sequence-specific DNA binding IBA MGI:MGI:97168 more ... 13792537 PMID:21873635 GO_Central sequence-specific DNA binding ISO RGD:731563 1624291 (MGI:MGI:83223, PMID:8858134) RGD MGI:MGI:83223 , PMID:8858134
Gene-Chemical Interaction Annotations
