Mfsd10 (major facilitator superfamily domain containing 10) - Rat Genome Database

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Gene: Mfsd10 (major facilitator superfamily domain containing 10) Rattus norvegicus
Analyze
Symbol: Mfsd10
Name: major facilitator superfamily domain containing 10
RGD ID: 1311900
Description: Predicted to enable organic anion transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within sodium-independent organic anion transport. Predicted to be located in cytoplasmic vesicle membrane and nuclear inner membrane. Predicted to be active in brush border membrane. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305449; major facilitator superfamily domain-containing protein 10; RGD1311900; similar to tetracycline transporter-like protein; tetracycline transporter-like protein; Tetran
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,327,961 - 80,331,984 (+)NCBIGRCr8
mRatBN7.21476,103,762 - 76,107,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,103,815 - 76,107,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,556,983 - 80,559,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,797,636 - 81,800,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,242,864 - 78,245,691 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,362,594 - 81,366,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,362,618 - 81,366,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,050,058 - 82,053,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,745,997 - 81,748,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,747,986 - 81,751,563 (+)NCBI
Celera1475,028,736 - 75,031,563 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18638446   PMID:31142202  


Genomics

Comparative Map Data
Mfsd10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81480,327,961 - 80,331,984 (+)NCBIGRCr8
mRatBN7.21476,103,762 - 76,107,385 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,103,815 - 76,107,377 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,556,983 - 80,559,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,797,636 - 81,800,463 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,242,864 - 78,245,691 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01481,362,594 - 81,366,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1481,362,618 - 81,366,055 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,050,058 - 82,053,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,745,997 - 81,748,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,747,986 - 81,751,563 (+)NCBI
Celera1475,028,736 - 75,031,563 (+)NCBICelera
Cytogenetic Map14q21NCBI
MFSD10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3842,930,567 - 2,934,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl42,930,561 - 2,934,834 (-)EnsemblGRCh38hg38GRCh38
GRCh3742,932,294 - 2,936,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3642,902,093 - 2,905,567 (-)NCBINCBI36Build 36hg18NCBI36
Celera42,843,479 - 2,847,778 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef42,870,691 - 2,874,989 (-)NCBIHuRef
CHM1_142,930,229 - 2,934,528 (-)NCBICHM1_1
T2T-CHM13v2.042,929,030 - 2,933,288 (-)NCBIT2T-CHM13v2.0
Mfsd10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,790,988 - 34,794,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,790,986 - 34,794,556 (-)EnsemblGRCm39 Ensembl
GRCm38534,633,644 - 34,637,215 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,633,642 - 34,637,212 (-)EnsemblGRCm38mm10GRCm38
MGSCv37534,976,296 - 34,979,763 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,950,504 - 34,953,971 (-)NCBIMGSCv36mm8
Celera532,104,582 - 32,108,049 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.9NCBI
Mfsd10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555141,813,259 - 1,815,834 (-)NCBIChiLan1.0ChiLan1.0
MFSD10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,266,193 - 3,272,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,202,130 - 3,207,759 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,073,071 - 3,077,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,975,493 - 2,979,800 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,975,493 - 2,979,791 (-)Ensemblpanpan1.1panPan2
MFSD10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1361,352,047 - 61,357,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl361,352,109 - 61,355,997 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,935,657 - 63,940,415 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,827,565 - 61,832,305 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,827,601 - 61,832,305 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1361,319,400 - 61,323,050 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,523,807 - 61,528,529 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,883,404 - 61,888,132 (+)NCBIUU_Cfam_GSD_1.0
Mfsd10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,989,776 - 66,992,821 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647720,691,433 - 20,694,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,710,530 - 1,715,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,710,524 - 1,715,015 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,292,447 - 1,298,825 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MFSD10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,806,889 - 45,811,122 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2745,807,306 - 45,810,849 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660512,163,204 - 2,167,460 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfsd10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475524,851,095 - 24,854,355 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfsd10
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:66
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000017386
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 26 18 18 18 67 22 34 8
Low 15 31 23 1 23 8 11 7 13 7 3 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000017386   ⟹   ENSRNOP00000017386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,103,857 - 76,107,377 (+)Ensembl
Rnor_6.0 Ensembl1481,362,618 - 81,366,055 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098136   ⟹   ENSRNOP00000084501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,103,815 - 76,107,134 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104363   ⟹   ENSRNOP00000095916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,103,818 - 76,107,166 (+)Ensembl
RefSeq Acc Id: NM_001191680   ⟹   NP_001178609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,328,434 - 80,331,984 (+)NCBI
mRatBN7.21476,103,835 - 76,107,385 (+)NCBI
Rnor_6.01481,363,033 - 81,365,860 (+)NCBI
Rnor_5.01482,050,058 - 82,053,663 (+)NCBI
Celera1475,028,736 - 75,031,563 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001412512   ⟹   NP_001399441
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,328,434 - 80,331,984 (+)NCBI
mRatBN7.21476,103,835 - 76,107,385 (+)NCBI
RefSeq Acc Id: NM_001412513   ⟹   NP_001399442
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,328,434 - 80,331,984 (+)NCBI
mRatBN7.21476,103,835 - 76,107,385 (+)NCBI
RefSeq Acc Id: XM_006251246   ⟹   XP_006251308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,328,361 - 80,331,983 (+)NCBI
mRatBN7.21476,103,762 - 76,107,385 (+)NCBI
Rnor_6.01481,362,594 - 81,366,208 (+)NCBI
Rnor_5.01482,050,058 - 82,053,663 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091974   ⟹   XP_038947902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,327,961 - 80,331,351 (+)NCBI
mRatBN7.21476,103,785 - 76,106,873 (+)NCBI
RefSeq Acc Id: XR_005492957
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81480,327,961 - 80,331,255 (+)NCBI
mRatBN7.21476,103,785 - 76,106,656 (+)NCBI
RefSeq Acc Id: NP_001178609   ⟸   NM_001191680
- UniProtKB: D3ZD83 (UniProtKB/TrEMBL),   A0A8I5ZZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251308   ⟸   XM_006251246
- Peptide Label: isoform X1
- UniProtKB: D3ZD83 (UniProtKB/TrEMBL),   A0A8I5ZZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017386   ⟸   ENSRNOT00000017386
RefSeq Acc Id: XP_038947902   ⟸   XM_039091974
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000084501   ⟸   ENSRNOT00000098136
RefSeq Acc Id: ENSRNOP00000095916   ⟸   ENSRNOT00000104363
RefSeq Acc Id: NP_001399441   ⟸   NM_001412512
- UniProtKB: D3ZD83 (UniProtKB/TrEMBL),   A0A8I5ZZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001399442   ⟸   NM_001412513
- UniProtKB: D3ZD83 (UniProtKB/TrEMBL),   A0A8I5ZZQ6 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD83-F1-model_v2 AlphaFold D3ZD83 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699397
Promoter ID:EPDNEW_R9922
Type:initiation region
Name:Mfsd10_1
Description:major facilitator superfamily domain containing 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,362,658 - 81,362,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311900 AgrOrtholog
BioCyc Gene G2FUF-15298 BioCyc
Ensembl Genes ENSRNOG00000012534 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017386 ENTREZGENE
  ENSRNOT00000017386.6 UniProtKB/TrEMBL
  ENSRNOT00000098136.1 UniProtKB/TrEMBL
  ENSRNOT00000104363.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro Major_facilitator_SF UniProtKB/TrEMBL
  MFS_1 UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/TrEMBL
KEGG Report rno:305449 UniProtKB/TrEMBL
NCBI Gene 305449 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 UniProtKB/TrEMBL
  MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Mfsd10 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
  SUGAR_TRANSPORT_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012534 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt A0A8I5ZZQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKT5_RAT UniProtKB/TrEMBL
  D3ZD83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-19 Mfsd10  major facilitator superfamily domain containing 10  Tetran  tetracycline transporter-like protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Tetran  tetracycline transporter-like protein  RGD1311900_predicted  similar to tetracycline transporter-like protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311900_predicted  similar to tetracycline transporter-like protein (predicted)  LOC305449_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305449_predicted  similar to tetracycline transporter-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL