Lrpap1 (LDL receptor related protein associated protein 1) - Rat Genome Database

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Gene: Lrpap1 (LDL receptor related protein associated protein 1) Rattus norvegicus
Analyze
Symbol: Lrpap1
Name: LDL receptor related protein associated protein 1
RGD ID: 620700
Description: Exhibits lipase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; negative regulation of amyloid-beta clearance; and negative regulation of very-low-density lipoprotein particle clearance. Localizes to rough endoplasmic reticulum lumen and vesicle. Used to study membranous glomerulonephritis. Biomarker of membranous glomerulonephritis. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1); PARTICIPATES IN Hedgehog signaling pathway; Reelin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; gp330-binding 45 kDa protein; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; RAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21475,651,371 - 75,663,380 (+)NCBI
Rnor_6.0 Ensembl1480,911,270 - 80,924,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01480,911,281 - 80,923,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,599,969 - 81,611,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,292,661 - 81,304,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,295,093 - 81,308,456 (+)NCBI
Celera1474,577,874 - 74,589,883 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abbate M, etal., Eur J Cell Biol. 1993 Jun;61(1):139-49.
2. Abbate M, etal., J Am Soc Nephrol. 1994 Jun;4(12):2003-15.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gonzalez P, etal., Coron Artery Dis. 2002 Aug;13(5):251-4.
5. Hiesberger T, etal., Neuron. 1999 Oct;24(2):481-9.
6. Huang J and Makker SP, Kidney Int. 1995 Feb;47(2):432-41.
7. Kanalas JJ and Makker SP, J Biol Chem 1993 Apr 15;268(11):8188-92.
8. Makker SP, etal., Am J Pathol. 1995 Jun;146(6):1481-7.
9. McCarthy JJ, etal., Hum Genet. 2003 Dec;114(1):87-98. Epub 2003 Oct 14.
10. MGD data from the GO Consortium
11. NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline
13. Page S, etal., J Biol Chem. 2006 May 19;281(20):13931-8. Epub 2006 Mar 3.
14. Pandey P, etal., Genes Brain Behav. 2008 Nov;7(8):943-50. doi: 10.1111/j.1601-183X.2008.00436.x. Epub 2008 Aug 21.
15. Pietromonaco S, etal., Proc Natl Acad Sci U S A 1990 Mar;87(5):1811-5.
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. RGD comprehensive gene curation
21. Sanchez L, etal., Am J Med Genet 2001 Jan 8;105(1):76-8.
22. Thirone AC, etal., Diabetes. 2006 Apr;55(4):942-51.
23. Willnow TE, etal., Proc Natl Acad Sci U S A 1995 May 9;92(10):4537-41.
24. Zhang RK, etal., Zhongguo Gu Shang. 2014 Jan;27(1):54-7.
Additional References at PubMed
PMID:1718973   PMID:7774585   PMID:8083232   PMID:11294867   PMID:12477932   PMID:15082773   PMID:15489334   PMID:16227578   PMID:16263759   PMID:19098903   PMID:23386614   PMID:26005850  
PMID:26514267  


Genomics

Comparative Map Data
Lrpap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21475,651,371 - 75,663,380 (+)NCBI
Rnor_6.0 Ensembl1480,911,270 - 80,924,831 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01480,911,281 - 80,923,290 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,599,969 - 81,611,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,292,661 - 81,304,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11481,295,093 - 81,308,456 (+)NCBI
Celera1474,577,874 - 74,589,883 (+)NCBICelera
Cytogenetic Map14q21NCBI
LRPAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl43,503,612 - 3,532,446 (-)EnsemblGRCh38hg38GRCh38
GRCh3843,503,612 - 3,532,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3743,505,339 - 3,534,149 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,484,093 - 3,503,941 (-)NCBINCBI36hg18NCBI36
Build 3443,551,263 - 3,571,113NCBI
Celera43,424,737 - 3,444,504 (-)NCBI
Cytogenetic Map4p16.3NCBI
HuRef43,444,900 - 3,473,683 (-)NCBIHuRef
CHM1_143,503,272 - 3,531,989 (-)NCBICHM1_1
Lrpap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,248,834 - 35,263,043 (-)NCBIGRCm39mm39
GRCm39 Ensembl535,248,845 - 35,263,110 (-)Ensembl
GRCm38535,091,490 - 35,105,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,091,501 - 35,105,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37535,434,155 - 35,448,346 (-)NCBIGRCm37mm9NCBIm37
MGSCv36535,408,367 - 35,422,558 (-)NCBImm8
Celera532,566,121 - 32,580,312 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map518.01NCBI
Lrpap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,195,228 - 2,208,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,195,228 - 2,208,258 (-)NCBIChiLan1.0ChiLan1.0
LRPAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.143,646,179 - 3,666,098 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,646,179 - 3,666,098 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v043,663,649 - 3,683,450 (-)NCBIMhudiblu_PPA_v0panPan3
LRPAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,840,804 - 60,852,821 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,840,882 - 60,901,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,491,109 - 63,503,659 (+)NCBI
ROS_Cfam_1.0361,316,241 - 61,328,837 (+)NCBI
UMICH_Zoey_3.1360,810,231 - 60,822,660 (+)NCBI
UNSW_CanFamBas_1.0361,016,034 - 61,028,737 (+)NCBI
UU_Cfam_GSD_1.0361,371,717 - 61,384,645 (+)NCBI
Lrpap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,532,896 - 66,549,059 (+)NCBI
SpeTri2.0NW_00493647720,234,582 - 20,250,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRPAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl82,125,405 - 2,145,647 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.182,129,492 - 2,145,632 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,826,228 - 1,842,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRPAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,206,455 - 45,225,766 (+)NCBI
ChlSab1.1 Ensembl2745,206,618 - 45,225,767 (+)Ensembl
Vero_WHO_p1.0NW_0236660511,560,408 - 1,579,681 (+)NCBI
Lrpap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475524,436,128 - 24,447,923 (+)NCBI

Position Markers
RH132960  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,664,418 - 75,664,638 (+)MAPPER
Rnor_6.01480,924,329 - 80,924,548NCBIRnor6.0
Rnor_5.01481,613,017 - 81,613,236UniSTSRnor5.0
RGSC_v3.41481,305,709 - 81,305,928UniSTSRGSC3.4
Celera1474,590,922 - 74,591,141UniSTS
Cytogenetic Map14q21UniSTS
BI281742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,663,074 - 75,663,278 (+)MAPPER
Rnor_6.01480,922,985 - 80,923,188NCBIRnor6.0
Rnor_5.01481,611,673 - 81,611,876UniSTSRnor5.0
RGSC_v3.41481,304,365 - 81,304,568UniSTSRGSC3.4
Celera1474,589,578 - 74,589,781UniSTS
Cytogenetic Map14q21UniSTS
D12S1329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,660,750 - 75,661,576 (+)MAPPER
mRatBN7.21207,115,949 - 207,117,499 (+)MAPPER
Rnor_6.01226,520,548 - 226,522,097NCBIRnor6.0
Rnor_6.01480,920,661 - 80,921,486NCBIRnor6.0
Rnor_5.01481,609,349 - 81,610,174UniSTSRnor5.0
Rnor_5.01233,466,755 - 233,468,304UniSTSRnor5.0
RGSC_v3.41212,956,967 - 212,958,516UniSTSRGSC3.4
RGSC_v3.41481,302,041 - 81,302,866UniSTSRGSC3.4
Celera1474,587,254 - 74,588,079UniSTS
Celera1204,609,452 - 204,611,001UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)144031561085315610Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)144031561085315610Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)144031561085315610Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)144031561085315610Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)146187332388870994Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147339146788870994Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:486
Count of miRNA genes:252
Interacting mature miRNAs:307
Transcripts:ENSRNOT00000012665
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 6 7 74 35 36 11 6
Low 2 4 5 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012665   ⟹   ENSRNOP00000012665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1480,911,270 - 80,924,831 (+)Ensembl
RefSeq Acc Id: NM_001169113   ⟹   NP_001162584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21475,651,371 - 75,663,380 (+)NCBI
Rnor_6.01480,911,281 - 80,923,290 (+)NCBI
Rnor_5.01481,599,969 - 81,611,978 (+)NCBI
RGSC_v3.41481,292,661 - 81,304,670 (+)RGD
Celera1474,577,874 - 74,589,883 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001162584   ⟸   NM_001169113
- Peptide Label: precursor
- UniProtKB: Q99068 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012665   ⟸   ENSRNOT00000012665

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699391
Promoter ID:EPDNEW_R9916
Type:multiple initiation site
Name:Lrpap1_1
Description:LDL receptor related protein associated protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01480,911,306 - 80,911,366EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620700 AgrOrtholog
Ensembl Genes ENSRNOG00000009313 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000012665 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012665 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.81.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7129428 IMAGE-MGC_LOAD
  IMAGE:7460622 IMAGE-MGC_LOAD
InterPro A2-macroglobuin_RAP UniProtKB/Swiss-Prot
  Alpha_2_MRAP_C UniProtKB/Swiss-Prot
  MG_RAP_rcpt_1 UniProtKB/Swiss-Prot
  RAP_D2 UniProtKB/Swiss-Prot
  RAP_D3 UniProtKB/Swiss-Prot
  RAP_sf UniProtKB/Swiss-Prot
KEGG Report rno:116565 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114561 IMAGE-MGC_LOAD
  MGC:95147 IMAGE-MGC_LOAD
NCBI Gene 116565 ENTREZGENE
PANTHER PTHR16560 UniProtKB/Swiss-Prot
Pfam Alpha-2-MRAP_C UniProtKB/Swiss-Prot
  Alpha-2-MRAP_N UniProtKB/Swiss-Prot
PhenoGen Lrpap1 PhenoGen
PROSITE ER_TARGET UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47045 UniProtKB/Swiss-Prot
UniProt AMRP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4FZX8 UniProtKB/Swiss-Prot
  Q642A1 UniProtKB/Swiss-Prot
  Q64723 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrpap1  LDL receptor related protein associated protein 1  Lrpap1  low density lipoprotein receptor-related protein associated protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lrpap1  low density lipoprotein receptor-related protein associated protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lrpap1  low density lipoprotein receptor-related protein associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL