Lif (LIF, interleukin 6 family cytokine) - Rat Genome Database

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Gene: Lif (LIF, interleukin 6 family cytokine) Rattus norvegicus
Symbol: Lif
Name: LIF, interleukin 6 family cytokine
RGD ID: 620865
Description: Enables leukemia inhibitory factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cholinergic neuronal differentiation factor; leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,575,221 - 83,577,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,815,297 - 84,818,070 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,261,251 - 81,264,024 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
azathioprine  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
benzyl alcohol  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
calyculin a  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlorambucil  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clomiphene  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (EXP,ISO)
coumaphos  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimethylselenide  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
Ethyl acrylate  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
herbicide  (EXP)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
imidacloprid  (ISO)
isoflavones  (ISO)
kenpaullone  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
letrozole  (ISO)
limonene  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
MeIQx  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-Nitrosopyrrolidine  (ISO)
nicardipine  (EXP)
nickel sulfate  (ISO)
nitric oxide  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
physostigmine  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
puerarin  (EXP)
PX-866  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
ritonavir  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vanadyl sulfate  (ISO)
verapamil  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP,IMP)
astrocyte differentiation  (IMP)
blood vessel remodeling  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway via STAT  (ISO)
decidualization  (ISO)
embryo implantation  (ISO)
fibroblast proliferation  (ISO)
gene expression  (ISO)
immune response  (IEA)
leukemia inhibitory factor signaling pathway  (IBA,IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lung lobe morphogenesis  (ISO)
lung vasculature development  (ISO)
maternal process involved in female pregnancy  (ISO)
meiotic nuclear division  (ISO)
muscle organ morphogenesis  (ISO)
negative regulation of angiogenesis  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of hormone secretion  (ISO)
negative regulation of meiotic nuclear division  (ISO)
neuron development  (ISO)
positive regulation of astrocyte differentiation  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell population proliferation  (IBA,IEA,ISO)
positive regulation of corticotropin secretion  (IDA)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of neuron projection development  (IDA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of cell communication  (IEA)
regulation of cell differentiation  (IBA,IEA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO)
regulation of signaling  (IEA)
response to hypoxia  (ISO)
retina development in camera-type eye  (IDA)
signal transduction  (ISO)
somatic stem cell population maintenance  (ISO)
spongiotrophoblast differentiation  (ISO)
stem cell differentiation  (ISO)
transdifferentiation  (IMP)
trophoblast giant cell differentiation  (ISO)

Cellular Component
cytosol  (ISO)
extracellular space  (IBA,IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. TGFbeta1 stimulates the over-production of white matter astrocytes from precursors of the "brain marrow" in a rodent model of neonatal encephalopathy. Bain JM, etal., PLoS One. 2010 Mar 5;5(3):e9567.
2. Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. De Breuck S, etal., Diabetologia. 2006 Jan;49(1):108-16. Epub 2005 Dec 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents. Kanazawa H, etal., J Clin Invest. 2010 Feb 1;120(2):408-21. doi: 10.1172/JCI39778. Epub 2010 Jan 4.
6. Expression of leukemia inhibitory factor (LIF)/interleukin-6 family cytokines and receptors during in vitro osteogenesis: differential regulation by dexamethasone and LIF. Liu F, etal., Bone 2002 Jul;31(1):212-9.
7. Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis. McColm JR, etal., Exp Eye Res. 2006 Aug;83(2):438-46. Epub 2006 Apr 27.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Kainic acid induces leukemia inhibitory factor mRNA expression in the rat brain: differences in the time course of mRNA expression between the dentate gyrus and hippocampal CA1/CA3 subfields. Minami M, etal., Brain Res Mol Brain Res 2002 Oct 30;107(1):39-46.
10. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Nakanishi M, etal., Eur J Neurosci. 2007 Feb;25(3):649-58.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons. Sango K, etal., Histochem Cell Biol. 2008 Oct;130(4):669-79. Epub 2008 Aug 5.
16. Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway. Simamura E, etal., Endocrinology. 2010 Apr;151(4):1853-62. Epub 2010 Feb 16.
17. Leukaemia inhibitory factor is over-expressed by ischaemic brain tissue concomitant with reduced plasma expression following acute stroke. Slevin M, etal., Eur J Neurol. 2008 Jan;15(1):29-37. Epub 2007 Nov 27.
18. ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes. Yamakuni H, etal., J Neuroimmunol 2002 Aug;129(1-2):43-50.
19. The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Yamamori T, etal., Science 1989 Dec 15;246(4936):1412-6.
20. Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. Yoshino J, etal., J Am Soc Nephrol. 2003 Dec;14(12):3090-101.
21. Magnolin promotes autophagy and cell cycle arrest via blocking LIF/Stat3/Mcl-1 axis in human colorectal cancers. Yu H, etal., Cell Death Dis. 2018 Jun 13;9(6):702. doi: 10.1038/s41419-018-0660-4.
Additional References at PubMed
PMID:1522892   PMID:7508917   PMID:7867561   PMID:7957045   PMID:7959007   PMID:8385113   PMID:8999038   PMID:9671398   PMID:10486560   PMID:11203703   PMID:12397370   PMID:12643274  
PMID:15012602   PMID:15044319   PMID:15131589   PMID:15358627   PMID:15572029   PMID:15716414   PMID:16258063   PMID:16409782   PMID:16489116   PMID:16691571   PMID:17001659   PMID:17045017  
PMID:17828489   PMID:18032527   PMID:18258298   PMID:18469139   PMID:20624457   PMID:20629319   PMID:21385842   PMID:21446866   PMID:22291973   PMID:22783022   PMID:22905257   PMID:22939972  
PMID:22949634   PMID:24006456   PMID:24008729   PMID:25229963   PMID:25639936   PMID:25907681   PMID:26352383   PMID:26723254   PMID:27661001   PMID:29222114   PMID:33376583  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21479,131,049 - 79,140,486 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,575,221 - 83,577,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,815,297 - 84,818,070 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,261,251 - 81,264,024 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,482,652 - 84,500,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,163,603 - 85,181,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,887,856 - 84,890,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,907,000 - 84,909,775 (+)NCBI
Celera1478,044,967 - 78,047,741 (+)NCBICelera
Cytogenetic Map14q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382230,240,453 - 30,246,759 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,240,453 - 30,246,759 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,636,442 - 30,642,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,966,441 - 28,972,748 (-)NCBINCBI36Build 36hg18NCBI36
Build 342228,960,996 - 28,967,302NCBI
Celera2214,436,129 - 14,442,479 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,598,220 - 13,604,620 (-)NCBIHuRef
CHM1_12230,595,573 - 30,601,977 (-)NCBICHM1_1
T2T-CHM13v2.02230,703,775 - 30,710,077 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39114,207,587 - 4,222,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,207,557 - 4,222,514 (+)EnsemblGRCm39 Ensembl
GRCm38114,257,568 - 4,272,514 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,257,557 - 4,272,514 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,157,571 - 4,172,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,157,571 - 4,172,517 (+)NCBIMGSCv36mm8
Celera114,756,756 - 4,771,684 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554554,489,421 - 4,497,940 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,489,515 - 4,505,439 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12242,906,197 - 42,912,484 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,276,576 - 11,282,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,078,862 - 29,095,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,078,862 - 29,095,608 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12623,400,226 - 23,418,538 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,403,364 - 23,406,851 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,274,713 - 23,278,054 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,784,273 - 23,806,847 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,784,274 - 23,790,798 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,489,168 - 23,492,514 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,752,037 - 23,755,369 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,812,337 - 23,815,691 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118116,317,865 - 116,334,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936904410,043 - 413,257 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936904410,043 - 413,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1447,221,560 - 47,238,749 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,221,540 - 47,239,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,263,470 - 50,277,784 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11913,121,261 - 13,127,663 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,121,297 - 13,127,679 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,007,597 - 113,025,154 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247476,558,817 - 6,565,281 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,558,872 - 6,565,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Lif
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:114
Interacting mature miRNAs:124
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 3 8 18 1 1 5 23 29 11 1
Below cutoff 41 36 28 1 28 7 10 61 12 12 7


RefSeq Acc Id: ENSRNOT00000009313   ⟹   ENSRNOP00000009313
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,134,574 - 79,140,482 (+)Ensembl
Rnor_6.0 Ensembl1484,482,674 - 84,500,642 (+)Ensembl
RefSeq Acc Id: NM_022196   ⟹   NP_071532
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,134,597 - 79,140,486 (+)NCBI
Rnor_6.01484,496,470 - 84,499,244 (+)NCBI
Rnor_5.01485,163,603 - 85,181,855 (+)NCBI
RGSC_v3.41484,887,856 - 84,890,630 (+)RGD
Celera1478,044,967 - 78,047,741 (+)RGD
RefSeq Acc Id: XM_006251364   ⟹   XP_006251426
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,131,114 - 79,140,486 (+)NCBI
Rnor_6.01484,492,909 - 84,500,574 (+)NCBI
Rnor_5.01485,163,603 - 85,181,855 (+)NCBI
RefSeq Acc Id: XM_008770359   ⟹   XP_008768581
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,134,709 - 79,140,486 (+)NCBI
Rnor_6.01484,496,266 - 84,500,574 (+)NCBI
RefSeq Acc Id: XM_039092388   ⟹   XP_038948316
Rat AssemblyChrPosition (strand)Source
mRatBN7.21479,131,049 - 79,140,486 (+)NCBI
RefSeq Acc Id: NP_071532   ⟸   NM_022196
- Peptide Label: precursor
- UniProtKB: P17777 (UniProtKB/Swiss-Prot),   O88211 (UniProtKB/TrEMBL),   A6IKF9 (UniProtKB/TrEMBL),   F7FFY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251426   ⟸   XM_006251364
- Peptide Label: isoform X1
- UniProtKB: P17777 (UniProtKB/Swiss-Prot),   O88211 (UniProtKB/TrEMBL),   A6IKF9 (UniProtKB/TrEMBL),   F7FFY1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768581   ⟸   XM_008770359
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000009313   ⟸   ENSRNOT00000009313
RefSeq Acc Id: XP_038948316   ⟸   XM_039092388
- Peptide Label: isoform X1
- UniProtKB: P17777 (UniProtKB/Swiss-Prot),   O88211 (UniProtKB/TrEMBL),   A6IKF9 (UniProtKB/TrEMBL),   F7FFY1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17777-F1-model_v2 AlphaFold P17777 1-202 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699445
Promoter ID:EPDNEW_R9968
Type:multiple initiation site
Description:LIF, interleukin 6 family cytokine
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01484,496,408 - 84,496,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620865 AgrOrtholog
BioCyc Gene G2FUF-15179 BioCyc
Ensembl Genes ENSRNOG00000007002 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009313 ENTREZGENE
  ENSRNOT00000009313.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukemia_IF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukemia_IF/oncostatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leukemia_IF/oncostatin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60584 UniProtKB/TrEMBL
  PTHR10633 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIF_OSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lif PhenoGen
RatGTEx ENSRNOG00000007002 RatGTEx
SMART LIF_OSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIF_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88211 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-27 Lif  LIF, interleukin 6 family cytokine  Lif  leukemia inhibitory factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-18 Lif  leukemia inhibitory factor  Lif  leukemia inhibitory factor (cholinergic differentiation factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Lif  leukemia inhibitory factor (cholinergic differentiation factor)  Lif  leukemia inhibitory factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Lif  leukemia inhibitory factor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Lif  leukemia inhibitory factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process regulates growth and differentiation in the embryo and in the adult 728949
gene_process may be involved in neurogenesis in the granule cell layer and in ectopic migration of granule cells to the polymorph and molecular layers of the dentate gyrus 729116