protein phosphatase 3, regulatory subunit B, alpha
RGD ID:
69230
Description:
Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in sarcolemma. Predicted to be part of calcineurin complex. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha); PARTICIPATES IN calcineurin signaling pathway; interleukin-12 signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
calcineurin subunit B type 1; protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); protein phospatase 3, regulatory subunit B, alpha isoform,type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 3 regulatory subunit B alpha; protein phosphatase 3 regulatory subunit B alpha isoform (calcineurin B type I); protein phosphatase 3, regulatory subunit B, alpha isoform; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PPP3R1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PPP3R1 mRNA
PPP3R1 gene mutant form inhibits the reaction [ATP2A2 protein affects the transport of Calcium], PPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium]
PPP3R1 gene mutant form inhibits the reaction [ATP2A2 protein affects the transport of Calcium], PPP3R1 gene mutant form inhibits the reaction [SLC8A1 protein affects the transport of Calcium]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PPP3R1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP3R1 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PPP3R1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP3R1 mRNA
[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP3R1 mRNA
Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit.
Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein.
Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.
