Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha) - Rat Genome Database

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Gene: Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha) Rattus norvegicus
Analyze
Symbol: Ppp3r1
Name: protein phosphatase 3, regulatory subunit B, alpha
RGD ID: 69230
Description: Enables phosphoprotein phosphatase activity. Predicted to be involved in several processes, including calcineurin-mediated signaling; postsynaptic modulation of chemical synaptic transmission; and regulation of vesicle-mediated transport. Predicted to act upstream of or within several processes, including calcineurin-NFAT signaling cascade; circulatory system development; and myelination in peripheral nervous system. Predicted to be located in postsynapse and sarcolemma. Predicted to be part of calcineurin complex. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha); PARTICIPATES IN calcineurin signaling pathway; interleukin-12 signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: calcineurin subunit B type 1; protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); protein phospatase 3, regulatory subunit B, alpha isoform,type 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 3 regulatory subunit B alpha; protein phosphatase 3 regulatory subunit B alpha isoform (calcineurin B type I); protein phosphatase 3, regulatory subunit B, alpha isoform; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,556,743 - 91,606,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,875,569 - 95,913,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,119,906 - 97,157,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,584,970 - 93,623,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,311,224 - 100,360,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,311,173 - 100,360,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,178,695 - 100,227,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,060,302 - 98,099,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,079,446 - 98,118,237 (+)NCBI
Celera1490,614,429 - 90,652,365 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lithium chloride  (ISO)
methamphetamine  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
O-palmitoylcarnitine  (ISO)
ochratoxin A  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perindopril  (EXP)
potassium dichromate  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Bales JW, etal., Brain Res. 2010 Oct 28;1358:211-20. doi: 10.1016/j.brainres.2010.08.029. Epub 2010 Aug 13.
3. cDNA cloning of an alternatively spliced isoform of the regulatory subunit of Ca2+/calmodulin-dependent protein phosphatase (calcineurin B alpha 2). Chang CD, etal., Biochim Biophys Acta 1994 Mar 1;1217(2):174-80.
4. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Diedrichs H, etal., Eur J Heart Fail. 2004 Jan;6(1):3-9.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Mammucari C, etal., Dev Cell. 2005 May;8(5):665-76.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. Perrino BA, etal., Eur J Biochem 2002 Jul;269(14):3540-8.
12. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Peterson D, etal., Alzheimers Dement. 2014 May;10(3):366-71. doi: 10.1016/j.jalz.2013.02.010. Epub 2013 May 30.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Robinson RA, etal., Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9.
17. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Sanna B, etal., Mol Cell Biol. 2005 Feb;25(3):865-78.
18. Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. Schomisch SJ, etal., J Thorac Cardiovasc Surg. 2005 Oct;130(4):1151.
19. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. Tang W, etal., Am Heart J. 2005 Oct;150(4):845-51.
20. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:10200328   PMID:11439183   PMID:11733061   PMID:12218175   PMID:12357034   PMID:12477932   PMID:15339668   PMID:15489334   PMID:16998587   PMID:17888887   PMID:18755154   PMID:19179536  
PMID:20639889   PMID:20797538   PMID:22343722   PMID:22688515   PMID:22757692   PMID:22871113   PMID:22926314   PMID:23468591   PMID:24018048   PMID:24413018   PMID:26794871   PMID:27974827  
PMID:29973623   PMID:34791930  


Genomics

Comparative Map Data
Ppp3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21491,556,743 - 91,606,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,875,569 - 95,913,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,119,906 - 97,157,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,584,970 - 93,623,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,311,224 - 100,360,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,311,173 - 100,360,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,178,695 - 100,227,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,060,302 - 98,099,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,079,446 - 98,118,237 (+)NCBI
Celera1490,614,429 - 90,652,365 (+)NCBICelera
Cytogenetic Map14q22NCBI
PPP3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,178,857 - 68,252,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,178,857 - 68,256,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,405,989 - 68,479,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,259,493 - 68,333,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,317,639 - 68,391,302NCBI
Celera268,255,597 - 68,329,209 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,143,447 - 68,181,703 (-)NCBIHuRef
CHM1_1268,336,792 - 68,410,397 (-)NCBICHM1_1
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBIT2T-CHM13v2.0
Ppp3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
Ppp3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,623,917 - 16,690,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,624,214 - 16,690,783 (+)NCBIChiLan1.0ChiLan1.0
PPP3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12A58,160,135 - 58,233,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,227,282 - 68,300,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,242,552 - 67,308,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,244,329 - 67,275,487 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,135,373 - 67,199,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,263,516 - 68,327,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,261,752 - 68,325,387 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,946,324 - 68,012,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,243,919 - 68,309,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,541,451 - 68,605,689 (-)NCBIUU_Cfam_GSD_1.0
Ppp3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,826,513 - 15,947,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,718,720 - 12,744,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649112,623,349 - 12,654,502 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,623,931 - 12,654,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,000,517 - 74,068,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,004,620 - 74,068,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,531,587 - 77,598,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,832,976 - 38,907,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,832,809 - 38,905,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,068,593 - 73,142,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,087,705 - 5,156,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,087,726 - 5,156,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp3r1
363 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:492
Count of miRNA genes:187
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000031275, ENSRNOT00000067846
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat

Markers in Region
BE113504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21491,606,474 - 91,606,679 (+)MAPPERmRatBN7.2
Rnor_6.014100,360,958 - 100,361,162NCBIRnor6.0
Rnor_5.014100,178,246 - 100,178,450UniSTSRnor5.0
RGSC_v3.41498,099,345 - 98,099,549UniSTSRGSC3.4
Celera1490,652,617 - 90,652,821UniSTS
RH 3.4 Map14698.3UniSTS
Cytogenetic Map14q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 57 41 19 41 8 11 74 35 40 11 8
Low 3 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000031275   ⟹   ENSRNOP00000037143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl14100,311,173 - 100,359,239 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067846   ⟹   ENSRNOP00000058834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)Ensembl
Rnor_6.0 Ensembl14100,322,568 - 100,360,879 (+)Ensembl
RefSeq Acc Id: NM_017309   ⟹   NP_059005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21491,568,218 - 91,606,391 (+)NCBI
Rnor_6.014100,322,735 - 100,360,706 (+)NCBI
Rnor_5.014100,178,695 - 100,227,295 (-)NCBI
RGSC_v3.41498,060,302 - 98,099,092 (+)RGD
Celera1490,614,429 - 90,652,365 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251517   ⟹   XP_006251579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21491,556,743 - 91,606,230 (+)NCBI
Rnor_6.014100,311,224 - 100,360,879 (+)NCBI
Rnor_5.014100,178,695 - 100,227,295 (-)NCBI
Sequence:
RefSeq Acc Id: NP_059005   ⟸   NM_017309
- UniProtKB: P63100 (UniProtKB/Swiss-Prot),   A6JPY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251579   ⟸   XM_006251517
- Peptide Label: isoform X1
- UniProtKB: P63100 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037143   ⟸   ENSRNOT00000031275
RefSeq Acc Id: ENSRNOP00000058834   ⟸   ENSRNOT00000067846
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63100-F1-model_v2 AlphaFold P63100 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699502
Promoter ID:EPDNEW_R10025
Type:initiation region
Name:Ppp3r1_1
Description:protein phosphatase 3, regulatory subunit B, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.014100,322,726 - 100,322,786EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69230 AgrOrtholog
BioCyc Gene G2FUF-14935 BioCyc
Ensembl Genes ENSRNOG00000043210 Ensembl
  ENSRNOG00055008015 UniProtKB/Swiss-Prot
  ENSRNOG00060015185 UniProtKB/Swiss-Prot
  ENSRNOG00065005530 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055013521 UniProtKB/Swiss-Prot
  ENSRNOT00060026061 UniProtKB/Swiss-Prot
  ENSRNOT00065008210 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317429 IMAGE-MGC_LOAD
InterPro Calcineur_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29748 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105458 IMAGE-MGC_LOAD
NCBI Gene 29748 ENTREZGENE
PANTHER PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 UniProtKB/Swiss-Prot
  PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 UniProtKB/TrEMBL
  PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 UniProtKB/TrEMBL
  PTHR45942 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp3r1 PhenoGen
PRINTS PARVALBUMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043210 RatGTEx
  ENSRNOG00055008015 RatGTEx
  ENSRNOG00060015185 RatGTEx
  ENSRNOG00065005530 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EF-hand UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JPY9 ENTREZGENE, UniProtKB/TrEMBL
  A6JPZ0_RAT UniProtKB/TrEMBL
  CANB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P06705 UniProtKB/Swiss-Prot
  P15117 UniProtKB/Swiss-Prot
  Q08044 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-03 Ppp3r1  protein phosphatase 3, regulatory subunit B, alpha  Ppp3r1  protein phosphatase 3, regulatory subunit B, alpha isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-18 Ppp3r1  protein phosphatase 3, regulatory subunit B, alpha isoform  Ppp3r1  protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-01 Pcsk6  protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)  Ppp3r1  protein phospatase 3, regulatory subunit B, alpha isoform,type 1  Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Ppp3r1  protein phospatase 3, regulatory subunit B, alpha isoform,type 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference