Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	69230
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Ppp3r1
Name:	protein phosphatase 3, regulatory subunit B, alpha

Acc ID:	GO:0033173
Term:	calcineurin-NFAT signaling cascade
Definition:	Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).
Definition Source(s):	GOC:lm, GOC:mah, PMID:12975316, PMID:15928679

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ppp3r1	acts_upstream_of_or_within	ISO	Ppp3r1 (Mus musculus)	1624291	RGD	MGI:103296 MGI:1920431 PMID:19179536	PMID:19179536
Ppp3r1	involved_in	ISO	PPP3R1 (Homo sapiens)	1624291	RGD	PMID:22688515	PMID:22688515

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