Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)) - Rat Genome Database

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Gene: Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)) Mus musculus
Analyze
Symbol: Ppp3r1
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
RGD ID: 735592
MGI Page MGI
Description: Enables phosphatase binding activity and phosphoprotein phosphatase activity. Involved in postsynaptic modulation of chemical synaptic transmission; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle cycle. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; circulatory system development; and myelination in peripheral nervous system. Located in sarcolemma. Part of calcineurin complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is expressed in brain; heart; jaw skeleton; lung; and tooth. Used to study dilated cardiomyopathy and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcineurin subunit B type 1; CaN; CaNB1; Cnb; Cnb1; MCIP1; PP2B beta 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 3 regulatory subunit B alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
Brodifacoum  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP)
cannabigerol  (EXP)
CGP 52608  (ISO)
chromium(6+)  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lithium chloride  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
miconazole  (EXP)
monosodium L-glutamate  (EXP)
morphine  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
O-palmitoylcarnitine  (EXP)
ochratoxin A  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
tamoxifen  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal angiogenesis  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal heart morphology  (IAGP)
abnormal kidney pelvis morphology  (IAGP)
abnormal latent inhibition of conditioning behavior  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal positive T cell selection  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal ureter development  (IAGP)
abnormal vascular endothelial cell development  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
absent vitelline blood vessels  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
decreased body size  (IAGP)
decreased cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased heart left ventricle muscle contractility  (IAGP)
decreased thymocyte number  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated kidney calyx  (IAGP)
dilated renal tubule  (IAGP)
disorganized yolk sac vascular plexus  (IAGP)
distended pericardium  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
hydronephrosis  (IAGP)
hyperactivity  (IAGP)
impaired ureteric peristalsis  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased heart left ventricle size  (IAGP)
increased heart right ventricle size  (IAGP)
increased vertical activity  (IAGP)
kidney atrophy  (IAGP)
kidney failure  (IAGP)
premature death  (IAGP)
reduced long-term depression  (IAGP)
reduced sensorimotor gating  (IAGP)
renal interstitial fibrosis  (IAGP)
social withdrawal  (IAGP)
thin ventricular wall  (IAGP)
thymus hypoplasia  (IAGP)
ureteropelvic junction obstruction  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Bales JW, etal., Brain Res. 2010 Oct 28;1358:211-20. doi: 10.1016/j.brainres.2010.08.029. Epub 2010 Aug 13.
2. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Diedrichs H, etal., Eur J Heart Fail. 2004 Jan;6(1):3-9.
3. Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
4. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Mammucari C, etal., Dev Cell. 2005 May;8(5):665-76.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Peterson D, etal., Alzheimers Dement. 2014 May;10(3):366-71. doi: 10.1016/j.jalz.2013.02.010. Epub 2013 May 30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Robinson RA, etal., Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9.
14. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Sanna B, etal., Mol Cell Biol. 2005 Feb;25(3):865-78.
15. Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. Schomisch SJ, etal., J Thorac Cardiovasc Surg. 2005 Oct;130(4):1151.
16. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. Tang W, etal., Am Heart J. 2005 Oct;150(4):845-51.
17. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:1325794   PMID:8631904   PMID:9017603   PMID:10349636   PMID:11015619   PMID:11042159   PMID:11076861   PMID:11123943   PMID:11217851   PMID:11439183   PMID:11733061   PMID:12466851  
PMID:12477932   PMID:12851457   PMID:15030770   PMID:15057312   PMID:15082723   PMID:15173172   PMID:15262994   PMID:15339668   PMID:15757646   PMID:16141072   PMID:16141073   PMID:16251439  
PMID:16473827   PMID:16554754   PMID:16648474   PMID:16717086   PMID:16988714   PMID:16998587   PMID:17198697   PMID:17237284   PMID:17289669   PMID:17640527   PMID:17884821   PMID:18046413  
PMID:18799693   PMID:18818667   PMID:19169262   PMID:19179536   PMID:19318421   PMID:19463978   PMID:19700627   PMID:19710169   PMID:20037164   PMID:20308572   PMID:20421389   PMID:20485437  
PMID:20639889   PMID:20797538   PMID:21267068   PMID:21677750   PMID:21689596   PMID:21821099   PMID:21873635   PMID:22116828   PMID:22300732   PMID:22306086   PMID:22343722   PMID:22814600  
PMID:22984995   PMID:23303818   PMID:23825400   PMID:23904597   PMID:23946498   PMID:24139046   PMID:24413018   PMID:24478374   PMID:24698271   PMID:24742621   PMID:25009293   PMID:26058076  
PMID:26365185   PMID:26411342   PMID:26443861   PMID:26794871   PMID:27043494   PMID:27301880   PMID:27694923   PMID:27805050   PMID:28126489   PMID:28462391   PMID:28824366   PMID:29305867  
PMID:29382714   PMID:29427598   PMID:29444424   PMID:29488389   PMID:29500351   PMID:29515579   PMID:29549257   PMID:29661826   PMID:29709916   PMID:29723192   PMID:30561331   PMID:30699351  
PMID:31113954   PMID:31189649   PMID:31626368   PMID:32130954   PMID:32325033   PMID:32445858   PMID:32641402   PMID:32882262   PMID:33879538   PMID:34021041   PMID:34157302   PMID:34910904  
PMID:35364006   PMID:36417873   PMID:37310791   PMID:37508531   PMID:38288580   PMID:38527808  


Genomics

Comparative Map Data
Ppp3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
PPP3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,178,857 - 68,252,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,178,857 - 68,256,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,405,989 - 68,479,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,259,493 - 68,333,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,317,639 - 68,391,302NCBI
Celera268,255,597 - 68,329,209 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,143,447 - 68,181,703 (-)NCBIHuRef
CHM1_1268,336,792 - 68,410,397 (-)NCBICHM1_1
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBIT2T-CHM13v2.0
Ppp3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,758,333 - 95,808,015 (+)NCBIGRCr8
mRatBN7.21491,556,743 - 91,606,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,875,569 - 95,913,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,119,906 - 97,157,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,584,970 - 93,623,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,311,224 - 100,360,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,311,173 - 100,360,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,178,695 - 100,227,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,060,302 - 98,099,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,079,446 - 98,118,237 (+)NCBI
Celera1490,614,429 - 90,652,365 (+)NCBICelera
Cytogenetic Map14q22NCBI
Ppp3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,623,917 - 16,690,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,624,214 - 16,690,783 (+)NCBIChiLan1.0ChiLan1.0
PPP3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,156,551 - 58,229,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,160,135 - 58,233,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,227,282 - 68,300,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,242,552 - 67,308,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,244,329 - 67,275,487 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,135,373 - 67,199,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,263,516 - 68,327,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,261,752 - 68,325,387 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,946,324 - 68,012,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,243,919 - 68,309,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,541,451 - 68,605,689 (-)NCBIUU_Cfam_GSD_1.0
Ppp3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,826,513 - 15,947,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,718,720 - 12,744,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649112,623,349 - 12,654,502 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,623,931 - 12,654,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,000,517 - 74,068,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,004,620 - 74,068,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,531,587 - 77,598,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,832,976 - 38,907,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,832,809 - 38,905,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,068,593 - 73,142,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,087,705 - 5,156,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,087,726 - 5,156,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp3r1
1658 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:640
Count of miRNA genes:411
Interacting mature miRNAs:486
Transcripts:ENSMUST00000102880, ENSMUST00000154425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
10412216Eae44_mexperimental allergic encephalomyelitis susceptibility 44 (mouse)Not determined111226863739950840Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
Ppp3r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B3UniSTS
Cytogenetic Map11A3.1UniSTS
cM Map11 UniSTS
cM Map4 UniSTS
UniSTS:236523  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,199,650 - 17,199,851UniSTSGRCm38
MGSCv371117,099,653 - 17,099,854UniSTSGRCm37
Celera1117,573,314 - 17,573,515UniSTS
Cytogenetic Map11A3.1UniSTS
D2S2724  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,198,415 - 17,198,738UniSTSGRCm38
MGSCv371117,098,418 - 17,098,741UniSTSGRCm37
Celera1117,572,079 - 17,572,402UniSTS
Cytogenetic Map11A3.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000102880   ⟹   ENSMUSP00000099944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)Ensembl
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,142,844 - 17,145,109 (+)Ensembl
GRCm38.p6 Ensembl1117,192,844 - 17,195,109 (+)Ensembl
RefSeq Acc Id: NM_024459   ⟹   NP_077779
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391117,109,298 - 17,150,380 (+)NCBI
GRCm381117,159,298 - 17,200,380 (+)ENTREZGENE
MGSCv371117,059,301 - 17,100,383 (+)RGD
Celera1117,532,396 - 17,574,044 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_077779   ⟸   NM_024459
- UniProtKB: Q3V067 (UniProtKB/Swiss-Prot),   Q5F225 (UniProtKB/Swiss-Prot),   Q63810 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099944   ⟸   ENSMUST00000102880
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63810-F1-model_v2 AlphaFold Q63810 1-170 view protein structure

Promoters
RGD ID:6821601
Promoter ID:MM_KWN:6515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000011611
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361117,058,934 - 17,059,434 (+)MPROMDB
RGD ID:8674028
Promoter ID:EPDNEW_M15042
Type:initiation region
Name:Ppp3r1_1
Description:Mus musculus protein phosphatase 3, regulatory subunit B, alphaisoform (calcineurin B, type I) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381117,159,317 - 17,159,377EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107172 AgrOrtholog
Ensembl Genes ENSMUSG00000033953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102880 ENTREZGENE
  ENSMUST00000102880.5 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro Calcineur_B UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19058 UniProtKB/Swiss-Prot
MGD MGI:107172 ENTREZGENE
NCBI Gene 19058 ENTREZGENE
PANTHER PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1 UniProtKB/Swiss-Prot
  PTHR45942 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Ppp3r1 PhenoGen
PRINTS PARVALBUMIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt CANB1_MOUSE UniProtKB/Swiss-Prot
  Q3V067 ENTREZGENE
  Q5F225 ENTREZGENE
  Q63810 ENTREZGENE
UniProt Secondary Q3V067 UniProtKB/Swiss-Prot
  Q5F225 UniProtKB/Swiss-Prot