Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ppp3r1 (protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)) Mus musculus
Analyze
Symbol: Ppp3r1
Name: protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
RGD ID: 735592
MGI Page MGI
Description: Enables phosphatase binding activity and phosphoprotein phosphatase activity. Involved in postsynaptic modulation of chemical synaptic transmission; regulation of postsynaptic neurotransmitter receptor internalization; and regulation of synaptic vesicle cycle. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; circulatory system development; and myelination in peripheral nervous system. Located in sarcolemma. Part of calcineurin complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is expressed in brain; heart; jaw skeleton; lung; and tooth. Used to study dilated cardiomyopathy and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcineurin subunit B type 1; CaN; CaNB1; Cnb; Cnb1; MCIP1; PP2B beta 1; protein phosphatase 2B regulatory subunit 1; protein phosphatase 3 regulatory subunit B alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1MouseAlzheimer's disease disease_progressionISORGD:135043213830878DNA:SNP: :rs1868402 (human)RGD 
Ppp3r1MouseAlzheimer's disease  IEP 13830879 RGD 
Ppp3r1Mousedilated cardiomyopathy  ISORGD:13504321580709 RGD 
Ppp3r1MouseLeft Ventricular Hypertrophy  ISORGD:13504321580708 RGD 
Ppp3r1MouseLeft Ventricular Hypertrophy  ISORGD:13504321580706 RGD 
Ppp3r1MouseMyocardial Ischemia  ISORGD:692301580707 RGD 
Ppp3r1Mousetraumatic brain injury  ISORGD:6923013830881 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mouseautosomal dominant nonsyndromic deafness 58  ISORGD:13504328554872ClinVar Annotator: match by term: Deafness, autosomal dominant 58ClinVarPMID:36553541
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1MouseLeft Ventricular Hypertrophy  ISORGD:135043211554173CTD Direct Evidence: marker/mechanismCTDPMID:18344631
Ppp3r1MouseMyocardial Ischemia  ISORGD:135043211554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mousedilated cardiomyopathy  IAGP 13592920 MouseDO 
Ppp3r1Mouseschizophrenia  IAGP 13592920OMIM:181500MouseDO 

1 to 20 of 107 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mouse(+)-pilocarpine decreases expressionISORGD:692306480464Pilocarpine results in decreased expression of PPP3R1 mRNACTDPMID:14656328
Ppp3r1Mouse(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of PPP3R1 mRNACTDPMID:21955143
Ppp3r1Mouse1,2-dimethylhydrazine multiple interactionsEXP 6480464Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of PPP3R1 mRNA]CTDPMID:22206623
Ppp3r1Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of PPP3R1 mRNACTDPMID:22206623
Ppp3r1Mouse1,3-dinitrobenzene increases expressionISORGD:6923064804643-dinitrobenzene results in increased expression of PPP3R1 mRNACTDPMID:21983209
Ppp3r1Mouse17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of PPP3R1 mRNACTDPMID:17555576
Ppp3r1Mouse17beta-estradiol affects expressionISORGD:13504326480464Estradiol affects the expression of PPP3R1 mRNACTDPMID:22574217
Ppp3r1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PPP3R1 mRNACTDPMID:19770486
Ppp3r1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:692306480464Tetrachlorodibenzodioxin results in increased expression of PPP3R1 mRNACTDPMID:34747641
Ppp3r1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:692306480464Tetrachlorodibenzodioxin affects the expression of PPP3R1 mRNACTDPMID:32109520
Ppp3r1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PPP3R1 mRNACTDPMID:21570461
Ppp3r1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:692306480464Tetrachlorodibenzodioxin results in decreased expression of PPP3R1 mRNACTDPMID:21215274|PMID:33387578
Ppp3r1Mouse2,3,7,8-Tetrachlorodibenzofuran decreases expressionISORGD:6923064804642,3,7,8-tetrachlorodibenzofuran results in decreased expression of PPP3R1 mRNACTDPMID:32109520
Ppp3r1Mouse2,4-dinitrotoluene affects expressionISORGD:6923064804642,4-dinitrotoluene affects the expression of PPP3R1 mRNACTDPMID:21346803
Ppp3r1Mouse2-hydroxypropanoic acid increases expressionISORGD:13504326480464Lactic Acid results in increased expression of PPP3R1 mRNACTDPMID:30851411
Ppp3r1Mouse2-methylcholine affects expressionISORGD:13504326480464beta-methylcholine affects the expression of PPP3R1 mRNACTDPMID:21179406
Ppp3r1Mouse3,4-methylenedioxymethamphetamine increases expressionEXP 6480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PPP3R1 mRNACTDPMID:19285098|PMID:20188158
Ppp3r1Mouse3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PPP3R1 mRNACTDPMID:26251327
Ppp3r1Mouse3-isobutyl-1-methyl-7H-xanthine multiple interactionsISORGD:13504326480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ...CTDPMID:28628672
Ppp3r1Mouse4,4'-diaminodiphenylmethane increases expressionEXP 64804644,4'-diaminodiphenylmethane results in increased expression of PPP3R1 mRNACTDPMID:18648102

1 to 20 of 107 rows

Biological Process
1 to 20 of 24 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mousebranching involved in blood vessel morphogenesis acts_upstream_of_or_withinIMPMGI:30439862290270 PMID:11439183MGIPMID:11439183
Ppp3r1Mousecalcineurin-NFAT signaling cascade involved_inIBAPANTHER:PTN000551474|UniProtKB:P63098|MGI:1071722290270 GO_CentralGO_REF:0000033
Ppp3r1Mousecalcineurin-NFAT signaling cascade acts_upstream_of_or_withinIGIMGI:103296|MGI:19204312290270 PMID:19179536MGIPMID:19179536
Ppp3r1Mousecalcineurin-NFAT signaling cascade involved_inISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mouseepithelial to mesenchymal transition acts_upstream_of_or_withinIMPMGI:30440312290270 PMID:15339668MGIPMID:15339668
Ppp3r1Mouseheart development acts_upstream_of_or_withinIMPMGI:30440312290270 PMID:15339668MGIPMID:15339668
Ppp3r1Mouselung epithelial cell differentiation acts_upstream_of_or_withinIMPMGI:30440312290270 PMID:16998587MGIPMID:16998587
Ppp3r1Mousemyelination in peripheral nervous system acts_upstream_of_or_withinIMPMGI:30440312290270 PMID:19179536MGIPMID:19179536
Ppp3r1Mousenegative regulation of calcium ion import across plasma membrane involved_inNAS 2290270 PMID:17640527ComplexPortalPMID:17640527
Ppp3r1Mousepositive regulation of calcineurin-NFAT signaling cascade involved_inNAS 2290270 PMID:22343722, PMID:8631904ComplexPortalPMID:22343722|PMID:8631904
Ppp3r1Mousepositive regulation of calcium ion import across plasma membrane involved_inNAS 2290270 PMID:17640527ComplexPortalPMID:17640527
Ppp3r1Mousepositive regulation of transcription by RNA polymerase II involved_inISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mousepositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P63098|ensembl:ENSP000002343102290270 EnsemblGO_REF:0000107
Ppp3r1Mousepostsynaptic modulation of chemical synaptic transmission involved_inIMP 2290270 PMID:11733061, PMID:20797538SynGOPMID:11733061|PMID:20797538
Ppp3r1Mousepostsynaptic modulation of chemical synaptic transmission involved_inIDA 2290270 PMID:11733061, PMID:20797538SynGOPMID:11733061|PMID:20797538
Ppp3r1Mouseprotein dephosphorylation  ISORGD:692309068941 RGDPMID:12135494|REF_RGD_ID:729536
Ppp3r1Mouseprotein dephosphorylation acts_upstream_of_or_withinIMPMGI:30439862290270 PMID:11439183MGIPMID:11439183
Ppp3r1Mouseprotein import into nucleus acts_upstream_of_or_withinIMPMGI:30439862290270 PMID:11439183MGIPMID:11439183
Ppp3r1Mouseprotein localization to nucleus acts_upstream_of_or_withinIMPMGI:30440222290270 PMID:16998587MGIPMID:16998587
Ppp3r1Mouseregulation of postsynaptic neurotransmitter receptor internalization involved_inIMP 2290270 PMID:11733061SynGOPMID:11733061
1 to 20 of 24 rows

Cellular Component
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mousecalcineurin complex part_ofNAS 2290270 PMID:11123943ComplexPortalPMID:11123943
Ppp3r1Mousecalcineurin complex part_ofISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mousecalcineurin complex part_ofIBAPANTHER:PTN000551259|UniProtKB:P63099|UniProtKB:Q8IKV9|MGI:107172|UniProtKB:P63098|SGD:S000001673|dictyBase:DDB_G0267446|PomBase:SPCC830.06|MGI:1071712290270 GO_CentralGO_REF:0000033
Ppp3r1Mousecalcineurin complex part_ofIDA 2290270 PMID:26794871UniProtPMID:26794871
Ppp3r1Mousecytosol located_inNAS 2290270 PMID:22343722, PMID:28126489ComplexPortalPMID:22343722|PMID:28126489
Ppp3r1Mousecytosol located_inTAS 2290270 ReactomeReactome:R-MMU-2025936
Ppp3r1Mouseglutamatergic synapse is_active_inIMP 2290270 PMID:11733061, PMID:23825400SynGOPMID:11733061|PMID:23825400
Ppp3r1Mouseglutamatergic synapse is_active_inIDA 2290270 PMID:11733061, PMID:23825400, PMID:24413018SynGOPMID:11733061|PMID:23825400|PMID:24413018
Ppp3r1Mouseglutamatergic synapse is_active_inEXP 2290270 PMID:24413018SynGOPMID:24413018
Ppp3r1Mousehippocampal mossy fiber to CA3 synapse is_active_inIMP 2290270 PMID:23825400SynGOPMID:23825400
Ppp3r1Mousehippocampal mossy fiber to CA3 synapse is_active_inIDA 2290270 PMID:23825400SynGOPMID:23825400
Ppp3r1Mouseparallel fiber to Purkinje cell synapse is_active_inIDA 2290270 PMID:20797538SynGOPMID:20797538
Ppp3r1Mouseparallel fiber to Purkinje cell synapse is_active_inIMP 2290270 PMID:20797538SynGOPMID:20797538
Ppp3r1Mousepostsynapse located_inIEAGO:00991702290270 GOCGO_REF:0000108
Ppp3r1Mouseprotein serine/threonine phosphatase complex part_ofNAS 2290270 PMID:15757646ComplexPortalPMID:15757646
Ppp3r1Mousesarcolemma located_inIDA 2290270 PMID:20639889BHF-UCLPMID:20639889
Ppp3r1MouseSchaffer collateral - CA1 synapse is_active_inIMP 2290270 PMID:11733061SynGOPMID:11733061
Ppp3r1MouseSchaffer collateral - CA1 synapse is_active_inIDA 2290270 PMID:11733061SynGOPMID:11733061
Ppp3r1Mousesynapse is_active_inEXP 2290270 PMID:24413018SynGOPMID:24413018
Ppp3r1Mousesynapse is_active_inIDA 2290270 PMID:24413018SynGOPMID:24413018
1 to 20 of 20 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mousecalcium ion binding enablesIEAInterPro:IPR0020482290270 InterProGO_REF:0000002
Ppp3r1Mousecalcium-dependent protein serine/threonine phosphatase regulator activity enablesIBAPANTHER:PTN000551259|UniProtKB:Q8IKV9|UniProtKB:Q96LZ3|dictyBase:DDB_G0267446|MGI:1071712290270 GO_CentralGO_REF:0000033
Ppp3r1Mousecyclosporin A binding enablesISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mouseenzyme binding enablesIPIUniProtKB:P633282290270 PMID:20639889BHF-UCLPMID:20639889
Ppp3r1Mousephosphatase binding enablesISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mousephosphatase binding enablesIPIUniProtKB:P633282290270 PMID:26794871UniProtPMID:26794871
Ppp3r1Mousephosphatase binding enablesIBAPANTHER:PTN000551259|dictyBase:DDB_G0267446|UniProtKB:P63099|UniProtKB:P63098|MGI:1071722290270 GO_CentralGO_REF:0000033
Ppp3r1Mousephosphoprotein phosphatase activity enablesISORGD:692302290270 GO_CentralGO_REF:0000096
Ppp3r1Mousephosphoprotein phosphatase activity enablesIMPMGI:30439862290270 PMID:11439183MGIPMID:11439183
Ppp3r1Mousephosphoprotein phosphatase activity  ISORGD:692309068941 RGDPMID:12135494|REF_RGD_ID:729536
Ppp3r1Mouseprotein binding enablesIPIUniProtKB:Q99828|UniProtKB:Q9Z0F42290270 PMID:20639889BHF-UCLPMID:20639889
Ppp3r1Mouseprotein binding  ISORGD:6201039068941 RGDPMID:15120593|REF_RGD_ID:1579942
Ppp3r1Mouseprotein binding enablesIPIUniProtKB:O350992290270 PMID:16648474IntActPMID:16648474
Ppp3r1Mouseprotein domain specific binding enablesISOUniProtKB:P630982290270 GO_CentralGO_REF:0000119
Ppp3r1Mouseprotein domain specific binding enablesIEAUniProtKB:P63098|ensembl:ENSP000002343102290270 EnsemblGO_REF:0000107
1 to 15 of 15 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mousecalcineurin signaling pathway  ISORGD:13504321579951 RGD 

Imported Annotations - KEGG (archival)

1 to 11 of 11 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1MouseAlzheimer's disease pathway   IEA 6907045 KEGGmmu:05010
Ppp3r1Mouseamyotrophic lateral sclerosis pathway  IEA 6907045 KEGGmmu:05014
Ppp3r1Mouseapoptotic cell death pathway  IEA 6907045 KEGGmmu:04210
Ppp3r1MouseB cell receptor signaling pathway  IEA 6907045 KEGGmmu:04662
Ppp3r1Mouseglutamate signaling pathway  IEA 6907045 KEGGmmu:04724
Ppp3r1Mouselong term potentiation  IEA 6907045 KEGGmmu:04720
Ppp3r1Mousemitogen activated protein kinase signaling pathway   IEA 6907045 KEGGmmu:04010
Ppp3r1MouseT cell receptor signaling pathway  IEA 6907045 KEGGmmu:04660
Ppp3r1Mousetuberculosis pathway  IEA 6907045 KEGGmmu:05152
Ppp3r1Mousevascular endothelial growth factor signaling pathway   IEA 6907045 KEGGmmu:04370
Ppp3r1MouseWnt signaling pathway  IEA 6907045 KEGGmmu:04310
1 to 11 of 11 rows

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mouseinterleukin-12 signaling pathway  ISORGD:13504326484113 PIDPID:200045
1 to 20 of 60 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp3r1Mouseabnormal angiogenesis  IAGP 5509061 MGIPMID:11439183
Ppp3r1Mouseabnormal angiogenesis  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal blood vessel morphology  IAGP 5509061 MGIPMID:11439183
Ppp3r1Mouseabnormal blood vessel morphology  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal enzyme/coenzyme activity  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal extraembryonic tissue morphology  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal heart development  IAGP 5509061 MGIPMID:19710169
Ppp3r1Mouseabnormal heart echocardiography feature  IAGP 5509061 MGIPMID:32882262
Ppp3r1Mouseabnormal heart morphology  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal kidney pelvis morphology  IAGP 5509061 MGIPMID:15057312
Ppp3r1Mouseabnormal latent inhibition of conditioning behavior  IAGP 5509061 MGIPMID:12851457
Ppp3r1Mouseabnormal learning/memory/conditioning  IAGP 5509061 MGIPMID:11733061
Ppp3r1Mouseabnormal lymph node cell ratio  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal myocardial fiber morphology  IAGP 5509061 MGIPMID:32882262
Ppp3r1Mouseabnormal nest building behavior  IAGP 5509061 MGIPMID:12851457
Ppp3r1Mouseabnormal positive T cell selection  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal spatial working memory  IAGP 5509061 MGIPMID:11733061
Ppp3r1Mouseabnormal splenic cell ratio  IAGP 5509061 MGIPMID:15030770
Ppp3r1Mouseabnormal ureter development  IAGP 5509061 MGIPMID:15057312
Ppp3r1Mouseabnormal vascular endothelial cell development  IAGP 5509061 MGIPMID:19710169
1 to 20 of 60 rows

1 to 17 of 17 rows
#
Reference Title
Reference Citation
1. Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Bales JW, etal., Brain Res. 2010 Oct 28;1358:211-20. doi: 10.1016/j.brainres.2010.08.029. Epub 2010 Aug 13.
2. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Diedrichs H, etal., Eur J Heart Fail. 2004 Jan;6(1):3-9.
3. Calcineurin and matrix protein expression in cardiac hypertrophy : Evidence for calcineurin B to control excessive hypertrophic signaling. Grammer JB, etal., Basic Res Cardiol. 2006 Jul;101(4):292-300. Epub 2006 May 10.
4. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Mammucari C, etal., Dev Cell. 2005 May;8(5):665-76.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Peterson D, etal., Alzheimers Dement. 2014 May;10(3):366-71. doi: 10.1016/j.jalz.2013.02.010. Epub 2013 May 30.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Robinson RA, etal., Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9.
14. Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth. Sanna B, etal., Mol Cell Biol. 2005 Feb;25(3):865-78.
15. Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. Schomisch SJ, etal., J Thorac Cardiovasc Surg. 2005 Oct;130(4):1151.
16. Identification of a novel 5-base pair deletion in calcineurin B (PPP3R1) promoter region and its association with left ventricular hypertrophy. Tang W, etal., Am Heart J. 2005 Oct;150(4):845-51.
17. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
1 to 17 of 17 rows
1 to 10 of 10 rows
PMID:1325794   PMID:8631904   PMID:9017603   PMID:10349636   PMID:11015619   PMID:11042159   PMID:11076861   PMID:11123943   PMID:11217851   PMID:11439183   PMID:11733061   PMID:12466851  
PMID:12477932   PMID:12851457   PMID:15030770   PMID:15057312   PMID:15082723   PMID:15173172   PMID:15262994   PMID:15339668   PMID:15757646   PMID:16141072   PMID:16141073   PMID:16251439  
PMID:16473827   PMID:16554754   PMID:16648474   PMID:16717086   PMID:16988714   PMID:16998587   PMID:17198697   PMID:17237284   PMID:17289669   PMID:17640527   PMID:17884821   PMID:18046413  
PMID:18799693   PMID:18818667   PMID:19169262   PMID:19179536   PMID:19318421   PMID:19463978   PMID:19700627   PMID:19710169   PMID:20037164   PMID:20308572   PMID:20421389   PMID:20485437  
PMID:20639889   PMID:20797538   PMID:21267068   PMID:21677750   PMID:21689596   PMID:21821099   PMID:21873635   PMID:22116828   PMID:22300732   PMID:22306086   PMID:22343722   PMID:22814600  
PMID:22984995   PMID:23303818   PMID:23825400   PMID:23904597   PMID:23946498   PMID:24139046   PMID:24413018   PMID:24478374   PMID:24698271   PMID:24742621   PMID:25009293   PMID:26058076  
PMID:26365185   PMID:26411342   PMID:26443861   PMID:26794871   PMID:27043494   PMID:27301880   PMID:27694923   PMID:27805050   PMID:28126489   PMID:28462391   PMID:28824366   PMID:29305867  
PMID:29382714   PMID:29427598   PMID:29444424   PMID:29488389   PMID:29500351   PMID:29515579   PMID:29549257   PMID:29661826   PMID:29709916   PMID:29723192   PMID:30561331   PMID:30699351  
PMID:30710276   PMID:31113954   PMID:31189649   PMID:31626368   PMID:32130954   PMID:32325033   PMID:32445858   PMID:32641402   PMID:32882262   PMID:33879538   PMID:34021041   PMID:34157302  
PMID:34910904   PMID:35364006   PMID:36417873   PMID:37310791   PMID:37508531   PMID:38288580   PMID:38527808   PMID:39196243  
1 to 10 of 10 rows



Ppp3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391117,109,298 - 17,150,380 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)EnsemblGRCm39 Ensembl
GRCm381117,159,298 - 17,200,380 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371117,059,301 - 17,100,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361117,059,301 - 17,100,383 (+)NCBIMGSCv36mm8
Celera1117,532,396 - 17,574,044 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.71NCBI
PPP3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,178,857 - 68,252,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,178,857 - 68,256,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,405,989 - 68,479,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,259,493 - 68,333,155 (-)NCBINCBI36Build 36hg18NCBI36
Build 34268,317,639 - 68,391,302NCBI
Celera268,255,597 - 68,329,209 (-)NCBICelera
Cytogenetic Map2p14NCBI
HuRef268,143,447 - 68,181,703 (-)NCBIHuRef
CHM1_1268,336,792 - 68,410,397 (-)NCBICHM1_1
T2T-CHM13v2.0268,189,412 - 68,263,096 (-)NCBIT2T-CHM13v2.0
Ppp3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,758,333 - 95,808,015 (+)NCBIGRCr8
mRatBN7.21491,556,743 - 91,606,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,604,121 - 91,606,907 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,875,569 - 95,913,609 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01497,119,906 - 97,157,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,584,970 - 93,623,011 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,311,224 - 100,360,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,311,173 - 100,360,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,178,695 - 100,227,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41498,060,302 - 98,099,092 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11498,079,446 - 98,118,237 (+)NCBI
Celera1490,614,429 - 90,652,365 (+)NCBICelera
Cytogenetic Map14q22NCBI
Ppp3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,623,917 - 16,690,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,624,214 - 16,690,783 (+)NCBIChiLan1.0ChiLan1.0
PPP3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21258,156,551 - 58,229,424 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A58,160,135 - 58,233,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,227,282 - 68,300,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,242,552 - 67,308,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,244,329 - 67,275,487 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,135,373 - 67,199,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,263,516 - 68,327,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,261,752 - 68,325,387 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11067,946,324 - 68,012,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,243,919 - 68,309,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,541,451 - 68,605,689 (-)NCBIUU_Cfam_GSD_1.0
Ppp3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,826,513 - 15,947,768 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,718,720 - 12,744,428 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649112,623,349 - 12,654,502 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,623,931 - 12,654,463 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl374,000,517 - 74,068,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1374,004,620 - 74,068,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,531,587 - 77,598,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3R1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,832,976 - 38,907,425 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,832,809 - 38,905,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,068,593 - 73,142,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3r1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247625,087,705 - 5,156,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247625,087,726 - 5,156,526 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ppp3r1
1658 total Variants

Predicted Target Of
Summary Value
Count of predictions:640
Count of miRNA genes:411
Interacting mature miRNAs:486
Transcripts:ENSMUST00000102880, ENSMUST00000154425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse

1 to 10 of 45 rows
Ppp3r1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4B3UniSTS
Cytogenetic Map11A3.1UniSTS
cM Map11 UniSTS
cM Map4 UniSTS
UniSTS:236523  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,199,650 - 17,199,851UniSTSGRCm38
MGSCv371117,099,653 - 17,099,854UniSTSGRCm37
Celera1117,573,314 - 17,573,515UniSTS
Cytogenetic Map11A3.1UniSTS
D2S2724  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381117,198,415 - 17,198,738UniSTSGRCm38
MGSCv371117,098,418 - 17,098,741UniSTSGRCm37
Celera1117,572,079 - 17,572,402UniSTS
Cytogenetic Map11A3.1UniSTS







Ensembl Acc Id: ENSMUST00000102880   ⟹   ENSMUSP00000099944
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,109,263 - 17,150,375 (+)Ensembl
GRCm38.p6 Ensembl1117,159,263 - 17,200,375 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1117,142,844 - 17,145,109 (+)Ensembl
GRCm38.p6 Ensembl1117,192,844 - 17,195,109 (+)Ensembl
RefSeq Acc Id: NM_024459   ⟹   NP_077779
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391117,109,298 - 17,150,380 (+)NCBI
GRCm381117,159,298 - 17,200,380 (+)ENTREZGENE
MGSCv371117,059,301 - 17,100,383 (+)RGD
Celera1117,532,396 - 17,574,044 (+)RGD
cM Map11 ENTREZGENE
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_077779 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB23171 (Get FASTA)   NCBI Sequence Viewer  
  BAE21637 (Get FASTA)   NCBI Sequence Viewer  
  BAE26495 (Get FASTA)   NCBI Sequence Viewer  
  BAE36102 (Get FASTA)   NCBI Sequence Viewer  
  BAE37251 (Get FASTA)   NCBI Sequence Viewer  
  EDL40683 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000099944
  ENSMUSP00000099944.5
GenBank Protein Q63810 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_077779   ⟸   NM_024459
- UniProtKB: Q3V067 (UniProtKB/Swiss-Prot),   Q5F225 (UniProtKB/Swiss-Prot),   Q63810 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099944   ⟸   ENSMUST00000102880
EF-hand

Name Modeler Protein Id AA Range Protein Structure
AF-Q63810-F1-model_v2 AlphaFold Q63810 1-170 view protein structure

RGD ID:6821601
Promoter ID:MM_KWN:6515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000011611
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361117,058,934 - 17,059,434 (+)MPROMDB
RGD ID:8674028
Promoter ID:EPDNEW_M15042
Type:initiation region
Name:Ppp3r1_1
Description:Mus musculus protein phosphatase 3, regulatory subunit B, alphaisoform (calcineurin B, type I) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381117,159,317 - 17,159,377EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000033953 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000102880 ENTREZGENE
  ENSMUST00000102880.5 UniProtKB/Swiss-Prot
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
KEGG Report mmu:19058 UniProtKB/Swiss-Prot
MGD MGI:107172 ENTREZGENE
NCBI Gene 19058 ENTREZGENE
PANTHER PTHR45942 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
PhenoGen Ppp3r1 PhenoGen
PRINTS PARVALBUMIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt CANB1_MOUSE UniProtKB/Swiss-Prot
  Q3V067 ENTREZGENE
  Q5F225 ENTREZGENE
  Q63810 ENTREZGENE
UniProt Secondary Q3V067 UniProtKB/Swiss-Prot
  Q5F225 UniProtKB/Swiss-Prot
1 to 24 of 24 rows