Bad (BCL2-associated agonist of cell death) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bad (BCL2-associated agonist of cell death) Rattus norvegicus
Analyze
Symbol: Bad
Name: BCL2-associated agonist of cell death
RGD ID: 620103
Description: Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of granulosa cell apoptotic process; and response to anesthetic. Located in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); brain ischemia; obesity; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; endometrial cancer pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Bad_v1; Bad_v2; bcl-2 associated death agonist; bcl-2-binding component 6; bcl-xL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; Bcl2-antagonist of cell death; BCL2-associated agonist of cell death, variant 1; BCL2-associated agonist of cell death, variant 2; bcl2-associated death promoter; MGC72439
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Brain Injuries  (IEP)
brain ischemia  (IEP)
breast cancer  (ISO)
Burns  (IEP)
Cardiomegaly  (IDA)
Chemical and Drug Induced Liver Injury  (IDA)
Chronic Pancreatitis  (IEP)
colon cancer  (IDA)
Diabetic Cardiomyopathies  (IDA)
Diabetic Cystopathy  (IDA)
diabetic neuropathy  (IDA)
endometrial cancer  (ISO)
Experimental Diabetes Mellitus  (IDA)
Experimental Mammary Neoplasms  (IDA,IEP)
Experimental Seizures  (IEP)
gastric ulcer  (IDA)
glaucoma  (IEP)
Hemorrhagic Shock  (IEP)
high grade glioma  (IEP)
hypertension  (IEP)
hypothyroidism  (IEP)
impotence  (IDA)
Insulin Resistance  (IDA)
intellectual disability  (ISO)
intermittent claudication  (IEP)
leukemia  (ISO)
leukocyte adhesion deficiency 3  (ISO)
Liver Reperfusion Injury  (IEP)
lung non-small cell carcinoma  (ISO)
macular degeneration  (ISO)
middle cerebral artery infarction  (IDA)
morphine withdrawal syndrome  (ISO)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
obesity  (IEP)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
Parkinsonism  (IDA)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
Retina Reperfusion Injury  (IDA)
Sepsis  (IDA,IEP)
Small-For-Size Syndrome  (IDA)
Spinal Cord Reperfusion Injury  (IDA)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IEP)
traumatic brain injury  (IEP)
type 2 diabetes mellitus  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(-)-Arctigenin  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,3-Dinitropyrene  (ISO)
1,8-cineole  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-naphthylamine  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
9,10-anthraquinone  (ISO)
9-Methoxycamptothecin  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
AH23848  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
alpha-Solamarine  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
andrographolide  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprepitant  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arjunolic acid  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
azadirachtin A  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
betaxolol  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfide  (ISO)
calciol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
citalopram  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
coumarin  (ISO)
cucurbitacin B  (ISO)
curcumin  (EXP,ISO)
cyclizine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
D-mannitol  (EXP)
dehydroepiandrosterone  (EXP)
delphinidin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethanolamine  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
erlotinib hydrochloride  (ISO)
escitalopram  (EXP)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
farrerol  (ISO)
flufenamic acid  (ISO)
flufenoxuron  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
gamma-aminobutyric acid  (EXP)
gefitinib  (ISO)
genistein  (EXP)
ginsenoside Rg1  (EXP)
glucose  (EXP,ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
Idoxifene  (EXP)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoflurane  (EXP)
isopimaric acid  (ISO)
juglone  (ISO)
kaempferol  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP,ISO)
lead diacetate  (EXP)
Licochalcone A  (ISO)
lipopolysaccharide  (EXP)
LY 379268  (EXP)
LY294002  (EXP,ISO)
Maduramicin  (ISO)
melamine  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
MK-2206  (EXP,ISO)
monodansylcadaverine  (ISO)
N-(4-aminobutyl)-5-chloronaphthalene-2-sulfonamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (EXP,ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nicotine  (EXP,ISO)
NORCANTHARIDIN  (ISO)
norfloxacin  (ISO)
Obacunone  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (ISO)
oxybenzone  (EXP)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PD 168393  (ISO)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
PF-3758309  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
PK-11195  (EXP)
plumbagin  (EXP)
potassium dichromate  (EXP)
Pranoprofen  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propylparaben  (ISO)
pterostilbene  (ISO)
PX-866  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
ruthenium atom  (ISO)
rutin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
Salvianolic acid A  (EXP)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sorafenib  (ISO)
spironolactone  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP)
Suillin  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
tacrolimus hydrate  (EXP,ISO)
taiwanin C  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
tigecycline  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
tomelukast  (EXP)
triamcinolone acetonide  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
withaferin A  (ISO)
wortmannin  (EXP,ISO)
Xanthorrhizol  (ISO)
Y-27632  (ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ADP metabolic process  (IEA,ISO,ISS)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (ISO)
ATP metabolic process  (IEA,ISO,ISS)
cellular response to chromate  (IEP)
cellular response to hypoxia  (IEA,ISO)
cellular response to lipid  (IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nicotine  (IEA,ISO,ISS)
cerebral cortex development  (IEP)
cytokine-mediated signaling pathway  (IEA,ISO)
epithelial cell proliferation  (ISO)
extrinsic apoptotic signaling pathway  (IBA,ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose catabolic process  (IEA,ISO)
glucose homeostasis  (IEA,ISO,ISS)
intrinsic apoptotic signaling pathway  (IBA,ISO,ISS)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
pore complex assembly  (IEA,ISO,ISS)
positive regulation of apoptotic process  (ISO)
positive regulation of B cell differentiation  (IEA,ISO)
positive regulation of epithelial cell proliferation  (IEA,ISO,ISS)
positive regulation of granulosa cell apoptotic process  (IDA)
positive regulation of insulin secretion  (ISO,ISS)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,ISO)
positive regulation of mitochondrial membrane potential  (IEA,ISO,ISS)
positive regulation of proteolysis  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive regulation of T cell differentiation  (IEA,ISO)
positive regulation of type B pancreatic cell development  (IEA,ISO,ISS)
regulation of apoptotic process  (ISO)
regulation of mitochondrial membrane permeability  (IBA,IEA,ISO,ISS)
release of cytochrome c from mitochondria  (IBA,IEA,ISO)
response to amino acid  (IEP)
response to anesthetic  (IEP)
response to benzene  (IEP)
response to calcium ion  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (IEP)
response to hormone  (IEP)
response to hydrogen peroxide  (IEP)
response to hypoxia  (IEP)
response to oleic acid  (IEP)
response to progesterone  (IEP)
response to testosterone  (IEP)
response to wortmannin  (IEP)
response to xenobiotic stimulus  (IEP)
spermatogenesis  (IEP)
type B pancreatic cell proliferation  (IEA,ISO,ISS)

Cellular Component
BAD-BCL-2 complex  (IEA,ISO)
cytoplasm  (ISO)
cytosol  (IBA,IDA,IEA,ISO)
mitochondrial outer membrane  (IEA,ISO,ISS)
mitochondrion  (IBA,IDA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway. Ain R, etal., J Endocrinol. 2005 May;185(2):253-63.
3. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Banu SK, etal., Toxicol Appl Pharmacol. 2011 Mar 15;251(3):253-66. Epub 2011 Jan 22.
4. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. Berquin IM, etal., J Clin Invest. 2007 Jul;117(7):1866-75.
5. pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model. Bhaskara VK, etal., Neurochem Res. 2006 Sep;31(9):1163-70. Epub 2006 Aug 31.
6. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
7. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Calon F, etal., Neuron. 2004 Sep 2;43(5):633-45.
8. Bad expression predicts outcome in patients treated with tamoxifen. Cannings E, etal., Breast Cancer Res Treat. 2007 Apr;102(2):173-9. Epub 2006 Sep 27.
9. Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes. Ciccarelli R, etal., Mol Pharmacol. 2007 May;71(5):1369-80. Epub 2007 Feb 9.
10. Regulation of BAD protein by PKA, PKCdelta and phosphatases in adult rat cardiac myocytes subjected to oxidative stress. Cieslak D and Lazou A, Mol Cells. 2007 Oct 31;24(2):224-31.
11. Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling. Clark CJ, etal., J Neurochem. 2007 Aug;102(4):1024-34.
12. Cloning and expression of the programmed cell death regulator Bad in the rat brain. D'Agata V, etal., Neurosci Lett 1998 Feb 27;243(1-3):137-40.
13. Bad and Bid - potential background players in preneoplastic to neoplastic shift in human endometrium. Driak D, etal., Neoplasma. 2014;61(4):411-5. doi: 10.4149/neo_2014_050.
14. Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration. Ecker SM, etal., Mol Vis. 2012;18:1658-67. Epub 2012 Jun 20.
15. Modulation of apoptosis in the mouse brain after morphine treatments and morphine withdrawal. Emeterio EP, etal., J Neurosci Res. 2006 May 15;83(7):1352-61. doi: 10.1002/jnr.20812.
16. Edaravone protects cortical neurons from apoptosis by inhibiting the translocation of BAX and Increasing the interaction between 14-3-3 and p-BAD. Fan J, etal., Int J Neurosci. 2012 Nov;122(11):665-74. doi: 10.3109/00207454.2012.707714. Epub 2012 Aug 21.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Protective effect of cyanidin-3-O-beta-D-glucopyranoside fraction from mulberry fruit pigment against oxidative damage in streptozotocin-induced diabetic rat bladder. Ha US, etal., Neurourol Urodyn. 2013 Jun;32(5):493-9. doi: 10.1002/nau.22334. Epub 2012 Nov 5.
20. Functional characterization of two splice variants of rat bad and their interaction with Bcl-w in sympathetic neurons.PG - 97-106 Hamner S, etal., Mol Cell Neurosci 2001 Jan;17(1):97-106.
21. Akt activation in renal cell carcinoma: contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor. Hara S, etal., Ann Oncol. 2005 Jun;16(6):928-33. Epub 2005 Apr 25.
22. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Hsu SY, etal., Mol Endocrinol 1997 Nov;11(12):1858-67.
23. Activation of PI3-kinase/PKB contributes to delay in neutrophil apoptosis after thermal injury. Hu Z and Sayeed MM, Am J Physiol Cell Physiol. 2005 May;288(5):C1171-8. Epub 2004 Dec 29.
24. Cytoprotective effect of American ginseng in a rat ethanol gastric ulcer model. Huang CC, etal., Molecules. 2013 Dec 27;19(1):316-26. doi: 10.3390/molecules19010316.
25. Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma. Huang W, etal., Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12242-7. Epub 2005 Aug 15.
26. Loss of Bad expression confers poor prognosis in non-small cell lung cancer. Huang Y, etal., Med Oncol. 2012 Sep;29(3):1648-55. doi: 10.1007/s12032-011-0060-4. Epub 2011 Sep 15.
27. D-lactate increases pulmonary apoptosis by restricting phosphorylation of bad and eNOS in a rat model of hemorrhagic shock. Jaskille A, etal., J Trauma. 2004 Aug;57(2):262-69; discussion 269-70.
28. Cluster analysis of mRNA expression levels identifies multiple sequential patterns following focal cerebral ischemia. Kaido T, etal., Turk Neurosurg. 2012;22(4):441-7. doi: 10.5137/1019-5149.JTN.5523-11.0.
29. Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary. Kaipia A, etal., Endocrinology. 1997 Dec;138(12):5497-504. doi: 10.1210/endo.138.12.5588.
30. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
31. N-acetylcysteine attenuates glycerol-induced acute kidney injury by regulating MAPKs and Bcl-2 family proteins. Kim JH, etal., Nephrol Dial Transplant. 2010 May;25(5):1435-43. doi: 10.1093/ndt/gfp659. Epub 2009 Dec 27.
32. Age-related differences in hepatic ischemia/reperfusion: gene activation, liver injury, and protective effect of melatonin. Kireev RA, etal., J Surg Res. 2012 Dec;178(2):922-34. doi: 10.1016/j.jss.2012.04.060. Epub 2012 May 14.
33. Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats. Kishi T, etal., Hypertension. 2010 Feb;55(2):291-7. doi: 10.1161/HYPERTENSIONAHA.109.138636. Epub 2010 Jan 11.
34. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Kitamura Y, etal., Brain Res. 1998 Jan 12;780(2):260-9.
35. Melatonin attenuates the focal cerebral ischemic injury by inhibiting the dissociation of pBad from 14-3-3. Koh PO J Pineal Res. 2008 Jan;44(1):101-6.
36. Ethanol exposure suppresses survival kinases activation in adult rat testes. Koh PO J Vet Med Sci. 2007 Jan;69(1):21-4.
37. Streptozotocin-induced diabetes increases the interaction of Bad/Bcl-XL and decreases the binding of pBad/14-3-3 in rat testis. Koh PO Life Sci. 2007 Sep 8;81(13):1079-84. Epub 2007 Aug 25.
38. Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Bad phosphorylation. Koh PO Neurosci Lett. 2007 Jan 22;412(1):68-72. Epub 2006 Dec 15.
39. Ferulic acid prevents the cerebral ischemic injury-induced decrease of Akt and Bad phosphorylation. Koh PO Neurosci Lett. 2012 Jan 24;507(2):156-60. doi: 10.1016/j.neulet.2011.12.012. Epub 2011 Dec 17.
40. The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Lakshmanan AP, etal., Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29.
41. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury. Lee D, etal., PLoS One. 2012;7(10):e47098. doi: 10.1371/journal.pone.0047098. Epub 2012 Oct 9.
42. Therapeutic hypothermia attenuates liver injury in polymicrobial sepsis model of rats via Akt survival pathway. Lee JH, etal., J Surg Res. 2013 May 1;181(1):114-20. doi: 10.1016/j.jss.2012.05.045. Epub 2012 Jun 1.
43. Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart. Lee SD, etal., Int J Cardiol. 2006 Apr 14;108(3):376-84. Epub 2005 Jul 11.
44. Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, etal., Endocrinology 1999 Dec;140(12):5469-77.
45. [Dephosphorelation of Bad and upregulation of Bcl-2 in hippocampus of rats following limbic seizure induced by kainic acid injection into amygdaloid nucleus] Li TF, etal., Sheng Li Xue Bao. 2005 Jun 25;57(3):310-8.
46. PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats. Li WJ, etal., J Sex Med. 2011 Apr;8(4):1072-82. doi: 10.1111/j.1743-6109.2010.02176.x. Epub 2011 Jan 14.
47. iNOS participates in apoptosis of spinal cord neurons via p-BAD dephosphorylation following ischemia/reperfusion (I/R) injury in rat spinal cord. Li Y, etal., Neurosci Lett. 2013 Jun 17;545:117-22. doi: 10.1016/j.neulet.2013.04.043. Epub 2013 May 2.
48. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Li YZ, etal., Mol Cell Biol. 2008 Jan;28(2):564-74. Epub 2007 Nov 12.
49. Exercise training improves systolic function in hypertensive myocardium. Libonati JR, etal., J Appl Physiol (1985). 2011 Dec;111(6):1637-43. doi: 10.1152/japplphysiol.00292.2011. Epub 2011 Sep 15.
50. Defining the role of the Bcl-2 family of proteins in the nervous system. Lindsten T, etal., Neuroscientist. 2005 Feb;11(1):10-5.
51. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
52. More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Lu MC, etal., Obesity (Silver Spring). 2007 Nov;15(11):2634-42.
53. Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism. Lui NP, etal., PLoS One. 2012;7(12):e51294. doi: 10.1371/journal.pone.0051294. Epub 2012 Dec 12.
54. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
55. Implanted adipose-derived stem cells attenuate small-for-size liver graft injury by secretion of VEGF in rats. Ma T, etal., Am J Transplant. 2012 Mar;12(3):620-9. doi: 10.1111/j.1600-6143.2011.03870.x. Epub 2011 Dec 7.
56. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
57. Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons. Miyawaki T, etal., Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4892-7. Epub 2008 Mar 17.
58. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. Murriel CL, etal., J Biol Chem. 2004 Nov 12;279(46):47985-91. Epub 2004 Aug 31.
59. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
60. Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. Nguyen TV, etal., J Neurochem. 2005 Sep;94(6):1639-51. Epub 2005 Jul 11.
61. p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression. Park AM, etal., Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2284-91. doi: 10.1016/j.freeradbiomed.2012.03.010. Epub 2012 Apr 16.
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
64. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
65. Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the PKA-Bad-14-3-3 signaling pathway in glutamate-induced retinal injury in neonatal rats. Racz B, etal., Neurotox Res. 2007 Sep;12(2):95-104.
66. The hexosamine biosynthetic pathway can mediate myocardial apoptosis in a rat model of diet-induced insulin resistance. Rajamani U, etal., Acta Physiol (Oxf). 2011 Jun;202(2):151-7. doi: 10.1111/j.1748-1716.2011.02275.x. Epub 2011 Apr 19.
67. Long-term hormonal promotion overcomes genetic resistance to mammary cancer. Rajkumar L, etal., Steroids. 2011 Jan;76(1-2):31-7. doi: 10.1016/j.steroids.2010.08.004. Epub 2010 Aug 21.
68. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
69. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
70. Immunoexpressions of p21, Rb, mcl-1 and bad gene products in normal, hyperplastic and carcinomatous human prostates. Royuela M, etal., Eur Cytokine Netw. 2001 Oct-Dec;12(4):654-63.
71. Novel and extensive aspects of paraquat-induced pulmonary fibrogenesis: comparative and time-course microarray analyses in fibrogenic and non-fibrogenic rats. Satomi Y, etal., J Toxicol Sci. 2007 Dec;32(5):529-53.
72. Subcellular distribution of Bcl-2 family proteins and 14-3-3 within the hippocampus during seizure-induced neuronal death in the rat. Schindler CK, etal., Neurosci Lett. 2004 Feb 19;356(3):163-6.
73. High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. Serpe L, etal., Technol Cancer Res Treat. 2011 Feb;10(1):85-93.
74. beta-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions. Sharma V, etal., Eur J Pharmacol. 2011 Apr 25;657(1-3):117-25. doi: 10.1016/j.ejphar.2011.01.044. Epub 2011 Feb 4.
75. Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: potential role in therapy. Shimizu T, etal., Cancer Lett. 2013 Aug 19;336(2):270-80. doi: 10.1016/j.canlet.2013.03.017. Epub 2013 Mar 21.
76. Differential expression of rat brain bcl-2 family proteins in development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 1998 Nov 9;252(1):92-6.
77. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. Shinoda S, etal., J Neurochem. 2003 Jul;86(2):460-9.
78. Effects of acute ethanol exposure on regulatory mechanisms of Bcl-2-associated apoptosis promoter, bad, in neonatal rat cerebellum: differential effects during vulnerable and resistant developmental periods. Siler-Marsiglio KI, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):1031-8. doi: 10.1111/j.1530-0277.2006.000126.x.
79. Propylthiouracil-induced hypothyroidism delays apoptosis during the first wave of spermatogenesis. Silva D, etal., Biol Res. 2011;44(2):181-8. doi: /S0716-97602011000200010. Epub 2011 Sep 20.
80. Expression and prognostic relevance of MET and phospho-BAD in non-small cell lung cancer. Sun W, etal., Onco Targets Ther. 2013 Sep 18;6:1315-23. doi: 10.2147/OTT.S50428. eCollection 2013.
81. Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury. Sung JH, etal., J Vet Med Sci. 2012 Jan;74(1):35-41. Epub 2011 Sep 2.
82. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer. Terakawa N, etal., Endocr Relat Cancer. 2003 Jun;10(2):203-8.
83. Early inactivation of PKCepsilon associates with late mitochondrial translocation of Bad and apoptosis in ventricle of septic rat. Tsai KL, etal., J Surg Res. 2014 Jan;186(1):278-86. doi: 10.1016/j.jss.2013.08.010. Epub 2013 Aug 30.
84. Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A. Valks DM, etal., J Mol Cell Cardiol. 2002 Jul;34(7):749-63.
85. Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. Vukosavic S, etal., J Neurochem. 1999 Dec;73(6):2460-8.
86. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
87. Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad. Wang YC, etal., Cytotherapy. 2014 Jul;16(7):1000-10. doi: 10.1016/j.jcyt.2013.12.009. Epub 2014 Feb 28.
88. Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia. Weaver CV and Liu SP, Exp Toxicol Pathol. 2008 Mar;59(5):265-72. Epub 2008 Feb 21.
89. Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts. Wei C, etal., J Cardiovasc Pharmacol. 2013 May;61(5):416-22. doi: 10.1097/FJC.0b013e318287d501.
90. Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint. Weng LH, etal., Osteoarthritis Cartilage. 2009 Jul;17(7):933-43. doi: 10.1016/j.joca.2008.12.008. Epub 2008 Dec 30.
91. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Muller cells. Xi X, etal., Biochem Biophys Res Commun. 2005 Jan 21;326(3):548-53.
92. Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats. Xu K and Yu FS, Invest Ophthalmol Vis Sci. 2011 Feb 17.
93. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl -induced hepatotoxicity in rats. Yang CH, etal., Environ Toxicol. 2014 Nov 28. doi: 10.1002/tox.22078.
94. Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. Yang YY, etal., Liver Transpl. 2012 Nov;18(11):1371-83. doi: 10.1002/lt.23520.
95. Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats. Yao XL, etal., J Neurotrauma. 2005 Jun;22(6):656-68.
96. Gastrodin Ameliorates Acute Rejection via IRE1α/TRAF2/NF-κB in Rats Receiving Liver Allografts. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
97. Oleic acid causes apoptosis and dephosphorylates Bad. Zhu Y, etal., Neurochem Int. 2005 Jan;46(2):127-35.
98. Traditional chinese medicine tang-luo-ning ameliorates sciatic nerve injuries in streptozotocin-induced diabetic rats. Zou DW, etal., Evid Based Complement Alternat Med. 2013;2013:989670. doi: 10.1155/2013/989670. Epub 2013 Oct 28.
Additional References at PubMed
PMID:7834748   PMID:9176392   PMID:9388232   PMID:10407019   PMID:11146504   PMID:11717309   PMID:11980919   PMID:12115603   PMID:12142566   PMID:12431371   PMID:12472766   PMID:12477932  
PMID:12531534   PMID:12761242   PMID:12838582   PMID:12931191   PMID:12944463   PMID:14967141   PMID:15231831   PMID:15451022   PMID:15469889   PMID:15896972   PMID:15978696   PMID:16087293  
PMID:16116448   PMID:16446153   PMID:16565486   PMID:16603546   PMID:16937528   PMID:17080661   PMID:17270021   PMID:17289999   PMID:17555943   PMID:17940884   PMID:18223655   PMID:18387192  
PMID:18402937   PMID:18614015   PMID:18640115   PMID:18676776   PMID:18779656   PMID:18832722   PMID:18852119   PMID:18936092   PMID:19171933   PMID:19593445   PMID:19667065   PMID:19885947  
PMID:19915011   PMID:20651836   PMID:20700721   PMID:20810912   PMID:20850791   PMID:21081150   PMID:21095239   PMID:21546903   PMID:21716255   PMID:21789211   PMID:21818658   PMID:22006182  
PMID:22099262   PMID:25072152   PMID:27690136   PMID:30911955   PMID:31784847   PMID:34315852  


Genomics

Comparative Map Data
Bad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,562,719 - 213,572,034 (+)NCBIGRCr8
mRatBN7.21204,133,502 - 204,142,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,484,073 - 212,493,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01219,579,167 - 219,588,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01212,270,220 - 212,279,142 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,198,516 - 222,207,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01229,189,271 - 229,198,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41209,617,373 - 209,626,292 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11209,775,802 - 209,784,722NCBI
Celera1201,667,864 - 201,676,765 (+)NCBICelera
Cytogenetic Map1q43NCBI
BAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,269,828 - 64,284,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,269,830 - 64,284,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371164,037,300 - 64,052,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,793,878 - 63,808,740 (-)NCBINCBI36Build 36hg18NCBI36
Build 341163,793,877 - 63,808,740NCBI
Celera1161,364,184 - 61,379,075 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1160,365,093 - 60,379,900 (-)NCBIHuRef
CHM1_11163,920,295 - 63,935,173 (-)NCBICHM1_1
T2T-CHM13v2.01164,259,856 - 64,274,668 (-)NCBIT2T-CHM13v2.0
Bad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,919,229 - 6,929,273 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,919,229 - 6,929,267 (+)EnsemblGRCm39 Ensembl
GRCm38196,941,861 - 6,951,905 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,941,861 - 6,951,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37197,016,345 - 7,026,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36197,008,899 - 7,018,937 (+)NCBIMGSCv36mm8
Celera196,718,946 - 6,728,897 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.1NCBI
Bad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542220,795,676 - 20,809,245 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542220,795,585 - 20,809,039 (+)NCBIChiLan1.0ChiLan1.0
BAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2965,497,028 - 65,511,872 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11166,542,163 - 66,557,017 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,626,981 - 59,641,824 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,971,808 - 62,986,304 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,971,808 - 62,986,257 (-)Ensemblpanpan1.1panPan2
BAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11852,781,335 - 52,791,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1852,781,921 - 52,791,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1851,388,992 - 51,398,261 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01853,826,736 - 53,836,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1853,827,323 - 53,836,575 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11852,929,992 - 52,939,466 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01852,505,744 - 52,514,998 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01853,289,648 - 53,298,901 (+)NCBIUU_Cfam_GSD_1.0
Bad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049478,481,976 - 8,491,335 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365994,924,789 - 4,933,368 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365994,924,349 - 4,933,683 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl27,830,920 - 7,842,863 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.127,831,192 - 7,842,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.226,897,866 - 6,909,685 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.119,949,717 - 9,964,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl19,949,762 - 9,964,432 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,289,663 - 107,305,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476722,026,133 - 22,037,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476722,025,721 - 22,037,283 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bad
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:77
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000028712, ENSRNOT00000067068
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
6480783Insul19Insulin level QTL 194.33blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1203300512213659238Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat

Markers in Region
RH134341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,142,556 - 204,142,747 (+)MAPPERmRatBN7.2
Rnor_6.01222,207,187 - 222,207,377NCBIRnor6.0
Rnor_5.01229,198,039 - 229,198,229UniSTSRnor5.0
RGSC_v3.41209,626,026 - 209,626,216UniSTSRGSC3.4
Celera1201,676,499 - 201,676,689UniSTS
RH 3.4 Map11509.7UniSTS
Cytogenetic Map1q43UniSTS
AW530352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21204,132,630 - 204,132,782 (+)MAPPERmRatBN7.2
Rnor_6.01222,197,261 - 222,197,412NCBIRnor6.0
Rnor_5.01229,188,115 - 229,188,266UniSTSRnor5.0
RGSC_v3.41209,616,152 - 209,616,303UniSTSRGSC3.4
Celera1201,666,631 - 201,666,782UniSTS
RH 3.4 Map11521.1UniSTS
Cytogenetic Map1q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000028712   ⟹   ENSRNOP00000028712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,131,501 - 204,142,823 (+)Ensembl
Rnor_6.0 Ensembl1222,198,534 - 222,207,453 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101503   ⟹   ENSRNOP00000096573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1204,133,489 - 204,142,599 (+)Ensembl
RefSeq Acc Id: NM_022698   ⟹   NP_073189
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,114 - 213,572,033 (+)NCBI
mRatBN7.21204,133,904 - 204,142,823 (+)NCBI
Rnor_6.01222,198,534 - 222,207,453 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
RGSC_v3.41209,617,373 - 209,626,292 (+)RGD
Celera1201,667,864 - 201,676,765 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230896   ⟹   XP_006230958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,572,034 (+)NCBI
mRatBN7.21204,133,502 - 204,142,828 (+)NCBI
Rnor_6.01222,198,516 - 222,207,454 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230897   ⟹   XP_006230959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,260 - 213,572,034 (+)NCBI
mRatBN7.21204,134,068 - 204,142,829 (+)NCBI
Rnor_6.01222,198,708 - 222,207,459 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230898   ⟹   XP_006230960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,563,369 - 213,572,034 (+)NCBI
mRatBN7.21204,134,068 - 204,142,828 (+)NCBI
Rnor_6.01222,198,712 - 222,207,458 (+)NCBI
Rnor_5.01229,189,271 - 229,198,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089714   ⟹   XP_038945642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,572,034 (+)NCBI
mRatBN7.21204,133,502 - 204,142,824 (+)NCBI
RefSeq Acc Id: XM_063272784   ⟹   XP_063128854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,565,037 (+)NCBI
RefSeq Acc Id: XR_010057342
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,562,719 - 213,570,840 (+)NCBI
RefSeq Acc Id: NP_073189   ⟸   NM_022698
- UniProtKB: O70256 (UniProtKB/Swiss-Prot),   Q9JHX1 (UniProtKB/Swiss-Prot),   O35147 (UniProtKB/Swiss-Prot),   A6HZK1 (UniProtKB/TrEMBL),   A0A8I6AQN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230958   ⟸   XM_006230896
- Peptide Label: isoform X1
- UniProtKB: A6HZK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230960   ⟸   XM_006230898
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006230959   ⟸   XM_006230897
- Peptide Label: isoform X3
- UniProtKB: A6HZK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028712   ⟸   ENSRNOT00000028712
RefSeq Acc Id: XP_038945642   ⟸   XM_039089714
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UKI4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096573   ⟸   ENSRNOT00000101503
RefSeq Acc Id: XP_063128854   ⟸   XM_063272784
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35147-F1-model_v2 AlphaFold O35147 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620103 AgrOrtholog
BIND 133989
  133990
BioCyc Gene G2FUF-56577 BioCyc
Ensembl Genes ENSRNOG00000021147 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028712.6 UniProtKB/TrEMBL
  ENSRNOT00000101503.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598682 IMAGE-MGC_LOAD
InterPro BAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72439 IMAGE-MGC_LOAD
NCBI Gene 64639 ENTREZGENE
PANTHER BCL2-ASSOCIATED AGONIST OF CELL DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR28540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Bcl-2_BAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bad PhenoGen
RatGTEx ENSRNOG00000021147 RatGTEx
UniProt A0A8I6AQN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKI4 ENTREZGENE, UniProtKB/TrEMBL
  A6HZK0 ENTREZGENE, UniProtKB/TrEMBL
  A6HZK1 ENTREZGENE, UniProtKB/TrEMBL
  BAD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O70256 ENTREZGENE
  Q6P7C5_RAT UniProtKB/TrEMBL
  Q9JHX1 ENTREZGENE
UniProt Secondary O70256 UniProtKB/Swiss-Prot
  Q9JHX1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-28 Bad  BCL2-associated agonist of cell death  Bad_v2  BCL2-associated agonist of cell death, variant 2  Data merged from RGD:728344 737654 PROVISIONAL
2018-08-28 Bad  BCL2-associated agonist of cell death  Bad_v1  BCL2-associated agonist of cell death, variant 1  Data merged from RGD:728296 737654 PROVISIONAL
2009-11-05 Bad  BCL2-associated agonist of cell death  Bad  Bcl2-antagonist of cell death  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-01 Bad  Bcl2-antagonist of cell death  Bad  bcl2-associated death promoter  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Bad_v1  bcl-2 associated death agonist, variant 1    bcl-2 associated death agonist,variant 1  Name updated 1299863 APPROVED
2004-12-14 Bad_v2  bcl-2 associated death agonist, variant 2      Symbol and Name status set to approved 1299863 APPROVED
2004-12-14 Bad  bcl2-associated death promoter    bcl-2 associated death agonist  Name updated 1299863 APPROVED
2002-08-07 Bad  bcl-2 associated death agonist      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Bcl-2 homology 3(BH3) domain 625527
gene_domains contains a Bcl2 homology 3(BH3) -domain 625527
gene_expression expressed in several brain regions, liver, and spleen 625527
gene_expression mRNA expressed in several brain regions, liver, and spleen 625527
gene_expression mRNA expressed in several brain regions, liver, and spleen 625527
gene_physical_interaction both variants interact with Bcl-w 625527
gene_physical_interaction interacts with Bcl-w 625527
gene_process links growth factor receptor signaling and apoptotic pathways 625527
gene_product a BH3-only proapoptotic Bcl-2 family member 625527
gene_product member of the Bcl-2 family of proteins 727627
gene_transcript two splice variants observed with differences only in C-terminal from alternative usage of downstream splice acceptor in the fourth exon 625527
gene_transcript usage of downstream splice acceptor in the fourth exon results in translation of a part of 3-UTR giving rise to a unique C-terminal 625527