Ywhah (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta) - Rat Genome Database

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Gene: Ywhah (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta) Rattus norvegicus
Analyze
Symbol: Ywhah
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
RGD ID: 3978
Description: Predicted to enable several functions, including nuclear glucocorticoid receptor binding activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; and substantia nigra development. Predicted to act upstream of or within intracellular protein transport and negative regulation of dendrite morphogenesis. Is active in synapse. Orthologous to human YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mTOR signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein eta; 14-3-3 protein eta-subtype; 14-3-3e; MGC93547; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21477,696,332 - 77,705,715 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1477,696,333 - 77,705,741 (-)Ensembl
Rnor_6.01483,053,041 - 83,062,424 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,053,041 - 83,062,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,739,009 - 83,748,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,448,395 - 83,457,778 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11483,454,749 - 83,464,132 (-)NCBI
Celera1476,611,913 - 76,621,296 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cannabidiol  (ISO)
carmustine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. Davare MA, etal., J Biol Chem. 2004 Dec 10;279(50):52191-9. Epub 2004 Oct 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding. Ichimura T, etal., FEBS Lett. 2008 Mar 5;582(5):661-5. doi: 10.1016/j.febslet.2008.01.037. Epub 2008 Jan 31.
6. RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Kaeser PS, etal., Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14680-5. doi: 10.1073/pnas.0806679105. Epub 2008 Sep 17.
7. Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies. Martin H, etal., J Neurochem. 1994 Dec;63(6):2259-65.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. Pulina MV, etal., J Biol Chem. 2006 Jul 14;281(28):19645-54. Epub 2006 May 5.
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus. Sun L, etal., J Biol Chem 2003 Oct 3;278(40):38301-9. Epub 2003 Jul 18.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. Tokumitsu H, etal., FEBS Lett. 2006 Oct 16;580(24):5797-801. Epub 2006 Sep 27.
20. Molecular cloning of cDNA to rat 14-3-3 eta chain polypeptide and the neuronal expression of the mRNA in the central nervous system. Watanabe M, etal., Brain Res Mol Brain Res 1991 May;10(2):151-8.
21. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:9079630   PMID:9738002   PMID:11953308   PMID:12176032   PMID:12446771   PMID:12650640   PMID:14741381   PMID:15489334   PMID:15543142   PMID:15677482   PMID:15790729   PMID:16728661  
PMID:17085597   PMID:17255105   PMID:17455326   PMID:17900529   PMID:17979178   PMID:19056867   PMID:19199708   PMID:20458337   PMID:22871113   PMID:22926577   PMID:25931508  


Genomics

Comparative Map Data
Ywhah
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21477,696,332 - 77,705,715 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1477,696,333 - 77,705,741 (-)Ensembl
Rnor_6.01483,053,041 - 83,062,424 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,053,041 - 83,062,424 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01483,739,009 - 83,748,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,448,395 - 83,457,778 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11483,454,749 - 83,464,132 (-)NCBI
Celera1476,611,913 - 76,621,296 (-)NCBICelera
Cytogenetic Map14q21NCBI
YWHAH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,944,535 - 31,957,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2231,944,522 - 31,957,603 (+)EnsemblGRCh38hg38GRCh38
GRCh372232,340,521 - 32,353,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,670,479 - 30,683,590 (+)NCBINCBI36hg18NCBI36
Build 342230,665,082 - 30,678,143NCBI
Celera2216,140,927 - 16,154,032 (+)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2215,296,794 - 15,309,903 (+)NCBIHuRef
CHM1_12232,299,883 - 32,312,993 (+)NCBICHM1_1
T2T-CHM13v2.02232,408,656 - 32,421,713 (+)NCBI
Ywhah
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,176,160 - 33,185,310 (+)NCBIGRCm39mm39
GRCm39 Ensembl533,176,160 - 33,185,310 (+)Ensembl
GRCm38533,018,816 - 33,027,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,018,816 - 33,027,966 (+)EnsemblGRCm38mm10GRCm38
MGSCv37533,361,465 - 33,370,615 (+)NCBIGRCm37mm9NCBIm37
MGSCv36533,329,757 - 33,344,823 (+)NCBImm8
Celera530,495,248 - 30,504,397 (+)NCBICelera
Cytogenetic Map5B1NCBI
Ywhah
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554556,045,919 - 6,057,729 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554556,045,919 - 6,057,729 (+)NCBIChiLan1.0ChiLan1.0
YWHAH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12230,814,699 - 30,832,613 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,819,821 - 30,831,804 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02212,966,653 - 12,979,695 (+)NCBIMhudiblu_PPA_v0panPan3
YWHAH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,785,374 - 24,796,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,785,368 - 24,795,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2624,653,699 - 24,664,927 (+)NCBI
ROS_Cfam_1.02625,171,660 - 25,183,107 (+)NCBI
ROS_Cfam_1.0 Ensembl2625,170,742 - 25,183,121 (+)Ensembl
UMICH_Zoey_3.12624,870,912 - 24,882,134 (+)NCBI
UNSW_CanFamBas_1.02625,132,984 - 25,144,210 (+)NCBI
UU_Cfam_GSD_1.02625,195,163 - 25,206,388 (+)NCBI
Ywhah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118118,339,882 - 118,351,331 (-)NCBI
SpeTri2.0NW_0049367551,597,487 - 1,608,915 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1448,544,173 - 48,556,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11448,544,031 - 48,556,496 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,861,302 - 51,873,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,825,963 - 14,839,668 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,826,135 - 14,840,325 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045111,267,273 - 111,281,244 (-)NCBIVero_WHO_p1.0
Ywhah
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247478,350,474 - 8,363,576 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247478,350,552 - 8,362,610 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
Ywhah  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,697,240 - 77,697,399 (+)MAPPERmRatBN7.2
Rnor_6.01483,053,950 - 83,054,108NCBIRnor6.0
Rnor_5.01483,739,918 - 83,740,076UniSTSRnor5.0
RGSC_v3.41483,449,304 - 83,449,462UniSTSRGSC3.4
Celera1476,612,822 - 76,612,980UniSTS
Cytogenetic Map14q21UniSTS
RH128993  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,696,437 - 77,696,628 (+)MAPPERmRatBN7.2
Rnor_6.01483,053,147 - 83,053,337NCBIRnor6.0
Rnor_5.01483,739,115 - 83,739,305UniSTSRnor5.0
RGSC_v3.41483,448,501 - 83,448,691UniSTSRGSC3.4
Celera1476,612,019 - 76,612,209UniSTS
RH 3.4 Map14516.46UniSTS
Cytogenetic Map14q21UniSTS
REN75940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,697,461 - 77,697,712 (+)MAPPERmRatBN7.2
Rnor_6.01483,054,171 - 83,054,421NCBIRnor6.0
Rnor_5.01483,740,139 - 83,740,389UniSTSRnor5.0
RGSC_v3.41483,449,525 - 83,449,775UniSTSRGSC3.4
Celera1476,613,043 - 76,613,293UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:304
Count of miRNA genes:178
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000024388
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 17
Medium 3 43 57 41 19 41 8 11 57 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085735   ⟹   ENSRNOP00000075701
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1477,696,333 - 77,705,741 (-)Ensembl
Rnor_6.0 Ensembl1483,053,041 - 83,062,424 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086769   ⟹   ENSRNOP00000072179
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1477,696,391 - 77,705,615 (-)Ensembl
Rnor_6.0 Ensembl1483,053,041 - 83,062,302 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097691   ⟹   ENSRNOP00000092588
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1477,696,335 - 77,705,624 (-)Ensembl
RefSeq Acc Id: NM_013052   ⟹   NP_037184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21477,696,332 - 77,705,715 (-)NCBI
Rnor_6.01483,053,041 - 83,062,424 (-)NCBI
Rnor_5.01483,739,009 - 83,748,391 (-)NCBI
RGSC_v3.41483,448,395 - 83,457,778 (-)RGD
Celera1476,611,913 - 76,621,296 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037184 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81825 (Get FASTA)   NCBI Sequence Viewer  
  BAA04259 (Get FASTA)   NCBI Sequence Viewer  
  EDM00135 (Get FASTA)   NCBI Sequence Viewer  
  EDM00136 (Get FASTA)   NCBI Sequence Viewer  
  P68511 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037184   ⟸   NM_013052
- UniProtKB: P68511 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075701   ⟸   ENSRNOT00000085735
RefSeq Acc Id: ENSRNOP00000072179   ⟸   ENSRNOT00000086769
RefSeq Acc Id: ENSRNOP00000092588   ⟸   ENSRNOT00000097691
Protein Domains
14_3_3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68511-F1-model_v2 AlphaFold P68511 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699415
Promoter ID:EPDNEW_R9940
Type:multiple initiation site
Name:Ywhah_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, eta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01483,062,432 - 83,062,492EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3978 AgrOrtholog
BioCyc Gene G2FUF-15249 BioCyc
Ensembl Genes ENSRNOG00000055471 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000072179.1 UniProtKB/TrEMBL
  ENSRNOP00000075701 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000092588.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085735 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086769.2 UniProtKB/TrEMBL
  ENSRNOT00000097691.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192904 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25576 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93547 IMAGE-MGC_LOAD
NCBI Gene 25576 ENTREZGENE
PANTHER PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ywhah PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217055
UniProt 1433F_RAT UniProtKB/Swiss-Prot
  A0A0G2K2B8_RAT UniProtKB/TrEMBL
  A0A8I6AI74_RAT UniProtKB/TrEMBL
  P68511 ENTREZGENE
UniProt Secondary P11576 UniProtKB/Swiss-Prot
  P70198 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhah  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta  Ywhah  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ywhah  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution 14-3-3 protein family is highly conserved in both plants and mammals 727984
gene_expression mRNA expressed in specific nuclei in the central nervous system 727984
gene_homology aa sequence is 100% identical to bovine ywhah 727984