Fgfr3 (fibroblast growth factor receptor 3) - Rat Genome Database

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Gene: Fgfr3 (fibroblast growth factor receptor 3) Rattus norvegicus
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Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
RGD ID: 620714
Description: Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in cell-cell signaling; fibroblast growth factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface; cytoplasm; and nucleus. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; LADD syndrome; SADDAN; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3); PARTICIPATES IN fibroblast growth factor signaling pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,987,242 - 77,002,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,439,608 - 81,454,998 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01482,680,217 - 82,695,599 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01479,125,523 - 79,140,901 (-)NCBIRnor_WKY
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
absence epilepsy  (ISO)
acanthosis nigricans  (ISO)
achondroplasia  (ISO)
Achondroplastic Dwarfism  (ISO)
acrocephalosyndactylia  (ISO)
asphyxiating thoracic dystrophy  (ISO)
autosomal dominant disease  (ISS)
bladder carcinoma  (ISO)
bladder urothelial carcinoma  (ISO)
bone development disease  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
camptodactyly-tall stature-scoliosis-hearing loss syndrome  (ISO)
carcinoma  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervix carcinoma  (ISO)
cherubism  (ISO)
chondrosarcoma  (IEP)
chronic myeloid leukemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Craniosynostosis 3  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO)
Crouzon syndrome-acanthosis nigricans syndrome  (ISO)
demyelinating disease  (ISO)
Developmental Disabilities  (ISO)
Dwarfism  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
epilepsy  (ISO)
Facial Asymmetry  (ISO)
genetic disease  (ISO)
Hamartoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatoblastoma  (ISO)
Hodgkin's lymphoma  (ISO)
hypochondroplasia  (ISO)
Knee Osteoarthritis  (ISO)
LADD syndrome  (ISO)
LADD Syndrome 2  (ISO)
Larsen syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Merkel cell carcinoma  (ISO)
mucopolysaccharidosis I  (ISO)
Muenke syndrome  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
Nervous System Malformations  (ISO)
neuroblastoma  (ISO)
oral squamous cell carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papillomavirus infectious disease  (ISO)
Paraproteinemias  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
plasma cell neoplasm  (ISO)
SADDAN  (ISO)
Saethre-Chotzen syndrome  (ISO)
sarcoma  (ISO)
scoliosis  (ISS)
seborrheic keratosis  (ISO)
seminoma  (ISO)
spermatocytoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
syndromic microphthalmia 5  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thanatophoric dysplasia  (ISO)
Thanatophoric Dysplasia, Type I  (ISO)
Thanatophoric Dysplasia, Type II  (ISO)
tongue cancer  (ISO)
tonsil squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
caffeine  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorthalidone  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimercaprol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gossypol  (ISO)
heparan sulfate  (ISO)
heparin  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lenalidomide  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
masitinib  (ISO)
metacetamol  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitrofen  (EXP,ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (EXP)
PD173074  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
ponatinib  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
triacsin C  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
astrocyte differentiation  (ISO)
axonogenesis involved in innervation  (ISO)
bone development  (ISO)
bone maturation  (ISO)
bone mineralization  (ISO)
bone morphogenesis  (ISO)
bone trabecula morphogenesis  (ISO)
calcium ion homeostasis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cell population proliferation  (ISO)
cell-cell signaling  (IDA)
central nervous system myelination  (ISO)
cochlea development  (ISO)
digestive tract morphogenesis  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell fate commitment  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway  (IDA,ISO)
forebrain development  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
inner ear development  (ISO)
inner ear receptor cell differentiation  (ISO)
lens fiber cell development  (ISO)
lens morphogenesis in camera-type eye  (ISO)
MAPK cascade  (ISO)
mitotic nuclear division  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of developmental growth  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuroblast proliferation  (ISO)
neuroepithelial cell differentiation  (ISO)
neuron apoptotic process  (ISO)
oligodendrocyte development  (ISO)
p38MAPK cascade  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
post-anal tail morphogenesis  (ISO)
protein autophosphorylation  (ISO)
protein ubiquitination  (ISO)
regulation of bone remodeling  (ISO)
regulation of collagen metabolic process  (ISO)
regulation of ossification  (ISO)
regulation of osteoclast differentiation  (ISO)
response to axon injury  (ISO)
response to sodium phosphate  (ISO)
somatic stem cell population maintenance  (ISO)
substantia nigra development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur. Barbisan F, etal., Cancer. 2008 Feb 1;112(3):636-44.
2. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Bellus GA, etal., Am J Med Genet. 1999 Jul 2;85(1):53-65.
3. Overexpression of FGFR3 in HPV-positive Tonsillar and Base of Tongue Cancer Is Correlated to Outcome. Bersani C, etal., Anticancer Res. 2018 Aug;38(8):4683-4690. doi: 10.21873/anticanres.12774.
4. Prediction of Progression of Non-Muscle-Invasive Bladder Cancer by WHO 1973 and 2004 Grading and by FGFR3 Mutation Status: A Prospective Study. Burger M, etal., Eur Urol. 2008 Oct;54(4):835-44. Epub 2007 Dec 26.
5. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Cappellen D, etal., Nat Genet. 1999 Sep;23(1):18-20.
6. Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene? Castro-Feijoo L, etal., Eur J Endocrinol. 2008 Sep;159(3):243-9. doi: 10.1530/EJE-08-0393. Epub 2008 Jun 26.
7. A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Chen L, etal., Hum Mol Genet. 2001 Mar 1;10(5):457-65.
8. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. Cinaroglu A, etal., J Neurosci Res. 2005 Feb 1;79(3):329-39.
9. Molecular cloning and developmental expression of rat fibroblast growth factor receptor 3. Claus P and Grothe C, Histochem Cell Biol 2001 Feb;115(2):147-55.
10. Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia fetuses. Delezoide AL, etal., Hum Mol Genet. 1997 Oct;6(11):1899-906.
11. Fibroblast growth factor-9, a local regulator of ovarian function. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
12. Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia. Dvorak P, etal., Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Human papillomavirus and the landscape of secondary genetic alterations in oral cancers. Gillison ML, etal., Genome Res. 2019 Jan;29(1):1-17. doi: 10.1101/gr.241141.118. Epub 2018 Dec 18.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Expression of FGFR3 Protein and Gene Amplification in Urinary Bladder Lesions in Relation to Schistosomiasis. Hammam O, etal., Open Access Maced J Med Sci. 2017 Apr 8;5(2):160-166. doi: 10.3889/oamjms.2017.048. eCollection 2017 Apr 15.
17. Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Jin C, etal., Cancer Res 2004 Jul 1;64(13):4555-62.
18. Fibroblast growth factor receptor 3 mutations in bladder tumors correlate with low frequency of chromosome alterations. Junker K, etal., Neoplasia. 2008 Jan;10(1):1-7.
19. Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Martinez-Torrecuadrada JL, etal., Mol Cancer Ther. 2008 Apr;7(4):862-73.
20. Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. Matsushita M, etal., Endocrinology. 2015 Feb;156(2):548-54. doi: 10.1210/en.2014-1914. Epub 2014 Dec 2.
21. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
22. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Meyers GA, etal., Nat Genet. 1995 Dec;11(4):462-4.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. New Zealand Maori family with the pro250arg fibroblast growth factor receptor 3 mutation associated with craniosynostosis. Moko SB and Blandin de Chalain TM, J Craniomaxillofac Surg. 2001 Feb;29(1):22-4.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes. Oji GS, etal., Iowa Orthop J. 2007;27:9-16.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Pringle NP, etal., Development 2003 Jan;130(1):93-102.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Comprehensive gene review and curation RGD comprehensive gene curation
35. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Rousseau F, etal., Nature. 1994 Sep 15;371(6494):252-4.
36. Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. Sawai H, etal., Prenat Diagn. 1999 Jan;19(1):21-4.
37. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Seiwert TY, etal., Clin Cancer Res. 2015 Feb 1;21(3):632-41. doi: 10.1158/1078-0432.CCR-13-3310. Epub 2014 Jul 23.
38. Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas. Shotelersuk V, etal., Oncol Rep. 2001 Nov-Dec;8(6):1301-4. doi: 10.3892/or.8.6.1301.
39. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Sibley K, etal., Oncogene. 2001 Feb 8;20(6):686-91.
40. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Sibley K, etal., Oncogene. 2001 Jul 19;20(32):4416-8.
41. Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice. Tang J, etal., Arthritis Rheumatol. 2016 Oct;68(10):2432-43. doi: 10.1002/art.39739.
42. Aberrant expression of ALK and EZH2 in Merkel cell carcinoma. Veija T, etal., BMC Cancer. 2017 Mar 31;17(1):236. doi: 10.1186/s12885-017-3233-5.
43. Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer. Zammit C, etal., J Pathol. 2001 May;194(1):27-34.
Additional References at PubMed
PMID:8663044   PMID:8875318   PMID:9716527   PMID:9811582   PMID:11290300   PMID:11294897   PMID:12417662   PMID:12574417   PMID:12815063   PMID:14699054   PMID:14732692   PMID:15292251  
PMID:15708559   PMID:15781473   PMID:16009496   PMID:16291864   PMID:17117437   PMID:17192470   PMID:17234579   PMID:17467696   PMID:17555714   PMID:17557302   PMID:17561467   PMID:17708356  
PMID:18061161   PMID:18187602   PMID:18455718   PMID:19407216   PMID:20053668   PMID:20356821   PMID:20362703   PMID:20582225   PMID:21691921   PMID:21994076   PMID:23696738   PMID:23972473  
PMID:24120763   PMID:28964968   PMID:29626475   PMID:33470768  


Genomics

Comparative Map Data
Fgfr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,987,242 - 77,002,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,439,608 - 81,454,998 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01482,680,217 - 82,695,599 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01479,125,523 - 79,140,901 (-)NCBIRnor_WKY
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
FGFR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,793,293 - 1,808,867 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl41,793,293 - 1,808,872 (+)EnsemblGRCh38hg38GRCh38
GRCh3741,795,020 - 1,810,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBINCBI36Build 36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
T2T-CHM13v2.041,791,772 - 1,807,344 (+)NCBIT2T-CHM13v2.0
Fgfr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)EnsemblGRCm39 Ensembl
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBIMGSCv36mm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Fgfr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
FGFR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.141,843,780 - 1,858,635 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,843,774 - 1,861,692 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v041,933,172 - 1,948,742 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FGFR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,309,128 - 62,318,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,303,756 - 62,323,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,826,871 - 64,841,704 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,784,572 - 62,799,405 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,783,114 - 62,800,195 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,278,095 - 62,292,924 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,481,623 - 62,496,456 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,840,834 - 62,855,656 (-)NCBIUU_Cfam_GSD_1.0
Fgfr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,890,080 - 67,904,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,591,792 - 21,606,296 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647721,591,772 - 21,606,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8879,159 - 894,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18879,151 - 894,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28336,714 - 341,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,958,444 - 46,974,032 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,957,254 - 46,973,392 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,334,868 - 3,350,469 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,635,165 - 25,646,932 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,633,690 - 25,647,361 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgfr3
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:248
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000023144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH144549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21477,003,197 - 77,003,437 (+)MAPPERmRatBN7.2
Rnor_6.01482,288,272 - 82,288,511NCBIRnor6.0
Rnor_5.01482,977,649 - 82,977,888UniSTSRnor5.0
RGSC_v3.41482,698,393 - 82,698,632UniSTSRGSC3.4
Celera1475,926,793 - 75,927,032UniSTS
RH 3.4 Map14504.98UniSTS
Cytogenetic Map14q21UniSTS
Fgfr3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,990,393 - 76,990,604 (+)MAPPERmRatBN7.2
Rnor_6.01482,275,471 - 82,275,681NCBIRnor6.0
Rnor_5.01482,965,027 - 82,965,237UniSTSRnor5.0
Celera1475,913,745 - 75,913,955UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 30 30 3 30 74 35 27 11
Low 37 27 11 16 11 8 11 14 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023144   ⟹   ENSRNOP00000023144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)Ensembl
Rnor_6.0 Ensembl1482,273,070 - 82,287,108 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080695   ⟹   ENSRNOP00000072062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)Ensembl
Rnor_6.0 Ensembl1482,273,657 - 82,287,706 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109689   ⟹   ENSRNOP00000077634
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1476,987,993 - 77,003,341 (-)Ensembl
RefSeq Acc Id: NM_053429   ⟹   NP_445881
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,993 - 77,002,033 (-)NCBI
Rnor_6.01482,273,070 - 82,287,108 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
RGSC_v3.41482,683,191 - 82,697,229 (-)RGD
Celera1475,911,344 - 75,925,631 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251390   ⟹   XP_006251452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251392   ⟹   XP_006251454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251393   ⟹   XP_006251455
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251394   ⟹   XP_006251456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251395   ⟹   XP_006251457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,670 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251396   ⟹   XP_006251458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,670 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445881   ⟸   NM_053429
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006251458   ⟸   XM_006251396
- Peptide Label: isoform X6
- UniProtKB: F1LSN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251457   ⟸   XM_006251395
- Peptide Label: isoform X5
- UniProtKB: F1LSN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251456   ⟸   XM_006251394
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006251455   ⟸   XM_006251393
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K210 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251454   ⟸   XM_006251392
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K210 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251452   ⟸   XM_006251390
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000072062   ⟸   ENSRNOT00000080695
RefSeq Acc Id: ENSRNOP00000023144   ⟸   ENSRNOT00000023144
RefSeq Acc Id: ENSRNOP00000077634   ⟸   ENSRNOT00000109689
Protein Domains
Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K210-F1-model_v2 AlphaFold A0A0G2K210 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699417
Promoter ID:EPDNEW_R9933
Type:single initiation site
Name:Fgfr3_1
Description:fibroblast growth factor receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01482,287,731 - 82,287,791EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620714 AgrOrtholog
BioCyc Gene G2FUF-15267 BioCyc
Ensembl Genes ENSRNOG00000016818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023144 ENTREZGENE
  ENSRNOP00000023144.5 UniProtKB/TrEMBL
  ENSRNOP00000072062 ENTREZGENE
  ENSRNOP00000072062.2 UniProtKB/TrEMBL
  ENSRNOP00000077634 ENTREZGENE
  ENSRNOP00000077634.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023144 ENTREZGENE
  ENSRNOT00000023144.7 UniProtKB/TrEMBL
  ENSRNOT00000080695 ENTREZGENE
  ENSRNOT00000080695.2 UniProtKB/TrEMBL
  ENSRNOT00000109689 ENTREZGENE
  ENSRNOT00000109689.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_fibroblast_GF_rcpt UniProtKB/TrEMBL
KEGG Report rno:84489 UniProtKB/TrEMBL
NCBI Gene 84489 ENTREZGENE
Pfam I-set UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Fgfr3 PhenoGen
PIRSF FGFR UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K210 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y7R6_RAT UniProtKB/TrEMBL
  F1LSN4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHX9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Fgfr3  fibroblast growth factor receptor 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgfr3  fibroblast growth factor receptor 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in lung and brain 632790