Fgfr3 (fibroblast growth factor receptor 3) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Fgfr3 (fibroblast growth factor receptor 3) Rattus norvegicus
Analyze
Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
RGD ID: 620714
Description: Exhibits fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Involved in cell-cell signaling; fibroblast growth factor receptor signaling pathway; and positive regulation of cell population proliferation. Localizes to cell surface; cytoplasm; and nucleus. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Crouzon syndrome-acanthosis nigricans syndrome; LADD syndrome; SADDAN; bone development disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3); PARTICIPATES IN fibroblast growth factor signaling pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
achondroplasia  (ISO)
Achondroplastic Dwarfism  (ISO)
asphyxiating thoracic dystrophy  (ISO)
autosomal dominant disease  (ISS)
bladder carcinoma  (ISO)
bladder urothelial carcinoma  (ISO)
bone development disease  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
camptodactyly-tall stature-scoliosis-hearing loss syndrome  (ISO)
carcinoma  (ISO)
cervical cancer  (ISO,ISS)
cervical squamous cell carcinoma  (ISO)
cervix carcinoma  (ISO)
chondrosarcoma  (IEP)
chronic myeloid leukemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO)
Crouzon syndrome-acanthosis nigricans syndrome  (ISO)
demyelinating disease  (ISO)
Developmental Disabilities  (ISO)
Dwarfism  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypochondroplasia  (ISO)
Knee Osteoarthritis  (ISO)
LADD syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Merkel cell carcinoma  (ISO)
Muenke syndrome  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
neuroblastoma  (ISO)
oral squamous cell carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
SADDAN  (ISO)
Saethre-Chotzen syndrome  (ISO)
scoliosis  (ISS)
seborrheic keratosis  (ISO)
seminoma  (ISO)
spermatocytoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
syndromic microphthalmia 5  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISS)
Testicular Germ Cell Tumor  (ISO)
thanatophoric dysplasia  (ISO)
Thanatophoric Dysplasia, Type I  (ISO)
Thanatophoric Dysplasia, Type II  (ISO)
tongue cancer  (ISO)
tonsil squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chlorthalidone  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimercaprol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
genistein  (ISO)
gossypol  (ISO)
heparan sulfate  (ISO)
heparin  (ISO)
hydrogen chloride  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lenalidomide  (ISO)
maneb  (ISO)
metacetamol  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitrofen  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
PD173074  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pomalidomide  (ISO)
ponatinib  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
retinyl acetate  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
triacsin C  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
axonogenesis involved in innervation  (ISO)
bone development  (ISO)
bone maturation  (ISO)
bone mineralization  (ISO)
bone morphogenesis  (ISO)
bone trabecula morphogenesis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cell-cell signaling  (IDA)
central nervous system myelination  (ISO)
cochlea development  (ISO)
digestive tract morphogenesis  (ISO)
epithelial cell fate commitment  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway  (IDA,ISO)
forebrain development  (ISO)
inner ear development  (ISO)
inner ear receptor cell differentiation  (ISO)
lens fiber cell development  (ISO)
lens morphogenesis in camera-type eye  (ISO)
morphogenesis of an epithelium  (ISO)
multicellular organism development  (IBA)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of developmental growth  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte development  (ISO)
p38MAPK cascade  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell population proliferation  (IDA,ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
post-anal tail morphogenesis  (ISO)
protein autophosphorylation  (ISO)
regulation of bone remodeling  (ISO)
regulation of collagen metabolic process  (ISO)
regulation of ossification  (ISO)
regulation of osteoclast differentiation  (ISO)
response to axon injury  (ISO)
somatic stem cell population maintenance  (ISO)
substantia nigra development  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)

Cellular Component

References

References - curated
1. Barbisan F, etal., Cancer. 2008 Feb 1;112(3):636-44.
2. Bellus GA, etal., Am J Med Genet. 1999 Jul 2;85(1):53-65.
3. Bersani C, etal., Anticancer Res. 2018 Aug;38(8):4683-4690. doi: 10.21873/anticanres.12774.
4. Burger M, etal., Eur Urol. 2008 Oct;54(4):835-44. Epub 2007 Dec 26.
5. Cappellen D, etal., Nat Genet. 1999 Sep;23(1):18-20.
6. Castro-Feijoo L, etal., Eur J Endocrinol. 2008 Sep;159(3):243-9. doi: 10.1530/EJE-08-0393. Epub 2008 Jun 26.
7. Chen L, etal., Hum Mol Genet. 2001 Mar 1;10(5):457-65.
8. Cinaroglu A, etal., J Neurosci Res. 2005 Feb 1;79(3):329-39.
9. Claus P and Grothe C, Histochem Cell Biol 2001 Feb;115(2):147-55.
10. Delezoide AL, etal., Hum Mol Genet. 1997 Oct;6(11):1899-906.
11. Drummond AE, etal., Endocrinology. 2007 Aug;148(8):3711-21. Epub 2007 May 10.
12. Dvorak P, etal., Leukemia. 2003 Dec;17(12):2418-25. doi: 10.1038/sj.leu.2403152.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Gillison ML, etal., Genome Res. 2019 Jan;29(1):1-17. doi: 10.1101/gr.241141.118. Epub 2018 Dec 18.
15. GOA data from the GO Consortium
16. Hammam O, etal., Open Access Maced J Med Sci. 2017 Apr 8;5(2):160-166. doi: 10.3889/oamjms.2017.048. eCollection 2017 Apr 15.
17. Jin C, etal., Cancer Res 2004 Jul 1;64(13):4555-62.
18. Junker K, etal., Neoplasia. 2008 Jan;10(1):1-7.
19. Martinez-Torrecuadrada JL, etal., Mol Cancer Ther. 2008 Apr;7(4):862-73.
20. Matsushita M, etal., Endocrinology. 2015 Feb;156(2):548-54. doi: 10.1210/en.2014-1914. Epub 2014 Dec 2.
21. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
22. Meyers GA, etal., Nat Genet. 1995 Dec;11(4):462-4.
23. MGD data from the GO Consortium
24. Moko SB and Blandin de Chalain TM, J Craniomaxillofac Surg. 2001 Feb;29(1):22-4.
25. NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Oji GS, etal., Iowa Orthop J. 2007;27:9-16.
27. OMIM Disease Annotation Pipeline
28. Online Mendelian Inheritance in Man, OMIM (TM).
29. Pipeline to import KEGG annotations from KEGG into RGD
30. Pringle NP, etal., Development 2003 Jan;130(1):93-102.
31. RGD automated data pipeline
32. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. RGD automated import pipeline for gene-chemical interactions
34. RGD comprehensive gene curation
35. Rousseau F, etal., Nature. 1994 Sep 15;371(6494):252-4.
36. Sawai H, etal., Prenat Diagn. 1999 Jan;19(1):21-4.
37. Seiwert TY, etal., Clin Cancer Res. 2015 Feb 1;21(3):632-41. doi: 10.1158/1078-0432.CCR-13-3310. Epub 2014 Jul 23.
38. Shotelersuk V, etal., Oncol Rep. 2001 Nov-Dec;8(6):1301-4. doi: 10.3892/or.8.6.1301.
39. Sibley K, etal., Oncogene. 2001 Feb 8;20(6):686-91.
40. Sibley K, etal., Oncogene. 2001 Jul 19;20(32):4416-8.
41. Tang J, etal., Arthritis Rheumatol. 2016 Oct;68(10):2432-43. doi: 10.1002/art.39739.
42. Veija T, etal., BMC Cancer. 2017 Mar 31;17(1):236. doi: 10.1186/s12885-017-3233-5.
43. Zammit C, etal., J Pathol. 2001 May;194(1):27-34.
Additional References at PubMed
PMID:8663044   PMID:8875318   PMID:9716527   PMID:9811582   PMID:11290300   PMID:11294897   PMID:12417662   PMID:12574417   PMID:12815063   PMID:14699054   PMID:14732692   PMID:15292251  
PMID:15708559   PMID:15781473   PMID:16009496   PMID:16291864   PMID:17117437   PMID:17192470   PMID:17234579   PMID:17467696   PMID:17555714   PMID:17557302   PMID:17561467   PMID:17708356  
PMID:18061161   PMID:18187602   PMID:18455718   PMID:19407216   PMID:20053668   PMID:20356821   PMID:20362703   PMID:20582225   PMID:21691921   PMID:21994076   PMID:23696738   PMID:23972473  
PMID:24120763   PMID:28964968   PMID:29626475  


Genomics

Comparative Map Data
Fgfr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
FGFR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl41,793,293 - 1,808,872 (+)EnsemblGRCh38hg38GRCh38
GRCh3841,793,293 - 1,808,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3741,795,020 - 1,810,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBINCBI36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
Fgfr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)Ensembl
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIGRCm37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBImm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Fgfr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
FGFR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.141,843,780 - 1,858,635 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v041,933,172 - 1,948,742 (+)NCBIMhudiblu_PPA_v0panPan3
FGFR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,309,128 - 62,318,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,303,756 - 62,323,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,826,871 - 64,841,704 (-)NCBI
ROS_Cfam_1.0362,784,572 - 62,799,405 (-)NCBI
UMICH_Zoey_3.1362,278,095 - 62,292,924 (-)NCBI
UNSW_CanFamBas_1.0362,481,623 - 62,496,456 (-)NCBI
UU_Cfam_GSD_1.0362,840,834 - 62,855,656 (-)NCBI
Fgfr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,890,080 - 67,904,598 (-)NCBI
SpeTri2.0NW_00493647721,591,772 - 21,606,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8879,151 - 895,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18879,151 - 894,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28336,714 - 341,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,958,444 - 46,974,032 (-)NCBI
ChlSab1.1 Ensembl2746,957,254 - 46,973,392 (-)Ensembl
Fgfr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475525,633,690 - 25,647,361 (-)NCBI

Position Markers
RH144549  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01482,288,272 - 82,288,511NCBIRnor6.0
Rnor_5.01482,977,649 - 82,977,888UniSTSRnor5.0
RGSC_v3.41482,698,393 - 82,698,632UniSTSRGSC3.4
Celera1475,926,793 - 75,927,032UniSTS
RH 3.4 Map14504.98UniSTS
Cytogenetic Map14q21UniSTS
Fgfr3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01482,275,471 - 82,275,681NCBIRnor6.0
Rnor_5.01482,965,027 - 82,965,237UniSTSRnor5.0
Celera1475,913,745 - 75,913,955UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1412680424106641756Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143259392686191589Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)144031561085315610Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)144031561085315610Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)144031561085315610Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)144031561085315610Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1442442731108833671Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1443910761105074364Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1451818462105074364Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1460980905105980905Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1460980905105980905Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)146187332388870994Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1461993178106993178Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1463548095108548095Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147339146788870994Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)1478172765102549388Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1478172765102549388Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765102549388Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1478172765106641756Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1478446303110402569Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1480049285115493446Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1480049285115493446Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:248
Interacting mature miRNAs:299
Transcripts:ENSRNOT00000023144
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 30 30 3 30 74 35 27 11
Low 37 27 11 16 11 8 11 14 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023144   ⟹   ENSRNOP00000023144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1482,273,070 - 82,287,108 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080695   ⟹   ENSRNOP00000072062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1482,273,657 - 82,287,706 (-)Ensembl
RefSeq Acc Id: NM_053429   ⟹   NP_445881
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,993 - 77,002,033 (-)NCBI
Rnor_6.01482,273,070 - 82,287,108 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
RGSC_v3.41482,683,191 - 82,697,229 (-)RGD
Celera1475,911,344 - 75,925,631 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251390   ⟹   XP_006251452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251392   ⟹   XP_006251454
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251393   ⟹   XP_006251455
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251394   ⟹   XP_006251456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251395   ⟹   XP_006251457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,670 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251396   ⟹   XP_006251458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21476,987,242 - 77,002,670 (-)NCBI
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Rnor_5.01482,961,882 - 82,977,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599397   ⟹   XP_017454886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01482,272,322 - 82,287,739 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445881   ⟸   NM_053429
- Peptide Label: precursor
- UniProtKB: Q9JHX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251458   ⟸   XM_006251396
- Peptide Label: isoform X6
- UniProtKB: F1LSN4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251457   ⟸   XM_006251395
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006251456   ⟸   XM_006251394
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006251455   ⟸   XM_006251393
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K210 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251454   ⟸   XM_006251392
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006251452   ⟸   XM_006251390
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017454886   ⟸   XM_017599397
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000072062   ⟸   ENSRNOT00000080695
RefSeq Acc Id: ENSRNOP00000023144   ⟸   ENSRNOT00000023144
Protein Domains
Ig-like   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699417
Promoter ID:EPDNEW_R9933
Type:single initiation site
Name:Fgfr3_1
Description:fibroblast growth factor receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01482,287,731 - 82,287,791EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620714 AgrOrtholog
Ensembl Genes ENSRNOG00000016818 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023144 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072062 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023144 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080695 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FGFR_TM UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_fibroblast_GF_rcpt UniProtKB/TrEMBL
KEGG Report rno:84489 UniProtKB/TrEMBL
NCBI Gene 84489 ENTREZGENE
Pfam FGFR3_TM UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Fgfr3 PhenoGen
PIRSF FGFR UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K210 ENTREZGENE, UniProtKB/TrEMBL
  F1LSN4 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHX9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Fgfr3  fibroblast growth factor receptor 3      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgfr3  fibroblast growth factor receptor 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in lung and brain 632790