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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgfr3increases expressionISOFGFR3 (Homo sapiens)6480464CTDEstradiol results in increased expression of FGFR3 mRNA alternative formPMID:14602803
Fgfr3increases expressionISOFgfr3 (Mus musculus)6480464CTDEstradiol results in increased expression of FGFR3 mRNAPMID:25210133
Fgfr3multiple interactionsISOFGFR3 (Homo sapiens)6480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of FGFR3 mRNA; [Estradiol co-treated with TGFB1 protein] results in decreased expression of FGFR3 mRNAPMID:20404318 PMID:30165855
Fgfr3multiple interactionsISOFgfr3 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of FGFR3 mRNA]PMID:25210133
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