Fgfr3 (fibroblast growth factor receptor 3) - Rat Genome Database

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Gene: Fgfr3 (fibroblast growth factor receptor 3) Chinchilla lanigera
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Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
RGD ID: 9065689
Description: ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); fibroblast growth factor-activated receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); axonogenesis involved in innervation (ortholog); bone development (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH acanthosis nigricans (ortholog); achondroplasia (ortholog); Achondroplastic Dwarfism (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
achondroplasia  (ISO)
Achondroplastic Dwarfism  (ISO)
asphyxiating thoracic dystrophy  (ISO)
bladder carcinoma  (ISO)
bladder urothelial carcinoma  (ISO)
bone development disease  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
camptodactyly-tall stature-scoliosis-hearing loss syndrome  (ISO)
carcinoma  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
cervix carcinoma  (ISO)
chondrosarcoma  (ISO)
chronic myeloid leukemia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Crouzon syndrome  (ISO)
Crouzon syndrome-acanthosis nigricans syndrome  (ISO)
demyelinating disease  (ISO)
Developmental Disabilities  (ISO)
Dwarfism  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
genetic disease  (ISO)
Growth Disorders  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypochondroplasia  (ISO)
Knee Osteoarthritis  (ISO)
LADD syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Merkel cell carcinoma  (ISO)
Muenke syndrome  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
neuroblastoma  (ISO)
oral squamous cell carcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
SADDAN  (ISO)
Saethre-Chotzen syndrome  (ISO)
seborrheic keratosis  (ISO)
seminoma  (ISO)
spermatocytoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
syndromic microphthalmia 5  (ISO)
testicular cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
thanatophoric dysplasia  (ISO)
Thanatophoric Dysplasia, Type I  (ISO)
Thanatophoric Dysplasia, Type II  (ISO)
tongue cancer  (ISO)
tonsil squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alveolar secondary septum development  (ISO)
axonogenesis involved in innervation  (ISO)
bone development  (ISO)
bone maturation  (ISO)
bone mineralization  (ISO)
bone morphogenesis  (ISO)
bone trabecula morphogenesis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cell-cell signaling  (ISO)
central nervous system myelination  (ISO)
cochlea development  (ISO)
digestive tract morphogenesis  (ISO)
epithelial cell fate commitment  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor apoptotic signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
forebrain development  (ISO)
inner ear development  (ISO)
inner ear receptor cell differentiation  (ISO)
lens fiber cell development  (ISO)
lens morphogenesis in camera-type eye  (ISO)
morphogenesis of an epithelium  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of developmental growth  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitotic nuclear division  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
oligodendrocyte development  (ISO)
p38MAPK cascade  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phospholipase activity  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
post-anal tail morphogenesis  (ISO)
protein autophosphorylation  (ISO)
regulation of bone remodeling  (ISO)
regulation of collagen metabolic process  (ISO)
regulation of ossification  (ISO)
regulation of osteoclast differentiation  (ISO)
response to axon injury  (ISO)
somatic stem cell population maintenance  (ISO)
substantia nigra development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Fgfr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBIChiLan1.0ChiLan1.0
FGFR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl41,793,293 - 1,808,872 (+)EnsemblGRCh38hg38GRCh38
GRCh3841,793,293 - 1,808,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3741,795,020 - 1,810,594 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBINCBI36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
Fgfr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39533,879,068 - 33,894,412 (+)NCBIGRCm39mm39
GRCm39 Ensembl533,879,018 - 33,894,412 (+)Ensembl
GRCm38533,721,724 - 33,737,068 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,721,674 - 33,737,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv37534,064,373 - 34,079,713 (+)NCBIGRCm37mm9NCBIm37
MGSCv36534,038,581 - 34,053,924 (+)NCBImm8
Celera531,197,840 - 31,213,180 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Fgfr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21476,987,242 - 77,002,671 (-)NCBI
Rnor_6.0 Ensembl1482,273,070 - 82,287,706 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01482,272,322 - 82,287,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01482,961,882 - 82,977,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,683,191 - 82,697,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11482,685,581 - 82,699,620 (-)NCBI
Celera1475,911,344 - 75,925,631 (-)NCBICelera
Cytogenetic Map14q21NCBI
FGFR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.141,843,780 - 1,858,635 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,843,774 - 1,861,692 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v041,933,172 - 1,948,742 (+)NCBIMhudiblu_PPA_v0panPan3
FGFR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,309,128 - 62,318,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,303,756 - 62,323,896 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,826,871 - 64,841,704 (-)NCBI
ROS_Cfam_1.0362,784,572 - 62,799,405 (-)NCBI
UMICH_Zoey_3.1362,278,095 - 62,292,924 (-)NCBI
UNSW_CanFamBas_1.0362,481,623 - 62,496,456 (-)NCBI
UU_Cfam_GSD_1.0362,840,834 - 62,855,656 (-)NCBI
Fgfr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,890,080 - 67,904,598 (-)NCBI
SpeTri2.0NW_00493647721,591,772 - 21,606,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8879,151 - 895,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18879,151 - 894,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28336,714 - 341,509 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,958,444 - 46,974,032 (-)NCBI
ChlSab1.1 Ensembl2746,957,254 - 46,973,392 (-)Ensembl
Fgfr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475525,633,690 - 25,647,361 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000010209   ⟹   ENSCLAP00000010079
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000010210   ⟹   ENSCLAP00000010080
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555141,025,600 - 1,038,590 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000010211   ⟹   ENSCLAP00000010081
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555141,030,246 - 1,037,179 (+)Ensembl
RefSeq Acc Id: XM_013506763   ⟹   XP_013362217
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555141,030,244 - 1,038,590 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362217 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013362217   ⟸   XM_013506763
- Sequence:
RefSeq Acc Id: ENSCLAP00000010079   ⟸   ENSCLAT00000010209
RefSeq Acc Id: ENSCLAP00000010080   ⟸   ENSCLAT00000010210
RefSeq Acc Id: ENSCLAP00000010081   ⟸   ENSCLAT00000010211


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006986 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000010079 ENTREZGENE
Ensembl Transcript ENSCLAT00000010209 ENTREZGENE
NCBI Gene Fgfr3 ENTREZGENE