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Gene: FGFR3 (fibroblast growth factor receptor 3) Homo sapiens
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Symbol: FGFR3
Name: fibroblast growth factor receptor 3
Description: Exhibits fibroblast growth factor binding activity; fibroblast growth factor-activated receptor activity; and identical protein binding activity. Involved in several processes, including fibroblast growth factor receptor apoptotic signaling pathway; positive regulation of phosphorylation; and protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to colocalize with the focal adhesion. Implicated in several diseases, including LADD syndrome; SADDAN; acanthosis nigricans; bone disease (multiple); and camptodactyly-tall stature-scoliosis-hearing loss syndrome. Biomarker of breast cancer; thanatophoric dysplasia; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACH; achondroplasia, thanatophoric dwarfism; CD333; CEK2; FGFR-3; fibroblast growth factor receptor 3 variant 4; fibroblast growth factor receptor 3-S; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; tyrosine kinase JTK4
Orthologs:
Mus musculus (house mouse) : Fgfr3 (fibroblast growth factor receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fgfr3 (fibroblast growth factor receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fgfr3 (fibroblast growth factor receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : FGFR3 (fibroblast growth factor receptor 3)
Canis lupus familiaris (dog) : FGFR3 (fibroblast growth factor receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fgfr3 (fibroblast growth factor receptor 3)
Sus scrofa (pig) : FGFR3 (fibroblast growth factor receptor 3)
more info ...
Related Pseudogenes: FGFR3P1   FGFR3P2   FGFR3P3   FGFR3P4   FGFR3P5   FGFR3P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,793,293 - 1,808,872 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3741,795,039 - 1,810,599 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,765,421 - 1,780,396 (+)NCBINCBI36hg18NCBI36
Build 3441,762,853 - 1,777,829NCBI
Celera41,707,555 - 1,723,113 (+)NCBI
Cytogenetic Map4p16.3NCBI
HuRef41,725,137 - 1,753,471 (+)NCBIHuRef
CHM1_141,792,977 - 1,808,551 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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