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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgfr3
Name: fibroblast growth factor receptor 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgfr3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of FGFR3 mRNAPMID:16960034 PMID:21215274 PMID:33387578
Fgfr3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of FGFR3 mRNAPMID:32109520
Fgfr3affects expressionISOFGFR3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of FGFR3 mRNAPMID:36370075
Fgfr3multiple interactionsISOFgfr3 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of FGFR3 mRNA; Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to FGFR3 promoter]PMID:19654925 PMID:25975270
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