Rpa2 (replication protein A2) - Rat Genome Database

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Gene: Rpa2 (replication protein A2) Rattus norvegicus
Analyze
Symbol: Rpa2
Name: replication protein A2
RGD ID: 619714
Description: Enables single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Part of DNA replication factor A complex. Orthologous to human RPA2 (replication protein A2); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p32-subunit of replication protein A; replication factor A protein 2; replication protein A 32 kDa subunit; RF-A protein 2; RP-A p32
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25144,976,789 - 144,989,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,976,748 - 144,987,350 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,676,577 - 147,687,100 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,446,166 - 149,456,689 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,434,752 - 149,445,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,957,041 - 150,967,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,957,001 - 150,968,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,623,986 - 154,634,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,369,550 - 152,380,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,379,590 - 152,390,409 (-)NCBI
Celera5143,400,981 - 143,411,495 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-quinic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
artesunate  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
CX-5461  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
progesterone  (EXP)
quizartinib  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
veliparib  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
chromosome, telomeric region  (IBA,IEA,ISO,ISS)
DNA replication factor A complex  (IBA,IDA,IEA,ISO)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO,ISS)
PML body  (ISO,ISS)
site of double-strand break  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
4. Calmodulin is involved in the induction of DNA polymerases alpha and delta activities in normal rat kidney cells activated to proliferate. Lopez-Girona A, etal., Biochem Biophys Res Commun. 1995 Dec 14;217(2):566-74.
5. A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. Nagelhus TA, etal., J Biol Chem 1997 Mar 7;272(10):6561-6.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. The multi-replication protein A (RPA) system--a new perspective. Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.
12. Replication protein A is the major single-stranded DNA binding protein detected in mammalian cell extracts by gel retardation assays and UV cross-linking of long and short single-stranded DNA molecules. Seroussi E and Lavi S, J Biol Chem. 1993 Apr 5;268(10):7147-54.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1908076   PMID:2406247   PMID:7700386   PMID:9430682   PMID:9765279   PMID:10336450   PMID:10715114   PMID:10982866   PMID:11927569   PMID:12814551   PMID:15489334   PMID:16135809  
PMID:17765923   PMID:17959650   PMID:19010961   PMID:19135898   PMID:19793862   PMID:19793863   PMID:20154705   PMID:21504906   PMID:21731742   PMID:24747047   PMID:27723717   PMID:27723720  


Genomics

Comparative Map Data
Rpa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25144,976,789 - 144,989,445 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,976,748 - 144,987,350 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,676,577 - 147,687,100 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,446,166 - 149,456,689 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,434,752 - 149,445,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,957,041 - 150,967,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,957,001 - 150,968,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,623,986 - 154,634,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,369,550 - 152,380,370 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,379,590 - 152,390,409 (-)NCBI
Celera5143,400,981 - 143,411,495 (+)NCBICelera
Cytogenetic Map5q36NCBI
RPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,891,524 - 27,914,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,891,524 - 27,914,746 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,218,035 - 28,241,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,090,636 - 28,113,823 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,902,191 - 27,925,378NCBI
Celera126,613,902 - 26,637,086 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,473,870 - 26,497,363 (-)NCBIHuRef
CHM1_1128,333,548 - 28,356,736 (-)NCBICHM1_1
T2T-CHM13v2.0127,733,626 - 27,756,900 (-)NCBIT2T-CHM13v2.0
Rpa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,495,671 - 132,506,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,495,643 - 132,506,063 (+)EnsemblGRCm39 Ensembl
GRCm384132,768,360 - 132,778,746 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,768,332 - 132,778,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,324,275 - 132,334,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,040,437 - 132,050,559 (+)NCBIMGSCv36mm8
Celera4130,929,794 - 130,940,162 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.88NCBI
Rpa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,080,579 - 7,097,742 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,080,641 - 7,098,009 (-)NCBIChiLan1.0ChiLan1.0
RPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11198,055,633 - 198,078,934 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,151,784 - 27,175,110 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,191,726 - 28,214,665 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,191,731 - 28,214,666 (-)Ensemblpanpan1.1panPan2
RPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,463,951 - 72,479,864 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,419,459 - 72,479,227 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,041,511 - 69,057,436 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,023,824 - 73,039,936 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,023,798 - 73,039,932 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,851,237 - 69,867,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,861,509 - 70,877,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,857,687 - 71,874,007 (+)NCBIUU_Cfam_GSD_1.0
Rpa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,302,244 - 46,322,308 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,126,245 - 12,147,130 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,127,026 - 12,147,120 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,031,582 - 85,045,915 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,032,604 - 85,045,899 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,572,938 - 78,586,231 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,882,739 - 104,904,612 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603311,565,047 - 11,586,556 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,736,129 - 11,764,080 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,737,234 - 11,763,862 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rpa2
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:258
Count of miRNA genes:169
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000017549
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 33 24 18 24 1 1 61 21 38 10 1
Low 1 15 24 17 1 17 7 10 13 14 3 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000017549   ⟹   ENSRNOP00000017549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,976,748 - 144,987,350 (+)Ensembl
Rnor_6.0 Ensembl5150,957,001 - 150,968,269 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105125   ⟹   ENSRNOP00000087831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,976,755 - 144,987,338 (+)Ensembl
RefSeq Acc Id: NM_021582   ⟹   NP_067593
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25144,976,789 - 144,987,346 (+)NCBI
Rnor_6.05150,957,041 - 150,967,597 (+)NCBI
Rnor_5.05154,623,986 - 154,634,568 (+)NCBI
RGSC_v3.45152,369,550 - 152,380,370 (-)RGD
Celera5143,400,981 - 143,411,495 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110696   ⟹   XP_038966624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25144,977,255 - 144,989,445 (+)NCBI
Protein Sequences
Protein RefSeqs NP_067593 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966624 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79180 (Get FASTA)   NCBI Sequence Viewer  
  CAA67116 (Get FASTA)   NCBI Sequence Viewer  
  EDL80650 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017549
  ENSRNOP00000017549.3
  ENSRNOP00000087831.1
  ENSRNOP00065040700
GenBank Protein Q63528 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067593   ⟸   NM_021582
- UniProtKB: Q6AY60 (UniProtKB/Swiss-Prot),   Q63528 (UniProtKB/Swiss-Prot),   A6ISU9 (UniProtKB/TrEMBL),   A0A8I6A4W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017549   ⟸   ENSRNOT00000017549
RefSeq Acc Id: XP_038966624   ⟸   XM_039110696
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000087831   ⟸   ENSRNOT00000105125
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63528-F1-model_v2 AlphaFold Q63528 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694102
Promoter ID:EPDNEW_R4627
Type:multiple initiation site
Name:Rpa2_1
Description:replication protein A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05150,957,007 - 150,957,067EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619714 AgrOrtholog
BioCyc Gene G2FUF-39664 BioCyc
Ensembl Genes ENSRNOG00000013005 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065028723 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017549 ENTREZGENE
  ENSRNOT00000017549.7 UniProtKB/Swiss-Prot
  ENSRNOT00000105125.1 UniProtKB/TrEMBL
  ENSRNOT00065049578 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130711 IMAGE-MGC_LOAD
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RFA2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rfa2/RPA32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RPA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94218 IMAGE-MGC_LOAD
NCBI Gene 59102 ENTREZGENE
PANTHER PTHR13989 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REPLICATION PROTEIN A 32 KDA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RPA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rpa2 PhenoGen
PIRSF RPA32 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013005 RatGTEx
  ENSRNOG00065028723 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A4W5 ENTREZGENE, UniProtKB/TrEMBL
  A6ISU9 ENTREZGENE, UniProtKB/TrEMBL
  Q63528 ENTREZGENE
  Q6AY60 ENTREZGENE
  RFA2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6AY60 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Rpa2  replication protein A2    p32-subunit of replication protein A  Name updated 1299863 APPROVED
2002-08-07 Rpa2  p32-subunit of replication protein A      Symbol and Name status set to provisional 70820 PROVISIONAL