RGD Reference Report - Mechanisms and functions of DNA mismatch repair. - Rat Genome Database

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Mechanisms and functions of DNA mismatch repair.

Authors: Li, GM 
Citation: Li GM Cell Res. 2008 Jan;18(1):85-98.
RGD ID: 2306716
Pubmed: PMID:18157157   (View Abstract at PubMed)
DOI: DOI:10.1038/cr.2007.115   (Journal Full-text)

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination. MMR also suppresses homeologous recombination and was recently shown to play a role in DNA damage signaling in eukaryotic cells. Escherichia coli MutS and MutL and their eukaryotic homologs, MutSalpha and MutLalpha, respectively, are key players in MMR-associated genome maintenance. Many other protein components that participate in various DNA metabolic pathways, such as PCNA and RPA, are also essential for MMR. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including hereditary non-polyposis colorectal cancer, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mismatch repair pathway   TAS 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716; 2306716 RGD 
mismatch repair pathway   ISOEXO1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOHMGB1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOLIG1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOMLH1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOMLH3 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOMSH2 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOMSH3 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISONCK1 (Homo sapiens)2306716 RGD 
mismatch repair pathway   ISOMSH6 (Homo sapiens)2306716 RGD 
mismatch repair pathway   ISOPCNA (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPMS1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPMS2 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPOLD1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPOLD2 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPOLD3 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISOPOLD4 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORFC1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORFC2 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORFC3 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORFC4 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORFC5 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORPA1 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORPA2 (Homo sapiens)2306716; 2306716 RGD 
mismatch repair pathway   ISORPA3 (Homo sapiens)2306716; 2306716 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Exo1  (exonuclease 1)
Hmgb1  (high mobility group box 1)
Lig1  (DNA ligase 1)
Mlh1  (mutL homolog 1)
Mlh3  (mutL homolog 3)
Msh2  (mutS homolog 2)
Msh3  (mutS homolog 3)
Msh6  (mutS homolog 6)
Pcna  (proliferating cell nuclear antigen)
Pms1  (PMS1 homolog 1, mismatch repair system component)
Pms2  (PMS1 homolog 2, mismatch repair system component)
Pold1  (DNA polymerase delta 1, catalytic subunit)
Pold2  (DNA polymerase delta 2, accessory subunit)
Pold3  (DNA polymerase delta 3, accessory subunit)
Pold4  (DNA polymerase delta 4, accessory subunit)
Rfc1  (replication factor C subunit 1)
Rfc2  (replication factor C subunit 2)
Rfc3  (replication factor C subunit 3)
Rfc4  (replication factor C subunit 4)
Rfc5  (replication factor C subunit 5)
Rpa1  (replication protein A1)
Rpa2  (replication protein A2)
Rpa3  (replication protein A3)

Genes (Mus musculus)
Exo1  (exonuclease 1)
Hmgb1  (high mobility group box 1)
Lig1  (ligase I, DNA, ATP-dependent)
Mlh1  (mutL homolog 1)
Mlh3  (mutL homolog 3)
Msh2  (mutS homolog 2)
Msh3  (mutS homolog 3)
Msh6  (mutS homolog 6)
Pcna  (proliferating cell nuclear antigen)
Pms1  (PMS1 homolog 1, mismatch repair system component)
Pms2  (PMS1 homolog2, mismatch repair system component)
Pold1  (polymerase (DNA directed), delta 1, catalytic subunit)
Pold2  (polymerase (DNA directed), delta 2, regulatory subunit)
Pold3  (polymerase (DNA-directed), delta 3, accessory subunit)
Pold4  (polymerase (DNA-directed), delta 4)
Rfc1  (replication factor C (activator 1) 1)
Rfc2  (replication factor C (activator 1) 2)
Rfc3  (replication factor C (activator 1) 3)
Rfc4  (replication factor C (activator 1) 4)
Rfc5  (replication factor C (activator 1) 5)
Rpa1  (replication protein A1)
Rpa2  (replication protein A2)
Rpa3  (replication protein A3)

Genes (Homo sapiens)
EXO1  (exonuclease 1)
HMGB1  (high mobility group box 1)
LIG1  (DNA ligase 1)
MLH1  (mutL homolog 1)
MLH3  (mutL homolog 3)
MSH2  (mutS homolog 2)
MSH3  (mutS homolog 3)
MSH6  (mutS homolog 6)
PCNA  (proliferating cell nuclear antigen)
PMS1  (PMS1 homolog 1, mismatch repair system component)
PMS2  (PMS1 homolog 2, mismatch repair system component)
POLD1  (DNA polymerase delta 1, catalytic subunit)
POLD2  (DNA polymerase delta 2, accessory subunit)
POLD3  (DNA polymerase delta 3, accessory subunit)
POLD4  (DNA polymerase delta 4, accessory subunit)
RFC1  (replication factor C subunit 1)
RFC2  (replication factor C subunit 2)
RFC3  (replication factor C subunit 3)
RFC4  (replication factor C subunit 4)
RFC5  (replication factor C subunit 5)
RPA1  (replication protein A1)
RPA2  (replication protein A2)
RPA3  (replication protein A3)
RPA4  (replication protein A4)


Additional Information