Rpa2 (replication protein A2) - Rat Genome Database

Name: Rpa2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Rpa2 (replication protein A2) Mus musculus

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Symbol:

Rpa2

Name:

replication protein A2

RGD ID:

734242

MGI Page

MGI

Description:

Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Predicted to be located in PML body and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; heart; and spermatocyte. Orthologous to human RPA2 (replication protein A2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

30-kDa protein; AA409079; AI325195; AU020965; replication factor A protein 2; replication protein A 32 kDa subunit; replication protein A 34 kDa subunit; Rf-; RF-A protein 2; Rf-A2; RP; RP-A p32; RP-A p34; RPA34

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPA2 (replication protein A2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPA2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpa2 (replication protein A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RPA4 (replication protein A4)	HGNC	Panther, PhylomeDB, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Rpa2 (replication protein A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RPA2 (replication protein A2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rpa2 (replication protein A2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	RFA2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	rpa-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	rpa-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rpa2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,495,671 - 132,506,057 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,495,643 - 132,506,063 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,768,360 - 132,778,746 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,768,332 - 132,778,752 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,324,275 - 132,334,661 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,040,437 - 132,050,559 (+)	NCBI		MGSCv36	mm8
Celera	4	130,929,794 - 130,940,162 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	65.88	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(-)-quinic acid (ISO)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

3,3',5-triiodo-L-thyronine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (EXP)

4-hydroxyphenyl retinamide (EXP)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

amitrole (ISO)

ammonium chloride (ISO)

arsenite(3-) (ISO)

artesunate (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

biphenyl-4-amine (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium atom (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (EXP)

chlorpyrifos (EXP)

cisplatin (ISO)

copper(II) sulfate (ISO)

corticosterone (ISO)

CX-5461 (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

endosulfan (ISO)

folic acid (EXP)

FR900359 (ISO)

fulvestrant (ISO)

glyphosate (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

leflunomide (ISO)

methimazole (ISO)

methyl methanesulfonate (ISO)

methylseleninic acid (ISO)

N-(6-acetamidohexyl)acetamide (EXP)

nickel atom (ISO)

oxaliplatin (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP,ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

piroxicam (ISO)

progesterone (ISO)

quizartinib (ISO)

resveratrol (EXP)

RGFP966 (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

Soman (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

tetrahydropalmatine (ISO)

thioacetamide (ISO)

titanium dioxide (EXP)

topotecan (ISO)

trimellitic anhydride (EXP)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (EXP)

veliparib (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (ISO,ISS)

DNA replication (IBA,ISO,ISS)

double-strand break repair via homologous recombination (IBA,ISO,ISS)

mismatch repair (ISO,ISS)

mitotic G1 DNA damage checkpoint signaling (IEA,ISO)

nucleotide-excision repair (IBA,ISO,ISS)

protein localization to chromosome (ISO,ISS)

regulation of DNA damage checkpoint (ISO,ISS)

regulation of double-strand break repair via homologous recombination (ISO,ISS)

telomere maintenance (ISO,ISS)

Cellular Component

chromatin (IEA,ISO)

chromosome, telomeric region (IBA,ISO,ISS)

DNA replication factor A complex (IBA,ISO,ISS)

nuclear body (ISO)

nucleoplasm (ISO,TAS)

nucleus (ISO,ISS)

PML body (ISO,ISS)

site of double-strand break (IBA,ISO,ISS)

Molecular Function

damaged DNA binding (ISO,ISS)

DNA binding (IDA)

enzyme binding (ISO)

G-rich strand telomeric DNA binding (IEA,ISO)

protein binding (IPI,ISO)

protein phosphatase binding (IEA,ISO)

single-stranded DNA binding (IBA,ISO,ISS)

telomeric DNA binding (IBA)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

DNA replication pathway (IEA)

homologous recombination pathway of double-strand break repair (IEA)

mismatch repair pathway (IEA,ISO)

nucleotide excision repair pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.	Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3.	Mechanisms and functions of DNA mismatch repair.	Li GM Cell Res. 2008 Jan;18(1):85-98.
4.	MGDs mouse GO annotations	MGD data from the GO Consortium
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	The multi-replication protein A (RPA) system--a new perspective.	Sakaguchi K, etal., FEBS J. 2009 Feb;276(4):943-63. doi: 10.1111/j.1742-4658.2008.06841.x. Epub 2009 Jan 12.

Additional References at PubMed

PMID:1908076	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11389549	PMID:11470540	PMID:12091911	PMID:12477932	PMID:12520002	PMID:12904583	PMID:14610273
PMID:15273694	PMID:15782199	PMID:16141072	PMID:16141073	PMID:16200063	PMID:17141802	PMID:18725516	PMID:18799693	PMID:21267068	PMID:21873635	PMID:22403008	PMID:24068956
PMID:24240703	PMID:24899707	PMID:26292757	PMID:26370502	PMID:26742488	PMID:26876348	PMID:27480124	PMID:28818995	PMID:29091030	PMID:29329290	PMID:30196744	PMID:30272023
PMID:30595499	PMID:30760716	PMID:30949703	PMID:31358751	PMID:31453335	PMID:32098917	PMID:32232159	PMID:32325033	PMID:33602822	PMID:34026442	PMID:34321999	PMID:35489071
PMID:35546066	PMID:35969748	PMID:36114006	PMID:36293380	PMID:36440627	PMID:37349316	PMID:38485951

Genomics

Comparative Map Data

Rpa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	132,495,671 - 132,506,057 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	132,495,643 - 132,506,063 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	132,768,360 - 132,778,746 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	132,768,332 - 132,778,752 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	132,324,275 - 132,334,661 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,040,437 - 132,050,559 (+)	NCBI		MGSCv36	mm8
Celera	4	130,929,794 - 130,940,162 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	65.88	NCBI

RPA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	27,891,524 - 27,914,797 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	27,891,524 - 27,914,746 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	28,218,035 - 28,241,308 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	28,090,636 - 28,113,823 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	27,902,191 - 27,925,378	NCBI
Celera	1	26,613,902 - 26,637,086 (-)	NCBI		Celera
Cytogenetic Map	1	p35.3	NCBI
HuRef	1	26,473,870 - 26,497,363 (-)	NCBI		HuRef
CHM1_1	1	28,333,548 - 28,356,736 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	27,733,626 - 27,756,900 (-)	NCBI		T2T-CHM13v2.0

Rpa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	150,260,668 - 150,271,329 (+)	NCBI		GRCr8
mRatBN7.2	5	144,976,789 - 144,989,445 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	144,976,748 - 144,987,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	147,676,577 - 147,687,100 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	149,446,166 - 149,456,689 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	149,434,752 - 149,445,307 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	150,957,041 - 150,967,597 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	150,957,001 - 150,968,269 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	154,623,986 - 154,634,568 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	152,369,550 - 152,380,370 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	152,379,590 - 152,390,409 (-)	NCBI
Celera	5	143,400,981 - 143,411,495 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Rpa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	7,080,579 - 7,097,742 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	7,080,641 - 7,098,009 (-)	NCBI	ChiLan1.0	ChiLan1.0

RPA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	198,938,671 - 198,961,968 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	198,055,633 - 198,078,934 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	27,151,784 - 27,175,110 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	28,191,726 - 28,214,665 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	28,191,731 - 28,214,666 (-)	Ensembl	panpan1.1		panPan2

RPA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	72,463,951 - 72,479,864 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	72,419,459 - 72,479,227 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,041,511 - 69,057,436 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,023,824 - 73,039,936 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,023,798 - 73,039,932 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	69,851,237 - 69,867,152 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	70,861,509 - 70,877,423 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	71,857,687 - 71,874,007 (+)	NCBI		UU_Cfam_GSD_1.0

Rpa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	46,302,244 - 46,322,308 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	12,126,245 - 12,147,130 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	12,127,026 - 12,147,120 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	85,031,582 - 85,045,915 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	85,032,604 - 85,045,899 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	78,572,938 - 78,586,231 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	104,882,739 - 104,904,612 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	11,565,047 - 11,586,556 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	11,736,129 - 11,764,080 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	11,737,234 - 11,763,862 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	983
Count of miRNA genes:	569
Interacting mature miRNAs:	703
Transcripts:	ENSMUST00000102561, ENSMUST00000130090, ENSMUST00000130444, ENSMUST00000133415, ENSMUST00000153046, ENSMUST00000156968
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4142139	Adip12_m	adiposity 12 (mouse)			Not determined		4	124621281	156860686	Mouse
25394567	Skmw55_m	skeletal muscle weight 55, gastroc (mouse)					4	131437804	133710576	Mouse
10047132	Albq19_m	albuminuria QTL 19 (mouse)			Not determined		4	112824389	146824389	Mouse
1301525	Lmb1_m	lupus in MRL and B6 F2 cross (mouse)			Not determined		4	124264957	150676858	Mouse
14746982	Manh56_m	mandible shape 56 (mouse)					4	117815917	151815917	Mouse
4141623	W6q13_m	weight 6 weeks QTL 13 (mouse)			Not determined			88982069	140468203	Mouse
14696808	Rbcn1_m	rod bipolar cell number 1 (mouse)					4	131947311	134047311	Mouse
12910797	Pwgrq4_m	pre-weaning growth rate QTL 4 (mouse)					4	105835310	141433838	Mouse
25314312	Syncl2_m	synaptonemal complex length 2 (mouse)					4	65718237	146584457	Mouse
25394568	Skmw56_m	skeletal muscle weight 56, EDL (mouse)					4	129859344	133710576	Mouse
12904009	Cfq9_m	conditioned fear QTL 9 (mouse)					4	130036287	133772722	Mouse
12910794	Pwbwq8_m	post-weaning body weight QTL 8 (mouse)					4	105835310	141433838	Mouse
1300743	Skull6_m	skull morphology 6 (mouse)			Not determined		4	111009051	145009280	Mouse
1301382	Arvm2_m	autoimmune renal vasculitis 2 (mouse)			Not determined		4	107791564	141791756	Mouse
1302149	Tlsr2_m	thymic lymphoma suppressor region 2 (mouse)			Not determined		4	124264957	142230960	Mouse
12910813	Pwbwq4_m	pre-weaning body weight QTL 4 (mouse)					4	105835310	141433838	Mouse
4141093	W3q17_m	weight 3 weeks QTL 17 (mouse)			Not determined			88982069	140468203	Mouse
27226757	Femd1_m	femur midshaft diameter 1, 5 week (mouse)					4	123993793	144326570	Mouse
12910808	Pwbwq9_m	post-weaning body weight QTL 9 (mouse)					4	105835310	141433838	Mouse
1300621	Tpnr1_m	thermal pain response 1 (mouse)			Not determined		4	125230872	156860686	Mouse
11567249	Elorr3_m	ethanol induced loss of righting response 3 (mouse)					4	3722677	156268235	Mouse
4142493	Femwf13_m	femur work to failure 13 (mouse)			Not determined			116154678	150154782	Mouse
1301815	Sles2_m	systemic lupus erythmatosus suppressor 2 (mouse)			Not determined		4	94957579	150676858	Mouse
1300663	Start2_m	startle response 2 (mouse)			Not determined		4	107264957	141265153	Mouse
1300917	Gasa1_m	gastritis type A susceptibility locus 1 (mouse)			Not determined		4	124055093	142438020	Mouse
1301823	Bmd7_m	bone mineral density 7 (mouse)			Not determined		4	88982069	151654550	Mouse
10412210	Cypr6_m	cytokine production 6 (mouse)			Not determined		4	120617848	154617995	Mouse
1302078	Sluc21_m	susceptibility to lung cancer 21 (mouse)			Not determined		4	117401141	151401275	Mouse
10045620	Heal22_m	wound healing/regeneration 22 (mouse)			Not determined		4	125230872	156860686	Mouse
4142481	Gct1_m	granulosa cell tumorigenesis 1 (mouse)			Not determined		4	127784226	156860686	Mouse
1301793	Tlsr3_m	thymic lymphoma suppressor region 3 (mouse)			Not determined		4	129465811	136864536	Mouse
4141065	Shali2_m	survival time to hyperoxic acute lung injury 2 (mouse)			Not determined			124055093	141572792	Mouse
10412072	Ssen1_m	suseptibility to Sendai virus 1 (mouse)			Not determined		4	109658132	133154782	Mouse
13503348	Bntq18_m	bone traits QTL 18 (mouse)					4	120617848	154617995	Mouse
13208562	Wght7_m	weight 7 (mouse)					4	90888237	148084457	Mouse
1300781	Lith8_m	lithogenic gene 8 (mouse)			Not determined		4	107264957	141265153	Mouse
39128212	Lwq21_m	liver weight QTL 21 (mouse)					4	88982069	140468203	Mouse
1301584	Lrdg2_m	light induced retinal degeneration 2 (mouse)			Not determined		4	129465811	151654550	Mouse
4141180	Ssic1_m	susceptibility to small intestinal cancer 1 (mouse)			Not determined			120674005	154674151	Mouse
1301847	Fecq2_m	fecundity QTL 2 (mouse)			Not determined		4	100071971	134072206	Mouse
1302102	Bis1_m	beta-carboline-induced seizures 1 (mouse)			Not determined		4	119864433	153864536	Mouse
10043996	Gct5_m	granulosa cell tumorigenesis 5 (mouse)			Not determined		4	127784226	156860686	Mouse
26884445	Sklq7_m	skull length QTL 7, 10 week (mouse)					4	68018237	150884457	Mouse
10043985	Stheal12_m	soft tissue heal 12 (mouse)			Not determined		4	121342649	155342753	Mouse
1301982	Pltiq1_m	phospholipid transfer protein inducibility QTL 1 (mouse)			Not determined		4	124621281	156860686	Mouse
26884437	Sklq13_m	skull length QTL 13, 16 week (mouse)					4	57700000	155684457	Mouse
1300803	Sluc6_m	susceptibility to lung cancer 6 (mouse)			Not determined		4	120674005	154674151	Mouse
4141549	W10q10_m	weight 10 weeks QTL 10 (mouse)			Not determined			88982069	140468203	Mouse
4142061	Chlq16_m	circulating hormone level QTL 16 (mouse)			Not determined		4	121342649	155342753	Mouse
1357895	Ctrcts_m	cataract severity (mouse)			Not determined		4	45709925	138342753	Mouse
1300933	Cdcs9_m	cytokine deficiency colitis susceptibility 9 (mouse)			Not determined		4	125230872	156860686	Mouse
1300809	Ccrs2_m	corpus callosum hemisphere surface size 2 (mouse)			Not determined		4	107264957	141265153	Mouse
4141154	Nba1_m	New Zealand Black autoimmunity 1 (mouse)			Not determined			131650724	140879275	Mouse
1301452	Elsgp1_m	elevated serum gp70 1 (mouse)			Not determined		4	121342649	155342753	Mouse
1301964	Bw8q2_m	body weight at 8 weeks QTL 2 (mouse)			Not determined		4	119864433	153864536	Mouse
1301106	Skts7_m	skin tumor susceptibility 7 (mouse)			Not determined		4	100071971	134072206	Mouse
10755520	Rbc1_m	red blood cell count 1 (mouse)					4	108477692	142477692	Mouse
10755521	Hct1_m	hematocrit 1 (mouse)					4	108477692	142477692	Mouse
10755522	Hgb1_m	hemoglobin 1 (mouse)					4	108477692	142477692	Mouse
1300858	Tafat_m	tally ho associated mesenteric fat pad weight (mouse)			Not determined		4	124621281	156860686	Mouse
10755531	Lymph3_m	lymphocyte differential 3 (mouse)					4	124553483	156860686	Mouse
15039382	Ltgq7_m	liver triglyceride QTL 7 (mouse)					4	105705794	139705794	Mouse
11533916	Mts1_m	mammary tumor susceptibility 1 (mouse)					4	125289325	156860686	Mouse
1300839	Dyscalc2_m	dystrophic cardiac calcinosis 2 (mouse)			Not determined		4	111009051	145009280	Mouse
15039377	Bw45_m	body weight QTL 45 (mouse)					4	105705794	139705794	Mouse
12880433	Fgf23lq1_m	FGF23 serum level QTL 1 (mouse)					4	101157197	135157197	Mouse
4141001	Tgq17_m	triglyceride QTL 17 (mouse)			Not determined			112523489	146523489	Mouse
15039378	Adip30_m	adiposity 30 (mouse)					4	105705794	139705794	Mouse
1357800	Tgq3_m	triglyceride QTL 3 (mouse)			Not determined		4	107055093	141055180	Mouse
15039385	Mvlq3_m	macrovesicular liver lesion QTL 3 (mouse)					4	112182386	146182386	Mouse

Markers in Region

RH136338

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	132,778,207 - 132,778,399	UniSTS	GRCm38
MGSCv37	4	132,334,122 - 132,334,314	UniSTS	GRCm37
Celera	4	130,939,623 - 130,939,815	UniSTS
Cytogenetic Map	4	D2.3	UniSTS

AI325195

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	132,778,145 - 132,778,228	UniSTS	GRCm38
MGSCv37	4	132,334,060 - 132,334,143	UniSTS	GRCm37
Celera	4	130,939,561 - 130,939,644	UniSTS
Cytogenetic Map	4	D2.3	UniSTS
Whitehead/MRC_RH	4	1753.42	UniSTS

RH124820

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	132,778,373 - 132,778,645	UniSTS	GRCm38
MGSCv37	4	132,334,288 - 132,334,560	UniSTS	GRCm37
Celera	4	130,939,789 - 130,940,061	UniSTS
Cytogenetic Map	4	D2.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001429787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_011284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK011530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK078006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK168680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK169847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK182332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL627130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC004578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D00812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000102561 ⟹ ENSMUSP00000099621

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,495,646 - 132,506,063 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,768,335 - 132,778,752 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000130090

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,495,687 - 132,501,546 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,768,376 - 132,774,235 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000130444

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,497,827 - 132,499,618 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,770,516 - 132,772,307 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000133415

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,495,946 - 132,499,430 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,768,635 - 132,772,119 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000153046

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,495,643 - 132,504,021 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,768,332 - 132,776,710 (+)	Ensembl

Ensembl Acc Id:

ENSMUST00000156968 ⟹ ENSMUSP00000123780

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	132,502,439 - 132,504,473 (+)	Ensembl
GRCm38.p6 Ensembl	4	132,775,128 - 132,777,162 (+)	Ensembl

RefSeq Acc Id:

NM_011284 ⟹ NP_035414

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	132,495,671 - 132,506,057 (+)	NCBI
GRCm38	4	132,768,360 - 132,778,746 (+)	ENTREZGENE
MGSCv37	4	132,324,275 - 132,334,661 (+)	RGD
Celera	4	130,929,794 - 130,940,162 (+)	RGD
cM Map	4		ENTREZGENE

Sequence:

show sequence

GAAGGCTGCCACGCCAGAGCGGCACAGAGTTCCCAAGTGTTCTTAGTTTTCGTGTCCGAGCGTC
TTGGGCCGCTCTCTCCGGAGAACTGCGACCAGGATGTGGAATAGCGGATTCGAAAGCTTCAGCA
GCTCCACCTATGGCGGAGCAGGCGGCTACACGCAGTCCCCCGGTGGCTTCGGGTCGCCCACACC
GTCGCAGGCGGAGAAGAAATCGAGAGTCCGAGCCCAGCATATTGTGCCCTGTACCATATCCCAG
CTGCTTTCTGCTACTCTGACTGATGAAGTGTTCAGAATTGGAGATGTCGAGATTTCACAGGTCA
CTATTGTGGGGATAATCAGACATGCGGAGAAGGCTCCAACCAACATTGTTTACAAGATAGACGA
TATGACAGCTCCGCCCATGGATGTTCGTCAGTGGGTTGACACGGATGATGCCAGTGGTGAGAAC
GCCGTGGTTCCTCCCGAAACATACGTGAAAGTCGCTGGTCACCTCAGGTCTTTCCAGAACAAAA
AGAGCTTGGTGGCCTTTAAGATCATTCCTCTGGAAGACATGAATGAGTTCACCGCACACATCCT
GGAAGTGGTCAATTCACACATGATGCTCAGCAAGCCCAACAGCCAGGCCTCTGCAGGGAGACCA
TCGATGAGCAACCCAGGAATGAGTGAGCCGGGGAACTTCAGCGGGAATAACTTCATGCCAGCAA
ATGGCCTCACTGTGGTCCAAAACCAGGTGCTGAATTTGATCAAGGCTTGCCCAAGACCTGAAGG
CCTGAACTTCCAGGACCTCAGGAGCCAGCTCCAGCATATGCCTGTTCCCTCAATCAAGCAAGCA
GTGGATTTTCTGTGCAACGAGGGCCACATTTACTCTACTGTGGACGACGATCACTTTAAGTCTA
CAGATGCAGAGTGACTGGAGTTTCCTGGGTGCCTGGAATCTGTCCAGCTGGGCCTGTGTTCCTC
TGTCGGCCCCAGCTCTGCGGGCTTTGGCCAGAGGCTTCTAGGACAGAACTTTGCTGTAGAAGGT
CTCACTCAGCTGAAGTCCTTTTGGAACTTAGTGCTCTCTGTTTTGTTGCTTGTTGTTTAGAGGT
TCAGAGGGAGATAGACAGTTGAGAAGGAAGTAAACCAGGACTGGATTTCTTGTAAGAAATTCCA
ATAAGCTAGTCAGGACTCCAGGATGGGTGGTCGGAATTGAAAGAGGAACACTGCCAAGATGTCA
GGGCAGGGCTTCAGCTTGCTTGAGAGCGACTGTTCTCCAAGGCTTCGTGTTGAGGACAAGCACT
GCTAGGGCCAAGGGCCAAAGAAGAACCTACCACCCTCTGCCAGTTTGCGCTGCCCTCTGGGTCT
GCGGGGTTACTTTCGGAATTGCACTTTCCTTCCCTTGTCTTGCCCGCCGTGGGAAGGAGGTTTA
AGTGAGCCTGAGGTTCTGACCTGGAGGCCTCGTGCGGCTGAGAGAAAGAAATGTTATTGCGTGG
TCTGTAATATAAGTGTTCATATGTTTGATAAAACAGTTCGATTGTAATAGCTTCTGAAATGTTG
GTTTTATTTTTAGCGCTTACTTACTGTGTGAGTGTGGAAGTCAGAGGACAGCTTGGTGGAGTCT
GCTTTCTCTTTGTACAGTGTACAGAGTCACCTTCTATCGTGTATTCCAGGGGTTCAACTCTGGT
CATCAGGCTTATTGGGGGGTTGTGGGTGTGCATAGCATGTGCCATGGCCACCGCAGATTGTGAC
TAGACCTTGAGCTGGGGCTACAGCTCACAGTAGTAAAGCACTTGCCTGCCATCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001416716	(Get FASTA)	NCBI Sequence Viewer
	NP_035414	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH04578	(Get FASTA)	NCBI Sequence Viewer
	BAA00693	(Get FASTA)	NCBI Sequence Viewer
	BAE40529	(Get FASTA)	NCBI Sequence Viewer
	BAE41408	(Get FASTA)	NCBI Sequence Viewer
	EDL30090	(Get FASTA)	NCBI Sequence Viewer
	EDL30091	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000099621
	ENSMUSP00000099621.5
	ENSMUSP00000123780.2
GenBank Protein	Q62193	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_035414 ⟸ NM_011284

- UniProtKB:

Q62193 (UniProtKB/Swiss-Prot), Q3TE40 (UniProtKB/TrEMBL), Q99KL9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWNSGFESFSSSTYGGAGGYTQSPGGFGSPTPSQAEKKSRVRAQHIVPCTISQLLSATLTDEVF
RIGDVEISQVTIVGIIRHAEKAPTNIVYKIDDMTAPPMDVRQWVDTDDASGENAVVPPETYVKV
AGHLRSFQNKKSLVAFKIIPLEDMNEFTAHILEVVNSHMMLSKPNSQASAGRPSMSNPGMSEPG
NFSGNNFMPANGLTVVQNQVLNLIKACPRPEGLNFQDLRSQLQHMPVPSIKQAVDFLCNEGHIY
STVDDDHFKSTDAE

hide sequence

Ensembl Acc Id:

ENSMUSP00000123780 ⟸ ENSMUST00000156968

Ensembl Acc Id:

ENSMUSP00000099621 ⟸ ENSMUST00000102561

Protein Domains

Replication protein A C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62193-F1-model_v2	AlphaFold	Q62193	1-270	view protein structure

Promoters

RGD ID:

6836311

Promoter ID:

MM_KWN:39970

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000023143, OTTMUST00000023145, OTTMUST00000023146, UC008VBT.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	132,323,786 - 132,324,557 (+)	MPROMDB

RGD ID:

6836313

Promoter ID:

MM_KWN:39972

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, BoneMarrow_4Hour, Liver

Transcripts:

OTTMUST00000023225

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	132,330,651 - 132,331,382 (+)	MPROMDB

RGD ID:

6884912

Promoter ID:

EPDNEW_M5907

Type:

initiation region

Name:

Rpa2_1

Description:

Mus musculus replication protein A2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	4	132,768,355 - 132,768,415	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1339939	AgrOrtholog
Ensembl Genes	ENSMUSG00000028884	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000102561	ENTREZGENE
	ENSMUST00000102561.11	UniProtKB/Swiss-Prot
	ENSMUST00000156968.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.50.140	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NA-bd_OB-fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RFA2-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rfa2/RPA32	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RPA_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:19891	UniProtKB/Swiss-Prot
MGD	MGI:1339939	ENTREZGENE
NCBI Gene	19891	ENTREZGENE
PANTHER	PTHR13989	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	REPLICATION PROTEIN A 32 KDA SUBUNIT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RPA_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rpa2	PhenoGen
PIRSF	RPA32	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50249	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	F6V8R7_MOUSE	UniProtKB/TrEMBL
	Q3TE40	ENTREZGENE
	Q62193	ENTREZGENE
	Q99KL9	ENTREZGENE, UniProtKB/TrEMBL
	RFA2_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q3TE40	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)