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DNA lesions, particularly double-strand breaks (DSBs), can have severe genotoxic effects if not promptly handled. DSBs can be initiated by DNA damaging agents such as ionizing radiation or arise during replication through exposure to metabolites and are also physiological intermediates generated during V(D)J [variable (V), diversity (D) and the joining (J) recombination] and class switch recombination in lymphocytes of the immune system. The cells possess a robust response mechanism to DNA damag

Pathway Diagram:

Elsevier Inc. Rpa complex MRN complex Rbbp8 Brca1 ataxia telangiectasia-mutated (ATM) signaling pathway Rad51paralogs/mediators Rad51 ---- Rad51paralogs/mediators Rad51 Brca1 ---- MRN complex Exo1 Dna2 Blm Brca1 ---- Rbbp8 Rad54b

Genes in Pathway:

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homologous recombination pathway of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1578504
G Blm Bloom syndrome RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:8662366
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1578504
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6907045
G Dna2 DNA replication helicase/nuclease 2 RGD:8662366
G Eme1 essential meiotic structure-specific endonuclease 1 JBrowse link 10 82,366,820 82,375,510 RGD:6907045
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:8662366
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1578504
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:6907045
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1578504
G Pold1 DNA polymerase delta 1, catalytic subunit JBrowse link 1 100,538,066 100,554,105 RGD:6907045
G Pold2 DNA polymerase delta 2, accessory subunit JBrowse link 14 86,111,416 86,117,578 RGD:6907045
G Pold3 DNA polymerase delta 3, accessory subunit JBrowse link 1 165,085,142 165,122,385 RGD:6907045
G Pold4 DNA polymerase delta 4, accessory subunit JBrowse link 1 219,480,841 219,483,244 RGD:6907045
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:1578504
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6907045
G Rad51b RAD51 paralog B JBrowse link 6 102,473,978 103,018,185 RGD:8662366
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:6907045
G Rad51d RAD51 paralog D JBrowse link 10 70,222,703 70,241,352 RGD:8662366
G Rad52 RAD52 homolog, DNA repair protein JBrowse link 4 152,429,826 152,451,875 RGD:6907045
G Rad54b RAD54 homolog B (S. cerevisiae) JBrowse link 5 25,140,531 25,214,469 RGD:6907045
G Rad54l RAD54 like JBrowse link 5 134,948,511 134,978,125 RGD:6907045
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:8661237
G Rpa1 replication protein A1 JBrowse link 10 62,140,419 62,191,518 RGD:6907045
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:6907045
G Rpa3 replication protein A3 JBrowse link 4 34,279,320 34,282,351 RGD:6907045
G Sem1 SEM1, 26S proteasome complex subunit JBrowse link 4 32,067,444 32,087,600 RGD:6907045
G Ssbp1 single stranded DNA binding protein 1 JBrowse link 4 68,634,844 68,645,112 RGD:6907045
G Top3a DNA topoisomerase III alpha JBrowse link 10 46,980,646 47,018,728 RGD:6907045
G Top3b DNA topoisomerase III beta JBrowse link 11 88,346,305 88,374,896 RGD:6907045
G Xrcc2 X-ray repair cross complementing 2 JBrowse link 4 5,842,013 5,860,516 RGD:6907045
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:8662366

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the homologous recombination pathway of double-strand break repair
Phenotype Annotations Associated with Genes in the homologous recombination pathway of double-strand break repair

References Associated with the homologous recombination pathway of double-strand break repair:

Ontology Path Diagram:

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