(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 mRNA] CTD PMID:31150632 1,1-dichloroethene decreases expression ISO RGD:1314002 6480464 vinylidene chloride results in decreased expression of PINK1 mRNA CTD PMID:26682919 1,4-benzoquinone multiple interactions ISO RGD:1314001 6480464 Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein] more ... CTD PMID:29567065 1,4-benzoquinone increases expression ISO RGD:1314001 6480464 quinone results in increased expression of PINK1 mRNA, quinone results in increased expression of PINK1 protein CTD PMID:29567065 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substance ISO RGD:1314002 6480464 PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:22511790 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:1314002 6480464 PARK7 protein inhibits the reaction [PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:22511790 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of PINK1 mRNA CTD PMID:30723492 17alpha-ethynylestradiol affects expression ISO RGD:1314002 6480464 Ethinyl Estradiol affects the expression of PINK1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1314002 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:1314002 6480464 Ethinyl Estradiol results in decreased expression of PINK1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1314001 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of PINK1 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1314002 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PINK1 mRNA CTD PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1314001 6480464 Tetrachlorodibenzodioxin results in increased expression of PINK1 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PINK1 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PINK1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PINK1 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1314001 6480464 Lactic Acid results in decreased expression of PINK1 mRNA CTD PMID:30851411 5-aza-2'-deoxycytidine affects expression ISO RGD:1314001 6480464 Decitabine affects the expression of PINK1 mRNA CTD PMID:23300844 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of PINK1 mRNA CTD PMID:31881176 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PINK1 mRNA CTD PMID:28959563 antimycin A multiple interactions ISO RGD:1314001 6480464 [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA more ... CTD PMID:28366621 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PINK1 protein CTD PMID:30551535 arsenous acid multiple interactions ISO RGD:1314001 6480464 3-(2 more ... CTD PMID:27318970 arsenous acid increases expression ISO RGD:1314001 6480464 Arsenic Trioxide results in increased expression of PINK1 protein CTD PMID:27318970 arsenous acid multiple interactions EXP 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PINK1 protein] CTD PMID:30551535 benzo[a]pyrene decreases expression ISO RGD:1314002 6480464 Benzo(a)pyrene results in decreased expression of PINK1 mRNA CTD PMID:20127859 bisphenol A increases expression ISO RGD:1314002 6480464 bisphenol A results in increased expression of PINK1 mRNA CTD PMID:26063408 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PINK1 mRNA, bisphenol A results in increased expression of PINK1 protein CTD PMID:25181051 more ... buspirone increases expression EXP 6480464 Buspirone results in increased expression of PINK1 mRNA CTD PMID:24136188 cadmium atom multiple interactions ISO RGD:1314002 6480464 Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] more ... CTD PMID:25464205 cadmium atom increases expression ISO RGD:1314002 6480464 Cadmium results in increased expression of PINK1 CTD PMID:25464205 cadmium dichloride increases expression ISO RGD:1314002 6480464 Cadmium Chloride results in increased expression of PINK1 mRNA CTD PMID:20883709 calcitriol increases expression ISO RGD:1314001 6480464 Calcitriol results in increased expression of PINK1 mRNA CTD PMID:16002434 carbon nanotube decreases expression ISO RGD:1314002 6480464 Nanotubes, Carbon analog results in decreased expression of PINK1 mRNA, Nanotubes, Carbon results in decreased expression of PINK1 mRNA CTD PMID:25554681 carbonyl cyanide p-trifluoromethoxyphenylhydrazone multiple interactions ISO RGD:1314002 6480464 PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 carnosic acid multiple interactions ISO RGD:1314001 6480464 PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]] more ... CTD PMID:30707903 CCCP multiple interactions ISO RGD:1314001 6480464 [Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein more ... CTD PMID:28673964 , PMID:29660402 CCCP increases expression ISO RGD:1314001 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased expression of PINK1 protein CTD PMID:27318970 , PMID:29371327 CCCP increases stability ISO RGD:1314001 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased stability of PINK1 protein CTD PMID:26070385 CCCP multiple interactions ISO RGD:1314002 6480464 PINK1 gene mutant form inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] CTD PMID:22872702 CCCP multiple interactions EXP 6480464 BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein], PINK1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] CTD PMID:24879156 CCCP affects localization EXP 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PINK1 protein CTD PMID:24879156 chlorpyrifos increases stability ISO RGD:1314001 6480464 Chlorpyrifos results in increased stability of PINK1 protein CTD PMID:26070385 chlorpyrifos decreases expression ISO RGD:1314002 6480464 Chlorpyrifos results in decreased expression of PINK1 mRNA CTD PMID:29156651 chromium(6+) increases expression ISO RGD:1314001 6480464 chromium hexavalent ion results in increased expression of PINK1 protein CTD PMID:30715550 cisplatin multiple interactions ISO RGD:1314001 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of PINK1 mRNA CTD PMID:21858171 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of PINK1 protein CTD PMID:28698153 cisplatin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein] CTD PMID:28698153 cisplatin affects expression ISO RGD:1314001 6480464 Cisplatin affects the expression of PINK1 mRNA CTD PMID:23300844 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of PINK1 mRNA CTD PMID:17602206 Colforsin dapropate hydrochloride multiple interactions ISO RGD:1314001 6480464 PINK1 protein affects the reaction [Colforsin results in decreased expression of DNM1L protein] CTD PMID:24792327 copper atom decreases expression EXP 6480464 Copper results in decreased expression of PINK1 mRNA CTD PMID:22465980 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of PINK1 mRNA CTD PMID:22465980 coumestrol decreases expression ISO RGD:1314001 6480464 Coumestrol results in decreased expression of PINK1 mRNA CTD PMID:19167446 curcumin multiple interactions EXP 6480464 Curcumin inhibits the reaction [Cisplatin results in increased expression of PINK1 protein] CTD PMID:28698153 cyclosporin A multiple interactions ISO RGD:1314002 6480464 Cyclosporine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 cyclosporin A multiple interactions ISO RGD:1314001 6480464 Cyclosporine inhibits the reaction [arsenic trioxide results in increased expression of PINK1 protein] more ... CTD PMID:27318970 , PMID:29567065 cyclosporin A decreases expression ISO RGD:1314001 6480464 Cyclosporine results in decreased expression of PINK1 protein CTD PMID:27318970 decabromodiphenyl ether decreases expression ISO RGD:1314002 6480464 decabromobiphenyl ether results in decreased expression of PINK1 mRNA CTD PMID:29699156 diarsenic trioxide increases expression ISO RGD:1314001 6480464 Arsenic Trioxide results in increased expression of PINK1 protein CTD PMID:27318970 diarsenic trioxide multiple interactions ISO RGD:1314001 6480464 3-(2 more ... CTD PMID:27318970 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PINK1 protein CTD PMID:30551535 diarsenic trioxide multiple interactions EXP 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PINK1 protein] CTD PMID:30551535 diazinon decreases expression EXP 6480464 Diazinon results in decreased expression of PINK1 mRNA CTD PMID:21968025 dioxygen multiple interactions ISO RGD:1314002 6480464 [Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein, genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein] CTD PMID:28477916 dioxygen multiple interactions EXP 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of PINK1 protein CTD PMID:21159781 dopamine multiple interactions ISO RGD:1314002 6480464 [PINK1 mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine, Paraquat affects the reaction [PINK1 protein affects the abundance of Dopamine] CTD PMID:22043175 dopamine affects abundance ISO RGD:1314002 6480464 PINK1 protein affects the abundance of Dopamine CTD PMID:22043175 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of PINK1 protein CTD PMID:26678157 , PMID:29966675 doxorubicin multiple interactions ISO RGD:1314001 6480464 3-(2 more ... CTD PMID:29729358 doxorubicin increases expression ISO RGD:1314001 6480464 Doxorubicin results in increased expression of PINK1 protein CTD PMID:29729358 doxorubicin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] CTD PMID:29966675 furosemide multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 Fusaric acid increases expression ISO RGD:1314001 6480464 Fusaric Acid results in increased expression of PINK1 protein CTD PMID:30582969 Genipin multiple interactions ISO RGD:1314002 6480464 genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in increased expression of PINK1 protein] CTD PMID:28477916 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of PINK1 mRNA CTD PMID:24136188 hydrogen peroxide multiple interactions ISO RGD:1314001 6480464 ARNTL protein affects the reaction [Polyphenols inhibits the reaction [Hydrogen Peroxide results in decreased expression of PINK1 mRNA]] more ... CTD PMID:21366594 , PMID:30316844 hydrogen peroxide decreases expression ISO RGD:1314001 6480464 Hydrogen Peroxide results in decreased expression of PINK1 mRNA CTD PMID:30316844 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of PINK1 protein CTD PMID:21159781 hydrogen peroxide multiple interactions ISO RGD:1314002 6480464 PINK1 protein affects the reaction [Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:21421046 hydrogen peroxide affects response to substance ISO RGD:1314001 6480464 PINK1 protein affects the susceptibility to Hydrogen Peroxide CTD PMID:21366594 iodixanol multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PINK1 protein CTD PMID:29860548 lead diacetate multiple interactions ISO RGD:1314001 6480464 lead acetate promotes the reaction [PINK1 protein binds to ATM protein], lead acetate results in increased expression of and results in increased phosphorylation of PINK1 protein CTD PMID:29660402 lead(0) affects expression ISO RGD:1314001 6480464 Lead affects the expression of PINK1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1314001 6480464 Lead affects the expression of PINK1 mRNA CTD PMID:28903495 manganese(II) chloride decreases expression ISO RGD:1314001 6480464 manganese chloride results in decreased expression of PINK1 mRNA CTD PMID:27913844 manganese(II) chloride increases methylation ISO RGD:1314001 6480464 manganese chloride results in increased methylation of PINK1 gene CTD PMID:27913844 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein], Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] CTD PMID:26882442 , PMID:29966675 methylmercury chloride decreases expression ISO RGD:1314001 6480464 methylmercuric chloride results in decreased expression of PINK1 mRNA CTD PMID:28001369 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases expression EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of PINK1 protein CTD PMID:29870751 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of PINK1 protein] CTD PMID:29870751 N-acetyl-L-cysteine multiple interactions ISO RGD:1314002 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 N-acetyl-L-cysteine multiple interactions ISO RGD:1314001 6480464 Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein] CTD PMID:29567065 N-acetylsphingosine decreases response to substance ISO RGD:1314001 6480464 PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 N-acetylsphingosine decreases response to substance ISO RGD:1314002 6480464 PINK1 protein results in decreased susceptibility to N-acetylsphingosine CTD PMID:24792327 N-ethyl-N-nitrosourea increases mutagenesis EXP 6480464 Ethylnitrosourea results in increased mutagenesis of PINK1 gene CTD PMID:16495775 N-methyl-4-phenylpyridinium affects response to substance ISO RGD:1314001 6480464 PINK1 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium CTD PMID:16226715 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PINK1 protein CTD PMID:24475098 N-methyl-4-phenylpyridinium increases response to substance ISO RGD:1314001 6480464 PINK1 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium CTD PMID:20547144 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1314001 6480464 PINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 mRNA], PINK1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein] CTD PMID:21366594 nefazodone increases expression EXP 6480464 nefazodone results in increased expression of PINK1 mRNA CTD PMID:24136188 O-acetyl-L-carnitine multiple interactions ISO RGD:1314002 6480464 Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of PINK1 mRNA CTD PMID:19717638 oligomycin A multiple interactions ISO RGD:1314001 6480464 [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA more ... CTD PMID:28366621 oxidopamine decreases expression ISO RGD:1314001 6480464 Oxidopamine results in decreased expression of PINK1 protein CTD PMID:30707903 oxidopamine multiple interactions ISO RGD:1314001 6480464 PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]] more ... CTD PMID:30707903 paracetamol affects expression ISO RGD:1314002 6480464 Acetaminophen affects the expression of PINK1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1314001 6480464 Acetaminophen results in increased expression of PINK1 mRNA CTD PMID:22230336 , PMID:25704631 paraquat decreases expression ISO RGD:1314002 6480464 Paraquat results in decreased expression of PINK1 mRNA CTD PMID:22563483 paraquat multiple interactions ISO RGD:1314001 6480464 PRKN protein affects the reaction [Paraquat results in increased expression of PINK1 protein] CTD PMID:30144575 paraquat increases expression ISO RGD:1314001 6480464 Paraquat results in increased expression of PINK1 protein CTD PMID:30144575 paraquat multiple interactions ISO RGD:1314002 6480464 [PINK1 mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Dopamine, Paraquat affects the reaction [PINK1 protein affects the abundance of Dopamine] CTD PMID:22043175 paraquat increases response to substance ISO RGD:1314002 6480464 PINK1 mutant form results in increased susceptibility to Paraquat CTD PMID:22043175 phlorizin increases expression ISO RGD:1314002 6480464 Phlorhizin results in increased expression of PINK1 mRNA CTD PMID:22538082 pirinixic acid multiple interactions ISO RGD:1314002 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PINK1 mRNA CTD PMID:19710929 piroxicam multiple interactions ISO RGD:1314001 6480464 [Piroxicam co-treated with Cisplatin] results in increased expression of PINK1 mRNA CTD PMID:21858171 rac-lactic acid decreases expression ISO RGD:1314001 6480464 Lactic Acid results in decreased expression of PINK1 mRNA CTD PMID:30851411 reactive oxygen species increases chemical synthesis ISO RGD:1314001 6480464 PINK1 gene mutant form results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:20547144 reactive oxygen species decreases chemical synthesis ISO RGD:1314002 6480464 PINK1 protein results in decreased chemical synthesis of Reactive Oxygen Species CTD PMID:21421046 reactive oxygen species multiple interactions ISO RGD:1314002 6480464 PINK1 protein affects the reaction [Hydrogen Peroxide results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:21421046 resveratrol increases expression ISO RGD:1314002 6480464 resveratrol results in increased expression of PINK1 mRNA CTD PMID:22610192 rotenone decreases response to substance ISO RGD:1314001 6480464 PINK1 protein results in decreased susceptibility to Rotenone CTD PMID:19492085 rotenone increases expression EXP 6480464 Rotenone results in increased expression of PINK1 mRNA CTD PMID:28374803 rotenone affects response to substance ISO RGD:1314002 6480464 PINK1 protein affects the susceptibility to Rotenone CTD PMID:21421046 , PMID:26916954 rotenone affects response to substance ISO RGD:1314001 6480464 PINK1 protein affects the susceptibility to Rotenone CTD PMID:16226715 , PMID:20940149 rotenone increases expression ISO RGD:1314002 6480464 Rotenone results in increased expression of PINK1 protein CTD PMID:20464527 silicon dioxide decreases expression ISO RGD:1314001 6480464 Silicon Dioxide analog results in decreased expression of PINK1 mRNA CTD PMID:25895662 sodium arsenite increases expression ISO RGD:1314002 6480464 sodium arsenite results in increased expression of PINK1 mRNA CTD PMID:20883709 sodium arsenite multiple interactions EXP 6480464 Rosiglitazone inhibits the reaction [sodium arsenite results in decreased expression of PINK1 protein], Taurine inhibits the reaction [sodium arsenite results in decreased expression of PINK1 protein] CTD PMID:30551535 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PINK1 protein CTD PMID:30551535 sodium arsenite affects methylation ISO RGD:1314001 6480464 sodium arsenite affects the methylation of PINK1 gene CTD PMID:28589171 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of PINK1 mRNA CTD PMID:25993096 sorafenib multiple interactions ISO RGD:1314001 6480464 [sorafenib co-treated with PRKN protein] results in increased expression of PINK1 protein, PINK1 protein affects the reaction [sorafenib affects the localization of PRKN protein] CTD PMID:28673964 sorafenib increases expression ISO RGD:1314002 6480464 sorafenib results in increased expression of PINK1 protein CTD PMID:28673964 sorafenib increases expression ISO RGD:1314001 6480464 sorafenib results in increased expression of PINK1 protein CTD PMID:28673964 sorafenib affects response to substance ISO RGD:1314002 6480464 PINK1 protein affects the susceptibility to sorafenib CTD PMID:28673964 succimer multiple interactions ISO RGD:1314001 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PINK1 mRNA CTD PMID:26378955 sulforaphane increases expression ISO RGD:1314001 6480464 sulforafan results in increased expression of PINK1 mRNA CTD PMID:26833863 sulforaphane decreases expression ISO RGD:1314001 6480464 sulforafan results in decreased expression of PINK1 mRNA CTD PMID:31838189 superoxide affects abundance ISO RGD:1314002 6480464 PINK1 protein affects the abundance of Superoxides CTD PMID:21421046 T-2 Toxin multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of PINK1 protein], NFE2L2 protein affects the reaction [T-2 Toxin results in increased expression of PINK1 protein] CTD PMID:29870751 T-2 Toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of PINK1 mRNA, T-2 Toxin results in increased expression of PINK1 protein CTD PMID:29870751 tacrolimus hydrate multiple interactions ISO RGD:1314001 6480464 PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein] CTD PMID:19492085 tamoxifen affects expression ISO RGD:1314002 6480464 Tamoxifen affects the expression of PINK1 mRNA CTD PMID:17555576 taurine multiple interactions EXP 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PINK1 protein], Taurine inhibits the reaction [sodium arsenite results in decreased expression of PINK1 protein] CTD PMID:30551535 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PINK1 mRNA, Carbon Tetrachloride results in decreased expression of PINK1 protein CTD PMID:26882442 , PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein], schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 mRNA] CTD PMID:26882442 , PMID:31150632 thapsigargin increases expression ISO RGD:1314001 6480464 Thapsigargin results in increased expression of PINK1 mRNA CTD PMID:22378314 titanium dioxide decreases expression ISO RGD:1314002 6480464 titanium dioxide results in decreased expression of PINK1 mRNA CTD PMID:23557971 titanium dioxide increases expression ISO RGD:1314001 6480464 titanium dioxide results in increased expression of PINK1 mRNA CTD PMID:30273564 trichostatin A affects expression ISO RGD:1314001 6480464 trichostatin A affects the expression of PINK1 mRNA CTD PMID:28542535 trifloxystrobin increases expression ISO RGD:1314001 6480464 trifloxystrobin results in increased expression of PINK1 protein CTD PMID:27853101 trifloxystrobin multiple interactions ISO RGD:1314001 6480464 MitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PINK1 protein] CTD PMID:27853101 trifluoperazine multiple interactions ISO RGD:1314001 6480464 [PINK1 protein affects the susceptibility to [Trifluoperazine co-treated with Antimycin A co-treated with oligomycin A]] which affects the expression of ATP6V1H mRNA more ... CTD PMID:28366621 trovafloxacin increases expression EXP 6480464 trovafloxacin results in increased expression of PINK1 mRNA CTD PMID:24136188 tunicamycin decreases expression ISO RGD:1314002 6480464 Tunicamycin results in decreased expression of PINK1 mRNA CTD PMID:17127020 tunicamycin increases expression ISO RGD:1314001 6480464 Tunicamycin results in increased expression of PINK1 mRNA CTD PMID:22378314 urethane increases expression ISO RGD:1314001 6480464 Urethane results in increased expression of PINK1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1314002 6480464 Valproic Acid affects the expression of PINK1 mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1314001 6480464 Valproic Acid results in increased expression of PINK1 mRNA CTD PMID:23179753 more ... vancomycin increases expression ISO RGD:1314002 6480464 Vancomycin results in increased expression of PINK1 mRNA CTD PMID:18930951 vitamin E increases expression ISO RGD:1314001 6480464 Vitamin E results in increased expression of PINK1 mRNA CTD PMID:19244175
Biological Process autophagy of mitochondrion ISO RGD:1314001 1624291 (PMID:20798600), (PMID:23933751), (PMID:24896179) RGD PMID:20798600 more ... autophagy of mitochondrion IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central cellular response to hydrogen sulfide IDA 13432560 RGD cellular response to hypoxia ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 cellular response to hypoxia ISO RGD:1314001 1624291 (PMID:24553947) RGD PMID:24553947 cellular response to oxidative stress ISO RGD:1314002 1624291 (MGI:MGI:3813389, PMID:18687901) RGD MGI:MGI:3813389 , PMID:18687901 cellular response to oxidative stress ISO RGD:1314001 1624291 (PMID:22764206) RGD PMID:22764206 cellular response to toxic substance ISO RGD:1314002 1624291 (MGI:MGI:5431185, PMID:22511790) RGD MGI:MGI:5431185 , PMID:22511790 establishment of protein localization to mitochondrion ISO RGD:1314001 1624291 (PMID:25527497) RGD PMID:25527497 intracellular signal transduction ISO RGD:1314001 1624291 (PMID:14607334) RGD PMID:14607334 intracellular signal transduction ISO RGD:1314002 1624291 (MGI:MGI:3587805, PMID:14607334) RGD MGI:MGI:3587805 , PMID:14607334 maintenance of protein location in mitochondrion ISO RGD:1314001 1624291 (PMID:25527497) RGD PMID:25527497 mitochondrion organization ISO RGD:1314001 1624291 (PMID:18560593) RGD PMID:18560593 mitochondrion to lysosome transport ISO RGD:1314001 1624291 (PMID:24446486) RGD PMID:24446486 negative regulation of apoptotic process IMP 8693356 RGD negative regulation of autophagosome assembly ISO RGD:1314001 1624291 (PMID:19279012) RGD PMID:19279012 negative regulation of autophagy of mitochondrion ISO RGD:1314001 1624291 (PMID:19279012) RGD PMID:19279012 negative regulation of gene expression ISO RGD:1314002 1624291 (MGI:MGI:5582017, PMID:24475098) RGD MGI:MGI:5582017 , PMID:24475098 negative regulation of gene expression IMP 10047288 PMID:24475098 ParkinsonsUK-UCL negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway ISO RGD:1314001 1624291 (PMID:21177249), (PMID:23261939) RGD PMID:21177249 , PMID:23261939 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 negative regulation of intrinsic apoptotic signaling pathway ISO RGD:1314001 1624291 (PMID:15087508) RGD PMID:15087508 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IMP 8693356 PMID:17579517 ParkinsonsUK-UCL negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO RGD:1314001 1624291 (PMID:17579517) RGD PMID:17579517 negative regulation of macroautophagy ISO RGD:1314001 1624291 (PMID:19279012) RGD PMID:19279012 negative regulation of mitochondrial fission ISO RGD:1314001 1624291 (PMID:19279012) RGD PMID:19279012 negative regulation of neuron apoptotic process ISO RGD:1314001 1624291 (PMID:18560593) RGD PMID:18560593 negative regulation of neuron apoptotic process ISO RGD:1314002 1624291 (MGI:MGI:3847070 more ... RGD MGI:MGI:3847070 more ... negative regulation of neuron death IMP 13463453 RGD negative regulation of oxidative stress-induced cell death ISO RGD:1314001 1624291 (PMID:16632486) RGD PMID:16632486 negative regulation of reactive oxygen species metabolic process ISO RGD:1314001 1624291 (PMID:18560593) RGD PMID:18560593 peptidyl-serine autophosphorylation ISO RGD:1314001 1624291 (PMID:25527497) RGD PMID:25527497 peptidyl-serine phosphorylation IMP 8693356 PMID:17579517 ParkinsonsUK-UCL peptidyl-serine phosphorylation ISO RGD:1314001 1624291 (PMID:17579517), (PMID:19880420) RGD PMID:17579517 , PMID:19880420 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization IMP 12904014 RGD positive regulation of catecholamine secretion ISO RGD:1314002 1624291 MGI:MGI:3716083 (MGI:MGI:3715376 , PMID:17563363) RGD MGI:MGI:3715376 , PMID:17563363 positive regulation of cristae formation ISO RGD:1314001 1624291 (PMID:19279012) RGD PMID:19279012 positive regulation of DNA-binding transcription factor activity ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 positive regulation of dopamine secretion ISO RGD:1314002 1624291 MGI:MGI:3716083 (MGI:MGI:3715376 , PMID:17563363) RGD MGI:MGI:3715376 , PMID:17563363 positive regulation of histone deacetylase activity ISO RGD:1314002 1624291 (MGI:MGI:5617128, PMID:25305081) RGD MGI:MGI:5617128 , PMID:25305081 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1314001 1624291 (PMID:19880420) RGD PMID:19880420 positive regulation of macroautophagy ISO RGD:1314001 1624291 (PMID:20871098) RGD PMID:20871098 positive regulation of mitochondrial electron transport, NADH to ubiquinone ISO RGD:1314002 1624291 (MGI:MGI:5568152, PMID:24652937) RGD MGI:MGI:5568152 , PMID:24652937 positive regulation of mitochondrial fission IMP 12903967 RGD positive regulation of mitochondrial fission IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central positive regulation of mitophagy in response to mitochondrial depolarization ISO RGD:1314001 1624291 (PMID:20871098) RGD PMID:20871098 positive regulation of NMDA glutamate receptor activity IMP 13463453 RGD positive regulation of peptidyl-serine phosphorylation ISO RGD:1314001 1624291 (PMID:21177249), (PMID:24660806) RGD PMID:21177249 , PMID:24660806 positive regulation of protein dephosphorylation ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 positive regulation of protein phosphorylation ISO RGD:1314001 1624291 (PMID:25244949) RGD PMID:25244949 positive regulation of protein phosphorylation IMP 8693356 RGD positive regulation of protein targeting to mitochondrion ISO RGD:1314001 9068941 (PMID:24270810) ParkinsonsUK-UCL PMID:24270810 positive regulation of release of cytochrome c from mitochondria ISO RGD:1314001 1624291 (PMID:19880420) RGD PMID:19880420 positive regulation of synaptic transmission, dopaminergic ISO RGD:1314002 1624291 MGI:MGI:3716083 (MGI:MGI:3715376 , PMID:17563363) RGD MGI:MGI:3715376 , PMID:17563363 positive regulation of translation ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 protein phosphorylation ISO RGD:1314001 1624291 (PMID:14607334), (PMID:21177249), (PMID:25527291), (PMID:25527497) RGD PMID:14607334 more ... protein phosphorylation IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central protein phosphorylation ISO RGD:1314002 1624291 (MGI:MGI:3587805, PMID:14607334) RGD MGI:MGI:3587805 , PMID:14607334 protein stabilization ISO RGD:1314001 1624291 (PMID:19229105) RGD PMID:19229105 protein stabilization ISO RGD:1314002 1624291 (MGI:MGI:3837120, PMID:19229105) RGD MGI:MGI:3837120 , PMID:19229105 protein ubiquitination ISO RGD:1314001 1624291 (PMID:23933751) RGD PMID:23933751 regulation of apoptotic process IBA MGI:MGI:1916193 more ... 13792537 PMID:21873635 GO_Central regulation of cellular response to oxidative stress ISO RGD:1314001 1624291 (PMID:24446486) RGD PMID:24446486 regulation of hydrogen peroxide metabolic process ISO RGD:1314002 1624291 (MGI:MGI:5558956, PMID:24553947) RGD MGI:MGI:5558956 , PMID:24553947 regulation of mitochondrial membrane potential ISO RGD:1314001 1624291 UniProtKB:Q9UL15 (PMID:18560593), (PMID:21138942), (PMID:24475098) RGD PMID:18560593 more ... regulation of mitochondrion organization ISO RGD:1314001 1624291 (PMID:21508222) RGD PMID:21508222 regulation of neuron apoptotic process ISO RGD:1314002 1624291 (MGI:MGI:5431185, PMID:22511790) RGD MGI:MGI:5431185 , PMID:22511790 regulation of oxidative phosphorylation ISO RGD:1314001 1624291 (PMID:20871098) RGD PMID:20871098 regulation of protein targeting to mitochondrion ISO RGD:1314001 1624291 UniProtKB:Q9BXM7 (PMID:21508222), (PMID:23212910), (PMID:25244949) RGD PMID:21508222 more ... regulation of protein ubiquitination ISO RGD:1314001 1624291 (PMID:19880420), (PMID:20871098), (PMID:23212910) RGD PMID:19880420 more ... regulation of protein-containing complex assembly ISO RGD:1314001 1624291 (PMID:19880420) RGD PMID:19880420 regulation of reactive oxygen species metabolic process ISO RGD:1314001 1624291 UniProtKB:Q9UL15 (PMID:21138942), (PMID:24475098) RGD PMID:21138942 , PMID:24475098 respiratory electron transport chain ISO RGD:1314002 1624291 (MGI:MGI:3813389, PMID:18687901) RGD MGI:MGI:3813389 , PMID:18687901 response to ischemia IEP 12903964 RGD response to oxidative stress ISO RGD:1314001 1624291 UniProtKB:Q9UL15 (PMID:24475098) RGD PMID:24475098 Cellular Component astrocyte projection ISO RGD:1314001 1624291 (PMID:16702191) RGD PMID:16702191 axon ISO RGD:1314001 1624291 (PMID:16702191) RGD PMID:16702191 cell body ISO RGD:1314001 1624291 (PMID:16702191) RGD PMID:16702191 chromatin ISO RGD:1314001 1624291 (PMID:24798695) RGD PMID:24798695 cytoplasm ISO RGD:1314001 1624291 (PMID:16702191) RGD PMID:16702191 cytoskeleton ISO RGD:1314001 1624291 (PMID:24798695) RGD PMID:24798695 cytosol ISO RGD:1314001 1624291 (PMID:19229105), (PMID:19880420), (PMID:20798600), (PMID:21138942), (PMID:21426348), (PMID:24798695) RGD PMID:19229105 more ... endoplasmic reticulum ISO RGD:1314001 1624291 (PMID:31536960) RGD PMID:31536960 endoplasmic reticulum ISO RGD:1314002 1624291 (MGI:MGI:6383486, PMID:31536960) RGD MGI:MGI:6383486 , PMID:31536960 endoplasmic reticulum IDA 15090841 PMID:31536960 UniProt growth cone IDA 12904027 RGD integral component of mitochondrial outer membrane ISO RGD:1314001 1624291 (PMID:18687899) RGD PMID:18687899 membrane ISO RGD:1314001 1624291 (PMID:24798695) RGD PMID:24798695 mitochondrial inner membrane IDA 2290300 RGD mitochondrial inner membrane ISO RGD:1314002 1624291 (MGI:MGI:5568152, PMID:24652937) RGD MGI:MGI:5568152 , PMID:24652937 mitochondrial inner membrane ISO RGD:1314001 1624291 (PMID:17579517), (PMID:21426348) RGD PMID:17579517 , PMID:21426348 mitochondrial inner membrane IDA 8693356 PMID:17579517 ParkinsonsUK-UCL mitochondrial intermembrane space IDA 8693356 PMID:17579517 ParkinsonsUK-UCL mitochondrial intermembrane space ISO RGD:1314001 1624291 (PMID:17579517), (PMID:21426348) RGD PMID:17579517 , PMID:21426348 mitochondrial outer membrane IDA 2290300 RGD mitochondrial outer membrane ISO RGD:1314001 1624291 (PMID:21426348), (PMID:25527497) RGD PMID:21426348 , PMID:25527497 mitochondrion ISO RGD:1314001 1624291 UniProtKB:Q9H300 (PMID:15087508), (PMID:15824318), (PMID:16702191), (PMID:19229105), (PMID:20798600), (PMID:21138942), (PMID:21355049), (PMID:22354088), (PMID:23933751), (PMID:24184327), (PMID:31536960) RGD PMID:15087508 more ... mitochondrion ISO RGD:1314002 1624291 (MGI:MGI:6383486, PMID:31536960) RGD MGI:MGI:6383486 , PMID:31536960 mitochondrion IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central mitochondrion IDA 15090841 PMID:31536960 UniProt nucleus ISO RGD:1314001 1624291 (PMID:24798695) RGD PMID:24798695 perinuclear region of cytoplasm ISO RGD:1314001 1624291 (PMID:16702191) RGD PMID:16702191 Molecular Function ATP binding ISO RGD:1314001 1624291 (PMID:14607334) RGD PMID:14607334 ATP binding ISO RGD:1314002 1624291 (MGI:MGI:3587805, PMID:14607334) RGD MGI:MGI:3587805 , PMID:14607334 C3HC4-type RING finger domain binding ISO RGD:1314001 1624291 UniProtKB:O60260 (PMID:19880420) RGD PMID:19880420 calcium-dependent protein kinase activity ISO RGD:1314001 1624291 (PMID:19880420) RGD PMID:19880420 kinase activity ISO RGD:1314001 1624291 (PMID:15824318) RGD PMID:15824318 kinase activity ISO RGD:1314002 1624291 (MGI:MGI:3587805, PMID:14607334) RGD MGI:MGI:3587805 , PMID:14607334 magnesium ion binding ISO RGD:1314001 1624291 (PMID:14607334) RGD PMID:14607334 magnesium ion binding ISO RGD:1314002 1624291 (MGI:MGI:3587805, PMID:14607334) RGD MGI:MGI:3587805 , PMID:14607334 protease binding ISO RGD:1314001 1624291 UniProtKB:Q9H300 (PMID:21138942) RGD PMID:21138942 protein binding IPI UniProtKB:Q5XHZ0 8693356 PMID:17579517 ParkinsonsUK-UCL protein binding ISO RGD:1314002 1624291 UniProtKB:Q9CQ45 (MGI:MGI:6383486 , PMID:31536960) RGD MGI:MGI:6383486 , PMID:31536960 protein binding IPI UniProtKB:Q6IUR5 15090841 PMID:31536960 UniProt protein binding ISO RGD:1314001 1624291 UniProtKB:O60260 more ... RGD PMID:16632486 more ... protein binding IPI RGD:1359733 8693356 RGD protein kinase activity ISO RGD:1314001 1624291 (PMID:25527497) RGD PMID:25527497 protein kinase activity IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central protein kinase B binding ISO RGD:1314001 1624291 (PMID:21177249) RGD PMID:21177249 protein serine/threonine kinase activity IMP 8693356 PMID:17579517 ParkinsonsUK-UCL protein serine/threonine kinase activity IBA FB:FBgn0029891 more ... 13792537 PMID:21873635 GO_Central protein serine/threonine kinase activity ISO RGD:1314002 1624291 (MGI:MGI:3587805 more ... RGD MGI:MGI:3587805 more ... protein serine/threonine kinase activity ISO RGD:1314001 1624291 (PMID:14607334), (PMID:17579517), (PMID:19880420), (PMID:24784582), (PMID:25527291) RGD PMID:14607334 more ... protein-containing complex binding ISO RGD:1314001 1624291 (PMID:24270810) RGD PMID:24270810 TORC2 complex binding ISO RGD:1314001 1624291 UniProtKB:Q6R327 (PMID:21177249) RGD PMID:21177249 ubiquitin protein ligase binding IPI RGD:61797 13432560 RGD ubiquitin protein ligase binding ISO RGD:1314001 1624291 UniProtKB:O60260 (PMID:20798600) RGD PMID:20798600
Gene-Chemical Interaction Annotations
