Pink1 (PTEN induced kinase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pink1 (PTEN induced kinase 1) Rattus norvegicus
Analyze
Symbol: Pink1
Name: PTEN induced kinase 1
RGD ID: 1305769
Description: Enables protein serine/threonine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen sulfide; positive regulation of mitochondrial fission; and regulation of signal transduction. Located in endoplasmic reticulum; growth cone; and mitochondrial envelope. Used to study Parkinson's disease and Parkinsonism. Biomarker of metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1); PARTICIPATES IN mitochondria dynamics pathway; altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC298575; MGC189438; PTEN induced putative kinase 1; serine/threonine-protein kinase PINK1, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pink1em1Sage
Genetic Models: LE-Pink1em1Sage-/- ; LE-Pink1em1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,813,838 - 155,825,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5155,813,838 - 155,825,950 (-)EnsemblGRCr8
mRatBN7.25150,530,523 - 150,542,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5153,226,264 - 153,238,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,000,550 - 155,012,551 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,982,571 - 154,994,572 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,677,146 - 156,689,415 (-)Ensemblrn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5148,924,018 - 148,936,130 (-)NCBICelera
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,4-benzoquinone  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
A-967079  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acetylcholine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
bafilomycin A1  (EXP)
Bardoxolone methyl  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bupivacaine  (ISO)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carnosic acid  (ISO)
CCCP  (EXP,ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dioxygen  (EXP,ISO)
dithionite(2-)  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
fructose  (ISO)
fumonisin B1  (ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
Genipin  (ISO)
ginsenoside Rb1  (EXP,ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycine betaine  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
inositol  (EXP)
iodixanol  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lidocaine  (EXP)
linagliptin  (EXP)
lipoic acid  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
metformin  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
O-acetyl-L-carnitine  (ISO)
ochratoxin A  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
oligomycin A  (ISO)
Ophiopogonin D  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
phlorizin  (ISO)
phytosphingosine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(vinylpyrrolidone)  (ISO)
ponasterone A  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
remifentanil  (EXP)
Repaglinide  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sorafenib  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toyocamycin  (ISO)
tricalcium bis(phosphate)  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifloxystrobin  (ISO)
trifluoperazine  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
Urolithin A  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (IEA)
autophagy of mitochondrion  (IBA,IEA,ISO)
catecholamine secretion  (IEA,ISO)
cellular response to hydrogen sulfide  (IDA)
cellular response to hypoxia  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to toxic substance  (IEA,ISO)
dopamine secretion  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
establishment of protein localization to mitochondrion  (IEA,ISO)
hemopoiesis  (IEA,ISO)
intracellular signal transduction  (IEA,ISO)
maintenance of protein location in mitochondrion  (IEA,ISO)
mitochondrial fission  (HMP)
mitochondrion organization  (IEA,ISO)
mitochondrion to lysosome vesicle-mediated transport  (IEA,ISO)
mitophagy  (IEA,IMP,ISO)
negative regulation of apoptotic process  (IEA,IMP)
negative regulation of autophagosome assembly  (IEA,ISO)
negative regulation of cellular process  (IMP)
negative regulation of fatty acid beta-oxidation  (HMP)
negative regulation of gene expression  (IEA,IMP,ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  (IEA,IMP,ISO)
negative regulation of macroautophagy  (IEA,ISO)
negative regulation of mitochondrial fission  (IEA,ISO)
negative regulation of mitophagy  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of catecholamine secretion  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cristae formation  (IEA,ISO)
positive regulation of dopamine secretion  (IEA,ISO)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (IEA,ISO)
positive regulation of mitochondrial fission  (IBA,IMP)
positive regulation of NMDA glutamate receptor activity  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive regulation of synaptic transmission, dopaminergic  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
positive regulation of type 2 mitophagy  (IEA,ISO)
protein phosphorylation  (ISO,ISS)
protein stabilization  (IEA,ISO)
protein ubiquitination  (IEA,ISO)
regulation of apoptotic process  (IBA)
regulation of cellular response to oxidative stress  (IEA,ISO)
regulation of hydrogen peroxide metabolic process  (IEA,ISO)
regulation of mitochondrial membrane potential  (IEA,ISO)
regulation of mitochondrion organization  (IEA,ISO)
regulation of neuron apoptotic process  (IEA,ISO)
regulation of oxidative phosphorylation  (IEA,ISO)
regulation of protein targeting to mitochondrion  (IEA,ISO)
regulation of protein ubiquitination  (IEA,ISO)
regulation of protein-containing complex assembly  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (IEA,ISO)
respiratory electron transport chain  (IEA,ISO)
response to ischemia  (IEP)
response to oxidative stress  (IEA,ISO)
response to stress  (IEA)
TORC2 signaling  (IEA,ISO)

Cellular Component
astrocyte projection  (IEA,ISO)
axon  (IEA,ISO)
cell body  (IEA,ISO)
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA,ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IDA,IEA,ISO)
growth cone  (IDA)
membrane  (IEA,ISO)
mitochondrial inner membrane  (IDA,IEA,ISO)
mitochondrial intermembrane space  (IDA,IEA,ISO)
mitochondrial outer membrane  (IDA,IEA,ISO)
mitochondrion  (IBA,IDA,IEA,ISO)
nucleus  (IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. Ashrafi G, etal., J Cell Biol. 2014 Sep 1;206(5):655-70. doi: 10.1083/jcb.201401070. Epub 2014 Aug 25.
2. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
3. Differential regulation of NMDA receptor function by DJ-1 and PINK1. Chang N, etal., Aging Cell. 2010 Oct;9(5):837-50. doi: 10.1111/j.1474-9726.2010.00615.x.
4. Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury. Chen SD, etal., Biochem Biophys Res Commun. 2015 May 1;460(2):397-403. doi: 10.1016/j.bbrc.2015.03.045. Epub 2015 Mar 17.
5. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
6. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
7. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
8. PINK1 protein in normal human brain and Parkinson's disease. Gandhi S, etal., Brain. 2006 Jul;129(Pt 7):1720-31. Epub 2006 May 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, etal., Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29.
11. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
12. Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate. Liu N, etal., J Cell Mol Med. 2017 Jun 13. doi: 10.1111/jcmm.13223.
13. Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. Matenia D, etal., J Biol Chem. 2012 Mar 9;287(11):8174-86. doi: 10.1074/jbc.M111.262287. Epub 2012 Jan 11.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, etal., iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057. Epub 2019 Sep 4.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. Pridgeon JW, etal., PLoS Biol. 2007 Jul;5(7):e172. Epub 2007 Jun 19.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Parkin and PINK1: much more than mitophagy. Scarffe LA, etal., Trends Neurosci. 2014 Jun;37(6):315-24. doi: 10.1016/j.tins.2014.03.004. Epub 2014 Apr 13.
23. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
24. Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats. Villeneuve LM, etal., Mol Neurobiol. 2016 Jan;53(1):171-86. doi: 10.1007/s12035-014-8927-y. Epub 2014 Nov 25.
25. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. Wang X, etal., PLoS One. 2014 Jan 24;9(1):e86276. doi: 10.1371/journal.pone.0086276. eCollection 2014.
26. Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses. Wei H, etal., Biochim Biophys Acta. 2015 Oct;1853(10 Pt B):2784-90. doi: 10.1016/j.bbamcr.2015.03.013. Epub 2015 Apr 1.
27. The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Yu W, etal., Hum Mol Genet. 2011 Aug 15;20(16):3227-40. doi: 10.1093/hmg/ddr235. Epub 2011 May 25.
Additional References at PubMed
PMID:12477932   PMID:14607334   PMID:15087508   PMID:15824318   PMID:16632486   PMID:16771836   PMID:17563363   PMID:17950257   PMID:18560593   PMID:18614015   PMID:18687899   PMID:18687901  
PMID:19229105   PMID:19279012   PMID:19880420   PMID:20164189   PMID:20798600   PMID:20871098   PMID:21138942   PMID:21177249   PMID:21355049   PMID:21426348   PMID:21508222   PMID:21606348  
PMID:22354088   PMID:22511790   PMID:22764206   PMID:23212910   PMID:23261939   PMID:23772688   PMID:23933751   PMID:24184327   PMID:24270810   PMID:24446486   PMID:24553947   PMID:24626860  
PMID:24652937   PMID:24660806   PMID:24784582   PMID:24798695   PMID:24896179   PMID:25229693   PMID:25244949   PMID:25305081   PMID:25527291   PMID:25527497   PMID:26234713   PMID:26465230  
PMID:26935412   PMID:27233610   PMID:27334109   PMID:27568932   PMID:28104397   PMID:28933786   PMID:29687347   PMID:29710734   PMID:30844333   PMID:31401305   PMID:31432320   PMID:31748499  
PMID:31978495   PMID:32065805   PMID:32173525   PMID:32353461   PMID:32555260   PMID:32900550   PMID:33064741   PMID:33125104   PMID:33296434   PMID:33321180   PMID:33387634   PMID:33529652  
PMID:34078833   PMID:34893682   PMID:35426609   PMID:35460769   PMID:35760846   PMID:36173508   PMID:36233236   PMID:36307912   PMID:36535484   PMID:36946264   PMID:36949296   PMID:37161651  
PMID:37162681   PMID:37193858   PMID:38393524   PMID:38438964   PMID:38580154   PMID:38685371   PMID:38788061   PMID:39097918  


Genomics

Comparative Map Data
Pink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,813,838 - 155,825,950 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5155,813,838 - 155,825,950 (-)EnsemblGRCr8
mRatBN7.25150,530,523 - 150,542,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5153,226,264 - 153,238,265 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,000,550 - 155,012,551 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,982,571 - 154,994,572 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,677,146 - 156,689,415 (-)Ensemblrn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5148,924,018 - 148,936,130 (-)NCBICelera
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Cytogenetic Map5q36NCBI
PINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,633,458 - 20,651,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,633,458 - 20,651,511 (+)Ensemblhg38GRCh38
GRCh37120,959,951 - 20,978,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,832,535 - 20,850,591 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34120,705,253 - 20,723,309NCBI
Celera119,284,119 - 19,302,182 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,206,074 - 19,224,136 (+)NCBIHuRef
CHM1_1121,070,747 - 21,088,823 (+)NCBICHM1_1
T2T-CHM13v2.0120,459,649 - 20,477,706 (+)NCBIT2T-CHM13v2.0
Pink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,040,718 - 138,053,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,040,720 - 138,053,618 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384138,313,409 - 138,326,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,313,409 - 138,326,307 (-)Ensemblmm10GRCm38
MGSCv374137,869,324 - 137,882,211 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364137,585,488 - 137,598,347 (-)NCBIMGSCv36mm8
Celera4140,093,554 - 140,110,379 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.14NCBI
Pink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,171,205 - 1,185,125 (+)Ensembl
ChiLan1.0NW_0049554521,171,115 - 1,186,338 (+)NCBIChiLan1.0ChiLan1.0
PINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,472,787 - 206,490,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,585,116 - 205,603,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,583,330 - 19,601,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,627,364 - 20,646,377 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,627,693 - 20,645,560 (+)EnsemblpanPan2panpan1.1
PINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,276,091 - 78,293,761 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,277,077 - 78,294,123 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha274,790,397 - 74,808,514 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0278,842,969 - 78,861,096 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,842,996 - 78,861,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,661,680 - 75,679,782 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,673,498 - 76,691,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,677,116 - 77,695,256 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,749,706 - 40,764,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,573,623 - 6,589,478 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,574,471 - 6,589,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,863,190 - 78,884,640 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1678,863,195 - 78,884,663 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,117,387 - 73,128,340 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,902,135 - 111,919,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,902,765 - 111,919,069 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660334,316,686 - 4,333,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,656,229 - 5,671,260 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247645,656,207 - 5,671,260 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Pink1
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:73
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000065497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
RH133507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,530,658 - 150,530,876 (+)MAPPERmRatBN7.2
Rnor_6.05156,677,282 - 156,677,499NCBIRnor6.0
Rnor_5.05160,425,851 - 160,426,068UniSTSRnor5.0
RGSC_v3.45157,091,317 - 157,091,534UniSTSRGSC3.4
Celera5148,924,154 - 148,924,371UniSTS
RH 3.4 Map51032.2UniSTS
Cytogenetic Map5q36UniSTS
RH141472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,531,029 - 150,531,247 (+)MAPPERmRatBN7.2
Rnor_6.05156,677,653 - 156,677,870NCBIRnor6.0
Rnor_5.05160,426,222 - 160,426,439UniSTSRnor5.0
RGSC_v3.45157,091,688 - 157,091,905UniSTSRGSC3.4
Celera5148,924,525 - 148,924,742UniSTS
RH 3.4 Map51032.2UniSTS
Cytogenetic Map5q36UniSTS
AI233191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,530,245 - 150,530,436 (+)MAPPERmRatBN7.2
Rnor_6.05156,676,869 - 156,677,059NCBIRnor6.0
Rnor_5.05160,425,438 - 160,425,628UniSTSRnor5.0
RGSC_v3.45157,090,904 - 157,091,094UniSTSRGSC3.4
Celera5148,923,741 - 148,923,931UniSTS
RH 3.4 Map51033.9UniSTS
Cytogenetic Map5q36UniSTS


Genetic Models
This gene Pink1 is modified in the following models/strains:
LE-Pink1em1Sage-/-     LE-Pink1em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065497   ⟹   ENSRNOP00000058880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5155,813,838 - 155,825,950 (-)Ensembl
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)Ensembl
Rnor_6.0 Ensembl5156,677,146 - 156,689,258 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083474   ⟹   ENSRNOP00000069316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5155,814,332 - 155,825,944 (-)Ensembl
mRatBN7.2 Ensembl5150,531,017 - 150,542,629 (-)Ensembl
Rnor_6.0 Ensembl5156,677,592 - 156,689,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100557   ⟹   ENSRNOP00000090196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5155,814,332 - 155,825,914 (-)Ensembl
mRatBN7.2 Ensembl5150,531,017 - 150,542,599 (-)Ensembl
RefSeq Acc Id: NM_001106694   ⟹   NP_001100164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,813,838 - 155,825,950 (-)NCBI
mRatBN7.25150,530,523 - 150,542,635 (-)NCBI
Rnor_6.05156,677,146 - 156,689,258 (-)NCBI
Rnor_5.05160,425,715 - 160,437,827 (-)NCBI
RGSC_v3.45157,091,181 - 157,103,293 (-)RGD
Celera5148,924,018 - 148,936,130 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100164 (Get FASTA)   NCBI Sequence Viewer  
  NP_001425048 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69047 (Get FASTA)   NCBI Sequence Viewer  
  B5DFG1 (Get FASTA)   NCBI Sequence Viewer  
  EDL80874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069316.1
RefSeq Acc Id: NP_001100164   ⟸   NM_001106694
- Sequence:
Ensembl Acc Id: ENSRNOP00000058880   ⟸   ENSRNOT00000065497
Ensembl Acc Id: ENSRNOP00000069316   ⟸   ENSRNOT00000083474
Ensembl Acc Id: ENSRNOP00000090196   ⟸   ENSRNOT00000100557
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DFG1-F1-model_v2 AlphaFold B5DFG1 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694189
Promoter ID:EPDNEW_R4713
Type:initiation region
Name:Pink1_1
Description:PTEN induced putative kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,689,283 - 156,689,343EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305769 AgrOrtholog
BioCyc Gene G2FUF-39457 BioCyc
Ensembl Genes ENSRNOG00000015385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083474.2 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MitoQC_Scaffold_Kinases UniProtKB/Swiss-Prot
  PINK1_STKc UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 298575 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Pink1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015385 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ADB8 ENTREZGENE, UniProtKB/TrEMBL
  A6ITH3_RAT UniProtKB/TrEMBL
  B5DFG1 ENTREZGENE
  D3Z9M9_RAT UniProtKB/TrEMBL
  PINK1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pink1  PTEN induced putative kinase 1   Pink1_predicted  PTEN induced putative kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pink1_predicted  PTEN induced putative kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED