Pink1 (PTEN induced kinase 1) - Rat Genome Database

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Gene: Pink1 (PTEN induced kinase 1) Rattus norvegicus
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Symbol: Pink1
Name: PTEN induced kinase 1
RGD ID: 1305769
Description: Enables protein serine/threonine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen sulfide; positive regulation of mitochondrial fission; and regulation of signal transduction. Located in endoplasmic reticulum; growth cone; and mitochondrial envelope. Used to study Parkinson's disease and Parkinsonism. Biomarker of metabolic dysfunction-associated steatohepatitis. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1); PARTICIPATES IN mitochondria dynamics pathway; altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dichloropropan-2-ol; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC298575; MGC189438; PTEN induced putative kinase 1; serine/threonine-protein kinase PINK1, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pink1em1Sage  
Genetic Models: LE-Pink1em1Sage-/- LE-Pink1em1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,813,838 - 155,825,950 (-)NCBIGRCr8
mRatBN7.25150,530,523 - 150,542,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,226,264 - 153,238,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,000,550 - 155,012,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,982,571 - 154,994,572 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,677,146 - 156,689,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Celera5148,924,018 - 148,936,130 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Pink1Rat3-hydroxy-3-methylglutaryl-CoA lyase deficiency  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of hydroxymethylglutaryl-CoA lyaseClinVarPMID:28492532
Pink1Ratcongenital disorder of glycosylation  ISOPINK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Pink1Ratcongenital disorder of glycosylation Ir  ISOPINK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Pink1Ratgenetic disease  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Pink1Rathyperprolinemia type 2  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperprolinemia type 2ClinVarPMID:28492532
Pink1Ratlate onset Parkinson's disease  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson disease and late-onsetClinVar 
Pink1Ratleprosy  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Leprosy more ...ClinVar 
Pink1Ratneuroblastoma  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: NeuroblastomaClinVarPMID:25741868
Pink1RatParkinson's disease  ISOPINK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson Disease and RecessiveClinVarPMID:25741868 and PMID:28492532
Pink1RatParkinson's disease 6  ISOPINK1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15087508 more ...
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Pink1Ratcognitive disorder  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36804394
Pink1RatNerve Degeneration  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24161480
Pink1Ratneuroblastoma  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23334666
Pink1RatParkinson's disease  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17010972 more ...
Pink1RatParkinson's disease 6  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19048950 more ...
Pink1RatParkinsonism  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11254447 more ...
Pink1RatReperfusion Injury  ISOPINK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35312153
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Pink1RatParkinson's disease 6  ISSPink1 (Mus musculus)13592920OMIM:605909MouseDO 
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Pink1RatParkinson's disease 6  ISOPINK1 (Homo sapiens)7240710 OMIM 

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Pink1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 mRNA]CTDPMID:31150632
Pink1Rat(R)-lipoic acid multiple interactionsISOPink1 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Sodium Fluoride results in increased expression of PINK1 mRNA]CTDPMID:37739047
Pink1Rat1,1-dichloroethene decreases expressionISOPink1 (Mus musculus)6480464vinylidene chloride results in decreased expression of PINK1 mRNACTDPMID:26682919
Pink1Rat1,3-dichloropropan-2-ol decreases expressionEXP 64804641 and 3-dichloro-2-propanol results in decreased expression of PINK1 proteinCTDPMID:36000575
Pink1Rat1,4-benzoquinone multiple interactionsISOPINK1 (Homo sapiens)6480464Acetylcysteine inhibits the reaction [quinone results in increased expression of PINK1 protein] more ...CTDPMID:29567065
Pink1Rat1,4-benzoquinone increases expressionISOPINK1 (Homo sapiens)6480464quinone results in increased expression of PINK1 mRNA and quinone results in increased expression of PINK1 proteinCTDPMID:29567065
Pink1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substanceISOPink1 (Mus musculus)6480464PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1 more ...CTDPMID:22511790
Pink1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOPink1 (Mus musculus)6480464AM 1241 inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:22511790 and PMID:28978077
Pink1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOPink1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:28978077
Pink1Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of PINK1 mRNACTDPMID:30723492
Pink1Rat17alpha-ethynylestradiol affects expressionISOPink1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PINK1 mRNACTDPMID:17555576
Pink1Rat17alpha-ethynylestradiol multiple interactionsISOPink1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNACTDPMID:17942748
Pink1Rat17alpha-ethynylestradiol decreases expressionISOPink1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of PINK1 mRNACTDPMID:17942748
Pink1Rat17beta-estradiol multiple interactionsISOPINK1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of PINK1 mRNACTDPMID:30165855
Pink1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PINK1 mRNACTDPMID:35192832
Pink1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PINK1 mRNACTDPMID:32145629
Pink1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPink1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PINK1 mRNACTDPMID:17942748
Pink1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PINK1 mRNACTDPMID:32109520 and PMID:34747641
Pink1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPINK1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of PINK1 mRNACTDPMID:20106945 and PMID:21632981
Pink1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PINK1 mRNACTDPMID:21215274

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Biological Process
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Pink1Ratautophagy involved_inIEAUniProtKB-KW:KW-00721600115GO_REF:0000043UniProtGO_REF:0000043
Pink1Ratautophagy of mitochondrion involved_inISOPINK1 (Homo sapiens)1624291 PMID:20798600 more ...RGDPMID:20798600 more ...
Pink1Ratautophagy of mitochondrion involved_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratautophagy of mitochondrion involved_inIBAFB:FBgn0029891 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pink1Ratcatecholamine secretion acts_upstream_ofISOPink1 (Mus musculus)1624291MGI:3716083 PMID:17563363RGDPMID:17563363
Pink1Ratcatecholamine secretion acts_upstream_ofIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to hydrogen sulfide  IDA 13432560 RGD 
Pink1Ratcellular response to hypoxia involved_inISOPINK1 (Homo sapiens)1624291 PMID:24553947RGDPMID:24553947
Pink1Ratcellular response to hypoxia involved_inISOPink1 (Mus musculus)1624291 PMID:24553947RGDPMID:24553947
Pink1Ratcellular response to hypoxia involved_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to hypoxia involved_inIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to oxidative stress involved_inISOPink1 (Mus musculus)1624291 PMID:18687901RGDPMID:18687901
Pink1Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to oxidative stress involved_inISOPINK1 (Homo sapiens)1624291 PMID:22764206RGDPMID:22764206
Pink1Ratcellular response to toxic substance involved_inIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcellular response to toxic substance involved_inISOPink1 (Mus musculus)1624291 PMID:22511790RGDPMID:22511790
Pink1Ratdopamine secretion acts_upstream_ofISOPink1 (Mus musculus)1624291MGI:3716083 PMID:17563363RGDPMID:17563363
Pink1Ratdopamine secretion acts_upstream_ofIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratestablishment of localization in cell acts_upstream_ofISOPink1 (Mus musculus)1624291MGI:3716083 PMID:17563363RGDPMID:17563363
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Cellular Component
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Pink1Ratastrocyte projection located_inISOPINK1 (Homo sapiens)1624291 PMID:16702191RGDPMID:16702191
Pink1Ratastrocyte projection located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Rataxon located_inISOPINK1 (Homo sapiens)1624291 PMID:16702191RGDPMID:16702191
Pink1Rataxon located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcell body located_inISOPINK1 (Homo sapiens)1624291 PMID:16702191RGDPMID:16702191
Pink1Ratcell body located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratchromatin located_inISOPINK1 (Homo sapiens)1624291 PMID:24798695RGDPMID:24798695
Pink1Ratchromatin located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcytoplasm located_inISOPINK1 (Homo sapiens)1624291 PMID:16702191RGDPMID:16702191
Pink1Ratcytoplasm located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Pink1Ratcytoskeleton located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcytoskeleton located_inISOPINK1 (Homo sapiens)1624291 PMID:24798695RGDPMID:24798695
Pink1Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Pink1Ratcytosol located_inIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratcytosol located_inISOPINK1 (Homo sapiens)1624291 PMID:18957282 more ...RGDPMID:18957282 more ...
Pink1Ratendoplasmic reticulum located_inISOPink1 (Mus musculus)1624291 PMID:31536960RGDPMID:31536960
Pink1Ratendoplasmic reticulum located_inIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratendoplasmic reticulum located_inISOPINK1 (Homo sapiens)1624291 PMID:31536960RGDPMID:31536960
Pink1Ratendoplasmic reticulum located_inIDA 15090841PMID:31536960UniProt 
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Molecular Function
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Pink1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Pink1RatATP binding enablesIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1RatATP binding enablesISOPink1 (Mus musculus)1624291 PMID:14607334RGDPMID:14607334
Pink1RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Pink1RatATP binding enablesIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1RatATP binding enablesISOPINK1 (Homo sapiens)1624291 PMID:14607334RGDPMID:14607334
Pink1RatC3HC4-type RING finger domain binding enablesISOPINK1 (Homo sapiens)1624291UniProtKB:O60260 and PMID:19880420RGDPMID:19880420
Pink1RatC3HC4-type RING finger domain binding enablesIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratkinase activity enablesISOPINK1 (Homo sapiens)1624291 PMID:15824318RGDPMID:15824318
Pink1Ratkinase activity enablesIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratkinase activity enablesISOPink1 (Mus musculus)1624291 PMID:14607334RGDPMID:14607334
Pink1Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Pink1Ratkinase activity enablesIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratkinase binding enablesISOPINK1 (Homo sapiens)1624291UniProtKB:P31749 and PMID:21177249RGDPMID:21177249
Pink1Ratkinase binding enablesIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratmagnesium ion binding enablesISOPINK1 (Homo sapiens)1624291 PMID:14607334RGDPMID:14607334
Pink1Ratmagnesium ion binding enablesIEAUniProtKB:Q9BXM7 and ensembl:ENSP000003642041600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratmagnesium ion binding enablesISOPink1 (Mus musculus)1624291 PMID:14607334RGDPMID:14607334
Pink1Ratmagnesium ion binding enablesIEAUniProtKB:Q99MQ3 and ensembl:ENSMUSP000000305361600115GO_REF:0000107EnsemblGO_REF:0000107
Pink1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Pink1RatParkinson's disease pathway   IEA 6907045 KEGGrno:05012
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Reference Title
Reference Citation
1. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. Ashrafi G, etal., J Cell Biol. 2014 Sep 1;206(5):655-70. doi: 10.1083/jcb.201401070. Epub 2014 Aug 25.
2. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
3. Differential regulation of NMDA receptor function by DJ-1 and PINK1. Chang N, etal., Aging Cell. 2010 Oct;9(5):837-50. doi: 10.1111/j.1474-9726.2010.00615.x.
4. Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury. Chen SD, etal., Biochem Biophys Res Commun. 2015 May 1;460(2):397-403. doi: 10.1016/j.bbrc.2015.03.045. Epub 2015 Mar 17.
5. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
6. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
7. Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. El-Derany MO and AbdelHamid SG, Biochem Pharmacol. 2021 Aug;190:114624. doi: 10.1016/j.bcp.2021.114624. Epub 2021 May 27.
8. PINK1 protein in normal human brain and Parkinson's disease. Gandhi S, etal., Brain. 2006 Jul;129(Pt 7):1720-31. Epub 2006 May 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, etal., Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29.
11. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
12. Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate. Liu N, etal., J Cell Mol Med. 2017 Jun 13. doi: 10.1111/jcmm.13223.
13. Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. Matenia D, etal., J Biol Chem. 2012 Mar 9;287(11):8174-86. doi: 10.1074/jbc.M111.262287. Epub 2012 Jan 11.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, etal., iScience. 2019 Sep 27;19:1114-1132. doi: 10.1016/j.isci.2019.08.057. Epub 2019 Sep 4.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. Pridgeon JW, etal., PLoS Biol. 2007 Jul;5(7):e172. Epub 2007 Jun 19.
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:12477932   PMID:14607334   PMID:15087508   PMID:15824318   PMID:16632486   PMID:16771836   PMID:17563363   PMID:17950257   PMID:18560593   PMID:18614015   PMID:18687899   PMID:18687901  
PMID:19229105   PMID:19279012   PMID:19880420   PMID:20164189   PMID:20798600   PMID:20871098   PMID:21138942   PMID:21177249   PMID:21355049   PMID:21426348   PMID:21508222   PMID:21606348  
PMID:22354088   PMID:22511790   PMID:22764206   PMID:23212910   PMID:23261939   PMID:23772688   PMID:23933751   PMID:24184327   PMID:24270810   PMID:24446486   PMID:24553947   PMID:24626860  
PMID:24652937   PMID:24660806   PMID:24784582   PMID:24798695   PMID:24896179   PMID:25229693   PMID:25244949   PMID:25305081   PMID:25527291   PMID:25527497   PMID:26234713   PMID:26465230  
PMID:26935412   PMID:27233610   PMID:27334109   PMID:27568932   PMID:28104397   PMID:28933786   PMID:29687347   PMID:29710734   PMID:30844333   PMID:31401305   PMID:31432320   PMID:31748499  
PMID:31978495   PMID:32065805   PMID:32173525   PMID:32353461   PMID:32555260   PMID:32900550   PMID:33064741   PMID:33125104   PMID:33296434   PMID:33321180   PMID:33387634   PMID:33529652  
PMID:34078833   PMID:34893682   PMID:35426609   PMID:35460769   PMID:35760846   PMID:36173508   PMID:36233236   PMID:36307912   PMID:36535484   PMID:36946264   PMID:36949296   PMID:37161651  
PMID:37162681   PMID:37193858   PMID:38393524   PMID:38438964   PMID:38580154   PMID:38685371   PMID:38788061   PMID:39097918  



Pink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,813,838 - 155,825,950 (-)NCBIGRCr8
mRatBN7.25150,530,523 - 150,542,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,226,264 - 153,238,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,000,550 - 155,012,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,982,571 - 154,994,572 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,677,146 - 156,689,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Celera5148,924,018 - 148,936,130 (-)NCBICelera
Cytogenetic Map5q36NCBI
PINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,633,458 - 20,651,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,633,458 - 20,651,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37120,959,951 - 20,978,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,832,535 - 20,850,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 34120,705,253 - 20,723,309NCBI
Celera119,284,119 - 19,302,182 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,206,074 - 19,224,136 (+)NCBIHuRef
CHM1_1121,070,747 - 21,088,823 (+)NCBICHM1_1
T2T-CHM13v2.0120,459,649 - 20,477,706 (+)NCBIT2T-CHM13v2.0
Pink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,040,718 - 138,053,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,040,720 - 138,053,618 (-)EnsemblGRCm39 Ensembl
GRCm384138,313,409 - 138,326,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,313,409 - 138,326,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,869,324 - 137,882,211 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,585,488 - 137,598,347 (-)NCBIMGSCv36mm8
Celera4140,093,554 - 140,110,379 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.14NCBI
Pink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,171,205 - 1,185,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,171,115 - 1,186,338 (+)NCBIChiLan1.0ChiLan1.0
PINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,472,787 - 206,490,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,585,116 - 205,603,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,583,330 - 19,601,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,627,364 - 20,646,377 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,627,693 - 20,645,560 (+)Ensemblpanpan1.1panPan2
PINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,276,091 - 78,293,761 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,277,077 - 78,294,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,790,397 - 74,808,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,842,969 - 78,861,096 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,842,996 - 78,861,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,661,680 - 75,679,782 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,673,498 - 76,691,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,677,116 - 77,695,256 (-)NCBIUU_Cfam_GSD_1.0
Pink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,749,706 - 40,764,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,573,623 - 6,589,478 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,574,471 - 6,589,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,863,190 - 78,884,640 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,863,195 - 78,884,663 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,117,387 - 73,128,340 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,902,135 - 111,919,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,902,765 - 111,919,069 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,316,686 - 4,333,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,656,229 - 5,671,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,656,207 - 5,671,260 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pink1
45 total Variants

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:73
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000065497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat

1 to 10 of 38 rows
RH133507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,530,658 - 150,530,876 (+)MAPPERmRatBN7.2
Rnor_6.05156,677,282 - 156,677,499NCBIRnor6.0
Rnor_5.05160,425,851 - 160,426,068UniSTSRnor5.0
RGSC_v3.45157,091,317 - 157,091,534UniSTSRGSC3.4
Celera5148,924,154 - 148,924,371UniSTS
RH 3.4 Map51032.2UniSTS
Cytogenetic Map5q36UniSTS
RH141472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,531,029 - 150,531,247 (+)MAPPERmRatBN7.2
Rnor_6.05156,677,653 - 156,677,870NCBIRnor6.0
Rnor_5.05160,426,222 - 160,426,439UniSTSRnor5.0
RGSC_v3.45157,091,688 - 157,091,905UniSTSRGSC3.4
Celera5148,924,525 - 148,924,742UniSTS
RH 3.4 Map51032.2UniSTS
Cytogenetic Map5q36UniSTS
AI233191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,530,245 - 150,530,436 (+)MAPPERmRatBN7.2
Rnor_6.05156,676,869 - 156,677,059NCBIRnor6.0
Rnor_5.05160,425,438 - 160,425,628UniSTSRnor5.0
RGSC_v3.45157,090,904 - 157,091,094UniSTSRGSC3.4
Celera5148,923,741 - 148,923,931UniSTS
RH 3.4 Map51033.9UniSTS
Cytogenetic Map5q36UniSTS


This gene Pink1 is modified in the following models/strains:
LE-Pink1em1Sage-/-     LE-Pink1em1Sage    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000065497   ⟹   ENSRNOP00000058880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)Ensembl
Rnor_6.0 Ensembl5156,677,146 - 156,689,258 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083474   ⟹   ENSRNOP00000069316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,531,017 - 150,542,629 (-)Ensembl
Rnor_6.0 Ensembl5156,677,592 - 156,689,415 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100557   ⟹   ENSRNOP00000090196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5150,531,017 - 150,542,599 (-)Ensembl
RefSeq Acc Id: NM_001106694   ⟹   NP_001100164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85155,813,838 - 155,825,950 (-)NCBI
mRatBN7.25150,530,523 - 150,542,635 (-)NCBI
Rnor_6.05156,677,146 - 156,689,258 (-)NCBI
Rnor_5.05160,425,715 - 160,437,827 (-)NCBI
RGSC_v3.45157,091,181 - 157,103,293 (-)RGD
Celera5148,924,018 - 148,936,130 (-)RGD
Sequence:
Protein RefSeqs NP_001100164 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69047 (Get FASTA)   NCBI Sequence Viewer  
  B5DFG1 (Get FASTA)   NCBI Sequence Viewer  
  EDL80874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058880
  ENSRNOP00000069316.1
RefSeq Acc Id: NP_001100164   ⟸   NM_001106694
- UniProtKB: D3Z9M9 (UniProtKB/TrEMBL),   A6ITH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058880   ⟸   ENSRNOT00000065497
Ensembl Acc Id: ENSRNOP00000069316   ⟸   ENSRNOT00000083474
Ensembl Acc Id: ENSRNOP00000090196   ⟸   ENSRNOT00000100557
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-B5DFG1-F1-model_v2 AlphaFold B5DFG1 1-580 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694189
Promoter ID:EPDNEW_R4713
Type:initiation region
Name:Pink1_1
Description:PTEN induced putative kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,689,283 - 156,689,343EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-39457 BioCyc
Ensembl Genes ENSRNOG00000015385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065497 ENTREZGENE
  ENSRNOT00000083474.2 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MitoQC_Scaffold_Kinases UniProtKB/Swiss-Prot
  PINK1_STKc UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 298575 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Pink1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015385 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ADB8_RAT UniProtKB/TrEMBL
  A6ITH3 ENTREZGENE, UniProtKB/TrEMBL
  B5DFG1 ENTREZGENE
  D3Z9M9 ENTREZGENE, UniProtKB/TrEMBL
  PINK1_RAT UniProtKB/Swiss-Prot
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pink1  PTEN induced putative kinase 1   Pink1_predicted  PTEN induced putative kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pink1_predicted  PTEN induced putative kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED