RGD Reference Report - Parkin and PINK1: much more than mitophagy. - Rat Genome Database

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Parkin and PINK1: much more than mitophagy.

Authors: Scarffe, LA  Stevens, DA  Dawson, VL  Dawson, TM 
Citation: Scarffe LA, etal., Trends Neurosci. 2014 Jun;37(6):315-24. doi: 10.1016/j.tins.2014.03.004. Epub 2014 Apr 13.
RGD ID: 10450527
Pubmed: PMID:24735649   (View Abstract at PubMed)
PMCID: PMC4075431   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tins.2014.03.004   (Journal Full-text)

Parkinson's disease (PD) is a progressive neurodegenerative disease that causes a debilitating movement disorder. Although most cases of PD appear to be sporadic, rare Mendelian forms have provided tremendous insight into disease pathogenesis. Accumulating evidence suggests that impaired mitochondria underpin PD pathology. In support of this theory, data from multiple PD models have linked Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and parkin, two recessive PD genes, in a common pathway impacting mitochondrial health, prompting a flurry of research to identify their mitochondrial targets. Recent work has focused on the role of PINK1 and parkin in mediating mitochondrial autophagy (mitophagy); however, emerging evidence casts parkin and PINK1 as key players in multiple domains of mitochondrial health and quality control.



Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Pink1  (PTEN induced kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)

Genes (Mus musculus)
Pink1  (PTEN induced putative kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)

Genes (Homo sapiens)
PINK1  (PTEN induced kinase 1)
PRKN  (parkin RBR E3 ubiquitin protein ligase)


Additional Information