(-)-selegiline multiple interactions ISO RGD:730938 6480464 Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein] CTD PMID:12880480 (S)-nicotine decreases expression ISO RGD:730938 6480464 Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 1,4-benzoquinone increases expression ISO RGD:730938 6480464 quinone results in increased expression of PRKN mRNA, quinone results in increased expression of PRKN protein CTD PMID:29567065 1,4-benzoquinone multiple interactions ISO RGD:730938 6480464 Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein] more ... CTD PMID:29567065 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:730938 6480464 PRKN protein inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:25447324 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 PRKN protein inhibits the reaction [PINK1 protein affects the susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:22511790 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases response to substance EXP 6480464 PRKN protein results in decreased susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:23643664 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:23643664 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:22342763 , PMID:27566062 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PRKN mRNA CTD PMID:21570461 3-BROMO-7-NITROINDAZOLE multiple interactions EXP 6480464 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein] CTD PMID:23985028 4,4'-sulfonyldiphenol decreases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of PARK2 mRNA CTD PMID:30951980 6-propyl-2-thiouracil increases expression ISO RGD:61797 6480464 Propylthiouracil results in increased expression of PRKN mRNA CTD PMID:24780913 aflatoxin B1 decreases expression ISO RGD:730938 6480464 Aflatoxin B1 results in decreased expression of PRKN mRNA CTD PMID:31555880 aflatoxin B1 affects methylation ISO RGD:730938 6480464 Aflatoxin B1 affects the methylation of PRKN intron CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:730938 6480464 Aflatoxin B1 results in decreased methylation of PRKN gene CTD PMID:27153756 aflatoxin B2 affects methylation ISO RGD:730938 6480464 aflatoxin B2 affects the methylation of PRKN intron CTD PMID:30157460 all-trans-retinoic acid multiple interactions ISO RGD:730938 6480464 Tretinoin affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PRKN protein alternative form] more ... CTD PMID:28688199 ammonium chloride affects expression ISO RGD:61797 6480464 Ammonium Chloride affects the expression of PRKN mRNA CTD PMID:16483693 amphetamine increases response to substance EXP 6480464 PRKN protein results in increased susceptibility to Amphetamine CTD PMID:12915482 amphetamine multiple interactions EXP 6480464 PRKN protein promotes the reaction [Amphetamine results in increased abundance of Dopamine] CTD PMID:12915482 androgen antagonist multiple interactions ISO RGD:61797 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA CTD PMID:25607892 antimycin A multiple interactions ISO RGD:730938 6480464 [oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein more ... CTD PMID:28366621 , PMID:28673964 antirheumatic drug increases expression ISO RGD:730938 6480464 Antirheumatic Agents results in increased expression of PRKN mRNA CTD PMID:24449571 Aroclor 1254 increases expression ISO RGD:61797 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of PRKN protein CTD PMID:16174552 arsane affects methylation ISO RGD:730938 6480464 Arsenic affects the methylation of PRKN gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:730938 6480464 Arsenic affects the methylation of PRKN gene CTD PMID:25304211 arsenous acid affects localization EXP 6480464 Arsenic Trioxide affects the localization of PRKN protein CTD PMID:24801902 arsenous acid decreases expression ISO RGD:61797 6480464 Arsenic Trioxide results in decreased expression of PRKN protein CTD PMID:30551535 arsenous acid multiple interactions ISO RGD:61797 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PRKN protein] CTD PMID:30551535 benzo[a]pyrene decreases expression ISO RGD:730938 6480464 Benzo(a)pyrene results in decreased expression of PRKN mRNA CTD PMID:31555880 benzo[a]pyrene affects methylation ISO RGD:730938 6480464 Benzo(a)pyrene affects the methylation of PRKN intron CTD PMID:30157460 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PRKN mRNA CTD PMID:21569818 benzo[e]pyrene increases methylation ISO RGD:730938 6480464 benzo(e)pyrene results in increased methylation of PRKN intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 bisphenol A multiple interactions ISO RGD:61797 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA more ... CTD PMID:25607892 , PMID:26139607 bisphenol A increases methylation ISO RGD:61797 6480464 bisphenol A results in increased methylation of PRKN gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PARK2 mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:61797 6480464 bisphenol A results in increased expression of PRKN mRNA CTD PMID:26139607 bisphenol A decreases expression ISO RGD:61797 6480464 bisphenol A results in decreased expression of PRKN mRNA CTD PMID:25181051 C60 fullerene decreases expression ISO RGD:61797 6480464 fullerene C60 results in decreased expression of PRKN mRNA CTD PMID:19167457 cadmium atom multiple interactions EXP 6480464 Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] more ... CTD PMID:25464205 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of PRKN CTD PMID:25464205 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of PRKN mRNA, Nanotubes, Carbon results in decreased expression of PRKN mRNA CTD PMID:25554681 , PMID:25620056 carbonyl cyanide p-trifluoromethoxyphenylhydrazone multiple interactions EXP 6480464 PINK1 protein affects the reaction [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein] CTD PMID:24879156 carbonyl cyanide p-trifluoromethoxyphenylhydrazone affects localization EXP 6480464 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone affects the localization of PRKN protein CTD PMID:24879156 carnosic acid multiple interactions ISO RGD:730938 6480464 PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]], salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein] CTD PMID:30707903 CCCP affects localization ISO RGD:61797 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein CTD PMID:24879156 CCCP decreases response to substance EXP 6480464 PRKN protein results in decreased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone CTD PMID:16517603 CCCP increases response to substance EXP 6480464 PRKN gene mutant form results in increased susceptibility to Carbonyl Cyanide m-Chlorophenyl Hydrazone CTD PMID:16517603 CCCP decreases expression ISO RGD:730938 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of PRKN protein CTD PMID:28688199 CCCP affects expression ISO RGD:730938 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the expression of PRKN protein alternative form CTD PMID:28688199 CCCP increases phosphorylation EXP 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein CTD PMID:29660402 CCCP multiple interactions EXP 6480464 1 more ... CTD PMID:22872702 , PMID:24879156 CCCP affects localization EXP 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein CTD PMID:22872702 CCCP affects localization ISO RGD:730938 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein CTD PMID:22872702 more ... CCCP multiple interactions ISO RGD:730938 6480464 [Carbonyl Cyanide m-Chlorophenyl Hydrazone co-treated with PRKN protein] results in increased expression of PINK1 protein more ... CTD PMID:24879156 more ... CCCP increases phosphorylation ISO RGD:61797 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in increased phosphorylation of PRKN protein CTD PMID:24879156 CCCP multiple interactions ISO RGD:61797 6480464 BECN1 protein affects the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] more ... CTD PMID:24879156 chlorpyrifos affects localization ISO RGD:730938 6480464 Chlorpyrifos affects the localization of PRKN protein CTD PMID:26070385 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of PRKN mRNA CTD PMID:29156651 chlorpyrifos multiple interactions ISO RGD:730938 6480464 PRKN protein inhibits the reaction [Chlorpyrifos results in decreased expression of NDUFS3 protein] more ... CTD PMID:26070385 chromium(6+) increases expression ISO RGD:730938 6480464 chromium hexavalent ion results in increased expression of PRKN protein CTD PMID:30715550 cinnarizine decreases response to substance EXP 6480464 PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 cisplatin increases expression ISO RGD:61797 6480464 Cisplatin results in increased expression of PRKN protein CTD PMID:28698153 cisplatin multiple interactions ISO RGD:61797 6480464 Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein] CTD PMID:28698153 curcumin multiple interactions ISO RGD:61797 6480464 Curcumin inhibits the reaction [Cisplatin results in increased expression of PRKN protein] CTD PMID:28698153 cyclosporin A multiple interactions EXP 6480464 Cyclosporine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 cyclosporin A multiple interactions ISO RGD:730938 6480464 Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN mRNA], Cyclosporine inhibits the reaction [quinone results in increased expression of PRKN protein] CTD PMID:29567065 DDE multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 diarsenic trioxide affects localization EXP 6480464 Arsenic Trioxide affects the localization of PRKN protein CTD PMID:24801902 diarsenic trioxide decreases expression ISO RGD:61797 6480464 Arsenic Trioxide results in decreased expression of PRKN protein CTD PMID:30551535 diarsenic trioxide multiple interactions ISO RGD:61797 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PRKN protein] CTD PMID:30551535 diazinon decreases expression ISO RGD:61797 6480464 Diazinon results in decreased expression of PRKN mRNA CTD PMID:21968025 dibutyl phthalate multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 dioxygen multiple interactions EXP 6480464 [Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein more ... CTD PMID:28477916 dopamine multiple interactions ISO RGD:730938 6480464 PRKN protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:15198987 dopamine multiple interactions EXP 6480464 PRKN mutant form results in increased abundance of and results in increased metabolism of Dopamine more ... CTD PMID:12915482 , PMID:15993444 dopamine increases expression ISO RGD:730938 6480464 Dopamine results in increased expression of PRKN mRNA CTD PMID:16987221 doxorubicin increases expression ISO RGD:61797 6480464 Doxorubicin results in increased expression of PRKN protein CTD PMID:26678157 , PMID:29966675 doxorubicin multiple interactions ISO RGD:730938 6480464 3-(2 more ... CTD PMID:29729358 doxorubicin increases expression ISO RGD:730938 6480464 Doxorubicin results in increased expression of PRKN protein CTD PMID:29729358 doxorubicin decreases expression ISO RGD:730938 6480464 Doxorubicin results in decreased expression of PRKN mRNA CTD PMID:29803840 emtricitabine decreases expression ISO RGD:730938 6480464 Emtricitabine results in decreased expression of PRKN protein CTD PMID:31545371 emtricitabine multiple interactions ISO RGD:730938 6480464 [Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein CTD PMID:31545371 enzacamene multiple interactions ISO RGD:61797 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of PRKN mRNA CTD PMID:25607892 epoxiconazole multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 epoxomicin decreases expression ISO RGD:730938 6480464 epoxomicin results in decreased expression of PRKN mRNA CTD PMID:18586549 epoxomicin decreases expression ISO RGD:61797 6480464 epoxomicin results in decreased expression of PRKN mRNA CTD PMID:18586549 epoxomicin multiple interactions ISO RGD:61797 6480464 epoxomicin inhibits the reaction [PRKN protein results in decreased susceptibility to Ceramides] CTD PMID:12588799 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of PRKN protein CTD PMID:25460735 ethanol affects expression EXP 6480464 Ethanol affects the expression of PRKN mRNA CTD PMID:30319688 furan increases methylation ISO RGD:61797 6480464 furan results in increased methylation of PRKN gene CTD PMID:22079235 furosemide multiple interactions ISO RGD:61797 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 Genipin multiple interactions EXP 6480464 genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein], sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 glutathione affects abundance EXP 6480464 PRKN protein affects the abundance of Glutathione CTD PMID:12915482 hydrogen peroxide increases expression ISO RGD:61797 6480464 Hydrogen Peroxide results in increased expression of PRKN mRNA, Hydrogen Peroxide results in increased expression of PRKN protein CTD PMID:25787151 hydrogen peroxide affects localization EXP 6480464 Hydrogen Peroxide affects the localization of PRKN protein CTD PMID:22872702 hydrogen peroxide multiple interactions EXP 6480464 PRKN gene mutant form inhibits the reaction [Hydrogen Peroxide affects the localization of PARK7 protein] CTD PMID:22872702 indole-3-methanol affects expression ISO RGD:61797 6480464 indole-3-carbinol affects the expression of PRKN mRNA CTD PMID:21396975 indometacin multiple interactions EXP 6480464 Indomethacin promotes the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 iodixanol multiple interactions ISO RGD:61797 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of PRKN protein CTD PMID:29860548 ketoconazole increases response to substance ISO RGD:61797 6480464 PRKN protein results in increased susceptibility to Ketoconazole CTD PMID:25787151 ketoconazole increases expression ISO RGD:61797 6480464 Ketoconazole results in increased expression of PRKN mRNA, Ketoconazole results in increased expression of PRKN protein CTD PMID:25787151 ketoconazole multiple interactions ISO RGD:61797 6480464 1 more ... CTD PMID:25787151 lead diacetate multiple interactions EXP 6480464 lead acetate results in increased phosphorylation of and affects the localization of PRKN protein CTD PMID:29660402 lead diacetate affects localization ISO RGD:730938 6480464 lead acetate affects the localization of PRKN protein CTD PMID:29660402 linsidomine increases expression ISO RGD:730938 6480464 linsidomine results in increased expression of PRKN protein CTD PMID:12880480 linsidomine multiple interactions ISO RGD:730938 6480464 Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein] CTD PMID:12880480 linuron multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 maneb multiple interactions EXP 6480464 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein] more ... CTD PMID:22563483 , PMID:23985028 manganese atom decreases expression ISO RGD:61797 6480464 Manganese results in decreased expression of PRKN mRNA CTD PMID:19781568 manganese atom decreases expression ISO RGD:730938 6480464 Manganese results in decreased expression of PRKN mRNA CTD PMID:28826884 manganese atom increases expression ISO RGD:61797 6480464 Manganese results in increased expression of PRKN protein CTD PMID:20798247 manganese atom affects response to substance ISO RGD:730938 6480464 PRKN gene mutant form affects the susceptibility to Manganese CTD PMID:22841634 manganese atom decreases transport ISO RGD:730938 6480464 PRKN protein results in decreased transport of Manganese CTD PMID:20089134 manganese(0) decreases expression ISO RGD:61797 6480464 Manganese results in decreased expression of PRKN mRNA CTD PMID:19781568 manganese(0) decreases expression ISO RGD:730938 6480464 Manganese results in decreased expression of PRKN mRNA CTD PMID:28826884 manganese(0) increases expression ISO RGD:61797 6480464 Manganese results in increased expression of PRKN protein CTD PMID:20798247 manganese(0) affects response to substance ISO RGD:730938 6480464 PRKN gene mutant form affects the susceptibility to Manganese CTD PMID:22841634 manganese(0) decreases transport ISO RGD:730938 6480464 PRKN protein results in decreased transport of Manganese CTD PMID:20089134 manganese(II) chloride increases expression ISO RGD:61797 6480464 manganese chloride results in increased expression of PRKN protein CTD PMID:20798247 manganese(II) chloride decreases expression ISO RGD:730938 6480464 manganese chloride results in decreased expression of PRKN mRNA CTD PMID:27913844 manganese(II) chloride increases methylation ISO RGD:730938 6480464 manganese chloride results in increased methylation of PRKN gene CTD PMID:27913844 manganese(II) chloride decreases expression ISO RGD:61797 6480464 manganese chloride results in decreased expression of PRKN mRNA CTD PMID:20635692 melatonin multiple interactions ISO RGD:61797 6480464 Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 methamphetamine decreases expression ISO RGD:61797 6480464 Methamphetamine results in decreased expression of PRKN protein CTD PMID:28661099 , PMID:31059759 methamphetamine multiple interactions ISO RGD:730938 6480464 CEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein] more ... CTD PMID:31059759 methamphetamine decreases expression ISO RGD:730938 6480464 Methamphetamine results in decreased expression of PRKN protein CTD PMID:31059759 methamphetamine multiple interactions ISO RGD:61797 6480464 CEBPB protein affects the reaction [Methamphetamine results in decreased expression of PRKN protein] CTD PMID:31059759 methapyrilene increases methylation ISO RGD:730938 6480464 Methapyrilene results in increased methylation of PRKN intron CTD PMID:30157460 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of PRKN mRNA CTD PMID:20061341 miconazole increases expression ISO RGD:61797 6480464 Miconazole results in increased expression of PRKN mRNA CTD PMID:22262564 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 N-acetyl-L-cysteine multiple interactions ISO RGD:730938 6480464 Acetylcysteine inhibits the reaction [quinone results in increased expression of PRKN protein] CTD PMID:29567065 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium results in increased expression of PRKN], Acetylcysteine inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone affects the localization of PRKN protein] CTD PMID:22872702 , PMID:25464205 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:730938 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Sorafenib co-treated with PRKN protein] results in decreased expression of MCL1 protein] more ... CTD PMID:20089134 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal affects expression ISO RGD:730938 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the expression of PRKN protein alternative form CTD PMID:28688199 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:730938 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN protein CTD PMID:28688199 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal decreases expression ISO RGD:61797 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PRKN mRNA CTD PMID:18586549 N-methyl-4-phenylpyridinium increases expression ISO RGD:730938 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PRKN mRNA CTD PMID:16987221 N-methyl-4-phenylpyridinium decreases expression ISO RGD:730938 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PRKN protein CTD PMID:28688199 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:730938 6480464 Tretinoin affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PRKN protein alternative form] CTD PMID:28688199 N-methyl-4-phenylpyridinium affects expression ISO RGD:730938 6480464 1-Methyl-4-phenylpyridinium affects the expression of PRKN protein alternative form CTD PMID:28688199 N-methyl-4-phenylpyridinium affects localization EXP 6480464 1-Methyl-4-phenylpyridinium affects the localization of PRKN protein CTD PMID:22872702 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PRKN mRNA CTD PMID:26558463 nicotine decreases expression ISO RGD:730938 6480464 Nicotine results in decreased expression of PRKN mRNA CTD PMID:16949557 O-acetyl-L-carnitine multiple interactions EXP 6480464 Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 oligomycin A multiple interactions ISO RGD:730938 6480464 [oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein, PINK1 protein affects the reaction [[oligomycin A co-treated with Antimycin A] affects the localization of PRKN protein] CTD PMID:28366621 oxidopamine decreases reaction ISO RGD:730938 6480464 PRKN protein inhibits the reaction Oxidopamine CTD PMID:15198987 oxidopamine multiple interactions ISO RGD:730938 6480464 PINK1 protein affects the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of PRKN protein]] more ... CTD PMID:28688199 , PMID:30707903 oxidopamine decreases expression ISO RGD:730938 6480464 Oxidopamine results in decreased expression of PRKN protein CTD PMID:28688199 , PMID:30707903 oxidopamine affects expression ISO RGD:730938 6480464 Oxidopamine affects the expression of PRKN protein alternative form CTD PMID:28688199 oxidopamine multiple interactions EXP 6480464 PRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein] CTD PMID:16914382 oxidopamine multiple interactions ISO RGD:61797 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] more ... CTD PMID:25129099 oxidopamine increases expression ISO RGD:61797 6480464 Oxidopamine results in increased expression of PRKN mRNA CTD PMID:25129099 paracetamol multiple interactions ISO RGD:61797 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PRKN mRNA CTD PMID:25607892 paracetamol multiple interactions EXP 6480464 [Acetaminophen co-treated with PRKN gene mutant form] results in decreased phosphorylation of GYS1 protein more ... CTD PMID:25752611 paracetamol decreases response to substance EXP 6480464 PRKN gene mutant form results in decreased susceptibility to Acetaminophen CTD PMID:25752611 paracetamol affects localization EXP 6480464 Acetaminophen affects the localization of PRKN protein CTD PMID:25752611 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of PRKN mRNA CTD PMID:22563483 paraquat multiple interactions ISO RGD:730938 6480464 Paraquat results in increased expression of and affects the localization of PRKN protein more ... CTD PMID:30144575 paraquat multiple interactions EXP 6480464 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein] more ... CTD PMID:22563483 , PMID:23985028 prochloraz multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 procymidone multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892 quercetin 3-O-beta-D-glucofuranoside multiple interactions ISO RGD:61797 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 quercetin 3-O-beta-D-glucopyranoside multiple interactions ISO RGD:61797 6480464 isoquercitrin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 reactive oxygen species decreases abundance ISO RGD:730938 6480464 PRKN protein results in decreased abundance of Reactive Oxygen Species CTD PMID:15198987 reactive oxygen species multiple interactions ISO RGD:730938 6480464 PRKN protein inhibits the reaction [Dopamine results in increased abundance of Reactive Oxygen Species] CTD PMID:15198987 resveratrol multiple interactions ISO RGD:730938 6480464 PRKN gene mutant form affects the reaction [resveratrol results in increased expression of COX1 mRNA] more ... CTD PMID:24582596 rotenone multiple interactions ISO RGD:730938 6480464 PRKN protein inhibits the reaction [LRRK2 gene polymorphism results in increased susceptibility to Rotenone] CTD PMID:19741132 rotenone affects localization EXP 6480464 Rotenone affects the localization of PRKN protein CTD PMID:22872702 rotenone multiple interactions EXP 6480464 Indomethacin promotes the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone], Minocycline inhibits the reaction [PRKN gene mutant form results in increased susceptibility to Rotenone] CTD PMID:16573651 rotenone decreases response to substance EXP 6480464 PRKN protein results in decreased susceptibility to Rotenone CTD PMID:16517603 rotenone increases response to substance EXP 6480464 PRKN gene mutant form results in increased susceptibility to Rotenone CTD PMID:16517603 , PMID:16573651 rotenone affects response to substance ISO RGD:730938 6480464 PRKN protein affects the susceptibility to Rotenone CTD PMID:20940149 rotenone decreases response to substance ISO RGD:730938 6480464 PRKN protein results in decreased susceptibility to Rotenone CTD PMID:17687034 , PMID:19741132 rotenone increases response to substance ISO RGD:730938 6480464 PRKN gene mutant form results in increased susceptibility to Rotenone CTD PMID:17687034 rutin multiple interactions ISO RGD:61797 6480464 Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA] CTD PMID:25129099 S-nitrosoglutathione multiple interactions ISO RGD:730938 6480464 [S-Nitrosoglutathione results in increased nitrosation of PRKN protein] inhibits the reaction [PRKN protein binds to TP53 promoter] more ... CTD PMID:23985028 silicon dioxide decreases expression ISO RGD:61797 6480464 Silicon Dioxide analog results in decreased expression of PRKN protein CTD PMID:27613482 sirtinol multiple interactions EXP 6480464 sirtinol inhibits the reaction [genipin inhibits the reaction [[Blood Glucose deficiency co-treated with Oxygen deficiency] results in decreased expression of PRKN protein]] CTD PMID:28477916 sodium arsenite affects methylation ISO RGD:730938 6480464 sodium arsenite affects the methylation of PRKN gene CTD PMID:28589171 sodium arsenite decreases expression ISO RGD:61797 6480464 sodium arsenite results in decreased expression of PRKN protein CTD PMID:30551535 sorafenib increases ubiquitination ISO RGD:730938 6480464 sorafenib results in increased ubiquitination of PRKN protein CTD PMID:28673964 sorafenib increases ubiquitination EXP 6480464 sorafenib results in increased ubiquitination of PRKN protein CTD PMID:28673964 sorafenib affects response to substance EXP 6480464 PRKN protein affects the susceptibility to sorafenib CTD PMID:28673964 sorafenib multiple interactions ISO RGD:730938 6480464 [sorafenib co-treated with PRKN protein] results in decreased expression of CASP3 protein more ... CTD PMID:28673964 sorafenib affects localization ISO RGD:730938 6480464 sorafenib affects the localization of PRKN protein CTD PMID:28673964 sunitinib increases expression ISO RGD:730938 6480464 Sunitinib results in increased expression of PRKN mRNA CTD PMID:31533062 T-2 Toxin increases expression ISO RGD:61797 6480464 T-2 Toxin results in increased expression of PRKN mRNA, T-2 Toxin results in increased expression of PRKN protein CTD PMID:29870751 taurine multiple interactions ISO RGD:61797 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased expression of PRKN protein] CTD PMID:30551535 tenofovir disoproxil fumarate multiple interactions ISO RGD:730938 6480464 [Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein CTD PMID:31545371 tetrachloromethane multiple interactions ISO RGD:61797 6480464 Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 tetrachloromethane decreases expression ISO RGD:61797 6480464 Carbon Tetrachloride results in decreased expression of PRKN protein CTD PMID:26882442 thioacetamide decreases expression ISO RGD:61797 6480464 Thioacetamide results in decreased expression of PRKN mRNA CTD PMID:23411599 Tiron multiple interactions ISO RGD:61797 6480464 1 more ... CTD PMID:25787151 Tiron multiple interactions EXP 6480464 1 more ... CTD PMID:22872702 titanium dioxide increases expression ISO RGD:730938 6480464 titanium dioxide results in increased expression of PRKN mRNA CTD PMID:30273564 trifloxystrobin increases expression ISO RGD:730938 6480464 trifloxystrobin results in increased expression of PRKN protein CTD PMID:27853101 trifloxystrobin multiple interactions ISO RGD:730938 6480464 MitoTEMPO inhibits the reaction [trifloxystrobin results in increased expression of PRKN protein] CTD PMID:27853101 trifluoperazine affects localization ISO RGD:730938 6480464 Trifluoperazine affects the localization of PRKN protein CTD PMID:28366621 trifluoperazine multiple interactions ISO RGD:730938 6480464 PRKN protein affects the reaction [Trifluoperazine affects the localization of PRKN protein] CTD PMID:28366621 trimellitic anhydride decreases expression EXP 6480464 trimellitic anhydride results in decreased expression of PRKN mRNA CTD PMID:19042947 tubocurarine decreases expression ISO RGD:730938 6480464 Tubocurarine results in decreased expression of PRKN mRNA CTD PMID:16949557 valproic acid decreases methylation ISO RGD:730938 6480464 Valproic Acid results in decreased methylation of PRKN gene CTD PMID:29154799 vinclozolin multiple interactions ISO RGD:61797 6480464 [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PRKN mRNA CTD PMID:25607892
Biological Process adult locomotory behavior IMP MGI:MGI:2678247 2290270 (MGI:MGI:3778106, PMID:18346797) MGI MGI:MGI:3778106 , PMID:18346797 aggresome assembly ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 autophagy IEA UniProtKB-KW:KW-0072 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 autophagy of mitochondrion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 autophagy of mitochondrion IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 autophagy of mitochondrion ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular protein catabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cellular protein catabolic process IMP 2290270 (MGI:MGI:4948386, PMID:21376232) ParkinsonsUK-UCL MGI:MGI:4948386 , PMID:21376232 cellular response to hydrogen sulfide ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular response to L-glutamate ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cellular response to toxic substance ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cellular response to toxic substance IDA 2290270 (MGI:MGI:5582177, PMID:12628165) ParkinsonsUK-UCL MGI:MGI:5582177 , PMID:12628165 dopamine metabolic process IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710, PMID:12915482) MGI MGI:MGI:2675710 , PMID:12915482 dopamine metabolic process NOT IMP MGI:MGI:3055212 2290270 (MGI:MGI:3525458, PMID:15684050) MGI MGI:MGI:3525458 , PMID:15684050 dopamine uptake involved in synaptic transmission IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710, PMID:12915482) MGI MGI:MGI:2675710 , PMID:12915482 free ubiquitin chain polymerization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 learning IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710, PMID:12915482) MGI MGI:MGI:2675710 , PMID:12915482 learning NOT IMP MGI:MGI:3055212 2290270 (MGI:MGI:3525458, PMID:15684050) MGI MGI:MGI:3525458 , PMID:15684050 locomotory behavior IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710 more ... MGI MGI:MGI:2675710 more ... locomotory behavior NOT IMP MGI:MGI:3055212 2290270 (MGI:MGI:3525458, PMID:15684050) MGI MGI:MGI:3525458 , PMID:15684050 locomotory behavior IMP MGI:MGI:2681404 2290270 (MGI:MGI:2679747, PMID:12930822) MGI MGI:MGI:2679747 , PMID:12930822 mitochondrial fragmentation involved in apoptotic process ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion localization ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion to lysosome transport ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitophagy IGI MGI:MGI:1921624 2290270 (MGI:MGI:5603233, PMID:24949970) MGI MGI:MGI:5603233 , PMID:24949970 modulation of chemical synaptic transmission IMP MGI:MGI:2681404 2290270 (MGI:MGI:2679747, PMID:12930822) MGI MGI:MGI:2679747 , PMID:12930822 negative regulation by host of viral genome replication ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of actin filament bundle assembly ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of canonical Wnt signaling pathway ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of cell death ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP 2290270 (MGI:MGI:5433837, PMID:21113145) ParkinsonsUK-UCL MGI:MGI:5433837 , PMID:21113145 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP 2290270 (MGI:MGI:5495588, PMID:23453807) ParkinsonsUK-UCL MGI:MGI:5495588 , PMID:23453807 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI UniProtKB:O15354 2290270 (MGI:MGI:3697528, PMID:17116640) ParkinsonsUK-UCL MGI:MGI:3697528 , PMID:17116640 negative regulation of excitatory postsynaptic potential ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of exosomal secretion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of gene expression ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of glucokinase activity ISO UniProtKB:O60260 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 negative regulation of insulin secretion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 negative regulation of intralumenal vesicle formation ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of mitochondrial fission ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of neuron apoptotic process ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of neuron apoptotic process IMP 2290270 (MGI:MGI:4365473 more ... ParkinsonsUK-UCL MGI:MGI:4365473 more ... negative regulation of neuron apoptotic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of neuron death ISO UniProtKB:Q9JK66 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 negative regulation of neuron death IMP 2290270 (MGI:MGI:4948386, PMID:21376232) ParkinsonsUK-UCL MGI:MGI:4948386 , PMID:21376232 negative regulation of neuron death ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of oxidative stress-induced neuron death ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP 2290270 (MGI:MGI:5543313, PMID:23858059) ParkinsonsUK-UCL MGI:MGI:5543313 , PMID:23858059 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of primary amine oxidase activity ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of protein phosphorylation ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of protein phosphorylation IBA PANTHER:PTN000188399 , UniProtKB:O60260 2290270 (PMID:21873635) GO_Central PMID:21873635 negative regulation of reactive oxygen species biosynthetic process ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of reactive oxygen species metabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of release of cytochrome c from mitochondria ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of spontaneous neurotransmitter secretion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 negative regulation of synaptic transmission, glutamatergic ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of transcription by RNA polymerase II ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 norepinephrine metabolic process IMP MGI:MGI:3050230 2290270 (MGI:MGI:3047192, PMID:15249681) MGI MGI:MGI:3047192 , PMID:15249681 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of apoptotic process ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of ATP biosynthetic process ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of autophagy of mitochondrion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of dendrite extension IGI UniProtKB:Q8VCM5 2290270 (MGI:MGI:5619681, PMID:24898855) ParkinsonsUK-UCL MGI:MGI:5619681 , PMID:24898855 positive regulation of DNA binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of gene expression ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of mitochondrial fusion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of mitochondrial membrane potential ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of mitophagy ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of mitophagy in response to mitochondrial depolarization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of neurotransmitter uptake ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of proteasomal protein catabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 2290270 (MGI:MGI:5543313, PMID:23858059) ParkinsonsUK-UCL MGI:MGI:5543313 , PMID:23858059 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA MGI:MGI:1355296 , PANTHER:PTN000188395 2290270 (PMID:21873635) GO_Central PMID:21873635 positive regulation of protein binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of protein linear polyubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of protein linear polyubiquitination IMP 2290270 (MGI:MGI:5495588, PMID:23453807) ParkinsonsUK-UCL MGI:MGI:5495588 , PMID:23453807 positive regulation of protein localization to membrane ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of transcription by RNA polymerase II ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of tumor necrosis factor-mediated signaling pathway ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 proteasomal protein catabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 proteasome-mediated ubiquitin-dependent protein catabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein autoubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein destabilization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein destabilization IMP 2290270 (MGI:MGI:4365473, PMID:19591802) ParkinsonsUK-UCL MGI:MGI:4365473 , PMID:19591802 protein K11-linked ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein K48-linked ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein K6-linked ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein K63-linked ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein localization to mitochondrion ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein localization to mitochondrion IMP 2290270 (MGI:MGI:5543313, PMID:23858059) ParkinsonsUK-UCL MGI:MGI:5543313 , PMID:23858059 protein metabolic process IMP MGI:MGI:2681404 2290270 (MGI:MGI:3040561, PMID:14985362) MGI MGI:MGI:3040561 , PMID:14985362 protein monoubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein polyubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein polyubiquitination IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein stabilization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein ubiquitination ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of apoptotic process IBA PANTHER:PTN000188399 , ZFIN:ZDB-GENE-050417-109 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of autophagy ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of cellular response to oxidative stress ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of cellular response to oxidative stress IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of dopamine metabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of gene expression ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 regulation of mitochondrial membrane potential IGI UniProtKB:Q8VCM5 2290270 (MGI:MGI:5619681, PMID:24898855) ParkinsonsUK-UCL MGI:MGI:5619681 , PMID:24898855 regulation of mitochondrion organization ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of mitochondrion organization IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 regulation of neurotransmitter secretion IMP MGI:MGI:2681404 2290270 (MGI:MGI:2679747, PMID:12930822) MGI MGI:MGI:2679747 , PMID:12930822 regulation of protein stability ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of protein ubiquitination ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of reactive oxygen species metabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to endoplasmic reticulum stress ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 response to endoplasmic reticulum stress IMP 2290270 (MGI:MGI:5433837, PMID:21113145) ParkinsonsUK-UCL MGI:MGI:5433837 , PMID:21113145 startle response IMP MGI:MGI:3050230 2290270 (MGI:MGI:3047192, PMID:15249681) MGI MGI:MGI:3047192 , PMID:15249681 synaptic transmission, dopaminergic IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710, PMID:12915482) MGI MGI:MGI:2675710 , PMID:12915482 synaptic transmission, glutamatergic IMP MGI:MGI:2678247 2290270 (MGI:MGI:2675710, PMID:12915482) MGI MGI:MGI:2675710 , PMID:12915482 ubiquitin-dependent protein catabolic process ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin-dependent protein catabolic process IBA FB:FBgn0017418 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Cellular Component aggresome ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 axon ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cell junction IEA UniProtKB-KW:KW-0965 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cell projection IEA UniProtKB-KW:KW-0966 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 cytoplasm IDA 2290270 (MGI:MGI:5554965, PMID:24187134) MGI MGI:MGI:5554965 , PMID:24187134 cytoplasm IBA FB:FBgn0017418 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytoplasm ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytoplasm ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cytoplasmic vesicle ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytosol ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 cytosol IBA PANTHER:PTN000188399 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytosol ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 endoplasmic reticulum ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 endoplasmic reticulum IBA PANTHER:PTN000188399 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 endoplasmic reticulum ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 endoplasmic reticulum membrane ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Golgi apparatus ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Golgi apparatus IBA PANTHER:PTN000188399 , UniProtKB:O60260 2290270 (PMID:21873635) GO_Central PMID:21873635 Golgi membrane ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 intracellular vesicle ISO RGD:61797 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 membrane raft ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion colocalizes_with ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion IBA FB:FBgn0041100 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 mitochondrion IDA 2290270 (MGI:MGI:5543313, PMID:23858059) ParkinsonsUK-UCL MGI:MGI:5543313 , PMID:23858059 mitochondrion ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 mitochondrion ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrion colocalizes_with ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 mitochondrion-derived vesicle colocalizes_with ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 neuron projection IDA 2290270 (MGI:MGI:2154577, PMID:11675120) MGI MGI:MGI:2154577 , PMID:11675120 neuron projection ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 neuron projection ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 neuronal cell body ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nuclear speck ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 nucleus IDA 2290270 (MGI:MGI:5554965, PMID:24187134) MGI MGI:MGI:5554965 , PMID:24187134 nucleus ISO RGD:61797 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 nucleus ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 perinuclear region of cytoplasm ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 perinuclear region of cytoplasm ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 postsynaptic density ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 postsynaptic membrane IEA UniProtKB-KW:KW-0628 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 presynapse ISO RGD:61797 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 protein-containing complex IDA 2290270 (MGI:MGI:3775364, PMID:18190519) MGI MGI:MGI:3775364 , PMID:18190519 synapse ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 synaptic vesicle membrane ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 terminal bouton ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 ubiquitin ligase complex ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin ligase complex IBA PANTHER:PTN000188395 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 Molecular Function actin binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 beta-catenin binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chaperone binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 cullin family protein binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 DNA-binding transcription repressor activity, RNA polymerase II-specific ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 enzyme binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 F-box domain binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 G protein-coupled receptor binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 heat shock protein binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 histone deacetylase binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 Hsp70 protein binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 identical protein binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 kinase binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 PDZ domain binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 phospholipase binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein binding IPI UniProtKB:P68510 2290270 (MGI:MGI:3611990, PMID:16096643) IntAct MGI:MGI:3611990 , PMID:16096643 protein binding IPI UniProtKB:Q8K1M6 , UniProtKB:Q9WUA5 2290270 (MGI:MGI:6142037, PMID:28063983) MGI MGI:MGI:6142037 , PMID:28063983 protein binding IPI UniProtKB:Q3U133 2290270 (MGI:MGI:4948386, PMID:21376232) UniProtKB MGI:MGI:4948386 , PMID:21376232 protein binding IPI UniProtKB:Q6IQX7-2 2290270 (MGI:MGI:5306701, PMID:22082830) IntAct MGI:MGI:5306701 , PMID:22082830 protein binding IPI UniProtKB:Q9ERU9 2290270 (MGI:MGI:3694289, PMID:16332688) IntAct MGI:MGI:3694289 , PMID:16332688 protein binding IPI UniProtKB:Q969H0 2290270 (MGI:MGI:5582177, PMID:12628165) ParkinsonsUK-UCL MGI:MGI:5582177 , PMID:12628165 protein binding IPI UniProtKB:Q9DAK2 2290270 (MGI:MGI:5586802, PMID:14532270) ParkinsonsUK-UCL MGI:MGI:5586802 , PMID:14532270 protein binding IPI UniProtKB:Q62420 2290270 (MGI:MGI:4421462, PMID:20064468) MGI MGI:MGI:4421462 , PMID:20064468 protein kinase binding ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein kinase binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein-containing complex binding ISO RGD:61797 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein-containing complex binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transcription regulatory region sequence-specific DNA binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 tubulin binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin conjugating enzyme binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin conjugating enzyme binding IBA FB:FBgn0017418 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin protein ligase activity ISO UniProtKB:O60260 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 ubiquitin protein ligase activity IDA 2290270 (MGI:MGI:4421462 more ... MGI MGI:MGI:4421462 more ... ubiquitin protein ligase activity IBA FB:FBgn0017418 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin protein ligase binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin-protein transferase activity ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin-specific protease binding ISO UniProtKB:O60260 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Gene-Chemical Interaction Annotations
