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Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Mus musculus
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Description: Exhibits ubiquitin protein ligase activity. Involved in several processes, including catecholamine metabolic process; chemical synaptic transmission; and negative regulation of intrinsic apoptotic signaling pathway. Localizes to several cellular components, including the mitochondrion; neuron projection; and nucleus. Predicted to colocalize with the mitochondrion-derived vesicle. Used to study Parkinson's disease 2. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Is expressed in several structures, including face; nervous system; pancreas; sensory organ; and skeleton. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; 3-BROMO-7-NITROINDAZOLE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 ubiquitin-protein ligase parkin; MGC130518; Park2; parkin protein; parkin RBR E3 ubiquitin-protein ligase; Parkinson disease (autosomal recessive, juvenile) 2, parkin
Homo sapiens (human) : PRKN (parkin RBR E3 ubiquitin protein ligase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prkn (parkin RBR E3 ubiquitin protein ligase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Sus scrofa (pig) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Chlorocebus sabaeus (green monkey) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Heterocephalus glaber (naked mole-rat) : Prkn (parkin RBR E3 ubiquitin protein ligase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1710,840,384 - 12,063,361 (+)Ensembl
GRCm381710,840,359 - 12,063,370 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371711,033,250 - 12,256,227 (+)NCBIGRCm37mm9NCBIm37
MGSCv361710,683,742 - 11,906,719 (+)NCBImm8
Celera1710,880,667 - 12,092,859 (+)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Prkn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62089
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.