Pink1 (PTEN induced kinase 1) - Rat Genome Database

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Gene: Pink1 (PTEN induced kinase 1) Heterocephalus glaber
Analyze
Symbol: Pink1
Name: PTEN induced kinase 1
RGD ID: 18936904
Description: ENCODES a protein that exhibits ATP binding (ortholog); C3HC4-type RING finger domain binding (ortholog); kinase activity (ortholog); INVOLVED IN autophagy of mitochondrion (ortholog); catecholamine secretion (ortholog); cellular response to hydrogen sulfide (ortholog); PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondria dynamics pathway; mitochondrial autophagy pathway; ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); cognitive disorder (ortholog); congenital disorder of glycosylation (ortholog); FOUND IN astrocyte projection (ortholog); axon (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: PTEN induced putative kinase 1; serine/threonine-protein kinase PINK1, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,656,229 - 5,671,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,656,207 - 5,671,260 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy of mitochondrion  (ISO)
catecholamine secretion  (ISO)
cellular response to hydrogen sulfide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to toxic substance  (ISO)
dopamine secretion  (ISO)
establishment of localization in cell  (ISO)
establishment of protein localization to mitochondrion  (ISO)
hemopoiesis  (ISO)
intracellular signal transduction  (ISO)
maintenance of protein location in mitochondrion  (ISO)
mitochondrial fission  (ISO)
mitochondrion organization  (ISO)
mitochondrion to lysosome vesicle-mediated transport  (ISO)
mitophagy  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagosome assembly  (ISO)
negative regulation of cellular process  (ISO)
negative regulation of fatty acid beta-oxidation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide  (ISO)
negative regulation of macroautophagy  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of mitophagy  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
obsolete positive regulation of mitophagy in response to mitochondrial depolarization  (ISO)
obsolete positive regulation of protein dephosphorylation  (ISO)
peptidyl-serine autophosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of catecholamine secretion  (ISO)
positive regulation of cristae formation  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine secretion  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of NMDA glutamate receptor activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic transmission, dopaminergic  (ISO)
positive regulation of translation  (ISO)
protein phosphorylation  (ISO)
protein stabilization  (ISO)
protein ubiquitination  (ISO)
regulation of cellular response to oxidative stress  (ISO)
regulation of hydrogen peroxide metabolic process  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of oxidative phosphorylation  (ISO)
regulation of protein targeting to mitochondrion  (ISO)
regulation of protein ubiquitination  (ISO)
regulation of protein-containing complex assembly  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
respiratory electron transport chain  (ISO)
response to ischemia  (ISO)
response to oxidative stress  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pink1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,656,229 - 5,671,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,656,207 - 5,671,260 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PINK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,633,458 - 20,651,511 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,633,458 - 20,651,511 (+)EnsemblGRCh38hg38GRCh38
GRCh37120,959,951 - 20,978,004 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,832,535 - 20,850,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 34120,705,253 - 20,723,309NCBI
Celera119,284,119 - 19,302,182 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef119,206,074 - 19,224,136 (+)NCBIHuRef
CHM1_1121,070,747 - 21,088,823 (+)NCBICHM1_1
T2T-CHM13v2.0120,459,649 - 20,477,706 (+)NCBIT2T-CHM13v2.0
Pink1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,040,718 - 138,053,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,040,720 - 138,053,618 (-)EnsemblGRCm39 Ensembl
GRCm384138,313,409 - 138,326,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,313,409 - 138,326,307 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,869,324 - 137,882,211 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,585,488 - 137,598,347 (-)NCBIMGSCv36mm8
Celera4140,093,554 - 140,110,379 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.14NCBI
Pink1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,813,838 - 155,825,950 (-)NCBIGRCr8
mRatBN7.25150,530,523 - 150,542,635 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5150,530,523 - 150,542,635 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,226,264 - 153,238,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,000,550 - 155,012,551 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,982,571 - 154,994,572 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,677,146 - 156,689,258 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,677,146 - 156,689,415 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,425,715 - 160,437,827 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,091,181 - 157,103,293 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,100,712 - 157,113,336 (-)NCBI
Celera5148,924,018 - 148,936,130 (-)NCBICelera
Cytogenetic Map5q36NCBI
Pink1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,171,205 - 1,185,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,171,115 - 1,186,338 (+)NCBIChiLan1.0ChiLan1.0
PINK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,472,787 - 206,490,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11205,585,116 - 205,603,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,583,330 - 19,601,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,627,364 - 20,646,377 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,627,693 - 20,645,560 (+)Ensemblpanpan1.1panPan2
PINK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,276,091 - 78,293,761 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,277,077 - 78,294,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,790,397 - 74,808,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,842,969 - 78,861,096 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,842,996 - 78,861,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1275,661,680 - 75,679,782 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,673,498 - 76,691,638 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,677,116 - 77,695,256 (-)NCBIUU_Cfam_GSD_1.0
Pink1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,749,706 - 40,764,701 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,573,623 - 6,589,478 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,574,471 - 6,589,478 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PINK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,863,190 - 78,884,640 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,863,195 - 78,884,663 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2673,117,387 - 73,128,340 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PINK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,902,135 - 111,919,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,902,765 - 111,919,069 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660334,316,686 - 4,333,643 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004850472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01044635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000026981   ⟹   ENSHGLP00000026743
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247645,656,229 - 5,671,260 (+)Ensembl
RefSeq Acc Id: XM_004850472   ⟹   XP_004850529
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247645,656,207 - 5,671,260 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004850529 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026743
RefSeq Acc Id: XP_004850529   ⟸   XM_004850472
Ensembl Acc Id: ENSHGLP00000026743   ⟸   ENSHGLT00000026981


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019022 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026981 ENTREZGENE
NCBI Gene Pink1 ENTREZGENE