Alpl (alkaline phosphatase, biomineralization associated) - Rat Genome Database

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Gene: Alpl (alkaline phosphatase, biomineralization associated) Rattus norvegicus
Analyze
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
RGD ID: 2100
Description: Exhibits alkaline phosphatase activity. Involved in cementum mineralization; response to glucocorticoid; and response to lipopolysaccharide. Localizes to extracellular space and plasma membrane. Biomarker of uremia. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; folate metabolic pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Akp2; alkaline phosphatase 2 liver; alkaline phosphatase 2, liver; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific; alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; MGC93545; PHOA; tissue-nonspecific alkaline phosphatase; tissue-nonspecific ALP alkaline phosphatase; TNSALP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,951,397 - 150,006,424 (-)NCBI
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,3-dinitrobenzene  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
acephate  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
Actein  (ISO)
aflatoxin B1  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldosterone  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (EXP)
apocynin  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
ATP  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcidiol  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
calcium dihydroxide  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chitosan  (ISO)
chloramphenicol  (ISO)
chlorpyrifos  (ISO)
chromium atom  (EXP)
chromium(3+) trichloride  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dimethoate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP)
enalapril  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
eugenol  (ISO)
Falecalcitriol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP,ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallocatechin  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (EXP)
hexane  (EXP)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
icariside II  (EXP)
indinavir  (ISO)
indometacin  (ISO)
isoproturon  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
levamisole  (ISO)
levonorgestrel  (ISO)
lithocholic acid  (ISO)
melatonin  (ISO)
menadione  (ISO)
menaquinone  (EXP)
menatetrenone  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP,ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myricitrin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naphthalene  (ISO)
nebivolol  (EXP)
niclosamide  (ISO)
Nonylphenol  (ISO)
orphenadrine  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP,ISO)
phenobarbital  (ISO)
phenol  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
procaine  (ISO)
progesterone  (ISO)
pyridoxal 5'-phosphate  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
resveratrol  (EXP)
Salidroside  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium cholate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (ISO)
spironolactone  (ISO)
sulindac  (ISO)
tamoxifen  (ISO)
terbutylazine  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triflumizole  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (EXP)
warfarin  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abbink EJ, etal., J Intern Med. 2006 Jan;259(1):107-16.
2. Fiore CE, etal., Atherosclerosis. 2006 Sep 28;.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Greenberg CR, etal., Genomics. 1993 Jul;17(1):215-7.
5. Hanley AJ, etal., Diabetes. 2005 Nov;54(11):3140-7.
6. Harada T, etal., Cell Tissue Res. 2002 Jan;307(1):69-77. Epub 2001 Oct 30.
7. KEGG
8. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Li Y, etal., J Med Dent Sci. 2008 Sep;55(3-4):255-65.
10. Lomashvili KA, etal., Kidney Int. 2008 May;73(9):1024-30. Epub 2008 Feb 20.
11. Lu LS, etal., Liver Int. 2007 May;27(4):529-37.
12. MGD data from the GO Consortium
13. Nair BC, etal., Arch Biochem Biophys. 1987 Apr;254(1):18-27.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Pipeline to import SMPDB annotations from SMPDB into RGD
18. RGD automated data pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. RGD comprehensive gene curation
22. Roelofs H, etal., J Pathol. 1999 Oct;189(2):236-44.
23. Stratopoulos C, etal., Obes Surg. 2005 Sep;15(8):1154-60.
24. Thiede MA, etal., Proc Natl Acad Sci U S A 1988 Jan;85(2):319-23.
25. Yamamoto T, etal., Histochem Cell Biol. 2007 Mar;127(3):303-11. Epub 2006 Oct 17.
26. Zernik J, etal., Biochem Biophys Res Commun. 1991 May 15;176(3):1149-56.
Additional References at PubMed
PMID:2133555   PMID:2544423   PMID:2834351   PMID:2895632   PMID:3484182   PMID:7533563   PMID:10787428   PMID:12477932   PMID:15489334   PMID:15728361   PMID:16210410   PMID:17023519  
PMID:17540358   PMID:18031938   PMID:19056867   PMID:19084045   PMID:19451200   PMID:19874193   PMID:19931660   PMID:20684022   PMID:21191615   PMID:21418901   PMID:21636885   PMID:22206666  
PMID:23376485   PMID:23533145   PMID:24888842   PMID:24894822   PMID:25411053   PMID:27590577   PMID:27885436   PMID:31969558  


Genomics

Comparative Map Data
Alpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,951,397 - 150,006,424 (-)NCBI
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
ALPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl121,509,397 - 21,578,410 (+)EnsemblGRCh38hg38GRCh38
GRCh38121,508,984 - 21,578,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37121,835,477 - 21,904,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,708,445 - 21,777,492 (+)NCBINCBI36hg18NCBI36
Build 34121,581,174 - 21,650,208NCBI
Celera120,158,568 - 20,227,624 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,079,620 - 20,148,672 (+)NCBIHuRef
CHM1_1121,947,884 - 22,016,920 (+)NCBICHM1_1
Alpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,469,042 - 137,523,695 (-)NCBIGRCm39mm39
GRCm39 Ensembl4137,469,044 - 137,523,695 (-)Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,741,733 - 137,796,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBImm8
Celera4135,949,159 - 136,007,413 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
Alpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,820,174 - 1,874,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,820,212 - 1,873,877 (+)NCBIChiLan1.0ChiLan1.0
ALPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1121,667,732 - 21,736,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,667,732 - 21,736,688 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0120,702,509 - 20,772,301 (+)NCBIMhudiblu_PPA_v0panPan3
ALPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBI
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBI
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBI
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBI
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBI
Alpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,362,174 - 41,405,120 (+)NCBI
SpeTri2.0NW_0049364747,209,196 - 7,229,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,588,659 - 79,649,648 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALPL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,055,583 - 111,124,143 (-)NCBI
ChlSab1.1 Ensembl20111,055,558 - 111,081,850 (-)Ensembl
Vero_WHO_p1.0NW_0236660335,163,162 - 5,231,388 (+)NCBI
Alpl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBI

Position Markers
RH139790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,938,708 - 149,938,927 (+)MAPPER
Rnor_6.05156,073,805 - 156,074,023NCBIRnor6.0
Rnor_5.05159,829,320 - 159,829,538UniSTSRnor5.0
RGSC_v3.45156,538,159 - 156,538,377UniSTSRGSC3.4
RGSC_v3.45156,489,046 - 156,489,264UniSTSRGSC3.4
Celera5148,334,678 - 148,334,896UniSTS
RH 3.4 Map51014.5UniSTS
Cytogenetic Map5q36UniSTS
RH128328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,529 - 149,951,731 (+)MAPPER
Rnor_6.05156,086,624 - 156,086,825NCBIRnor6.0
Rnor_5.05159,842,044 - 159,842,245UniSTSRnor5.0
RGSC_v3.45156,501,865 - 156,502,066UniSTSRGSC3.4
Celera5148,347,497 - 148,347,698UniSTS
RH 3.4 Map51010.6UniSTS
Cytogenetic Map5q36UniSTS
RH94490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,504 - 149,951,683 (+)MAPPER
Rnor_6.05156,086,599 - 156,086,777NCBIRnor6.0
Rnor_5.05159,842,019 - 159,842,197UniSTSRnor5.0
RGSC_v3.45156,501,840 - 156,502,018UniSTSRGSC3.4
Celera5148,347,472 - 148,347,650UniSTS
RH 3.4 Map51009.6UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:498363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25149,951,635 - 149,952,195 (+)MAPPER
Rnor_6.05156,086,730 - 156,087,289NCBIRnor6.0
Rnor_5.05159,842,150 - 159,842,709UniSTSRnor5.0
RGSC_v3.45156,501,971 - 156,502,530UniSTSRGSC3.4
Celera5148,347,603 - 148,348,162UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111278451156278451Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112279412157279412Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112279412157279412Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112279412157279412Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112279412157279412Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112279412157279412Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114140832159140832Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114140832159140832Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116767924161767924Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116767924161767924Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116767924161767924Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116767924161767924Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125455818157225114Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134502140157212422Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5149568588167739697Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149832180164807402Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5150340838164298744Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5150360936167946134Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:160
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000019004
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 10 6 6 22 29 28 11
Low 3 35 47 35 19 35 8 11 52 6 13 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019004   ⟹   ENSRNOP00000019004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078851   ⟹   ENSRNOP00000071620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5156,086,598 - 156,105,867 (-)Ensembl
RefSeq Acc Id: NM_013059   ⟹   NP_037191
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,951,404 - 150,006,424 (-)NCBI
Rnor_6.05156,086,498 - 156,141,513 (-)NCBI
Rnor_5.05159,841,916 - 159,897,391 (-)NCBI
RGSC_v3.45156,501,739 - 156,558,727 (-)RGD
Celera5148,347,371 - 148,402,292 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239136   ⟹   XP_006239198
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25149,951,397 - 149,980,897 (-)NCBI
Rnor_6.05156,086,496 - 156,115,986 (-)NCBI
Rnor_5.05159,841,916 - 159,897,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017593165   ⟹   XP_017448654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,086,496 - 156,112,994 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037191   ⟸   NM_013059
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006239198   ⟸   XM_006239136
- Peptide Label: isoform X1
- UniProtKB: P08289 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448654   ⟸   XM_017593165
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000019004   ⟸   ENSRNOT00000019004
RefSeq Acc Id: ENSRNOP00000071620   ⟸   ENSRNOT00000078851

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694182
Promoter ID:EPDNEW_R4707
Type:single initiation site
Name:Alpl_1
Description:alkaline phosphatase, liver/bone/kidney
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05156,141,528 - 156,141,588EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2100 AgrOrtholog
Ensembl Genes ENSRNOG00000013954 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071620 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019004 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000078851 UniProtKB/TrEMBL
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7128677 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25586 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93545 IMAGE-MGC_LOAD
NCBI Gene 25586 ENTREZGENE
PANTHER PTHR11596 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alpl PhenoGen
PRINTS ALKPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART alkPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0X8_RAT UniProtKB/TrEMBL
  P08289 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P14055 UniProtKB/Swiss-Prot
  P70707 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-27 Alpl  alkaline phosphatase, biomineralization associated  Alpl  alkaline phosphatase, liver/bone/kidney  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Alpl  alkaline phosphatase, liver/bone/kidney  Alpl  alkaline phosphatase, tissue-nonspecific  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-06-29 Alpl  alkaline phosphatase, tissue-nonspecific      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-06-29 Alpl  Tissue-nonspecific ALP alkaline phosphatase      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, bone, and kidney 632198
gene_function catalyzes the conversion of an orthophosphoric monoester to an alcohol phosphate 632198