Slc9a1 (solute carrier family 9 member A1) - Rat Genome Database

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Gene: Slc9a1 (solute carrier family 9 member A1) Rattus norvegicus
Analyze
Symbol: Slc9a1
Name: solute carrier family 9 member A1
RGD ID: 3718
Description: Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to cold; cellular response to electrical stimulus; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1); PARTICIPATES IN endothelin signaling pathway; bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: na(+)/H(+) exchanger 1; NHE-1; Nhe1; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1) antiporter Na+/H+ (amiloride sensitive); Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 member 1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,859,412 - 150,913,525 (+)NCBIGRCr8
mRatBN7.25145,576,341 - 145,629,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,278,173 - 148,331,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,047,784 - 150,101,012 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,034,322 - 150,087,546 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
Celera5143,998,303 - 144,051,177 (+)NCBICelera
RH 3.4 Map5977.9RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-methylcholine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
8-Br-cAMP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
amiloride  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbachol  (ISO)
carbon dioxide  (EXP)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlorpyrifos  (ISO)
citronellal  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
digoxin  (EXP)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
eplerenone  (EXP)
ethanol  (ISO)
ethylisopropylamiloride  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
hydrogen peroxide  (EXP)
ketamine  (EXP)
Licochalcone B  (ISO)
lithium atom  (ISO)
lithium chloride  (EXP)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptoethanol  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ouabain  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrolines  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP)
quercetin  (ISO)
reactive nitrogen species  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP,ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP)
tetrodotoxin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell contraction  (IEP)
cardiac muscle cell differentiation  (IEA,ISO)
cell differentiation  (IEP)
cellular response to acidic pH  (IEA,ISO,ISS)
cellular response to antibiotic  (IEP)
cellular response to cold  (IEP)
cellular response to electrical stimulus  (IEP)
cellular response to epinephrine stimulus  (IEA,ISO)
cellular response to hypoxia  (IDA)
cellular response to insulin stimulus  (IDA)
intracellular sodium ion homeostasis  (IEA,ISO)
monoatomic cation transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of apoptotic process  (IMP)
positive regulation of action potential  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,ISO)
positive regulation of cell growth  (IMP)
positive regulation of intracellular signal transduction  (IMP)
positive regulation of mitochondrial membrane permeability  (IMP)
positive regulation of the force of heart contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
potassium ion transmembrane transport  (IBA)
proton transmembrane transport  (IEA,ISO)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA,ISO)
regulation of intracellular pH  (IBA,IEA,IMP,ISO,ISS)
regulation of pH  (IEA,ISO,ISS)
regulation of the force of heart contraction  (IMP)
regulation of the force of heart contraction by cardiac conduction  (IEA,ISO)
response to acidic pH  (IDA,IEA,ISO,ISS)
response to muscle stretch  (IEA,ISO)
sodium ion export across plasma membrane  (ISS)
sodium ion import across plasma membrane  (IBA,IEA,ISO)
sodium ion transport  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
transmembrane transport  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased NHE1 expression is associated with serum deprivation-induced differentiation in immortalized rat proximal tubule cells. Carraro-Lacroix LR, etal., Am J Physiol Renal Physiol. 2006 Jul;291(1):F129-39. Epub 2006 Feb 21.
2. Role of the spinal Na+/H+ exchanger in formalin-induced nociception. Castaneda-Corral G, etal., Neurosci Lett. 2011 Aug 21;501(1):4-9. Epub 2011 Jul 6.
3. Sodium-hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes. Gan XT, etal., Cardiovasc Res. 2010 Jan 1;85(1):79-89. Epub .
4. Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. Gan XT, etal., J Pharmacol Exp Ther. 2005 Jan;312(1):27-34. Epub 2004 Sep 27.
5. Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart. Garciarena CD, etal., J Appl Physiol. 2009 Apr;106(4):1325-31. Epub 2009 Jan 29.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1 and CA isoenzymes II and XII in uterine fluid pH, volume and electrolyte regulation in rats under different sex-steroid influence. Gholami K, etal., Int J Med Sci. 2013 Jul 5;10(9):1121-34. doi: 10.7150/ijms.5918. Print 2013.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium. Hileeto D, etal., Diabetes Metab Res Rev 2002 Sep-Oct;18(5):386-94.
10. Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart. Howarth FC, etal., Mol Cell Biochem. 2012 Feb;361(1-2):267-80. Epub 2011 Oct 19.
11. Identification of a potent Sodium Hydrogen Exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. Huber JD, etal., J Med Chem. 2012 Jul 17.
12. c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis. Huc L, etal., Cancer Res. 2007 Feb 15;67(4):1696-705.
13. Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. Inoue H, etal., Biol Pharm Bull 2003 Feb;26(2):148-55.
14. Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. Khan I, etal., Nephron 2002 Oct;92(2):346-55.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling. Lawrence SP, etal., Biochem J. 2010 Dec 15;432(3):515-23. doi: 10.1042/BJ20100717.
17. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Li W, etal., Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142.
18. Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1). Li X, etal., J Biol Chem 2002 Aug 9;277(32):28656-62.
19. Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. Lin CY, etal., J Biol Chem 2003 Apr 25;278(17):15128-35. Epub 2003 Feb 3.
20. [Adenosine alleviates hypoxia-induced rat right ventricular hypertrophy through the NHE-1/CaN signal pathway]. Lin M, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 May;32(5):734-7.
21. [Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism]. Lin X, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010 Feb;27(1):132-7.
22. Na+/H+ exchanger-1 inhibitors reduce neuronal excitability and alter na+ channel inactivation properties in rat primary sensory neurons. Liu CN and Somps CJ, Toxicol Sci. 2008 Jun;103(2):346-53. Epub 2008 Mar 3.
23. Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis. Lupachyk S, etal., Int J Mol Med. 2012 Jun;29(6):989-98. doi: 10.3892/ijmm.2012.933. Epub 2012 Mar 7.
24. Apoptosis induction is associated with decreased NHE1 expression in neonatal unilateral ureteric obstruction. Manucha W, etal., BJU Int. 2007 Jul;100(1):191-8.
25. Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1. Matsushita M, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C280-8. doi: 10.1152/ajpcell.00404.2010. Epub 2011 May 4.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. ERK is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells. Mukhin YV, etal., J Biol Chem. 2004 Jan 16;279(3):1845-52. Epub 2003 Nov 4.
28. Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Nakamura TY, etal., Circ Res. 2008 Oct 10;103(8):891-9. Epub 2008 Sep 5.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. Orlowski J, etal., J Biol Chem 1992 May 5;267(13):9331-9.
31. The effect of Na(+)/H(+) exchanger-1 inhibition by sabiporide on blood-brain barrier dysfunction after ischemia/hypoxia in vivo and in vitro. Park SL, etal., Brain Res. 2010 Dec 17;1366:189-96. Epub 2010 Sep 29.
32. Silencing of NHE-1 blunts the slow force response to myocardial stretch. Perez NG, etal., J Appl Physiol. 2011 Sep;111(3):874-80. Epub 2011 Jun 9.
33. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
34. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Expression of Na(+)-H+ exchanger isoforms NHE1 and NHE3 in kidney and blood cells of rabbit and rat. Rutherford PA, etal., Exp Nephrol. 1997 Nov-Dec;5(6):490-7.
39. Cloning and expression of a chloride-dependent Na+-H+ exchanger. Sangan P, etal., J Biol Chem 2002 Mar 22;277(12):9668-75.
40. Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: Evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/beta-catenin signaling. Serafino A, etal., Biochim Biophys Acta. 2012 Jun;1822(6):1004-18. Epub 2012 Feb 25.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Na+/H+ exchange inhibition with cariporide prevents alterations of coronary endothelial function in streptozotocin-induced diabetes. Vial G, etal., Mol Cell Biochem. 2008 Mar;310(1-2):93-102. Epub 2007 Dec 5.
43. Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening. Villa-Abrille MC, etal., Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1237-51. Epub 2011 Feb 4.
44. Role of the sodium hydrogen exchanger in maitotoxin-induced cell death in cultured rat cortical neurons. Wang Y, etal., Toxicon. 2009 Aug;54(2):95-102. Epub 2009 Mar 26.
45. A physiogenomic approach to study the regulation of blood pressure. Westhoff TH, etal., Physiol Genomics. 2005 Sep 21;23(1):46-53. Epub 2005 Jun 7.
46. The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms. Williams IA, etal., Pflugers Arch. 2007 Mar 14;.
47. Localized Na+/H+ exchanger 1 expression protects Ca2+-regulated adenylyl cyclases from changes in intracellular pH. Willoughby D, etal., J Biol Chem. 2005 Sep 2;280(35):30864-72. Epub 2005 Jul 7.
48. Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor. Wu D, etal., Crit Care Med. 2009 Jun;37(6):1994-9.
49. Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Young M and Funder J, Endocrinology 2003 Sep;144(9):3848-51.
50. Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. Zaun HC, etal., J Biol Chem. 2008 May 2;283(18):12456-67. doi: 10.1074/jbc.M800267200. Epub 2008 Mar 5.
Additional References at PubMed
PMID:8901634   PMID:9688597   PMID:10666043   PMID:10673550   PMID:11350981   PMID:11369779   PMID:12619893   PMID:12791686   PMID:14610099   PMID:14724181   PMID:14737747   PMID:14753440  
PMID:15009712   PMID:15035633   PMID:15105296   PMID:15523538   PMID:15644322   PMID:16306134   PMID:16396499   PMID:16575514   PMID:16707501   PMID:16859700   PMID:17429605   PMID:18095144  
PMID:18448627   PMID:18650245   PMID:18660503   PMID:18703017   PMID:18715944   PMID:19011045   PMID:19028724   PMID:19199708   PMID:19248819   PMID:19419999   PMID:19458287   PMID:19542484  
PMID:19710385   PMID:19949839   PMID:20427472   PMID:20712402   PMID:20886221   PMID:21207853   PMID:21325644   PMID:21359875   PMID:21423176   PMID:21553168   PMID:21613418   PMID:21705333  
PMID:21856903   PMID:22154810   PMID:22688515   PMID:22731252   PMID:22898152   PMID:23055051   PMID:23059814   PMID:23509787   PMID:23545808   PMID:23677982   PMID:23709596   PMID:23837875  
PMID:24049114   PMID:24126173   PMID:24566932   PMID:24840010   PMID:25216745   PMID:25240639   PMID:25749446   PMID:25830299   PMID:26063808   PMID:26078707   PMID:26459736   PMID:26521941  
PMID:26724742   PMID:27009277   PMID:27633736   PMID:28019659   PMID:28719339   PMID:30627552   PMID:30838887   PMID:31622577   PMID:31694264   PMID:31742355   PMID:31811544   PMID:32469979  
PMID:32496418   PMID:33957206   PMID:34063987   PMID:34813134   PMID:35921220  


Genomics

Comparative Map Data
Slc9a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,859,412 - 150,913,525 (+)NCBIGRCr8
mRatBN7.25145,576,341 - 145,629,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,278,173 - 148,331,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,047,784 - 150,101,012 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,034,322 - 150,087,546 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
Celera5143,998,303 - 144,051,177 (+)NCBICelera
RH 3.4 Map5977.9RGD
Cytogenetic Map5q36NCBI
SLC9A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,098,809 - 27,155,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,098,809 - 27,166,981 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,425,300 - 27,481,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,297,894 - 27,353,990 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,109,448 - 27,165,543NCBI
Celera125,822,106 - 25,878,256 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,679,019 - 25,736,027 (-)NCBIHuRef
CHM1_1127,539,712 - 27,596,211 (-)NCBICHM1_1
T2T-CHM13v2.0126,938,788 - 26,996,283 (-)NCBIT2T-CHM13v2.0
Slc9a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,097,022 - 133,151,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)EnsemblGRCm39 Ensembl
GRCm384133,369,711 - 133,423,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,925,687 - 132,979,613 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,642,305 - 132,695,773 (+)NCBIMGSCv36mm8
Celera4131,535,491 - 131,589,316 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Slc9a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,409,833 - 6,467,841 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,409,833 - 6,467,841 (-)NCBIChiLan1.0ChiLan1.0
SLC9A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,713,762 - 199,772,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,817,765 - 198,876,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,359,818 - 26,418,910 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,414,937 - 27,475,089 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,414,937 - 27,475,089 (-)Ensemblpanpan1.1panPan2
SLC9A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,054,742 - 73,103,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,616,211 - 73,664,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBIUU_Cfam_GSD_1.0
Slc9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,635,479 - 45,692,666 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,459,929 - 11,517,478 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,460,266 - 11,517,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,944,221 - 77,996,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,613,289 - 105,670,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,613,338 - 105,674,208 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,772,194 - 10,834,851 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,039,051 - 11,095,885 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,041,118 - 11,095,892 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc9a1
342 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:126
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000011049
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH94564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,628,911 - 145,629,016 (+)MAPPERmRatBN7.2
Rnor_6.05151,625,642 - 151,625,746NCBIRnor6.0
Rnor_5.05155,289,692 - 155,289,796UniSTSRnor5.0
RGSC_v3.45151,681,310 - 151,681,414UniSTSRGSC3.4
Celera5144,050,459 - 144,050,563UniSTS
RH 3.4 Map5977.9UniSTS
Cytogenetic Map5q36UniSTS
Slc9a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,626,755 - 145,628,174 (+)MAPPERmRatBN7.2
Rnor_6.05151,623,486 - 151,624,904NCBIRnor6.0
Rnor_5.05155,287,536 - 155,288,954UniSTSRnor5.0
RGSC_v3.45151,682,152 - 151,683,570UniSTSRGSC3.4
Celera5144,048,303 - 144,049,721UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011049   ⟹   ENSRNOP00000011049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)Ensembl
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)Ensembl
RefSeq Acc Id: NM_012652   ⟹   NP_036784
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,860,285 - 150,913,523 (+)NCBI
mRatBN7.25145,576,390 - 145,629,630 (+)NCBI
Rnor_6.05151,573,122 - 151,626,360 (+)NCBI
Rnor_5.05155,237,482 - 155,290,410 (+)NCBI
RGSC_v3.45151,680,696 - 151,748,460 (-)RGD
Celera5143,998,303 - 144,051,177 (+)RGD
Sequence:
RefSeq Acc Id: XM_063287163   ⟹   XP_063143233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,859,412 - 150,910,051 (+)NCBI
RefSeq Acc Id: XM_063287164   ⟹   XP_063143234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,901,379 - 150,913,525 (+)NCBI
RefSeq Acc Id: XR_005504368
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85150,859,412 - 150,909,331 (+)NCBI
mRatBN7.25145,576,341 - 145,627,457 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036784 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143233 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143234 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98479 (Get FASTA)   NCBI Sequence Viewer  
  EDL80666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011049
  ENSRNOP00000011049.2
GenBank Protein P26431 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036784   ⟸   NM_012652
- UniProtKB: P26431 (UniProtKB/Swiss-Prot),   A6ISW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011049   ⟸   ENSRNOT00000011049
RefSeq Acc Id: XP_063143233   ⟸   XM_063287163
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143234   ⟸   XM_063287164
- Peptide Label: isoform X2
Protein Domains
Cation/H+ exchanger transmembrane   Sodium/hydrogen exchanger regulatory region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26431-F1-model_v2 AlphaFold P26431 1-820 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694114
Promoter ID:EPDNEW_R4637
Type:initiation region
Name:Slc9a1_1
Description:solute carrier family 9 member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,573,109 - 151,573,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3718 AgrOrtholog
BioCyc Gene G2FUF-39635 BioCyc
Ensembl Genes ENSRNOG00000007982 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011049 ENTREZGENE
  ENSRNOT00000011049.5 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.1330 UniProtKB/Swiss-Prot
  6.10.250.1040 UniProtKB/Swiss-Prot
  6.10.250.2020 UniProtKB/Swiss-Prot
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot
  Na/H_exchanger_1 UniProtKB/Swiss-Prot
  NaH_exchanger UniProtKB/Swiss-Prot
  NHE_CaM-bd UniProtKB/Swiss-Prot
KEGG Report rno:24782 UniProtKB/Swiss-Prot
NCBI Gene 24782 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot
  PTHR10110:SF59 UniProtKB/Swiss-Prot
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot
  NEXCaM_BD UniProtKB/Swiss-Prot
PhenoGen Slc9a1 PhenoGen
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot
  NAHEXCHNGR1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007982 RatGTEx
TIGR TC218885
UniProt A6ISW5 ENTREZGENE, UniProtKB/TrEMBL
  P26431 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Slc9a1  solute carrier family 9 member A1  Slc9a1  solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc9a1  solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1  Slc9a1  solute carrier family 9 (sodium/hydrogen exchanger), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc9a1  solute carrier family 9 (sodium/hydrogen exchanger), member 1  Slc9a1  solute carrier family 9, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc9a1  solute carrier family 9, member 1    Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)  Name updated 629478 APPROVED
2002-06-10 Slc9a1  Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may participate in development of coronary vasculitis produced by excess mineralocorticoid and salt 1299036
gene_disease may mediate changes in diabetic cardiomyopathy associated with increased endothelin-1 expression 730152
gene_expression expressed in all tissues examined 1299035
gene_expression expressed in coronary vascular smooth muscle 1299036
gene_product member of the Na/H exchanger family 1299035
gene_regulation G-protein coupled somatostatin receptor subtypes SSTR1, -3, and -4 inhibit exchanger activity 1299037
gene_regulation transcription is regulated by the thyroid hormone receptor alpha (Thra) 625454