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Gene: Slc9a1 (solute carrier family 9 member A1) Rattus norvegicus
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Symbol: Slc9a1
Name: solute carrier family 9 member A1
Description: Exhibits sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of mitochondrial membrane permeability; and regulation of apoptotic process. Localizes to several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1); PARTICIPATES IN endothelin signaling pathway; bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; aldosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: na(+)/H(+) exchanger 1; NHE-1; Nhe1; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1) antiporter Na+/H+ (amiloride sensitive); Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 member 1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Orthologs:
Homo sapiens (human) : SLC9A1 (solute carrier family 9 member A1)  HGNC  Alliance
Mus musculus (house mouse) : Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc9a1 (solute carrier family 9 member A1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC9A1 (solute carrier family 9 member A1)
Canis lupus familiaris (dog) : SLC9A1 (solute carrier family 9 member A1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc9a1 (solute carrier family 9 member A1)
Sus scrofa (pig) : SLC9A1 (solute carrier family 9 member A1)
Chlorocebus sabaeus (African green monkey) : SLC9A1 (solute carrier family 9 member A1)
Heterocephalus glaber (naked mole-rat) : Slc9a1 (solute carrier family 9 member A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
Celera5143,998,303 - 144,051,177 (+)NCBICelera
Cytogenetic Map5q36NCBI
RH 3.4 Map5977.9RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc9a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3718
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.