Gene: Slc9a1 (solute carrier family 9 member A1) Rattus norvegicus
Analyze
Symbol:
Slc9a1
Name:
solute carrier family 9 member A1
Description:
Exhibits sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of mitochondrial membrane permeability; and regulation of apoptotic process. Localizes to several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1); PARTICIPATES IN endothelin signaling pathway; bile acid transport pathway; INTERACTS WITH 17beta-estradiol; 3-iodobenzyl-5'-N-methylcarboxamidoadenosine; aldosterone.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
na(+)/H(+) exchanger 1; NHE-1; Nhe1; sodium/hydrogen exchanger 1; Solute carrier family 9 (sodium/hydrogen exchanger 1) antiporter Na+/H+ (amiloride sensitive); Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive); solute carrier family 9 (sodium/hydrogen exchanger), member 1; solute carrier family 9 member 1; solute carrier family 9, member 1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC9A1 (solute carrier family 9 member A1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1) HGNC
Treefam, EggNOG, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Slc9a1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC9A1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC9A1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc9a1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC9A1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SLC9A1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Slc9a1 (solute carrier family 9 member A1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SLC9A2 (solute carrier family 9 member A2) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Slc9a1 (solute carrier family 9 (sodium/hydrogen exchanger), member 1)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|OMA|TreeFam|OrthoInspector|OrthoFinder|PANTHER|Hieranoid)
Homo sapiens (human):
SLC9A1 (solute carrier family 9 member A1)
Alliance
DIOPT (Ensembl Compara|InParanoid|PhylomeDB|HGNC|OMA|PANTHER|OrthoInspector|OrthoFinder|TreeFam|Hieranoid)
Drosophila melanogaster (fruit fly):
Nhe2
Alliance
DIOPT (Ensembl Compara|PANTHER|OrthoFinder)
Caenorhabditis elegans (roundworm):
nhx-2
Alliance
DIOPT (OMA|Ensembl Compara|PhylomeDB|PANTHER)
Caenorhabditis elegans (roundworm):
nhx-6
Alliance
DIOPT (OMA|Ensembl Compara|PhylomeDB|PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 151,573,122 - 151,626,360 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 151,573,092 - 151,627,316 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 155,237,482 - 155,290,410 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 151,680,696 - 151,748,460 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 151,690,734 - 151,758,499 (-) NCBI Celera 5 143,998,303 - 144,051,177 (+) NCBI Celera Cytogenetic Map 5 q36 NCBI RH 3.4 Map 5 977.9 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autosomal recessive spinocerebellar ataxia 19 ISO RGD:736585 8554872 ClinVar Annotator: match by term: Lichtenstein-knorr syndrome ClinVar PMID:25205112 autosomal recessive spinocerebellar ataxia 19 ISO RGD:736585 8554872 ClinVar Annotator: match by term: Lichtenstein-knorr syndrome ClinVar PMID:25741868 genetic disease ISO RGD:736585 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10199808 more ... nonprogressive cerebellar ataxia with mental retardation ISO RGD:736585 8554872 ClinVar Annotator: match by term: Cerebellar ataxia, nonprogressive, with mental retardation ClinVar PMID:25741868
Imported Annotations - CTD
Barrett's esophagus ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21127259 congestive heart failure ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19027022 Diabetes Mellitus, Experimental ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20003708 Edema ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20553904 Hemorrhagic Shock ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17724433 hypertrophic cardiomyopathy ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19111554 Pain ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19248819 Reperfusion Injury ISO RGD:736585 11554173 CTD Direct Evidence: therapeutic CTD PMID:19027022 Ventricular Remodeling ISO RGD:736585 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20886221 Imported Annotations - OMIM
autosomal recessive spinocerebellar ataxia 19 ISO RGD:736585 7240710 OMIM
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO RGD:11317 6480464 [o, p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA CTD PMID:27325568 17beta-estradiol increases activity EXP 6480464 Estradiol results in increased activity of SLC9A1 protein CTD PMID:19111554 17beta-estradiol affects expression ISO RGD:736585 6480464 Estradiol affects the expression of SLC9A1 mRNA CTD PMID:22574217 17beta-estradiol multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of SLC9A1 protein] CTD PMID:19111554 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11317 6480464 Tetrachlorodibenzodioxin affects the expression of SLC9A1 mRNA CTD PMID:21570461 , PMID:24680724 2,4-dinitrobenzenesulfonic acid increases expression ISO RGD:11317 6480464 2, 4-dinitrobenzenesulfonic acid results in increased expression of SLC9A1 mRNA CTD PMID:30116771 2-methylcholine affects expression ISO RGD:736585 6480464 beta-methylcholine affects the expression of SLC9A1 mRNA CTD PMID:21179406 3-iodobenzyl-5'-N-methylcarboxamidoadenosine multiple interactions EXP 6480464 N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] CTD PMID:15452191 8-Br-cAMP increases expression ISO RGD:736585 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC9A1 mRNA CTD PMID:22079614 afimoxifene multiple interactions ISO RGD:736585 6480464 afimoxifene inhibits the reaction [Estrogens results in decreased expression of SLC9A1 mRNA] CTD PMID:21233418 aflatoxin B1 increases methylation ISO RGD:736585 6480464 Aflatoxin B1 results in increased methylation of SLC9A1 exon, Aflatoxin B1 results in increased methylation of SLC9A1 intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:736585 6480464 aflatoxin B2 results in increased methylation of SLC9A1 intron CTD PMID:30157460 aldosterone increases expression EXP 6480464 Aldosterone results in increased expression of SLC9A1 mRNA CTD PMID:16373419 aldosterone multiple interactions EXP 6480464 eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SLC9A1 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:736585 6480464 Arsenic affects the methylation of SLC9A1 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:736585 6480464 Arsenic affects the methylation of SLC9A1 gene CTD PMID:25304211 arsenous acid decreases expression ISO RGD:736585 6480464 Arsenic Trioxide results in decreased expression of SLC9A1 mRNA CTD PMID:20458559 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of SLC9A1 gene CTD PMID:28931070 benzo[a]pyrene multiple interactions ISO RGD:11317 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to SLC9A1 promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:736585 6480464 Benzo(a)pyrene results in increased expression of SLC9A1 mRNA CTD PMID:16269432 benzo[a]pyrene increases expression ISO RGD:11317 6480464 Benzo(a)pyrene results in increased expression of SLC9A1 mRNA CTD PMID:22228805 benzo[e]pyrene increases methylation ISO RGD:736585 6480464 benzo(e)pyrene results in increased methylation of SLC9A1 intron CTD PMID:30157460 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SLC9A1 mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SLC9A1 gene CTD PMID:28505145 cadmium dichloride decreases expression ISO RGD:736585 6480464 Cadmium Chloride results in decreased expression of SLC9A1 mRNA CTD PMID:12760830 cadmium dichloride increases expression ISO RGD:736585 6480464 Cadmium Chloride results in increased expression of SLC9A1 mRNA CTD PMID:12160620 calcium atom multiple interactions EXP 6480464 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] more ... CTD PMID:16236312 calcium(0) multiple interactions EXP 6480464 3-methylsulfonyl-4-piperidinobenzoyl guanidine inhibits the reaction [[Phenylephrine results in increased activity of SLC9A1 protein] which results in increased transport of Calcium] more ... CTD PMID:16236312 carbachol increases activity ISO RGD:11317 6480464 Carbachol results in increased activity of SLC9A1 protein CTD PMID:12842825 carbon dioxide affects response to substance EXP 6480464 SLC9A1 protein affects the susceptibility to Carbon Dioxide CTD PMID:16831598 CGS-21680 multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] CTD PMID:15452191 copper atom multiple interactions ISO RGD:736585 6480464 [Thiosemicarbazones binds to Copper] which results in increased expression of SLC9A1 protein CTD PMID:20931265 copper(0) multiple interactions ISO RGD:736585 6480464 [Thiosemicarbazones binds to Copper] which results in increased expression of SLC9A1 protein CTD PMID:20931265 cyclosporin A increases expression ISO RGD:736585 6480464 Cyclosporine results in increased expression of SLC9A1 mRNA CTD PMID:20106945 , PMID:25562108 DDT multiple interactions ISO RGD:11317 6480464 [o, p'-DDT co-treated with DDT] results in increased expression of SLC9A1 mRNA CTD PMID:27325568 diarsenic trioxide decreases expression ISO RGD:736585 6480464 Arsenic Trioxide results in decreased expression of SLC9A1 mRNA CTD PMID:20458559 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SLC9A1 mRNA CTD PMID:21266533 dicrotophos increases expression ISO RGD:736585 6480464 dicrotophos results in increased expression of SLC9A1 mRNA CTD PMID:28302478 digoxin increases expression EXP 6480464 Digoxin results in increased expression of SLC9A1 mRNA CTD PMID:19687166 digoxin multiple interactions EXP 6480464 N-(2-methyl-4, 5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Digoxin results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 disodium selenite increases expression ISO RGD:736585 6480464 Sodium Selenite results in increased expression of SLC9A1 mRNA CTD PMID:24383545 doxorubicin multiple interactions ISO RGD:736585 6480464 [ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin CTD PMID:15729714 doxorubicin decreases expression ISO RGD:736585 6480464 Doxorubicin results in decreased expression of SLC9A1 mRNA CTD PMID:29803840 doxorubicin decreases response to substance ISO RGD:736585 6480464 SLC9A1 protein results in decreased susceptibility to Doxorubicin CTD PMID:15729714 endosulfan increases expression ISO RGD:736585 6480464 Endosulfan results in increased expression of SLC9A1 mRNA CTD PMID:26615145 eplerenone multiple interactions EXP 6480464 eplerenone inhibits the reaction [Aldosterone results in increased expression of SLC9A1 mRNA] CTD PMID:16373419 ethanol affects splicing ISO RGD:11317 6480464 Ethanol affects the splicing of SLC9A1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:11317 6480464 Ethanol results in increased expression of SLC9A1 mRNA CTD PMID:30319688 ethylisopropylamiloride decreases activity EXP 6480464 ethylisopropylamiloride results in decreased activity of SLC9A1 protein CTD PMID:17552965 ethylisopropylamiloride decreases activity ISO RGD:736585 6480464 ethylisopropylamiloride results in decreased activity of SLC9A1 protein CTD PMID:12562776 ethylisopropylamiloride multiple interactions ISO RGD:736585 6480464 [ethylisopropylamiloride results in decreased activity of SLC9A1 protein] which results in increased abundance of Doxorubicin CTD PMID:15729714 formaldehyde increases expression ISO RGD:736585 6480464 Formaldehyde results in increased expression of SLC9A1 mRNA CTD PMID:23649840 hydrogen peroxide multiple interactions EXP 6480464 [resveratrol results in increased abundance of Hydrogen Peroxide] which results in decreased expression of SLC9A1 protein CTD PMID:18951995 ketamine increases expression EXP 6480464 Ketamine results in increased expression of SLC9A1 mRNA CTD PMID:20080153 lithium atom multiple interactions ISO RGD:736585 6480464 Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]], SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium] CTD PMID:12765964 lithium atom decreases expression ISO RGD:11317 6480464 Lithium results in decreased expression of SLC9A1 mRNA CTD PMID:18506424 lithium atom increases activity ISO RGD:11317 6480464 Lithium results in increased activity of SLC9A1 protein CTD PMID:18506424 lithium hydride multiple interactions ISO RGD:736585 6480464 Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]], SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium] CTD PMID:12765964 lithium hydride decreases expression ISO RGD:11317 6480464 Lithium results in decreased expression of SLC9A1 mRNA CTD PMID:18506424 lithium hydride increases activity ISO RGD:11317 6480464 Lithium results in increased activity of SLC9A1 protein CTD PMID:18506424 mercaptoethanol multiple interactions ISO RGD:11317 6480464 Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA], Mercaptoethanol affects the reaction [resveratrol results in decreased expression of SLC9A1 protein] CTD PMID:18951995 methapyrilene increases methylation ISO RGD:736585 6480464 Methapyrilene results in increased methylation of SLC9A1 intron CTD PMID:30157460 nickel atom increases expression ISO RGD:736585 6480464 Nickel results in increased expression of SLC9A1 mRNA CTD PMID:25583101 ouabain multiple interactions EXP 6480464 N-(2-methyl-4, 5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 ouabain increases expression EXP 6480464 Ouabain results in increased expression of SLC9A1 mRNA CTD PMID:19687166 paclitaxel decreases activity ISO RGD:736585 6480464 Paclitaxel results in decreased activity of SLC9A1 protein CTD PMID:12796407 paracetamol increases expression ISO RGD:736585 6480464 Acetaminophen results in increased expression of SLC9A1 mRNA CTD PMID:22230336 , PMID:29067470 pentanal decreases expression ISO RGD:736585 6480464 pentanal results in decreased expression of SLC9A1 mRNA CTD PMID:26079696 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of SLC9A1 mRNA CTD PMID:19162173 phenanthrolines multiple interactions ISO RGD:11317 6480464 Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA], Phenanthrolines affects the reaction [resveratrol results in decreased expression of SLC9A1 protein] CTD PMID:18951995 phenylephrine multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of SLC9A1 protein] more ... CTD PMID:15452191 more ... phenylephrine increases expression EXP 6480464 Phenylephrine results in increased expression of SLC9A1 mRNA, Phenylephrine results in increased expression of SLC9A1 protein CTD PMID:15452191 , PMID:16517124 phenylephrine increases activity EXP 6480464 Phenylephrine results in increased activity of SLC9A1 protein CTD PMID:16236312 phloretin multiple interactions ISO RGD:736585 6480464 Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]] CTD PMID:12765964 phloretin decreases activity ISO RGD:736585 6480464 Phloretin results in decreased activity of SLC9A1 protein, Phloretin results in decreased activity of SLC9A1 protein alternative form CTD PMID:12765964 pirinixic acid decreases expression ISO RGD:11317 6480464 pirinixic acid results in decreased expression of SLC9A1 mRNA CTD PMID:17426115 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of SLC9A1 mRNA CTD PMID:19162173 progesterone increases expression EXP 6480464 Progesterone results in increased expression of SLC9A1 mRNA, Progesterone results in increased expression of SLC9A1 protein CTD PMID:23509787 quercetin decreases expression ISO RGD:736585 6480464 Quercetin results in decreased expression of SLC9A1 mRNA CTD PMID:20596804 reactive nitrogen species multiple interactions EXP 6480464 [manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A1 CTD PMID:20003708 reactive oxygen species multiple interactions EXP 6480464 [manganese tetrakis-(N-methyl-2 pyridyl) porphyrin affects the abundance of [Reactive Oxygen Species co-treated with Reactive Nitrogen Species]] which affects the expression of SLC9A1 CTD PMID:20003708 resveratrol multiple interactions ISO RGD:11317 6480464 CASP3 protein affects the reaction [resveratrol results in decreased expression of SLC9A1 mRNA] more ... CTD PMID:18951995 resveratrol multiple interactions ISO RGD:736585 6480464 [resveratrol results in increased expression of SLC9A1 protein] which results in increased uptake of Sodium Chloride CTD PMID:21191669 resveratrol increases expression ISO RGD:736585 6480464 resveratrol results in increased expression of SLC9A1 protein CTD PMID:21191669 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SLC9A1 mRNA, resveratrol results in decreased expression of SLC9A1 protein CTD PMID:18951995 resveratrol multiple interactions EXP 6480464 [resveratrol results in increased abundance of Hydrogen Peroxide] which results in decreased expression of SLC9A1 protein more ... CTD PMID:18951995 resveratrol decreases expression ISO RGD:11317 6480464 Resveratrol results in decreased expression of SLC9A1 mRNA, Resveratrol results in decreased expression of SLC9A1 protein CTD PMID:18951995 sodium arsenite increases expression ISO RGD:736585 6480464 sodium arsenite results in increased expression of SLC9A1 mRNA CTD PMID:12760830 sodium arsenite decreases expression ISO RGD:11317 6480464 sodium arsenite results in decreased expression of SLC9A1 protein CTD PMID:29044176 sodium atom multiple interactions ISO RGD:736585 6480464 Phloretin inhibits the reaction [SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium]], SLC9A1 protein alternative form affects the transport of [Sodium co-treated with Lithium] CTD PMID:12765964 sodium atom affects transport ISO RGD:736585 6480464 SLC9A1 protein affects the transport of Sodium CTD PMID:12562776 sodium chloride multiple interactions ISO RGD:736585 6480464 [resveratrol results in increased expression of SLC9A1 protein] which results in increased uptake of Sodium Chloride CTD PMID:21191669 tebuconazole decreases expression ISO RGD:736585 6480464 tebuconazole results in decreased expression of SLC9A1 mRNA CTD PMID:30458266 tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of SLC9A1 mRNA CTD PMID:17805973 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of SLC9A1 mRNA CTD PMID:16644059 tetrodotoxin multiple interactions ISO RGD:11317 6480464 [cariporide co-treated with Tetrodotoxin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein], Tetrodotoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SLC9A1 protein] CTD PMID:24070585 troglitazone decreases activity ISO RGD:736585 6480464 troglitazone results in decreased activity of SLC9A1 protein CTD PMID:15501982 tungsten decreases expression ISO RGD:11317 6480464 Tungsten results in decreased expression of SLC9A1 mRNA CTD PMID:30912803 urethane increases expression ISO RGD:736585 6480464 Urethane results in increased expression of SLC9A1 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:736585 6480464 Valproic Acid affects the expression of SLC9A1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:736585 6480464 Valproic Acid results in increased expression of SLC9A1 mRNA CTD PMID:28001369 zidovudine increases expression ISO RGD:736585 6480464 Zidovudine results in increased expression of SLC9A1 mRNA CTD PMID:24292225 zinc dichloride increases expression ISO RGD:736585 6480464 zinc chloride results in increased expression of SLC9A1 mRNA CTD PMID:18947441
Biological Process anion transmembrane transport IEA GO:0015386 1600115 GO_REF:0000108 GOC GO_REF:0000108 cardiac muscle cell contraction IEP 7349316 RGD cardiac muscle cell differentiation ISO RGD:11317 1624291 (MGI:MGI:3837281, PMID:19011045) RGD MGI:MGI:3837281 , PMID:19011045 cell differentiation IEP 1625562 RGD cellular response to acidic pH ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 cellular response to acidic pH ISS UniProtKB:Q1PS52 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to antibiotic IEP 7349316 oligomycin RGD cellular response to cold IEP 1625557 RGD cellular response to electrical stimulus IEP 7349316 RGD cellular response to epinephrine stimulus ISO RGD:736585 1624291 (PMID:21359875) RGD PMID:21359875 cellular response to hypoxia IDA 7349316 RGD cellular response to insulin stimulus IDA 7349316 RGD cellular response to organic cyclic compound IEP 7349316 compound C RGD cellular sodium ion homeostasis ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 negative regulation of apoptotic process IMP 1625559 RGD neuron death IMP 6771335 RGD positive regulation of action potential IMP 6771338 RGD positive regulation of apoptotic process IMP 8693684 RGD positive regulation of calcineurin-NFAT signaling cascade ISO RGD:736585 1624291 (PMID:22688515) RGD PMID:22688515 positive regulation of calcium:sodium antiporter activity ISO RGD:736585 1624291 (PMID:15105296) RGD PMID:15105296 positive regulation of cardiac muscle hypertrophy ISO RGD:736585 1624291 (PMID:21359875) RGD PMID:21359875 positive regulation of cell growth IMP 6771333 RGD positive regulation of intracellular signal transduction IMP 1581388 RGD positive regulation of mitochondrial membrane permeability IMP 6771330 RGD positive regulation of the force of heart contraction ISO RGD:736585 1624291 (PMID:15105296) RGD PMID:15105296 positive regulation of transcription by RNA polymerase II ISO RGD:736585 1624291 (PMID:22688515) RGD PMID:22688515 potassium ion transmembrane transport IBA PANTHER:PTN000011605 more ... 13792537 PMID:21873635 GO_Central proton transmembrane transport ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 regulation of cardiac muscle contraction by calcium ion signaling ISO RGD:736585 1624291 (PMID:15105296) RGD PMID:15105296 regulation of intracellular pH IMP 6771326 RGD regulation of intracellular pH IBA FB:FBgn0040297 more ... 13792537 PMID:21873635 GO_Central regulation of intracellular pH ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of intracellular pH ISO RGD:736585 1624291 (PMID:15035633), (PMID:24840010) RGD PMID:15035633 , PMID:24840010 regulation of pH ISO RGD:736585 1624291 (PMID:8901634) RGD PMID:8901634 regulation of pH ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of pH ISO RGD:11317 1624291 MGI:MGI:2429323 (MGI:MGI:1353365 more ... RGD MGI:MGI:1353365 more ... regulation of sensory perception of pain IMP 6771328 RGD regulation of the force of heart contraction IMP 6771329 RGD regulation of the force of heart contraction by cardiac conduction ISO RGD:736585 1624291 (PMID:21359875) RGD PMID:21359875 response to acidic pH ISO RGD:736585 1624291 (PMID:8901634) RGD PMID:8901634 response to acidic pH ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 response to acidic pH ISO RGD:11317 1624291 MGI:MGI:2429323 (MGI:MGI:1353365 , PMID:10673550) RGD MGI:MGI:1353365 , PMID:10673550 response to acidic pH IDA 8554433 PMID:18321853 UniProt response to muscle stretch ISO RGD:736585 1624291 (PMID:15105296) RGD PMID:15105296 response to organic cyclic compound IDA 1625561 RGD sodium ion export across plasma membrane ISS UniProtKB:Q1PS52 1600115 GO_REF:0000024 UniProt GO_REF:0000024 sodium ion import across plasma membrane ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 sodium ion import across plasma membrane IBA PANTHER:PTN000011605 more ... 13792537 PMID:21873635 GO_Central sodium ion transport ISO RGD:11317 1624291 (MGI:MGI:2446396, PMID:10666043) RGD MGI:MGI:2446396 , PMID:10666043 Cellular Component apical plasma membrane ISO RGD:11317 1624291 (MGI:MGI:5292606, PMID:21705333) RGD MGI:MGI:5292606 , PMID:21705333 basolateral plasma membrane IDA 1625558 RGD cation-transporting ATPase complex ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 cell surface IDA 7349316 RGD cytoplasm ISO RGD:736585 1624291 (PMID:21553168) RGD PMID:21553168 cytoplasm ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 endoplasmic reticulum IDA 8554239 PMID:21543739 UniProt endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000044 UniProt GO_REF:0000044 integral component of plasma membrane ISO RGD:736585 1624291 (PMID:24840010) RGD PMID:24840010 intercalated disc IDA 7349316 RGD membrane ISO RGD:11317 1624291 (MGI:MGI:2655940, PMID:12619893) RGD MGI:MGI:2655940 , PMID:12619893 membrane raft IDA 1581387 RGD membrane raft ISO RGD:736585 1624291 (PMID:22688515) RGD PMID:22688515 mitochondrion IDA 6771330 RGD nucleoplasm ISO RGD:736585 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P19634 , ensembl:ENSP000002639801600115 GO_REF:0000107 Ensembl GO_REF:0000107 perinuclear region of cytoplasm IDA 7349316 RGD plasma membrane IDA 7349316 RGD plasma membrane IBA MGI:MGI:105064 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISS UniProtKB:Q1PS52 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane ISO RGD:736585 1624291 (PMID:15035633), (PMID:21553168) RGD GO_REF:0000052 more ... plasma membrane IDA 8554239 PMID:21543739 UniProt plasma membrane IDA 8554433 PMID:18321853 UniProt sarcolemma IDA 7349316 RGD T-tubule IDA 7349316 RGD Molecular Function calcium-dependent protein binding ISO RGD:736585 1624291 (PMID:15035633) RGD PMID:15035633 calcium-dependent protein binding ISS UniProtKB:P19634 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calmodulin binding IEA UniProtKB-KW:KW-0112 1600115 GO_REF:0000043 UniProt GO_REF:0000043 potassium:proton antiporter activity IBA MGI:MGI:1924281 more ... 13792537 PMID:21873635 GO_Central protein binding IPI UniProtKB:Q96BS2 8554433 PMID:18321853 UniProt protein binding ISO RGD:736585 1624291 UniProtKB:O43745 more ... RGD PMID:11350981 more ... protein binding IPI UniProtKB:Q810D1 1299552 PMID:12576672 IntAct protein phosphatase 2B binding ISO RGD:736585 1624291 UniProtKB:P16298 , UniProtKB:Q08209 (PMID:22688515) RGD PMID:22688515 sodium:proton antiporter activity IMP 1581387 RGD sodium:proton antiporter activity IBA MGI:MGI:102462 more ... 13792537 PMID:21873635 GO_Central sodium:proton antiporter activity ISO RGD:11317 1624291 (MGI:MGI:2446396 more ... RGD MGI:MGI:2446396 more ... sodium:proton antiporter activity IDA 8554433 PMID:18321853 UniProt sodium:proton antiporter activity ISO RGD:736585 1624291 (PMID:11350981), (PMID:24840010), (PMID:8901634) RGD PMID:11350981 more ...
Gene-Chemical Interaction Annotations
