SLC9A1 (solute carrier family 9 member A1) - Rat Genome Database

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Gene: SLC9A1 (solute carrier family 9 member A1) Sus scrofa
Analyze
Symbol: SLC9A1
Name: solute carrier family 9 member A1
RGD ID: 13970309
Description: ENCODES a protein that exhibits calcium-dependent protein binding (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN cardiac muscle cell contraction (ortholog); cardiac muscle cell differentiation (ortholog); cell differentiation (ortholog); PARTICIPATES IN endothelin signaling pathway; ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 19 (ortholog); Barrett's esophagus (ortholog); cataract (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH benzamide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NA(+)-H+ exchanger protein; Na(+)/H(+) exchanger 1; NHE-1; NHE1; sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,944,221 - 77,996,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
benzamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anion transmembrane transport  (IEA)
cardiac muscle cell contraction  (ISO)
cardiac muscle cell differentiation  (IEA,ISO)
cell differentiation  (ISO)
cellular response to acidic pH  (IEA,ISS)
cellular response to antibiotic  (ISO)
cellular response to cold  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to epinephrine stimulus  (IEA)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular sodium ion homeostasis  (IEA)
negative regulation of apoptotic process  (ISO)
neuron death  (ISO)
positive regulation of action potential  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IEA)
positive regulation of calcium:sodium antiporter activity  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of mitochondrial membrane permeability  (ISO)
positive regulation of the force of heart contraction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
potassium ion transmembrane transport  (IBA)
protein complex oligomerization  (ISS)
proton transmembrane transport  (IEA)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA)
regulation of intracellular pH  (IBA,ISO,ISS)
regulation of pH  (ISO,ISS)
regulation of sensory perception of pain  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA)
response to acidic pH  (ISO,ISS)
response to muscle stretch  (IEA)
response to organic cyclic compound  (ISO)
sodium ion export across plasma membrane  (ISS)
sodium ion import across plasma membrane  (IBA)
sodium ion transport  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1661081   PMID:19023020   PMID:24376615  


Genomics

Comparative Map Data
SLC9A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,944,221 - 77,996,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl127,098,809 - 27,166,981 (-)EnsemblGRCh38hg38GRCh38
GRCh38127,098,809 - 27,155,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,425,300 - 27,481,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,297,894 - 27,353,990 (-)NCBINCBI36hg18NCBI36
Build 34127,109,448 - 27,165,543NCBI
Celera125,822,106 - 25,878,256 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,679,019 - 25,736,027 (-)NCBIHuRef
CHM1_1127,539,712 - 27,596,211 (-)NCBICHM1_1
Slc9a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,097,022 - 133,151,013 (+)NCBIGRCm39mm39
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)Ensembl
GRCm384133,369,711 - 133,423,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,925,687 - 132,979,613 (+)NCBIGRCm37mm9NCBIm37
MGSCv364132,642,305 - 132,695,773 (+)NCBImm8
Celera4131,535,491 - 131,589,316 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Slc9a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,576,341 - 145,629,630 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)Ensembl
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
Celera5143,998,303 - 144,051,177 (+)NCBICelera
RH 3.4 Map5977.9RGD
Cytogenetic Map5q36NCBI
Slc9a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,409,833 - 6,467,841 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,409,833 - 6,467,841 (-)NCBIChiLan1.0ChiLan1.0
SLC9A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,414,937 - 27,475,089 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,414,937 - 27,475,089 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,359,818 - 26,418,910 (-)NCBIMhudiblu_PPA_v0panPan3
SLC9A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,054,742 - 73,103,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBI
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBI
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBI
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBI
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBI
Slc9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,635,479 - 45,692,666 (-)NCBI
SpeTri2.0NW_00493647411,460,266 - 11,517,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,613,289 - 105,670,868 (+)NCBI
ChlSab1.1 Ensembl20105,613,338 - 105,674,208 (+)Ensembl
Vero_WHO_p1.0NW_02366603310,772,194 - 10,834,851 (-)NCBI
Slc9a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476411,041,118 - 11,095,892 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 5 2 22 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003963   ⟹   ENSSSCP00000003872
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)Ensembl
RefSeq Acc Id: NM_001007103   ⟹   NP_001007104
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001007104 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31092 (Get FASTA)   NCBI Sequence Viewer  
  AAB20633 (Get FASTA)   NCBI Sequence Viewer  
  JAA74289 (Get FASTA)   NCBI Sequence Viewer  
  P48762 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001007104   ⟸   NM_001007103
- UniProtKB: P48762 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000003872   ⟸   ENSSSCT00000003963
Protein Domains
Na_H_Exchanger   NEXCaM_BD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003872 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003963 ENTREZGENE, UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/H_exchanger_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHE_CaM-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397458 UniProtKB/Swiss-Prot
NCBI Gene SLC9A1 ENTREZGENE
PANTHER PTHR10110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10110:SF59 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEXCaM_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS NAHEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAHEXCHNGR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs b_cpa1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1STQ3_PIG UniProtKB/TrEMBL
  P48762 ENTREZGENE, UniProtKB/Swiss-Prot