SLC9A1 (solute carrier family 9 member A1) - Rat Genome Database

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Gene: SLC9A1 (solute carrier family 9 member A1) Canis lupus familiaris
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Symbol: SLC9A1
Name: solute carrier family 9 member A1
RGD ID: 12144154
Description: ENCODES a protein that exhibits sodium:proton antiporter activity (ortholog); INVOLVED IN cardiac muscle cell contraction (ortholog); cell differentiation (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN endothelin signaling pathway; ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 19 (ortholog); Barrett's esophagus (ortholog); Brain Hypoxia-Ischemia (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cell surface (ortholog); INTERACTS WITH arsenous acid; diarsenic trioxide
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Na+/H+ exchanger; NHE1; sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,054,742 - 73,103,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,616,211 - 73,664,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle cell contraction  (ISO)
cardiac muscle cell differentiation  (IEA)
cell differentiation  (ISO)
cellular response to acidic pH  (IEA)
cellular response to antibiotic  (ISO)
cellular response to cold  (ISO)
cellular response to electrical stimulus  (ISO)
cellular response to epinephrine stimulus  (IEA)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
intracellular sodium ion homeostasis  (IEA)
monoatomic cation transport  (IEA)
monoatomic ion transport  (IEA)
negative regulation of apoptotic process  (ISO)
positive regulation of action potential  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcineurin-NFAT signaling cascade  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cell growth  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of mitochondrial membrane permeability  (ISO)
positive regulation of the force of heart contraction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
potassium ion transmembrane transport  (IBA)
proton transmembrane transport  (IEA)
regulation of cardiac muscle contraction by calcium ion signaling  (IEA)
regulation of intracellular pH  (IBA,IEA,ISO)
regulation of pH  (IEA)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA)
response to acidic pH  (IEA)
response to muscle stretch  (IEA)
sodium ion import across plasma membrane  (IBA,IEA)
sodium ion transmembrane transport  (IEA)
sodium ion transport  (IEA)
stem cell differentiation  (IEA)
transmembrane transport  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15121097   PMID:16037087   PMID:21832840   PMID:22301074   PMID:23678047   PMID:24557342   PMID:30032202   PMID:32980460  


Genomics

Comparative Map Data
SLC9A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,054,742 - 73,103,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,616,211 - 73,664,827 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
SLC9A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,098,809 - 27,155,125 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,098,809 - 27,166,981 (-)Ensemblhg38GRCh38
GRCh37127,425,300 - 27,481,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,297,894 - 27,353,990 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34127,109,448 - 27,165,543NCBI
Celera125,822,106 - 25,878,256 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,679,019 - 25,736,027 (-)NCBIHuRef
CHM1_1127,539,712 - 27,596,211 (-)NCBICHM1_1
T2T-CHM13v2.0126,938,788 - 26,996,283 (-)NCBIT2T-CHM13v2.0
Slc9a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,097,022 - 133,151,013 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,097,017 - 133,151,013 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384133,369,711 - 133,423,702 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,369,706 - 133,423,702 (+)Ensemblmm10GRCm38
MGSCv374132,925,687 - 132,979,613 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364132,642,305 - 132,695,773 (+)NCBIMGSCv36mm8
Celera4131,535,491 - 131,589,316 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Slc9a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,859,412 - 150,913,525 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5150,860,228 - 150,913,517 (+)EnsemblGRCr8
mRatBN7.25145,576,341 - 145,629,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,576,334 - 145,629,624 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5148,278,173 - 148,331,396 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,047,784 - 150,101,012 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,034,322 - 150,087,546 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,573,122 - 151,626,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,573,092 - 151,627,316 (+)Ensemblrn6Rnor6.0
Rnor_5.05155,237,482 - 155,290,410 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45151,680,696 - 151,748,460 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5143,998,303 - 144,051,177 (+)NCBICelera
RGSC_v3.15151,690,734 - 151,758,499 (-)NCBI
RH 3.4 Map5977.9RGD
Cytogenetic Map5q36NCBI
Slc9a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,409,833 - 6,467,841 (-)Ensembl
ChiLan1.0NW_0049554526,409,833 - 6,467,841 (-)NCBIChiLan1.0ChiLan1.0
SLC9A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,713,762 - 199,772,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11198,817,765 - 198,876,989 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,359,818 - 26,418,910 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,414,937 - 27,475,089 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,414,937 - 27,475,089 (-)EnsemblpanPan2panpan1.1
Slc9a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,635,479 - 45,692,666 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,459,929 - 11,517,478 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,460,266 - 11,517,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC9A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,372,649 - 84,426,997 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1684,373,921 - 84,426,447 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,944,221 - 77,996,927 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC9A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,613,289 - 105,670,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,613,338 - 105,674,208 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603310,772,194 - 10,834,851 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc9a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,039,051 - 11,095,885 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476411,041,118 - 11,095,892 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC9A1
530 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000019381   ⟹   ENSCAFP00000017978
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl273,054,742 - 73,103,364 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845019545   ⟹   ENSCAFP00845015284
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl273,616,211 - 73,664,827 (+)Ensembl
RefSeq Acc Id: NM_001287028   ⟹   NP_001273957
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1273,054,742 - 73,103,364 (+)NCBI
Dog10K_Boxer_Tasha269,631,268 - 69,679,864 (+)NCBI
ROS_Cfam_1.0273,616,211 - 73,664,827 (+)NCBI
UMICH_Zoey_3.1270,441,943 - 70,490,513 (+)NCBI
UNSW_CanFamBas_1.0271,447,299 - 71,495,908 (+)NCBI
UU_Cfam_GSD_1.0272,450,107 - 72,498,704 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273957 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG41970 (Get FASTA)   NCBI Sequence Viewer  
  AAG41971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000017978.3
  ENSCAFP00030020494.1
  ENSCAFP00040005724.1
  ENSCAFP00845015284
  ENSCAFP00845015284.1
RefSeq Acc Id: NP_001273957   ⟸   NM_001287028
- UniProtKB: A0A8C0LC46 (UniProtKB/TrEMBL),   A0A8C0N5D8 (UniProtKB/TrEMBL),   A0A8I3RW87 (UniProtKB/TrEMBL),   A0A8C0QA81 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000017978   ⟸   ENSCAFT00000019381
Ensembl Acc Id: ENSCAFP00845015284   ⟸   ENSCAFT00845019545
Protein Domains
Cation/H+ exchanger transmembrane   Sodium/hydrogen exchanger regulatory region

Promoters
RGD ID:13682581
Promoter ID:EPDNEW_C649
Type:single initiation site
Name:SLC9A1_1
Description:sodium/hydrogen exchanger 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1273,054,725 - 73,054,785EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012207 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030012705 UniProtKB/TrEMBL
  ENSCAFG00040003462 UniProtKB/TrEMBL
  ENSCAFG00845011051 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019381.5 UniProtKB/TrEMBL
  ENSCAFT00030023508.1 UniProtKB/TrEMBL
  ENSCAFT00040006615.1 UniProtKB/TrEMBL
  ENSCAFT00845019545 ENTREZGENE
  ENSCAFT00845019545.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.1330 UniProtKB/TrEMBL
  6.10.250.1040 UniProtKB/TrEMBL
  6.10.250.2020 UniProtKB/TrEMBL
InterPro Cation/H_exchanger UniProtKB/TrEMBL
  Cation/H_exchanger_CPA1 UniProtKB/TrEMBL
  Na/H_exchanger_1 UniProtKB/TrEMBL
  NaH_exchanger UniProtKB/TrEMBL
  NHE_CaM-bd UniProtKB/TrEMBL
KEGG Report cfa:478171 UniProtKB/TrEMBL
NCBI Gene SLC9A1 ENTREZGENE
PANTHER PTHR10110 UniProtKB/TrEMBL
  PTHR10110:SF59 UniProtKB/TrEMBL
Pfam Na_H_Exchanger UniProtKB/TrEMBL
  NEXCaM_BD UniProtKB/TrEMBL
PRINTS NAHEXCHNGR UniProtKB/TrEMBL
  NAHEXCHNGR1 UniProtKB/TrEMBL
UniProt A0A8C0LC46 ENTREZGENE
  A0A8C0N5D8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QA81 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RW87 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:53473 ENTREZGENE