Tal1 (TAL bHLH transcription factor 1, erythroid differentiation factor) - Rat Genome Database

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Gene: Tal1 (TAL bHLH transcription factor 1, erythroid differentiation factor) Rattus norvegicus
Analyze
Symbol: Tal1
Name: TAL bHLH transcription factor 1, erythroid differentiation factor
RGD ID: 1306748
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Predicted to contribute to DNA binding activity. Predicted to be involved in several processes, including basophil differentiation; positive regulation of cellular component organization; and regulation of DNA-templated transcription. Predicted to act upstream of with a positive effect on transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313507; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; Tal-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,823,093 - 133,837,737 (+)NCBIGRCr8
mRatBN7.25128,586,776 - 128,600,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,587,701 - 128,600,976 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,270,143 - 131,283,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05132,999,788 - 133,013,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,021,481 - 133,034,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,864,401 - 133,878,604 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,864,798 - 133,878,830 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,655,978 - 137,670,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,430,985 - 135,444,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,438,330 - 135,447,104 (+)NCBI
Celera5127,232,703 - 127,245,971 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. Aplan PD, etal., Blood. 1992 Mar 1;79(5):1327-33.
2. SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. D'Souza SL, etal., Blood. 2005 May 15;105(10):3862-70. Epub 2005 Jan 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Lecuyer E, etal., Blood. 2002 Oct 1;100(7):2430-40.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Shivdasani RA, etal., Nature. 1995 Feb 2;373(6513):432-4.
Additional References at PubMed
PMID:1396592   PMID:7624372   PMID:7678994   PMID:8760303   PMID:8861941   PMID:9111058   PMID:9269761   PMID:9391090   PMID:9472016   PMID:9819382   PMID:10373552   PMID:11439353  
PMID:11731461   PMID:12485991   PMID:12552125   PMID:12569129   PMID:14726374   PMID:14726394   PMID:15314159   PMID:15677556   PMID:15920471   PMID:16007160   PMID:16292311   PMID:16623824  
PMID:16673016   PMID:16763211   PMID:17644741   PMID:17962413   PMID:18184866   PMID:18550854   PMID:19011221   PMID:19182774   PMID:19200805   PMID:19323994   PMID:19497860   PMID:19799863  
PMID:19850742   PMID:20028976   PMID:20194619   PMID:20855495   PMID:22835905   PMID:23132581   PMID:23980096  


Genomics

Comparative Map Data
Tal1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85133,823,093 - 133,837,737 (+)NCBIGRCr8
mRatBN7.25128,586,776 - 128,600,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5128,587,701 - 128,600,976 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5131,270,143 - 131,283,468 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05132,999,788 - 133,013,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05133,021,481 - 133,034,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05133,864,401 - 133,878,604 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5133,864,798 - 133,878,830 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05137,655,978 - 137,670,144 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45135,430,985 - 135,444,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15135,438,330 - 135,447,104 (+)NCBI
Celera5127,232,703 - 127,245,971 (+)NCBICelera
Cytogenetic Map5q35NCBI
TAL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38147,216,290 - 47,232,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl147,216,290 - 47,232,225 (-)EnsemblGRCh38hg38GRCh38
GRCh37147,681,962 - 47,698,007 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36147,454,551 - 47,468,030 (-)NCBINCBI36Build 36hg18NCBI36
Build 34147,393,983 - 47,407,463NCBI
Celera145,968,230 - 45,981,708 (-)NCBICelera
Cytogenetic Map1p33NCBI
HuRef145,798,600 - 45,812,074 (-)NCBIHuRef
CHM1_1147,798,845 - 47,812,319 (-)NCBICHM1_1
T2T-CHM13v2.0147,094,699 - 47,110,742 (-)NCBIT2T-CHM13v2.0
Tal1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394114,913,623 - 114,928,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4114,913,623 - 114,928,952 (+)EnsemblGRCm39 Ensembl
GRCm384115,056,426 - 115,071,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4115,056,426 - 115,071,755 (+)EnsemblGRCm38mm10GRCm38
MGSCv374114,732,132 - 114,744,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364114,557,459 - 114,569,687 (+)NCBIMGSCv36mm8
Celera4113,806,727 - 113,818,916 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map452.73NCBI
Tal1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546411,310,628 - 11,315,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546411,304,611 - 11,317,420 (+)NCBIChiLan1.0ChiLan1.0
TAL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21179,570,869 - 179,586,982 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,712,653 - 178,728,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0146,524,484 - 46,540,595 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1148,039,155 - 48,054,021 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl148,042,594 - 48,048,622 (-)Ensemblpanpan1.1panPan2
TAL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11513,446,752 - 13,462,038 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1513,449,481 - 13,462,047 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1513,598,407 - 13,614,022 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01513,595,386 - 13,611,008 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1513,598,590 - 13,611,010 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11513,395,087 - 13,410,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01513,463,077 - 13,478,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01513,532,579 - 13,548,206 (+)NCBIUU_Cfam_GSD_1.0
Tal1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505862,223,080 - 62,238,124 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647428,047,808 - 28,056,065 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647428,049,326 - 28,061,495 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6164,283,366 - 164,295,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16164,282,242 - 164,297,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26151,830,187 - 151,846,169 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12085,681,247 - 85,697,887 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2085,688,155 - 85,694,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603331,381,681 - 31,398,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tal1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248595,586,977 - 5,601,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248595,586,489 - 5,601,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tal1
27 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:389
Count of miRNA genes:202
Interacting mature miRNAs:269
Transcripts:ENSRNOT00000035409
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5128033842133011550Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH129488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25128,600,753 - 128,600,918 (+)MAPPERmRatBN7.2
Rnor_6.05133,878,382 - 133,878,546NCBIRnor6.0
Rnor_5.05137,669,922 - 137,670,086UniSTSRnor5.0
RGSC_v3.45135,444,470 - 135,444,634UniSTSRGSC3.4
Celera5127,245,749 - 127,245,913UniSTS
RH 3.4 Map5833.7UniSTS
Cytogenetic Map5q36UniSTS
BE117264  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25128,592,686 - 128,592,867 (+)MAPPERmRatBN7.2
Rnor_6.05133,870,317 - 133,870,497NCBIRnor6.0
Rnor_5.05137,661,857 - 137,662,037UniSTSRnor5.0
RGSC_v3.45135,436,405 - 135,436,585UniSTSRGSC3.4
Celera5127,237,689 - 127,237,869UniSTS
RH 3.4 Map5829.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000035409   ⟹   ENSRNOP00000034958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5128,587,701 - 128,600,976 (+)Ensembl
Rnor_6.0 Ensembl5133,865,331 - 133,878,604 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091977   ⟹   ENSRNOP00000071897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5128,589,396 - 128,600,976 (+)Ensembl
Rnor_6.0 Ensembl5133,864,798 - 133,878,830 (+)Ensembl
RefSeq Acc Id: NM_001107958   ⟹   NP_001101428
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,824,464 - 133,837,737 (+)NCBI
mRatBN7.25128,587,701 - 128,600,976 (+)NCBI
Rnor_6.05133,865,331 - 133,878,604 (+)NCBI
Rnor_5.05137,655,978 - 137,670,144 (+)NCBI
RGSC_v3.45135,430,985 - 135,444,692 (+)RGD
Celera5127,232,703 - 127,245,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238615   ⟹   XP_006238677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,095 - 133,837,737 (+)NCBI
mRatBN7.25128,586,776 - 128,600,976 (+)NCBI
Rnor_6.05133,864,403 - 133,878,604 (+)NCBI
Rnor_5.05137,655,978 - 137,670,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238617   ⟹   XP_006238679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,690 - 133,837,737 (+)NCBI
mRatBN7.25128,587,067 - 128,600,976 (+)NCBI
Rnor_6.05133,864,606 - 133,878,604 (+)NCBI
Rnor_5.05137,655,978 - 137,670,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006238618   ⟹   XP_006238680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,093 - 133,837,737 (+)NCBI
mRatBN7.25128,586,789 - 128,600,976 (+)NCBI
Rnor_6.05133,864,401 - 133,878,604 (+)NCBI
Rnor_5.05137,655,978 - 137,670,144 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763967   ⟹   XP_008762189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,690 - 133,837,737 (+)NCBI
mRatBN7.25128,587,067 - 128,600,976 (+)NCBI
Rnor_6.05133,864,606 - 133,878,604 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109984   ⟹   XP_038965912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,688 - 133,837,737 (+)NCBI
mRatBN7.25128,587,067 - 128,600,976 (+)NCBI
RefSeq Acc Id: XM_039109985   ⟹   XP_038965913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,688 - 133,837,737 (+)NCBI
mRatBN7.25128,587,067 - 128,600,976 (+)NCBI
RefSeq Acc Id: XM_039109986   ⟹   XP_038965914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,824,446 - 133,837,737 (+)NCBI
mRatBN7.25128,587,683 - 128,600,976 (+)NCBI
RefSeq Acc Id: XM_063287732   ⟹   XP_063143802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85133,823,688 - 133,837,737 (+)NCBI
RefSeq Acc Id: NP_001101428   ⟸   NM_001107958
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238677   ⟸   XM_006238615
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238680   ⟸   XM_006238618
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238679   ⟸   XM_006238617
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762189   ⟸   XM_008763967
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034958   ⟸   ENSRNOT00000035409
Ensembl Acc Id: ENSRNOP00000071897   ⟸   ENSRNOT00000091977
RefSeq Acc Id: XP_038965912   ⟸   XM_039109984
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965913   ⟸   XM_039109985
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965914   ⟸   XM_039109986
- Peptide Label: isoform X2
- UniProtKB: D3Z921 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143802   ⟸   XM_063287732
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1M1 (UniProtKB/TrEMBL)
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z921-F1-model_v2 AlphaFold D3Z921 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306748 AgrOrtholog
BioCyc Gene G2FUF-40305 BioCyc
Ensembl Genes ENSRNOG00000025051 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035409.6 UniProtKB/TrEMBL
  ENSRNOT00000091977.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro HLH_DNA-bd UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  TAL-like UniProtKB/TrEMBL
KEGG Report rno:313507 UniProtKB/TrEMBL
NCBI Gene 313507 ENTREZGENE
PANTHER PTHR13864 UniProtKB/TrEMBL
  T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PhenoGen Tal1 PhenoGen
PROSITE HLH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025051 RatGTEx
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP HLH_basic UniProtKB/TrEMBL
UniProt A0A0G2K1M1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z921 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Tal1  TAL bHLH transcription factor 1, erythroid differentiation factor  Tal1  T-cell acute lymphocytic leukemia 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tal1  T-cell acute lymphocytic leukemia 1   Tal1_predicted  T-cell acute lymphocytic leukemia 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tal1_predicted  T-cell acute lymphocytic leukemia 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED