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Gene: Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase) Rattus norvegicus
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Symbol: Hmgcl
Name: 3-hydroxy-3-methylglutaryl-CoA lyase
Description: Exhibits carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including acyl-CoA metabolic process; ketone body biosynthetic process; and liver development. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxy-3-methylglutaryl CoA lyase; 3-hydroxy-3-methylglutaryl-Coenzyme A lyase; 3-hydroxymethyl-3-methylglutaryl-CoA lyase; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase; HL; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial
Orthologs:
Homo sapiens (human) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)  HGNC  Alliance
Mus musculus (house mouse) : Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Canis lupus familiaris (dog) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)
Sus scrofa (pig) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05154,294,841 - 154,308,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5154,294,806 - 154,308,640 (+)Ensembl
Rnor_5.05158,059,692 - 158,073,433 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45154,730,232 - 154,743,974 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15154,740,270 - 154,754,013 (+)NCBI
Celera5146,585,153 - 146,598,872 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hmgcl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620554
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.