Oprd1 (opioid receptor, delta 1) - Rat Genome Database

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Gene: Oprd1 (opioid receptor, delta 1) Rattus norvegicus
Symbol: Oprd1
Name: opioid receptor, delta 1
RGD ID: 3233
Description: Enables G protein-coupled enkephalin receptor activity and receptor serine/threonine kinase binding activity. Involved in several processes, including eating behavior; phospholipase C-activating G protein-coupled receptor signaling pathway; and regulation of calcium ion transport. Located in several cellular components, including axon terminus; dendrite membrane; and postsynaptic membrane. Is active in secretory vesicle; spine apparatus; and synaptic membrane. Used to study myocardial infarction. Orthologous to human OPRD1 (opioid receptor delta 1); INTERACTS WITH (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; (R)-noradrenaline; (R,R)-tramadol.
Type: protein-coding
Previously known as: D-OR-1; delta-type opioid receptor; DOR-1; opioid receptor A; Opioid receptor delta 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIRnor_WKY
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (EXP)
(R)-noradrenaline  (EXP)
(R,R)-tramadol  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7-Hydroxymitragynine  (ISO)
acetylmethadol  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
buprenorphine  (EXP,ISO)
butorphanol  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cannabidiol  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
clofibrate  (ISO)
cocaine  (EXP)
codeine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Deltorphin B  (EXP)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
dextropropoxyphene  (EXP)
dextrorphan  (EXP)
dibutyl phthalate  (EXP)
dynorphin A  (ISO)
eluxadoline  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fentanyl  (EXP)
hydralazine  (ISO)
hydrocodone  (EXP)
Leu-enkephalin  (ISO)
Levallorphan  (EXP)
Levorphanol  (EXP)
lipopolysaccharide  (ISO)
loperamide  (ISO)
magnesium atom  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
mesalamine  (EXP)
methadone  (EXP)
Mitragynine  (ISO)
morphine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
naloxone  (EXP)
naltrexone  (EXP)
Naltrindole  (EXP,ISO)
nicotine  (ISO)
Nonylphenol  (EXP)
oxycodone  (EXP)
paraquat  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serotonin  (EXP)
tapentadol  (EXP)
thioglycolic acid  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
U69593  (EXP)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Characterization of a delta opioid receptor in rat pheochromocytoma cells. Abood ME and Tao Q, J Pharmacol Exp Ther. 1995 Sep;274(3):1566-73.
2. Molecular cloning and expression of a delta-opioid receptor from rat brain. Abood ME, etal., J Neurosci Res. 1994 Apr 15;37(6):714-9.
3. delta opioid receptor modulation of several voltage-dependent Ca(2+) currents in rat sensory neurons. Acosta CG and Lopez HS, J Neurosci. 1999 Oct 1;19(19):8337-48.
4. Identification of a signaling cascade that maintains constitutive d-opioid receptor incompetence in peripheral sensory neurons. Brackley AD, etal., J Biol Chem. 2017 May 26;292(21):8762-8772. doi: 10.1074/jbc.M117.776799. Epub 2017 Apr 5.
5. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Charles AC, etal., Mol Pharmacol 2003 Jan;63(1):89-95.
6. Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. Cheng PY, etal., J Neurosci. 1995 Sep;15(9):5976-88.
7. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. Fryer RM, etal., J Pharmacol Exp Ther. 2000 Aug;294(2):451-7.
8. Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Fukuda K, etal., FEBS Lett 1993 Aug 2;327(3):311-4.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Huang P, etal., Biochem Pharmacol. 2007 Feb 15;73(4):534-49. Epub 2006 Nov 3.
12. Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Hurley RW, etal., Neuroscience. 2003;118(3):789-96.
13. NPY-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. Israel Y, etal., Peptides. 2005 Jul;26(7):1167-75. Epub 2005 Feb 26.
14. kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. Joshi SK, etal., J Neurosci. 2000 Aug 1;20(15):5874-9.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. [Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion] Lasukova TV, etal., Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):568-80.
17. Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. Lee JW, etal., J Neurochem. 1998 May;70(5):2203-11.
18. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
19. Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. Maslov LN, etal., Life Sci. 2003 Jul 4;73(7):947-52.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors. Patwardhan AM, etal., J Neurosci. 2005 Sep 28;25(39):8825-32.
23. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: comparison with plasmalemmal mu-opioid receptors. Wang H and Pickel VM, J Neurosci. 2001 May 1;21(9):3242-50.
29. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. Wang JB, etal., FEBS Lett 1994 Jul 4;348(1):75-9.
30. Ultrastructural localization of delta-1 opioid receptor in the dorsal raphe nucleus of the rat. Wang QP, etal., Synapse. 1997 Jul;26(3):243-53.
Additional References at PubMed
PMID:8393575   PMID:8738226   PMID:9548483   PMID:9915326   PMID:10835636   PMID:12113946   PMID:12855366   PMID:14608598   PMID:14689476   PMID:15467355   PMID:15862537   PMID:16159882  
PMID:16316997   PMID:16325578   PMID:16405927   PMID:16514101   PMID:17175187   PMID:17352824   PMID:17513490   PMID:18417105   PMID:18541716   PMID:18559244   PMID:18572383   PMID:18579738  
PMID:18602454   PMID:19036960   PMID:19056363   PMID:19180644   PMID:19279569   PMID:19295160   PMID:19545549   PMID:19581316   PMID:19619588   PMID:19686472   PMID:19709398   PMID:20399742  
PMID:20574683   PMID:20615975   PMID:20730419   PMID:20977770   PMID:21280046   PMID:21444630   PMID:21600884   PMID:22072818   PMID:22184124   PMID:22200548   PMID:22575599   PMID:22592774  
PMID:22796630   PMID:23272051   PMID:23272113   PMID:23286559   PMID:23843537   PMID:23844255   PMID:24033469   PMID:24416361   PMID:24613828   PMID:24758591   PMID:24847082   PMID:24976397  
PMID:25480575   PMID:25639363   PMID:27246300   PMID:27376372   PMID:27568556   PMID:28645621   PMID:29262398   PMID:29563057   PMID:29687347   PMID:30132200   PMID:30560518   PMID:31030416  
PMID:32228617   PMID:33197884   PMID:35674691   PMID:36592113  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIRnor_WKY
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38128,812,170 - 28,871,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl128,812,170 - 28,871,267 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,138,682 - 29,197,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,011,241 - 29,062,795 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,959,269 - 29,010,821NCBI
Celera127,534,800 - 27,586,335 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,391,067 - 27,442,611 (+)NCBIHuRef
CHM1_1129,254,016 - 29,305,583 (+)NCBICHM1_1
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm394131,834,980 - 131,872,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,838,037 - 131,871,797 (-)EnsemblGRCm39 Ensembl
GRCm384132,110,188 - 132,144,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,110,726 - 132,144,486 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,666,641 - 131,700,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,382,802 - 131,416,562 (-)NCBIMGSCv36mm8
Celera4130,271,660 - 130,305,734 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.78NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554527,866,758 - 7,913,399 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,866,790 - 7,913,399 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11197,090,112 - 197,149,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,068,053 - 28,143,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,112,328 - 29,163,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,112,152 - 29,163,464 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1271,685,129 - 71,721,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,689,084 - 71,721,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,264,922 - 68,297,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,248,368 - 72,280,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,247,773 - 72,281,077 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,077,265 - 69,109,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,084,707 - 70,117,198 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,082,831 - 71,115,319 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440505847,035,433 - 47,078,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,860,293 - 12,903,466 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647412,860,293 - 12,902,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl685,785,276 - 85,830,877 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,775,576 - 85,827,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,611,950 - 79,662,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.120103,950,505 - 104,002,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603312,520,984 - 12,574,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476412,604,164 - 12,676,279 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,604,051 - 12,676,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Oprd1
276 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:100
Interacting mature miRNAs:116
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,377,876 - 144,378,094 (+)MAPPERmRatBN7.2
Rnor_6.05150,360,936 - 150,361,153NCBIRnor6.0
Rnor_5.05154,034,053 - 154,034,270UniSTSRnor5.0
RGSC_v3.45151,060,403 - 151,060,621RGDRGSC3.4
RGSC_v3.45151,060,404 - 151,060,621UniSTSRGSC3.4
RGSC_v3.15151,070,442 - 151,070,660RGD
Celera5142,812,193 - 142,812,410UniSTS
RH 3.4 Map5988.6UniSTS
RH 3.4 Map5988.6RGD
RH 2.0 Map5157.0RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,358,090 - 144,358,281 (+)MAPPERmRatBN7.2
Rnor_6.05150,340,838 - 150,341,028NCBIRnor6.0
Rnor_5.05154,014,163 - 154,014,353UniSTSRnor5.0
RGSC_v3.45151,039,725 - 151,039,965RGDRGSC3.4
RGSC_v3.45151,039,766 - 151,039,956UniSTSRGSC3.4
RGSC_v3.15151,049,805 - 151,049,995RGD
Celera5142,792,480 - 142,792,670UniSTS
RH 3.4 Map5964.21UniSTS
RH 3.4 Map5964.21RGD
SHRSP x BN Map580.7699UniSTS
SHRSP x BN Map580.7699RGD
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,306,218 - 144,306,372 (+)MAPPERmRatBN7.2
Rnor_6.05150,288,157 - 150,288,309NCBIRnor6.0
Rnor_5.05153,962,798 - 153,962,950UniSTSRnor5.0
RGSC_v3.45150,979,283 - 150,979,435UniSTSRGSC3.4
Celera5142,741,037 - 142,741,188UniSTS
RH 3.4 Map5965.9UniSTS
Cytogenetic Map5q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25144,316,650 - 144,316,823 (+)MAPPERmRatBN7.2
Rnor_6.05150,298,478 - 150,298,650NCBIRnor6.0
Rnor_5.05153,973,040 - 153,973,212UniSTSRnor5.0
RGSC_v3.45150,990,090 - 150,990,262UniSTSRGSC3.4
Celera5142,751,643 - 142,751,815UniSTS
RH 3.4 Map5965.41UniSTS
Cytogenetic Map5q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 2 2 2 2 33 1 12
Below cutoff 3 23 13 5 3 5 4 5 37 25 22 1 4


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014084   ⟹   ENSRNOP00000014084
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)Ensembl
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)Ensembl
RefSeq Acc Id: NM_012617   ⟹   NP_036749
Rat AssemblyChrPosition (strand)Source
mRatBN7.25144,306,188 - 144,340,960 (-)NCBI
Rnor_6.05150,288,126 - 150,323,063 (-)NCBI
Rnor_5.05153,962,767 - 153,997,858 (-)NCBI
RGSC_v3.45150,979,252 - 151,014,066 (-)RGD
Celera5142,741,006 - 142,775,820 (-)RGD
Protein Sequences
Protein RefSeqs NP_036749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19939 (Get FASTA)   NCBI Sequence Viewer  
  BAA03851 (Get FASTA)   NCBI Sequence Viewer  
  EDL80617 (Get FASTA)   NCBI Sequence Viewer  
  P33533 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036749   ⟸   NM_012617
- UniProtKB: P33533 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014084   ⟸   ENSRNOT00000014084

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33533-F1-model_v2 AlphaFold P33533 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3233 AgrOrtholog
BioCyc Gene G2FUF-39716 BioCyc
Ensembl Genes ENSRNOG00000010531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014084 ENTREZGENE
  ENSRNOP00000014084.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014084 ENTREZGENE
  ENSRNOT00000014084.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Delta_opi_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Opioid_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24613 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oprd1 PhenoGen
  OPIOIDR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC224017

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Oprd1  Opioid receptor delta 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction may interact with micro-opioid receptors to effect action potentials in GH3 cells 729249