Stmn1 (stathmin 1) - Rat Genome Database

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Gene: Stmn1 (stathmin 1) Rattus norvegicus
Analyze
Symbol: Stmn1
Name: stathmin 1
RGD ID: 2992
Description: Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including establishment of skin barrier; negative regulation of signal transduction; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including axonogenesis; mitotic spindle organization; and negative regulation of microtubule polymerization. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm and neuron projection. Orthologous to human STMN1 (stathmin 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Lap18; Leukemia-associated cytosolic phosphoprotein stathmin; leukemia-associated gene; leukemia-associated phosphoprotein p18; metablastin; MGC72884; oncoprotein 18; OP18; phosphoprotein p19; PP17; PP19; PR22; prosolin; SMN; stathmin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25146,680,757 - 146,687,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,681,436 - 146,687,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5149,383,560 - 149,389,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05151,153,616 - 151,159,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05151,139,803 - 151,145,467 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05152,680,412 - 152,686,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,680,407 - 152,686,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,466,632 - 156,472,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45153,226,420 - 153,232,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15153,236,461 - 153,242,123 (+)NCBI
Celera5145,096,588 - 145,102,252 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-nitrofluorene  (EXP)
3,3'-Thiobispropanoic acid  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthracene-1,8,9-triol  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
chlorendic acid  (EXP)
cholic acid  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
etoposide  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gemfibrozil  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glycine betaine  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
iprodione  (EXP)
isobutanol  (ISO)
Isobutylparaben  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lomustine  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
maneb  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
Mezerein  (ISO)
microcystin-LR  (EXP)
minocycline  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium nitrate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
saccharin  (ISO)
sarin  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
sertraline  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium nitrite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
membrane  (ISO)
microtubule  (IEA)
neuron projection  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A single cDNA encodes two isoforms of stathmin, a developmentally regulated neuron-enriched phosphoprotein. Doye V, etal., J Biol Chem 1989 Jul 25;264(21):12134-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. Gavet O, etal., J Cell Sci 1998 Nov;111 ( Pt 22):3333-46.
4. miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. Imura S, etal., Anticancer Res. 2017 Oct;37(10):5877-5883. doi: 10.21873/anticanres.12033.
5. Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth. Kinoshita I, etal., Oncogene 2003 May 8;22(18):2710-22.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon S, etal., J Neurosci Res 1999 Jun 1;56(5):553-64.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Homology between the cDNAs encoding phosphoprotein p19 and SCG10 reveals a novel mammalian gene family preferentially expressed in developing brain. Schubart UK, etal., DNA 1989 Jul-Aug;8(6):389-98.
12. Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats. Tamura K, etal., Endocrinology 2003 Apr;144(4):1464-73.
Additional References at PubMed
PMID:9271428   PMID:9880330   PMID:10369391   PMID:10675326   PMID:10712642   PMID:11839567   PMID:12477932   PMID:12860982   PMID:14769823   PMID:15489334   PMID:15652749   PMID:15659612  
PMID:16110469   PMID:16401721   PMID:16548883   PMID:16982419   PMID:20458337   PMID:20569302   PMID:21625015   PMID:22535533   PMID:24302736   PMID:25122120   PMID:25198505   PMID:25285524  
PMID:26370173   PMID:31933182  


Genomics

Comparative Map Data
Stmn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25146,680,757 - 146,687,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5146,681,436 - 146,687,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5149,383,560 - 149,389,224 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05151,153,616 - 151,159,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05151,139,803 - 151,145,467 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05152,680,412 - 152,686,807 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5152,680,407 - 152,686,806 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,466,632 - 156,472,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45153,226,420 - 153,232,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15153,236,461 - 153,242,123 (+)NCBI
Celera5145,096,588 - 145,102,252 (+)NCBICelera
Cytogenetic Map5q36NCBI
STMN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,884,179 - 25,906,880 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,884,181 - 25,906,991 (-)EnsemblGRCh38hg38GRCh38
GRCh37126,210,670 - 26,233,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,099,194 - 26,105,955 (-)NCBINCBI36Build 36hg18NCBI36
Build 34125,910,750 - 25,917,510NCBI
Celera124,606,762 - 24,629,447 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef124,466,602 - 24,489,287 (-)NCBIHuRef
CHM1_1126,323,940 - 26,346,632 (-)NCBICHM1_1
T2T-CHM13v2.0125,721,609 - 25,744,310 (-)NCBIT2T-CHM13v2.0
Stmn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394134,195,631 - 134,201,154 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4134,195,631 - 134,201,154 (+)EnsemblGRCm39 Ensembl
GRCm384134,468,320 - 134,473,843 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4134,468,320 - 134,473,843 (+)EnsemblGRCm38mm10GRCm38
MGSCv374134,024,235 - 134,029,758 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364133,740,487 - 133,745,915 (+)NCBIMGSCv36mm8
Celera4132,647,807 - 132,653,538 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.76NCBI
Stmn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554525,388,150 - 5,391,518 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554525,387,696 - 5,393,337 (-)NCBIChiLan1.0ChiLan1.0
STMN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11200,065,138 - 200,071,427 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,159,241 - 25,165,535 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,208,731 - 26,230,957 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,208,731 - 26,230,925 (-)Ensemblpanpan1.1panPan2
STMN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1274,035,462 - 74,043,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl274,035,457 - 74,043,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha270,610,808 - 70,618,698 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0274,597,990 - 74,605,869 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl274,599,514 - 74,605,869 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,422,689 - 71,429,324 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,428,285 - 72,436,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0273,432,116 - 73,440,006 (+)NCBIUU_Cfam_GSD_1.0
Stmn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505844,645,226 - 44,651,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647410,468,728 - 10,475,594 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647410,470,006 - 10,475,557 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STMN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl683,356,412 - 83,362,500 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1683,356,404 - 83,362,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2676,904,244 - 76,934,107 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STMN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120106,866,719 - 106,873,314 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20106,868,838 - 106,874,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660339,543,680 - 9,549,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stmn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247649,996,124 - 10,001,197 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247649,996,119 - 10,001,253 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stmn1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:55
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000022574
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat

Markers in Region
RH94569  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2887,337,051 - 87,337,208 (+)MAPPERmRatBN7.2
mRatBN7.25146,686,949 - 146,687,106 (+)MAPPERmRatBN7.2
Rnor_6.0894,041,606 - 94,041,762NCBIRnor6.0
Rnor_6.05152,686,605 - 152,686,761NCBIRnor6.0
Rnor_5.0893,555,446 - 93,555,602UniSTSRnor5.0
Rnor_5.05156,472,203 - 156,472,359UniSTSRnor5.0
Cytogenetic Map8q31UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 47
Medium 3 39 41 29 19 29 2 2 27 35 41 11 2
Low 4 16 12 12 6 9 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022574   ⟹   ENSRNOP00000022574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,683,527 - 146,687,153 (+)Ensembl
Rnor_6.0 Ensembl5152,681,131 - 152,686,806 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076052   ⟹   ENSRNOP00000068006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,681,436 - 146,687,153 (+)Ensembl
Rnor_6.0 Ensembl5152,681,101 - 152,686,806 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5152,681,112 - 152,684,129 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076864   ⟹   ENSRNOP00000068405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,681,476 - 146,687,154 (+)Ensembl
Rnor_6.0 Ensembl5152,680,407 - 152,685,974 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105029   ⟹   ENSRNOP00000083571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5146,682,105 - 146,687,153 (+)Ensembl
RefSeq Acc Id: NM_017166   ⟹   NP_058862
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25146,681,487 - 146,687,147 (+)NCBI
Rnor_6.05152,681,142 - 152,686,806 (+)NCBI
Rnor_5.05156,466,632 - 156,472,404 (+)NCBI
RGSC_v3.45153,226,420 - 153,232,084 (+)RGD
Celera5145,096,588 - 145,102,252 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239123   ⟹   XP_006239185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25146,681,341 - 146,687,151 (+)NCBI
Rnor_6.05152,681,028 - 152,686,806 (+)NCBI
Rnor_5.05156,466,632 - 156,472,404 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593202   ⟹   XP_017448691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25146,680,757 - 146,687,154 (+)NCBI
Rnor_6.05152,680,412 - 152,686,807 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058862   ⟸   NM_017166
- UniProtKB: P13668 (UniProtKB/Swiss-Prot),   A6IT24 (UniProtKB/TrEMBL),   A0A8I5ZX99 (UniProtKB/TrEMBL),   A0A8L2QYX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239185   ⟸   XM_006239123
- Peptide Label: isoform X1
- UniProtKB: P13668 (UniProtKB/Swiss-Prot),   A6IT24 (UniProtKB/TrEMBL),   A0A8I5ZX99 (UniProtKB/TrEMBL),   A0A8L2QYX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448691   ⟸   XM_017593202
- Peptide Label: isoform X1
- UniProtKB: P13668 (UniProtKB/Swiss-Prot),   A6IT24 (UniProtKB/TrEMBL),   A0A8I5ZX99 (UniProtKB/TrEMBL),   A0A8L2QYX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022574   ⟸   ENSRNOT00000022574
RefSeq Acc Id: ENSRNOP00000068405   ⟸   ENSRNOT00000076864
RefSeq Acc Id: ENSRNOP00000068006   ⟸   ENSRNOT00000076052
RefSeq Acc Id: ENSRNOP00000083571   ⟸   ENSRNOT00000105029
Protein Domains
SLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13668-F1-model_v2 AlphaFold P13668 1-149 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2992 AgrOrtholog
BioCyc Gene G2FUF-39568 BioCyc
Ensembl Genes ENSRNOG00000016810 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022574 ENTREZGENE
  ENSRNOP00000022574.6 UniProtKB/TrEMBL
  ENSRNOP00000068006 ENTREZGENE
  ENSRNOP00000068006.2 UniProtKB/TrEMBL
  ENSRNOP00000068405.2 UniProtKB/TrEMBL
  ENSRNOP00000083571.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022574 ENTREZGENE
  ENSRNOT00000022574.6 UniProtKB/TrEMBL
  ENSRNOT00000076052 ENTREZGENE
  ENSRNOT00000076052.3 UniProtKB/TrEMBL
  ENSRNOT00000076864.3 UniProtKB/TrEMBL
  ENSRNOT00000105029.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.280.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6917958 IMAGE-MGC_LOAD
InterPro Stathmin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Stathmin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Stathmin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29332 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72884 IMAGE-MGC_LOAD
NCBI Gene 29332 ENTREZGENE
PANTHER PTHR10104 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STATHMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Stathmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stmn1 PhenoGen
PIRSF Stathmin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STATHMIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE STATHMIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STATHMIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STATHMIN_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MK73_RAT UniProtKB/TrEMBL
  A0A8I5ZX99 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QCZ4_RAT UniProtKB/TrEMBL
  A0A8L2QYX2 ENTREZGENE, UniProtKB/TrEMBL
  A6IT24 ENTREZGENE, UniProtKB/TrEMBL
  P13668 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Stmn1  stathmin 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Stmn1  stathmin 1      Symbol and Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in the development of neuroblastomas and melanomas 61521
gene_disease may be involved in the development of neuroblastomas and melanomas 61528
gene_process functions as an intracellular relay integrating regulatory signals of the cellular environment 61521
gene_process functions as an intracellular relay integrating regulatory signals of the cellular environment 61528