Maco1 (macoilin 1) - Rat Genome Database

Name: Maco1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: Maco1 (macoilin 1) Rattus norvegicus

Analyze

Symbol:

Maco1

Name:

macoilin 1

RGD ID:

1561685

Description:

Predicted to enable microtubule binding activity. Predicted to be involved in brain development; chemotaxis; and neuronal signal transduction. Predicted to be located in several cellular components, including axon; neuron projection terminus; and synapse. Predicted to be active in nuclear membrane and rough endoplasmic reticulum membrane. Orthologous to human MACO1 (macoilin 1); INTERACTS WITH acrylamide; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC100359758; LOC313618; macoilin; MGC116145; Tmem57; transmembrane protein 57

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MACO1 (macoilin 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Maco1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Maco1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MACO1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MACO1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Maco1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MACO1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MACO1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Maco1 (macoilin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Maco1 (macoilin 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MACO1 (macoilin 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG30389	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	maco-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	maco1a	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	maco1b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	maco1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	152,296,107 - 152,358,684 (-)	NCBI		GRCr8
mRatBN7.2	5	147,012,416 - 147,075,265 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	147,012,867 - 147,075,001 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	149,713,418 - 149,775,580 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	151,485,013 - 151,547,150 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	151,469,659 - 151,531,822 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	153,122,780 - 153,184,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	153,122,781 - 153,184,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	156,895,761 - 156,958,983 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	153,568,570 - 153,625,433 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	145,425,062 - 145,486,860 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Coronary Disease (ISO)

Dyslipidemias (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

Aroclor 1254 (ISO)

atrazine (EXP,ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

caffeine (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

choline (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

glyphosate (ISO)

L-methionine (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nefazodone (EXP)

paracetamol (ISO)

rac-lactic acid (ISO)

senecionine (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

thapsigargin (ISO)

thiram (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

chemotaxis (IBA)

neuronal signal transduction (IBA,ISO,ISS)

Cellular Component

axon (ISO)

neuron projection (ISO)

neuron projection terminus (ISO)

nuclear membrane (IBA,ISO)

nucleus (ISO)

rough endoplasmic reticulum membrane (IBA,ISO,ISS)

synapse (ISO)

Molecular Function

microtubule binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12459264	PMID:15255972	PMID:15489334	PMID:21589894

Genomics

Comparative Map Data

Maco1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	152,296,107 - 152,358,684 (-)	NCBI		GRCr8
mRatBN7.2	5	147,012,416 - 147,075,265 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	147,012,867 - 147,075,001 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	149,713,418 - 149,775,580 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	151,485,013 - 151,547,150 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	151,469,659 - 151,531,822 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	153,122,780 - 153,184,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	153,122,781 - 153,184,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	156,895,761 - 156,958,983 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	153,568,570 - 153,625,433 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	145,425,062 - 145,486,860 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

MACO1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	25,430,897 - 25,500,209 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	25,430,858 - 25,500,209 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	25,757,388 - 25,826,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	25,630,006 - 25,698,516 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	24,155,217 - 24,224,253 (+)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	24,014,350 - 24,083,703 (+)	NCBI		HuRef
CHM1_1	1	25,870,804 - 25,940,123 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	25,267,240 - 25,336,586 (+)	NCBI		T2T-CHM13v2.0

Maco1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	134,530,070 - 134,581,242 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	134,530,070 - 134,580,656 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	134,802,759 - 134,853,931 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	134,802,759 - 134,853,345 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	134,358,674 - 134,409,260 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	134,074,835 - 134,125,206 (-)	NCBI		MGSCv36	mm8
Celera	4	132,985,719 - 133,036,193 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	67.11	NCBI

Maco1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	4,968,500 - 5,030,868 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	4,966,357 - 5,030,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

MACO1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	201,361,675 - 201,431,447 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	200,459,545 - 200,529,229 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	24,701,352 - 24,771,038 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	25,771,235 - 25,839,635 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	25,771,175 - 25,839,635 (+)	Ensembl	panpan1.1		panPan2

MACO1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	74,397,715 - 74,458,126 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	74,397,715 - 74,458,126 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	70,971,562 - 71,031,722 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	74,958,973 - 75,019,065 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	74,958,973 - 75,019,061 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	71,782,199 - 71,842,536 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	72,788,781 - 72,848,832 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	73,793,316 - 73,853,360 (-)	NCBI		UU_Cfam_GSD_1.0

Maco1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	44,281,100 - 44,330,357 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	10,105,359 - 10,155,133 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	10,105,870 - 10,155,029 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MACO1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	82,933,826 - 82,997,142 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	82,934,083 - 82,995,688 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MACO1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	107,272,473 - 107,340,976 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	107,269,979 - 107,340,795 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	9,021,796 - 9,091,102 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Maco1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	9,568,909 - 9,633,589 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	9,569,419 - 9,633,589 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Maco1
234 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	97059760	147465714	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	124965598	166875058	Rat
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	143608201	161165651	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	111416838	156416838	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	135927956	166875058	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	135929696	166875058	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	144358090	157869054	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	129132447	151006154	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	128506074	166875058	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	131345754	166875058	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	106906205	151906205	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	106906205	151906205	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	127798274	166875058	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	143799107	158428037	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132717196	165560427	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	121846814	166846814	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	106906205	151906205	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	143069996	166846814	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	128506074	166875058	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	108938288	153938288	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	105999803	150999803	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	128924607	166875058	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	126424772	166875058	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	108845856	153845856	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	120740824	151018848	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	130130159	166875058	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	103689353	148689353	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	144377876	161317411	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	111416838	156416838	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	106906205	151906205	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	106906205	151906205	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	111416838	156416838	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	111416838	156416838	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	108845856	153845856	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	127798274	166875058	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	99216724	148607142	Rat

Markers in Region

D6S1937

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	147,013,854 - 147,014,118 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	153,123,769 - 153,124,032	NCBI	Rnor6.0
Rnor_5.0	5	156,897,200 - 156,897,463	UniSTS	Rnor5.0
Celera	5	145,426,051 - 145,426,314	UniSTS
Cytogenetic Map	5	q36	UniSTS

BF403341

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	147,035,495 - 147,035,655 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	153,145,442 - 153,145,601	NCBI	Rnor6.0
Rnor_5.0	5	156,918,682 - 156,918,841	UniSTS	Rnor5.0
RGSC_v3.4	5	153,586,182 - 153,586,341	UniSTS	RGSC3.4
Celera	5	145,447,529 - 145,447,688	UniSTS
RH 3.4 Map	5	992.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

UniSTS:235065

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	147,013,942 - 147,014,147 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	153,123,857 - 153,124,061	NCBI	Rnor6.0
Rnor_5.0	5	156,897,288 - 156,897,492	UniSTS	Rnor5.0
Celera	5	145,426,139 - 145,426,343	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY845021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000079536 ⟹ ENSRNOP00000069310

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	147,012,867 - 147,075,001 (-)	Ensembl
Rnor_6.0 Ensembl	5	153,122,781 - 153,184,940 (-)	Ensembl

RefSeq Acc Id:

NM_001025699 ⟹ NP_001020870

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	152,296,557 - 152,358,684 (-)	NCBI
mRatBN7.2	5	147,012,866 - 147,075,001 (-)	NCBI
Rnor_6.0	5	153,122,780 - 153,184,940 (-)	NCBI
Rnor_5.0	5	156,895,761 - 156,958,983 (-)	NCBI
Celera	5	145,425,062 - 145,486,860 (-)	RGD

Sequence:

show sequence

GCGGAGGAGGCTCGGCGCCCCCCTCCTGGCCCCCCTCCCCCCCCCCCCCCGGTGCTGGCTCCAT
GTCTGTGTGACCGGCCGCAGGGGTAGATTCCAGGCCCGACGCGGGGCGGGCGGGCGGCGGCGGC
TGAGGTGAGAGGCGGCGGCGGCGCGGCTCGGGCACCGGCCCCCCAGTGGGAGGATGAAGCGGCG
GAACGCCGACTGCAGTAAGCTCCGCCGCCCCCTGAAGCGGAACCGGATCACCGAGGGTATCTAC
GGCAGTACCTTTTTATACCTGAAATTCCTGGTAGTGTGGGCACTTGTCCTCCTGGCCGACTTTG
TCCTGGAGTTCCGATTTGAATACCTGTGGCCATTTTGGCTTTTCATCAGAAGCGTCTATGATTC
CTTCAGATACCAGGGACTGGCCTTCTCAGTATTTTTTGTTTGTGTAGCATTCACTTCAAATATC
ATATGTCTCCTCTTCATTCCCATACAATGGCTTTTTTTTGCTGCTAGCACATATGTATGGGTCC
AGTACGTATGGCACACAGAACGGGGAGTGTGTTTGCCTACAGTGTCCCTCTGGATACTCTTTGT
TTATATTGAAGCCGCAATTAGATTTAAAGATCTGAAAAATTTTCATGTAGACCTTTGTCGGCCA
TTTGCTGCTCACTGTATTGGGTACCCTGTGGTGACTTTGGGCTTTGGCTTCAAAAGTTATGTGA
GCTACAAAATGCGGTTAAGAAAGCAGAAGGAGGTTCAGAAGGAGAACGAGTTTTACATGCAGCT
TCTTCAGCAGGCCCTCCCTCCAGAGCAGCAGATGTTGCAGAAGCAGGAGAAGGAGGCCGAGGAA
GCAGCCAAAGGATTGCCGGACATGGACTCCTCGATCCTTATACACCACAACGGAGGCATCCCAG
CCAACAAAAAACTTTCCACAGCGTTGCCAGAGATAGAATATCGAGAAAAGGGGAAAGAGAAGGA
CAAGGATGCCAAGAAACACAACCTCGGAATAAATAACAACAACATTCTACAGCCTGTAGACTCT
AAGATACAAGAGATTGAGTATATGGAAAACCATATCAATAGTAAAAGATTAAACAATGTTCTTG
TGGGAAGTACAGAAAATCTCTTAAAAGAGGACTCATGCACTGCTTCCTCAAAAAATTACAAAAA
TGCCAGTGGAGTTGTGAACTCCTCGCCTCGAAGTCACAGCGCTACAAATGGAAGCATTCCTTCC
TCGTCCAGTAAAAACGAGAAGAAGCAGAGGTGCACCAGCAAGGGCCCGAGTGCACACAAGGACT
TAATGGAGAACTGTATTCCTAACAACCAGCTCAGCAAACCCGACGCTCTGGTAAGGCTGGAACA
AGATATTAAAAAGCTAAAGGCTGACCTGCAAGCCAGCCGGCAAGTGGAGCAAGAGCTGCGCAGT
CAGATCAGCTCCCTCTCAAGCACAGAGCGAGGGATCCGCTCAGAAATGGGCCAGCTCCGGCAGG
AGAACGAGCTGCTGCAGAACAAGCTACACAATGCTGTGCAAATGAAGCAAAAAGACAAACAGAA
CATCAGCCAGCTGGAGAAGAGGCTGAAAGCTGAGCAGGAGGCCCGAGGCTTTGTAGAAAAGCAG
CTCATGGAGGAGAAAAAAAGGAAGAAGCTAGAAGAAGCCACGGCTGCACGGGCTGTTGCCTTTG
CTGCTGCATCTAGGGGAGAGTGCACCGAAACCTTACGGAGTCGGATCAGAGAGCTAGAAGCTGA
GGGCAAGAAGCTCACAATGGACCTGAAGGTGAAGGAGGAGCAGATCAGGGAACTGGAGCTGAAG
GTGCAGGAGCTTCGGAAGTACAAAGAAAACGAGAAGGACACTGAGGTGTTGATGTCAGCCCTCT
CTGCCATGCAAGACAAAACGCAACACCTAGAGAACAGCCTCAGTGCAGAGACGAGGATCAAGCT
GGACCTGTTCTCTGCACTCGGTGATGCAAAGCGGCAGCTCGAGATTGCCCAGGGGCAAATCCTT
CAGAAAGACCAGGAAATCAAGGACCTAAAACAGAAGATAGCTGAAGTCATGGCCGTCATGCCCA
GCATAACATACAGTGCCGCCACCAGTCCCCTGAGCCCTGTGTCCCCCCACTACTCTTCCAAGTT
TGTGGAGACCAGCCCCTCTGGACTTGATCCTAATGCCTCTGTCTATCAGCCCCTGAAGAAATGA
AGGCCAACTGTGTGTTTGCCCAACATTTGGAACCAGAAGGCTTCGAAAAGCAGCGTCTCTGGCA
GTCAAGATAAAAAAGTTGATATTGTGTTTTGTGGGACTGTATATGTTGTCATTTTTAAAGGGGG
GAAATAACATCCAAGTCTGATTAGAACCGCCCATCAGTTGTTCTTGGAAGTTTTTAGAAGACCT
CACAGGACTTTGCAGTTTATTTTTCTTGGCCAACACATTAAAACCATTCTTGGATTTCAAGTAG
CCAATTTTGCCTTTTTATGTATTTTTACATAGTTTCCTCTTGAAGAAAAAAAAAGCAGAGTTTT
TTTTGCTTTTCAACCCTATTTTGTTCTTAAATAAGCAAGAAAATTGCACGTTGTATTCACGGAC
GACAACAAAGGCGTAGTTTCTAGTGCGAGAGGGCGGAGTAGCCCAGCAGCTCTGGTTCCATAGC
TGCATTAAAGATGATTGTCTCCATTACAGAAAAAAGAGCGATTGCCCCTCCAAGAACCAGACAG
ATTGAGAGAATGTCACTTAAGCTGAGAGAGACTTAAGGGTGAGGCTGGCTTGCAGGCGTGTGGC
CGTGTGTTTGGAGTATTGACATTCCCATTGCTGTTAGCTCCAGAGCACACCCAGGGCAGTCTTT
GCATTACCGTGAGAAAAGATGTTGCAAGAGGAAGCTTGATCATTGTCAACTCTGTCCCCTCCCC
CCTGTCATCTGTCTTCTATTTGTCCCGGTCACTGCTGAGCCTTTGCTCAGCTGGTTGGTGGCTC
GGCTGCTGGTCACCACGCCACCACTTGGGTTTTCCATGGGAAGCACACAGGGTTCTGCGCTTGC
CGCCAGTCAGGCACCTTAGGTGGCAGCCTGGTGGGTGTGAGAGAGGCCAAACGATGGCTGATGG
AAGCCGTGGTCTAGGAGTGGCCCCCACGTGCCATTTGCTGCTTTCTTCGCCCTCCTCATCTCGT
GTCCGATGGTTTACAGATGCCTGACAGTTCCTCAGCTCTTGTGCCAAGGAGGAGTGGTTGTTGG
TTTTTTTTGTTTGTTTGTTTGTTTGTTTTGAAGATTTAAACTCTGCGCAAAGATACCGGTTCAA
CTGTATTATACGTTGGTAGAAAGTGTCTGCACAGACCTTTGAAAGTGTGTTAAGAATCAGGGAG
TGGGAGGGCAGGGGAGAGGAGGGGCAAAGCAGAGTTGCTGTTTTGAAAGCTGGGGATATTAAAC
CAAATCGATTGGCTTGGCTTCCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039110045 ⟹ XP_038965973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	152,296,107 - 152,340,840 (-)	NCBI
mRatBN7.2	5	147,012,416 - 147,057,159 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020870	(Get FASTA)	NCBI Sequence Viewer
	XP_038965973	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97999	(Get FASTA)	NCBI Sequence Viewer
	AAX11919	(Get FASTA)	NCBI Sequence Viewer
	EDL80737	(Get FASTA)	NCBI Sequence Viewer
	EDL80738	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069310.1
	ENSRNOP00055035022
	ENSRNOP00060044008
	ENSRNOP00065038368
GenBank Protein	Q4V7D3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001020870 ⟸ NM_001025699

- UniProtKB:

Q2TLZ0 (UniProtKB/Swiss-Prot), Q4V7D3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRS
VYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLW
ILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEF
YMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILIHHNGGIPANKKLSTALPEIEYREKG
KEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSKRLNNVLVGSTENLLKEDSCTASSK
NYKNASGVVNSSPRSHSATNGSIPSSSSKNEKKQRCTSKGPSAHKDLMENCIPNNQLSKPDALV
RLEQDIKKLKADLQASRQVEQELRSQISSLSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQK
DKQNISQLEKRLKAEQEARGFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRE
LEAEGKKLTMDLKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAET
RIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAATSPLSPVSPHY
SSKFVETSPSGLDPNASVYQPLKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000069310 ⟸ ENSRNOT00000079536

RefSeq Acc Id:	XP_038965973 ⟸ XM_039110045
- Peptide Label:	isoform X1
- UniProtKB:	Q4V7D3 (UniProtKB/Swiss-Prot), Q2TLZ0 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V7D3-F1-model_v2	AlphaFold	Q4V7D3	1-664	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694144

Promoter ID:

EPDNEW_R4669

Type:

multiple initiation site

Name:

Maco1_1

Description:

macoilin 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	153,184,961 - 153,185,021	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561685	AgrOrtholog
BioCyc Gene	G2FUF-39557	BioCyc
Ensembl Genes	ENSRNOG00000056156	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055024878	UniProtKB/Swiss-Prot
	ENSRNOG00060030489	UniProtKB/Swiss-Prot
	ENSRNOG00065027145	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000079536.2	UniProtKB/Swiss-Prot
	ENSRNOT00055042888	UniProtKB/Swiss-Prot
	ENSRNOT00060052940	UniProtKB/Swiss-Prot
	ENSRNOT00065046792	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7453136	IMAGE-MGC_LOAD
InterPro	Macoilin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:313618	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116145	IMAGE-MGC_LOAD
NCBI Gene	313618	ENTREZGENE
PANTHER	MACOILIN	UniProtKB/Swiss-Prot
	MACOILIN	UniProtKB/Swiss-Prot
	MACOILIN	UniProtKB/TrEMBL
	MACOILIN	UniProtKB/TrEMBL
Pfam	Macoilin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Maco1	PhenoGen
RatGTEx	ENSRNOG00000056156	RatGTEx
	ENSRNOG00055024878	RatGTEx
	ENSRNOG00060030489	RatGTEx
	ENSRNOG00065027145	RatGTEx
UniProt	A6IT37_RAT	UniProtKB/TrEMBL
	MACOI_RAT	UniProtKB/Swiss-Prot
	Q2TLZ0	ENTREZGENE
	Q4V7D3	ENTREZGENE
UniProt Secondary	Q2TLZ0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-11-17	Maco1	macoilin 1	Tmem57	transmembrane protein 57	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-07-23	Tmem57	transmembrane protein 57	LOC100359758	transmembrane protein 57	Data merged from RGD:2323482	737654	APPROVED
2010-05-06	LOC100359758	transmembrane protein 57			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-05	Tmem57	transmembrane protein 57	LOC313618	macoilin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC313618	macoilin			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - CTD