Nr0b2 (nuclear receptor subfamily 0, group B, member 2) - Rat Genome Database

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Gene: Nr0b2 (nuclear receptor subfamily 0, group B, member 2) Rattus norvegicus
Analyze
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
RGD ID: 621032
Description: Enables nuclear retinoid X receptor binding activity; nuclear thyroid hormone receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including animal organ regeneration; negative regulation of transcription by RNA polymerase II; and positive regulation of insulin secretion. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetes mellitus; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; Shp; small heterodimer partner homologue
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nr0b2m1Mcwi  
Genetic Models: FHH-Nr0b2m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,063,160 - 151,066,475 (+)NCBIGRCr8
mRatBN7.25145,779,294 - 145,782,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,779,294 - 145,782,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,481,537 - 148,484,849 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,251,139 - 150,254,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,237,696 - 150,241,008 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,776,004 - 151,779,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,776,004 - 151,779,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,465,275 - 155,468,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,524,685 - 151,528,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,534,723 - 151,538,039 (-)NCBI
Celera5144,199,860 - 144,203,175 (+)NCBICelera
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetic acid  (EXP)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimony(0)  (ISO)
arsenite(3-)  (ISO)
atorvastatin calcium  (ISO)
Augmentin  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Boldine  (EXP)
bromuconazole  (EXP)
cadmium atom  (ISO)
calcipotriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorohydrocarbon  (EXP)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
ciprofloxacin  (ISO)
clavulanic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clomipramine  (ISO)
clothianidin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproterone acetate  (ISO)
D-glucose  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dimethylarsinic acid  (ISO)
Diosbulbin B  (ISO)
dioscin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disopyramide  (ISO)
dorsomorphin  (ISO)
emodin  (ISO)
enilconazole  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
fipronil  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucose  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (ISO)
GW 4064  (EXP,ISO)
GW 7647  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
imidacloprid  (EXP)
imipenem hydrate  (ISO)
imipramine  (ISO)
isoniazide  (EXP,ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lead nitrate  (EXP,ISO)
linagliptin  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
loratadine  (ISO)
LY294002  (ISO)
MeIQx  (ISO)
menadione  (ISO)
mesalamine  (EXP)
metformin  (ISO)
methimazole  (EXP)
methoxsalen  (EXP,ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (EXP)
metronidazole  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
neomycin  (ISO)
nickel dichloride  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paxilline  (ISO)
PD 0325901  (ISO)
pentamidine  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
senecionine  (EXP,ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotalol  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sumatriptan  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thioridazine  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zaragozic acid A  (EXP,ISO)
zimeldine  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
intracellular membrane-bounded organelle  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients. Enya M, etal., Hum Mutat. 2008 Nov;29(11):E271-7.
2. A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. Fiorucci S, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. Epub 2005 Apr 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors. Johansson L, etal., Mol Cell Biol. 2000 Feb;20(4):1124-33.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Lan Y, etal., Zhonghua Gan Zang Bing Za Zhi. 2008 Jun;16(6):453-6.
8. An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors. Masuda N, etal., Biochim Biophys Acta 1997 Jan 3;1350(1):27-32.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. Monte MJ, etal., Biochim Biophys Acta. 2005 May 15;1734(2):127-35. Epub 2005 Mar 8.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Nishigori H, etal., Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):575-80. Epub 2001 Jan 2.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partner. Park KG, etal., Diabetes. 2007 Feb;56(2):431-7.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
Additional References at PubMed
PMID:12477932   PMID:12842887   PMID:14752053   PMID:15489334   PMID:15521018   PMID:15721253   PMID:15976031   PMID:16709599   PMID:17686645   PMID:17895379   PMID:18450959   PMID:19085950  
PMID:19643931   PMID:19720831   PMID:19887897   PMID:20688914   PMID:23010719   PMID:25015078   PMID:25212631   PMID:25446530   PMID:27485016   PMID:28797635   PMID:29028359   PMID:30555544  


Genomics

Comparative Map Data
Nr0b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85151,063,160 - 151,066,475 (+)NCBIGRCr8
mRatBN7.25145,779,294 - 145,782,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5145,779,294 - 145,782,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5148,481,537 - 148,484,849 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05150,251,139 - 150,254,451 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05150,237,696 - 150,241,008 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05151,776,004 - 151,779,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5151,776,004 - 151,779,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05155,465,275 - 155,468,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,524,685 - 151,528,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,534,723 - 151,538,039 (-)NCBI
Celera5144,199,860 - 144,203,175 (+)NCBICelera
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
NR0B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,911,489 - 26,913,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,911,489 - 26,913,975 (-)EnsemblGRCh38hg38GRCh38
GRCh37127,237,980 - 27,240,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,110,566 - 27,113,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 34126,922,120 - 26,924,602NCBI
Celera125,635,071 - 25,637,663 (-)NCBICelera
Cytogenetic Map1p36.11NCBI
HuRef125,491,554 - 25,494,146 (-)NCBIHuRef
CHM1_1127,351,340 - 27,353,932 (-)NCBICHM1_1
T2T-CHM13v2.0126,749,548 - 26,752,039 (-)NCBIT2T-CHM13v2.0
Nr0b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,280,687 - 133,283,997 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4133,280,687 - 133,283,847 (+)EnsemblGRCm39 Ensembl
GRCm384133,553,376 - 133,556,686 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,553,376 - 133,556,536 (+)EnsemblGRCm38mm10GRCm38
MGSCv374133,109,305 - 133,112,451 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364132,825,466 - 132,828,612 (+)NCBIMGSCv36mm8
Celera4131,722,949 - 131,726,070 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Nr0b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,250,889 - 6,254,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,251,047 - 6,253,541 (-)NCBIChiLan1.0ChiLan1.0
NR0B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21199,956,001 - 199,958,461 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11199,060,102 - 199,062,634 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,174,055 - 26,176,689 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,230,362 - 27,232,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,230,362 - 27,232,942 (-)Ensemblpanpan1.1panPan2
NR0B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,234,482 - 73,236,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,234,586 - 73,236,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,812,568 - 69,814,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,798,290 - 73,800,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,798,352 - 73,800,322 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1270,623,285 - 70,625,309 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,628,711 - 71,630,736 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0272,631,901 - 72,633,925 (+)NCBIUU_Cfam_GSD_1.0
Nr0b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505845,491,739 - 45,495,184 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647411,316,700 - 11,319,669 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647411,316,857 - 11,319,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR0B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,225,694 - 84,228,481 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,225,670 - 84,228,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,795,866 - 77,798,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR0B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,850,328 - 105,853,076 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20105,850,598 - 105,853,060 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603310,579,506 - 10,582,085 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr0b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476410,892,481 - 10,899,215 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476410,896,728 - 10,899,898 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Nr0b2
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000009683
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH142412  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25145,779,642 - 145,779,862 (+)MAPPERmRatBN7.2
Rnor_6.05151,776,353 - 151,776,572NCBIRnor6.0
Rnor_5.05155,465,624 - 155,465,843UniSTSRnor5.0
RGSC_v3.45151,527,432 - 151,527,651UniSTSRGSC3.4
Celera5144,200,209 - 144,200,428UniSTS
RH 3.4 Map5977.8UniSTS
Cytogenetic Map5q36UniSTS


Genetic Models
This gene Nr0b2 is modified in the following models/strains:
FHH-Nr0b2m1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 89 91 90 59 25 59 6 218 97 69 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009683   ⟹   ENSRNOP00000009683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5145,779,294 - 145,782,609 (+)Ensembl
Rnor_6.0 Ensembl5151,776,004 - 151,779,319 (+)Ensembl
RefSeq Acc Id: NM_057133   ⟹   NP_476474
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85151,063,160 - 151,066,475 (+)NCBI
mRatBN7.25145,779,294 - 145,782,609 (+)NCBI
Rnor_6.05151,776,004 - 151,779,319 (+)NCBI
Rnor_5.05155,465,275 - 155,468,590 (+)NCBI
RGSC_v3.45151,524,685 - 151,528,000 (-)RGD
Celera5144,199,860 - 144,203,175 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88117 (Get FASTA)   NCBI Sequence Viewer  
  BAA13127 (Get FASTA)   NCBI Sequence Viewer  
  BAA13171 (Get FASTA)   NCBI Sequence Viewer  
  EDL80675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009683
  ENSRNOP00000009683.1
GenBank Protein P97947 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476474   ⟸   NM_057133
- UniProtKB: P97947 (UniProtKB/Swiss-Prot),   A6ISX4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009683   ⟸   ENSRNOT00000009683
Protein Domains
NR LBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97947-F1-model_v2 AlphaFold P97947 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694118
Promoter ID:EPDNEW_R4642
Type:single initiation site
Name:Nr0b2_1
Description:nuclear receptor subfamily 0, group B, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05151,776,004 - 151,776,064EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621032 AgrOrtholog
BioCyc Gene G2FUF-39629 BioCyc
Ensembl Genes ENSRNOG00000007229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009683 ENTREZGENE
  ENSRNOT00000009683.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7324177 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR0B1/2 UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:117274 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108613 IMAGE-MGC_LOAD
NCBI Gene 117274 ENTREZGENE
PANTHER NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 2 UniProtKB/Swiss-Prot
  PTHR24081 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
PhenoGen Nr0b2 PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007229 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot
UniProt A6ISX4 ENTREZGENE, UniProtKB/TrEMBL
  NR0B2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nr0b2  nuclear receptor subfamily 0, group B, member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nr0b2  nuclear receptor subfamily 0, group B, member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 633448
gene_product member of nuclear hormone receptor superfamily 633448