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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2increases expressionEXP 6480464CTDCholic Acid results in increased expression of NR0B2 mRNAPMID:14684380
Nr0b2multiple interactionsEXP 6480464CTD[Cholesterol, Dietary co-treated with Cholic Acid] results in increased expression of NR0B2 mRNAPMID:14684380
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTDCholic Acid results in increased expression of NR0B2 mRNAPMID:25055961
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTDCholic Acid results in increased expression of NR0B2 mRNAPMID:12072388 PMID:15694933 PMID:16002565 PMID:16269825 PMID:24189133 PMID:25582706
Nr0b2multiple interactionsISONr0b2 (Mus musculus)6480464CTD[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; IL1B protein inhibits the reaction [Cholic Acid results in increased expression of NR0B2 mRNA]PMID:12072388 PMID:22540009
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