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Gene: NR0B2 (nuclear receptor subfamily 0 group B member 2) Chlorocebus sabaeus

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Symbol:

NR0B2

Name:

nuclear receptor subfamily 0 group B member 2

RGD ID:

18339341

Description:

ENCODES a protein that exhibits nuclear retinoic acid receptor binding (ortholog); nuclear retinoid X receptor binding (ortholog); nuclear thyroid hormone receptor binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); negative regulation of DNA-binding transcription factor activity (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH alcoholic hepatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,850,328 - 105,853,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,850,598 - 105,853,060 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	10,579,506 - 10,582,085 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic hepatitis (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cognitive disorder (ISO)

Diabetes Complications (ISO)

diabetes mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (ISO)

intrahepatic cholestasis (ISO)

lipid storage disease (ISO)

Lynch syndrome (ISO)

obesity (ISO)

retinitis pigmentosa 59 (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

animal organ regeneration (ISO)

circadian regulation of gene expression (IEA)

circadian rhythm (IEA)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of gene expression (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

Notch signaling pathway (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of gene expression (IEA)

positive regulation of insulin secretion (ISO)

response to ethanol (ISO)

response to glucose (ISO)

Cellular Component

chromatin (IEA)

cytoplasm (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

nucleus (IEA)

protein-containing complex (ISO)

Molecular Function

nuclear retinoic acid receptor binding (ISO)

nuclear retinoid X receptor binding (ISO)

nuclear thyroid hormone receptor binding (ISO)

peroxisome proliferator activated receptor binding (ISO)

protein binding (ISO)

protein domain specific binding (IEA)

protein homodimerization activity (IEA)

protein-containing complex binding (ISO)

transcription corepressor activity (IEA)

transcription factor binding (ISO)

transcription regulator inhibitor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

NR0B2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	105,850,328 - 105,853,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	105,850,598 - 105,853,060 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	10,579,506 - 10,582,085 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NR0B2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,911,489 - 26,913,975 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,911,489 - 26,913,975 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	27,237,980 - 27,240,466 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	27,110,566 - 27,113,047 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	26,922,120 - 26,924,602	NCBI
Celera	1	25,635,071 - 25,637,663 (-)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	25,491,554 - 25,494,146 (-)	NCBI		HuRef
CHM1_1	1	27,351,340 - 27,353,932 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	26,749,548 - 26,752,039 (-)	NCBI		T2T-CHM13v2.0

Nr0b2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	133,280,687 - 133,283,997 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	133,280,687 - 133,283,847 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	133,553,376 - 133,556,686 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	133,553,376 - 133,556,536 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	133,109,305 - 133,112,451 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	132,825,466 - 132,828,612 (+)	NCBI		MGSCv36	mm8
Celera	4	131,722,949 - 131,726,070 (+)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.25	NCBI

Nr0b2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,063,160 - 151,066,475 (+)	NCBI		GRCr8
mRatBN7.2	5	145,779,294 - 145,782,609 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	145,779,294 - 145,782,609 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	148,481,537 - 148,484,849 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,251,139 - 150,254,451 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,237,696 - 150,241,008 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	151,776,004 - 151,779,319 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	151,776,004 - 151,779,319 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	155,465,275 - 155,468,590 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	151,524,685 - 151,528,000 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	151,534,723 - 151,538,039 (-)	NCBI
Celera	5	144,199,860 - 144,203,175 (+)	NCBI		Celera
RH 3.4 Map	5	977.8	RGD
Cytogenetic Map	5	q36	NCBI

Nr0b2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	6,250,889 - 6,254,541 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	6,251,047 - 6,253,541 (-)	NCBI	ChiLan1.0	ChiLan1.0

NR0B2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	199,956,001 - 199,958,461 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,060,102 - 199,062,634 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	26,174,055 - 26,176,689 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	27,230,362 - 27,232,949 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	27,230,362 - 27,232,942 (-)	Ensembl	panpan1.1		panPan2

NR0B2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,234,482 - 73,236,548 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,234,586 - 73,236,206 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	69,812,568 - 69,814,592 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	73,798,290 - 73,800,314 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	73,798,352 - 73,800,322 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	70,623,285 - 70,625,309 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	71,628,711 - 71,630,736 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	72,631,901 - 72,633,925 (+)	NCBI		UU_Cfam_GSD_1.0

Nr0b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	45,491,739 - 45,495,184 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	11,316,700 - 11,319,669 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	11,316,857 - 11,319,669 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NR0B2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	84,225,694 - 84,228,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	84,225,670 - 84,228,156 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	77,795,866 - 77,798,355 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Nr0b2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	10,892,481 - 10,899,215 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	10,896,728 - 10,899,898 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NR0B2
54 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
46	36	17	33	33	30	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007979862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000017549 ⟹ ENSCSAP00000017025

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	105,850,598 - 105,853,060 (+)	Ensembl

RefSeq Acc Id:

XM_007979862 ⟹ XP_007978053

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	105,850,328 - 105,853,076 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	10,579,506 - 10,582,085 (-)	NCBI

Sequence:

show sequence

TTGAGTCATCCGATAAGGGGCAGCTGAGTGAGCGGCAGGTGGCCCTGTGCCCTGCACCAGCCAC
TTCATTGACTGAAGTGATATCAGTGCCACGTGGGGTTCCCAATGCCCCCTCCCGCACCACTTCC
CCACCATTCCTGCCAGGGGCAGTGTCTGTGTGTTTTTTTCAATGAACATGACTTCTGGAGTCAA
GGTTGTCGGGCCCTTCCCCCCCTTCCACTCACTGGGAATATAAATAGCAGCCACAGCGCAGAAC
AGAGGGCCAGAGAGCTGGAAGTAAGGGCAGATCCCAACCATGAGCACCAGCCAACCAGGGGCCT
GCCCATGCCAGGGAGCTGCAAGCCGCCCAGCCATTCTCTACGCACTTCTGAGCTCCAGCCTCAG
GGCTGTCCCCCGACCCCGTAGCAGCTGCCTATGTAGGCAGCACCGGCCCGTCCAGCTATGTGCA
CCTCATCGCACCTGCCGGGAGGCCTTGGATGTTCTGGCCAAGACAGTGGCCTTCCTCAGGAACC
TGCCATCCTTCTGGCAGCTGCCTCCCCAGGACCAGCGGCGGCTGCTGCAGGGTTGCTGGGGCCC
CCTCTTCCTGCTTGGGTTGGCCCAAGATGCTGTGACCTTTGAAGTGGCTGAGGCCCCAGTGCCC
AGCATACTCAAGAAGATTCTACTGGAGGAGCCCAGCAGCAGTGGAGGCAGTGGCCAGCCGCCGG
ACAGACCGCAGCCCTCCCTGGCTGCGGTGCAGTGGCTTCAATGCTGTCTGGAGTCCTTCTGGGG
CCTGGAGCTGAGCCCCAAGGAATATGCCTGCCTGAAAGGGACCATCCTCTTCAACCCCGATGTG
CCAGGCCTCCAAGCCGCCTCCCACATTGGGCACCTGCAGCAGGAGGCTCACTGGGCGCTGTGTG
AAGTCCTGGAGCCCTGGTGCCCAGCAGCCCAAGGGCGCCTGGCCCATGTCCTCCTCACAGCCTC
CACCCTCAAGTCCATTCCGACCAGCCTGCTTGGGGACCTCTTCTTTCGCCCTATCATTGGAGAT
GTTGACATTGCTGGCCTTCTTGGGGACATGCTCTTGCTGAGGTGACCAGCTGCAGCCCAGGCAG
AGATCAGGTGGGCAGAGGTTGGCAGTGCTGATTCAGCCTGGCCATCCCCAGAGGTGACCCAATG
CTCCCGGAGGGGGCAAGGCTGTATAGACAGCACTTGGCTCCTTAGGAACAGCCCTTCACTCAGC
CACACCCCACATTGGACTTCCTTGGTTTGGACACAGTGCTCCAGCTGCCTGGAAGGCTCTTGGT
GGTCCCCACAGCCTCTGGGCCAAGACTCCTGTCCCTTGTTGGGATGGGAATGAAAGCTCAGGCT
GCTCATTGGACCAGAAGTCCTACTGACTTTATACAGAACTGAATTAAGTTATTGATTTTTGTAA
TAAAAGGTATGAAACACTTGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978053	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017025
	ENSCSAP00000017025.1

RefSeq Acc Id:	XP_007978053 ⟸ XM_007979862
- UniProtKB:	A0A0D9S836 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000017025 ⟸ ENSCSAT00000017549

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000984	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017549.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
InterPro	NHR-like_dom_sf	UniProtKB/TrEMBL
	NR0B1/2	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd	UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/TrEMBL
KEGG Report	csab:103225307	UniProtKB/TrEMBL
NCBI Gene	NR0B2	ENTREZGENE
PANTHER	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 2	UniProtKB/TrEMBL
	PTHR24081	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
PRINTS	STRDHORMONER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
SMART	HOLI	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48508	UniProtKB/TrEMBL
UniProt	A0A0D9S836	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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