NR0B2 (nuclear receptor subfamily 0 group B member 2) - Rat Genome Database
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Gene: NR0B2 (nuclear receptor subfamily 0 group B member 2) Homo sapiens
Analyze
Symbol: NR0B2
Name: nuclear receptor subfamily 0 group B member 2
RGD ID: 732873
HGNC Page HGNC
Description: Exhibits several functions, including protein homodimerization activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in circadian rhythm and regulation of gene expression. Localizes to chromatin; cytoplasm; and nucleus. Implicated in obesity and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ17090; nuclear receptor SHP; nuclear receptor subfamily 0, group B, member 2; orphan nuclear receptor SHP; SHP; SHP1; small heterodimer partner
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,911,489 - 26,913,975 (-)EnsemblGRCh38hg38GRCh38
GRCh38126,911,489 - 26,914,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,237,980 - 27,240,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,110,566 - 27,113,047 (-)NCBINCBI36hg18NCBI36
Build 34126,922,120 - 26,924,602NCBI
Celera125,635,071 - 25,637,663 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,491,554 - 25,494,146 (-)NCBIHuRef
CHM1_1127,351,340 - 27,353,932 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (ISO)
Actein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitriptyline  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (EXP)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bexarotene  (EXP,ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
calcipotriol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
cholic acid  (EXP,ISO)
choline  (EXP,ISO)
chromium atom  (EXP)
ciprofloxacin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
clomipramine  (EXP)
clothianidin  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
cyclosporin A  (EXP)
cyproterone acetate  (EXP)
D-glucose  (EXP)
deoxycholic acid  (EXP,ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dicrotophos  (EXP)
diethyl maleate  (ISO)
dihydroartemisinin  (ISO)
dioscin  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disopyramide  (EXP)
dorsomorphin  (EXP)
emodin  (ISO)
enilconazole  (EXP)
ethanol  (ISO)
farnesol  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
fipronil  (EXP)
flecainide  (EXP)
fluoxetine  (EXP)
flutamide  (ISO)
fructose  (ISO)
furan  (ISO)
gallocatechin  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
ginsenoside Re  (EXP)
ginsenoside Rg2  (EXP)
glucose  (EXP)
glutathione  (ISO)
glycyrrhizinic acid  (ISO)
guggulsterone  (EXP,ISO)
GW 3965  (EXP)
GW 4064  (EXP,ISO)
GW 7647  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (EXP)
ibuprofen  (ISO)
imipenem hydrate  (ISO)
imipramine  (EXP)
isoniazide  (EXP,ISO)
ketoconazole  (EXP)
L-methionine  (EXP,ISO)
Lasiocarpine  (EXP)
lead nitrate  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
Loratadine  (EXP)
LY294002  (EXP)
MeIQx  (EXP)
menadione  (EXP)
metformin  (ISO)
methoxsalen  (EXP,ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nickel dichloride  (EXP)
O-methyleugenol  (EXP)
obeticholic acid  (EXP,ISO)
oleic acid  (EXP)
paracetamol  (ISO)
Paxilline  (EXP)
PD 0325901  (EXP)
pentamidine  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
perhexiline  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenol  (EXP)
phosphatidylcholine  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (EXP,ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rotenone  (ISO)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
senecionine  (ISO)
sertraline  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sotalol  (EXP)
stigmasterol  (ISO)
streptozocin  (ISO)
sumatriptan  (EXP)
tamoxifen  (EXP,ISO)
taurocholic acid  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thioridazine  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zaragozic acid A  (ISO)
zimeldine  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA,ISA)
cytoplasm  (IBA,IDA)
nucleoplasm  (TAS)
nucleus  (IBA,IDA)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:8650544   PMID:9603951   PMID:9773978   PMID:10594021   PMID:10648597   PMID:11030331   PMID:11535594   PMID:11668176   PMID:11696534   PMID:11705994   PMID:11735420   PMID:11861507  
PMID:11890664   PMID:11964378   PMID:12181644   PMID:12198243   PMID:12324453   PMID:12477932   PMID:12716764   PMID:12716767   PMID:12842887   PMID:14593077   PMID:14627819   PMID:14672953  
PMID:14752053   PMID:14762685   PMID:14963109   PMID:15123650   PMID:15202934   PMID:15269224   PMID:15292277   PMID:15314177   PMID:15317749   PMID:15358835   PMID:15459958   PMID:15489334  
PMID:15604093   PMID:15707893   PMID:15723037   PMID:15835920   PMID:15973435   PMID:16123152   PMID:16282330   PMID:16344560   PMID:16455805   PMID:16488887   PMID:16709599   PMID:16710414  
PMID:16762922   PMID:16825495   PMID:17071613   PMID:17074765   PMID:17094771   PMID:17145766   PMID:17210713   PMID:17289919   PMID:17482455   PMID:17522048   PMID:17686645   PMID:17895379  
PMID:17909097   PMID:17910058   PMID:18187620   PMID:18234786   PMID:18276794   PMID:18307978   PMID:18325392   PMID:18385139   PMID:18459945   PMID:18657049   PMID:18660489   PMID:18775915  
PMID:18842595   PMID:19085950   PMID:19237537   PMID:19322021   PMID:19366697   PMID:19372104   PMID:19491387   PMID:19509248   PMID:19594294   PMID:19596656   PMID:19641626   PMID:19720831  
PMID:19793803   PMID:19793822   PMID:20175750   PMID:20211142   PMID:20233523   PMID:20346360   PMID:20375098   PMID:20516075   PMID:20734064   PMID:20853064   PMID:20882396   PMID:21262773  
PMID:21459093   PMID:21566081   PMID:21725089   PMID:21725320   PMID:21873635   PMID:21988832   PMID:22171277   PMID:22197810   PMID:22292081   PMID:22314666   PMID:22362755   PMID:22504882  
PMID:22575647   PMID:22737255   PMID:22977252   PMID:23010719   PMID:23038264   PMID:23042943   PMID:23824184   PMID:23874642   PMID:24097068   PMID:24318876   PMID:24343129   PMID:24365583  
PMID:24379397   PMID:24619556   PMID:25015078   PMID:25655831   PMID:25720568   PMID:25976932   PMID:26186194   PMID:26421305   PMID:26521940   PMID:26553876   PMID:26838806   PMID:27471003  
PMID:27485016   PMID:27661118   PMID:27803151   PMID:28128295   PMID:28396564   PMID:28514442   PMID:28797635   PMID:28873070   PMID:29562494   PMID:29666185   PMID:29989580   PMID:31296559  
PMID:31741433   PMID:32296183   PMID:32814053  


Genomics

Candidate Gene Status
NR0B2 is a candidate Gene for QTL BW413_H
NR0B2 is a candidate Gene for QTL BW396_H
Comparative Map Data
NR0B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl126,911,489 - 26,913,975 (-)EnsemblGRCh38hg38GRCh38
GRCh38126,911,489 - 26,914,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,237,980 - 27,240,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,110,566 - 27,113,047 (-)NCBINCBI36hg18NCBI36
Build 34126,922,120 - 26,924,602NCBI
Celera125,635,071 - 25,637,663 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,491,554 - 25,494,146 (-)NCBIHuRef
CHM1_1127,351,340 - 27,353,932 (-)NCBICHM1_1
Nr0b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394133,280,687 - 133,283,997 (+)NCBIGRCm39mm39
GRCm39 Ensembl4133,280,687 - 133,283,847 (+)Ensembl
GRCm384133,553,376 - 133,556,686 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4133,553,376 - 133,556,536 (+)EnsemblGRCm38mm10GRCm38
MGSCv374133,109,305 - 133,112,451 (+)NCBIGRCm37mm9NCBIm37
MGSCv364132,825,466 - 132,828,612 (+)NCBImm8
Celera4131,722,949 - 131,726,070 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map466.25NCBI
Nr0b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25145,779,294 - 145,782,609 (+)NCBI
Rnor_6.0 Ensembl5151,776,004 - 151,779,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05151,776,004 - 151,779,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05155,465,275 - 155,468,590 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,524,685 - 151,528,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15151,534,723 - 151,538,039 (-)NCBI
Celera5144,199,860 - 144,203,175 (+)NCBICelera
RH 3.4 Map5977.8RGD
Cytogenetic Map5q36NCBI
Nr0b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554526,250,889 - 6,254,541 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554526,251,047 - 6,253,541 (-)NCBIChiLan1.0ChiLan1.0
NR0B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1127,230,362 - 27,232,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,230,362 - 27,232,942 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0126,174,055 - 26,176,689 (-)NCBIMhudiblu_PPA_v0panPan3
NR0B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl273,234,586 - 73,236,206 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1273,234,482 - 73,236,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nr0b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647411,316,857 - 11,319,669 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR0B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl684,225,694 - 84,228,094 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1684,225,670 - 84,228,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2677,795,866 - 77,798,355 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR0B2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120105,850,328 - 105,853,076 (+)NCBI
ChlSab1.1 Ensembl20105,850,598 - 105,853,060 (+)Ensembl
Nr0b2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476410,896,728 - 10,899,898 (-)NCBI

Position Markers
D1S3511  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,238,031 - 27,238,175UniSTSGRCh37
Build 36127,110,618 - 27,110,762RGDNCBI36
Celera125,635,127 - 25,635,271RGD
Cytogenetic Map1p36.1UniSTS
HuRef125,491,610 - 25,491,754UniSTS
TNG Radiation Hybrid Map111351.0UniSTS
GeneMap99-GB4 RH Map192.73UniSTS
NCBI RH Map1142.5UniSTS
RH79895  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,238,120 - 27,238,318UniSTSGRCh37
Build 36127,110,707 - 27,110,905RGDNCBI36
Celera125,635,216 - 25,635,414RGD
Cytogenetic Map1p36.1UniSTS
HuRef125,491,699 - 25,491,897UniSTS
RH93759  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37127,238,246 - 27,238,404UniSTSGRCh37
Build 36127,110,833 - 27,110,991RGDNCBI36
Celera125,635,342 - 25,635,500RGD
Cytogenetic Map1p36.1UniSTS
HuRef125,491,825 - 25,491,983UniSTS
GeneMap99-GB4 RH Map192.73UniSTS
D1S1423  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.1-p11.2UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map6p22.3-p21.32UniSTS
Cytogenetic Map6q22.33UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map7q11.2UniSTS
Cytogenetic Map1p22.1UniSTS
Cytogenetic Map2q32UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map9q12UniSTS
Cytogenetic Map3q26.2UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map18q22.1UniSTS
Cytogenetic Map13q12UniSTS
Cytogenetic Map10p14-p13UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map11q23-q24UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map22cen-q12.3UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map15q11.2-q21.3UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map7q21.13UniSTS
Cytogenetic Map7q31.1UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map3q25UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map1p31.3UniSTS
Cytogenetic Map14q31.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map10p15.1UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map2p13.3UniSTS
Cytogenetic Map1p22UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map8q24.11UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map8p11.22UniSTS
Cytogenetic Map4q28UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map1q41-q42UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map20q11.21UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map12p13.1-p12.3UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic Map12q13.12UniSTS
Cytogenetic Map18p11.21UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map11q24.1UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map18p11.31UniSTS
Cytogenetic Map2q24.3UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map18p11.31-p11.21UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map3q13UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map7p21.2UniSTS
Cytogenetic Map12q21.1UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map1q42.1UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map1p34-p33UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map7p14UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map12q24.2UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map19q13.3-q13.4UniSTS
Cytogenetic Map17q21.32UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map8p23-p22UniSTS
Cytogenetic Map1p12UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map10p12.33UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map3q26UniSTS
Cytogenetic Map9p21.2UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map5q21.3UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map3q26.31UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.3UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map9q21.11UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map10q22.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map20p12.3-p11.21UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic MapXq27.2UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map4q31UniSTS
Cytogenetic Map22q13.1-q13.2UniSTS
Cytogenetic MapXq28UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q24.3UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map7q21-q22UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map11q22.1UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map20q11.21-q11.23UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map21p11.1UniSTS
Cytogenetic Map1p35-p34.3UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map12q24.31-q24.32UniSTS
Cytogenetic Map17q21.1UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map14q32.1UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map4q31.23UniSTS
Cytogenetic Map11p15.3UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map2p22.3UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map11q14UniSTS
Cytogenetic MapXq13.2UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic MapXq22.3UniSTS
Cytogenetic Map9p12UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map13q33.3UniSTS
Cytogenetic Map15q22-q24UniSTS
Cytogenetic Map14q32.11UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map14q21.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map15q23UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map1q22UniSTS
Cytogenetic Map20q13.1UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map15q22.1-q22.31UniSTS
Cytogenetic Map1q31-q41UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map14q23UniSTS
Cytogenetic Map12q11-q12UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map3p21.1-p14.2UniSTS
Cytogenetic Map12q22-q23.1UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map6q24.2UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map20q11.22-q11.23UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map10pter-q25.3UniSTS
Cytogenetic Map9p24.1UniSTS
Cytogenetic Map12p13.2UniSTS
Cytogenetic Map12q24UniSTS
Cytogenetic Map3q28-q29UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map6p22.2UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map12q24.2-q24.31UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map9p21UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map11q13.1-q13.3UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map15q26UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map4p15.1-p14UniSTS
Cytogenetic Map8q11.2UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map15q11-q13UniSTS
Cytogenetic Map7p12.3UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map2q12.3UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map14q32.2UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map7q32.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map9p13UniSTS
Cytogenetic Map2p24.2UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map11q12.2UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map3q21-q24UniSTS
Cytogenetic Map4q13UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map8q13.1UniSTS
Cytogenetic Map5q21.2UniSTS
Cytogenetic Map4q34.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map13q13.3UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map1q31UniSTS
Cytogenetic Map7q11.21UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map8q24.12UniSTS
Cytogenetic Map15q22UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map10q24.2UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map6q25.2UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map6q14.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map12q14.3UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map20pter-p12UniSTS
Cytogenetic MapXp22.11UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map7p14.2UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map18p11.22UniSTS
Cytogenetic Map18q21.33UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map14q22.2UniSTS
Cytogenetic Map20p11.22-p11.1UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map18q21.1UniSTS
Cytogenetic Map10p11.21UniSTS
Cytogenetic Map6p22-p21UniSTS
Cytogenetic Map17q21.1-q21.3UniSTS
Cytogenetic Map12q24.33UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map12p13.2-p12.3UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map5q22.2UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map4p15.3UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map9p22.3UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map8q21.11UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map5p15.2UniSTS
Cytogenetic Map5q11.2UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map18q12.2UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map13q33.1UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map12q23.1UniSTS
Cytogenetic Map16p12.1UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map5q12.1UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map10q22.3-q23.2UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map4q21.3UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map3q12.1UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map3q26.32UniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map2p13.2UniSTS
Cytogenetic Map3p12.3UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map3q11.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map11p11.2UniSTS
Cytogenetic Map6q16.2UniSTS
Cytogenetic Map3q21.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map1p13.2UniSTS
Cytogenetic Map6p24.2UniSTS
Cytogenetic Map20q13.33UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR141hsa-miR-141-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22314666
MIR141hsa-miR-141-3pOncomiRDBexternal_infoNANA22314666

Predicted Target Of
Summary Value
Count of predictions:320
Count of miRNA genes:270
Interacting mature miRNAs:298
Transcripts:ENST00000254227
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 354 190 644 434 201 436 27 58 2 136 5 72 1 26
Low 415 726 296 13 262 11 494 842 274 82 456 545 1 15 478 1 1
Below cutoff 818 903 665 89 701 8 1621 663 2190 84 556 795 88 407 1061 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000254227   ⟹   ENSP00000254227
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl126,911,489 - 26,913,975 (-)Ensembl
RefSeq Acc Id: NM_021969   ⟹   NP_068804
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,911,489 - 26,913,975 (-)NCBI
GRCh37127,237,975 - 27,240,567 (-)ENTREZGENE
Build 36127,110,566 - 27,113,047 (-)NCBI Archive
HuRef125,491,554 - 25,494,146 (-)ENTREZGENE
CHM1_1127,351,340 - 27,353,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542297   ⟹   XP_011540599
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,912,093 - 26,914,110 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_068804   ⟸   NM_021969
- UniProtKB: Q15466 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011540599   ⟸   XM_011542297
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000254227   ⟸   ENST00000254227
Protein Domains
NR LBD

Promoters
RGD ID:6854658
Promoter ID:EPDNEW_H494
Type:multiple initiation site
Name:NR0B2_1
Description:nuclear receptor subfamily 0 group B member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38126,913,972 - 26,914,032EPDNEW
RGD ID:6786148
Promoter ID:HG_KWN:1539
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NM_021969
Position:
Human AssemblyChrPosition (strand)Source
Build 36127,113,216 - 27,113,716 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_021969.3(NR0B2):c.160C>T (p.Arg54Cys) single nucleotide variant not provided [RCV000523542] Chr1:26913781 [GRCh38]
Chr1:27240272 [GRCh37]
Chr1:1p36.11
uncertain significance
NM_021969.3(NR0B2):c.100C>T (p.Arg34Ter) single nucleotide variant Obesity, mild, early-onset [RCV000005759] Chr1:26913841 [GRCh38]
Chr1:27240332 [GRCh37]
Chr1:1p36.11
pathogenic
NM_021969.3(NR0B2):c.583G>T (p.Ala195Ser) single nucleotide variant Obesity, mild, early-onset [RCV000005760] Chr1:26912036 [GRCh38]
Chr1:27238527 [GRCh37]
Chr1:1p36.11
pathogenic
GRCh38/hg38 1p36.11-35.3(chr1:26807012-27685191)x1 copy number loss See cases [RCV000053799] Chr1:26807012..27685191 [GRCh38]
Chr1:27133503..28011702 [GRCh37]
Chr1:27006090..27884289 [NCBI36]
Chr1:1p36.11-35.3
pathogenic
NM_021969.2(NR0B2):c.369G>A (p.Leu123=) single nucleotide variant Malignant melanoma [RCV000064696] Chr1:26913572 [GRCh38]
Chr1:27240063 [GRCh37]
Chr1:27112650 [NCBI36]
Chr1:1p36.11
not provided
NM_021969.2(NR0B2):c.195G>A (p.Lys65=) single nucleotide variant Malignant melanoma [RCV000064697] Chr1:26913746 [GRCh38]
Chr1:27240237 [GRCh37]
Chr1:27112824 [NCBI36]
Chr1:1p36.11
not provided
GRCh38/hg38 1p36.11-35.3(chr1:26854636-27645829)x1 copy number loss See cases [RCV000137657] Chr1:26854636..27645829 [GRCh38]
Chr1:27181127..27972340 [GRCh37]
Chr1:27053714..27844927 [NCBI36]
Chr1:1p36.11-35.3
uncertain significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
NM_021969.3(NR0B2):c.532G>A (p.Asp178Asn) single nucleotide variant not specified [RCV000192799] Chr1:26913409 [GRCh38]
Chr1:27239900 [GRCh37]
Chr1:1p36.11
likely benign
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
NM_021969.3(NR0B2):c.122G>A (p.Cys41Tyr) single nucleotide variant not specified [RCV000412948] Chr1:26913819 [GRCh38]
Chr1:27240310 [GRCh37]
Chr1:1p36.11
uncertain significance
NM_021969.3(NR0B2):c.512G>C (p.Gly171Ala) single nucleotide variant not specified [RCV000730964] Chr1:26913429 [GRCh38]
Chr1:27239920 [GRCh37]
Chr1:1p36.11
benign
GRCh37/hg19 1p36.11(chr1:27119557-27547784)x3 copy number gain See cases [RCV000448699] Chr1:27119557..27547784 [GRCh37]
Chr1:1p36.11
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_021969.3(NR0B2):c.13C>G (p.Gln5Glu) single nucleotide variant not provided [RCV000883581] Chr1:26913928 [GRCh38]
Chr1:27240419 [GRCh37]
Chr1:1p36.11
benign
NM_021969.3(NR0B2):c.227del (p.Phe76fs) deletion APC-mutation negative familial colorectal cancer [RCV000859986] Chr1:26913714 [GRCh38]
Chr1:27240205 [GRCh37]
Chr1:1p36.11
likely pathogenic
NM_021969.3(NR0B2):c.157_166del (p.His53fs) deletion APC-mutation negative familial colorectal cancer [RCV000859985] Chr1:26913775..26913784 [GRCh38]
Chr1:27240266..27240275 [GRCh37]
Chr1:1p36.11
likely pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_021969.3(NR0B2):c.473G>A (p.Ser158Asn) single nucleotide variant not provided [RCV000963748] Chr1:26913468 [GRCh38]
Chr1:27239959 [GRCh37]
Chr1:1p36.11
benign
NM_021969.3(NR0B2):c.293_301delinsAC (p.Leu98fs) indel APC-mutation negative familial colorectal cancer [RCV000859984] Chr1:26913640..26913648 [GRCh38]
Chr1:27240131..27240139 [GRCh37]
Chr1:1p36.11
likely pathogenic
NM_021969.3(NR0B2):c.450A>G (p.Gln150=) single nucleotide variant not provided [RCV000930066] Chr1:26913491 [GRCh38]
Chr1:27239982 [GRCh37]
Chr1:1p36.11
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7961 AgrOrtholog
COSMIC NR0B2 COSMIC
Ensembl Genes ENSG00000131910 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000254227 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000254227 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
GTEx ENSG00000131910 GTEx
HGNC ID HGNC:7961 ENTREZGENE
Human Proteome Map NR0B2 Human Proteome Map
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR0B1/2 UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
KEGG Report hsa:8431 UniProtKB/Swiss-Prot
NCBI Gene 8431 ENTREZGENE
OMIM 601665 OMIM
  604630 OMIM
PANTHER PTHR24081 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
PharmGKB PA31747 PharmGKB
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
SMART HOLI UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot
UniProt NR0B2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1D8P5 UniProtKB/Swiss-Prot
  Q5QP36 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 NR0B2  nuclear receptor subfamily 0 group B member 2    nuclear receptor subfamily 0, group B, member 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 NR0B2  nuclear receptor subfamily 0, group B, member 2  NR0B2  nuclear receptor subfamily 0, group B, member 2  Symbol and/or name change 5135510 APPROVED