TMEM159 (transmembrane protein 159) - Rat Genome Database
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Gene: TMEM159 (transmembrane protein 159) Homo sapiens
Analyze
Symbol: TMEM159
Name: transmembrane protein 159
RGD ID: 1601747
HGNC Page HGNC
Description: Involved in lipid droplet formation. Localizes to endoplasmic reticulum membrane and lipid droplet; INTERACTS WITH 2-hydroxypropanoic acid; 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: lipid droplet assembly factor 1; promethin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1621,158,377 - 21,180,616 (+)EnsemblGRCh38hg38GRCh38
GRCh381621,158,349 - 21,180,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371621,169,995 - 21,191,937 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371621,169,703 - 21,191,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361621,077,501 - 21,099,431 (+)NCBINCBI36hg18NCBI36
Celera1620,479,745 - 20,501,782 (+)NCBI
Cytogenetic Map16p12.3NCBI
HuRef1619,705,255 - 19,727,143 (+)NCBIHuRef
CHM1_11621,256,940 - 21,279,197 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8619474   PMID:9110174   PMID:12401792   PMID:12477932   PMID:15589683   PMID:16303743   PMID:16344560   PMID:16712791   PMID:17207965   PMID:17562024   PMID:19322201   PMID:20379614  
PMID:21516116   PMID:22810586   PMID:25416956   PMID:25910212   PMID:26186194   PMID:26871637   PMID:27107014   PMID:27634302   PMID:28065597   PMID:28514442   PMID:30901948   PMID:31708432  
PMID:31741433   PMID:32296183  


Genomics

Comparative Map Data
TMEM159
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1621,158,377 - 21,180,616 (+)EnsemblGRCh38hg38GRCh38
GRCh381621,158,349 - 21,180,616 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371621,169,995 - 21,191,937 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh371621,169,703 - 21,191,937 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361621,077,501 - 21,099,431 (+)NCBINCBI36hg18NCBI36
Celera1620,479,745 - 20,501,782 (+)NCBI
Cytogenetic Map16p12.3NCBI
HuRef1619,705,255 - 19,727,143 (+)NCBIHuRef
CHM1_11621,256,940 - 21,279,197 (+)NCBICHM1_1
Tmem159
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,701,566 - 119,720,210 (+)NCBIGRCm39mm39
GRCm387120,102,342 - 120,120,987 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7120,102,353 - 120,120,992 (+)EnsemblGRCm38mm10GRCm38
MGSCv377127,245,940 - 127,264,500 (+)NCBIGRCm37mm9NCBIm37
MGSCv367119,893,575 - 119,912,135 (+)NCBImm8
Celera7120,011,610 - 120,030,538 (+)NCBICelera
Cytogenetic Map7F2NCBI
Tmem159
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21174,484,438 - 174,503,037 (+)NCBI
Rnor_6.0 Ensembl1189,870,622 - 189,889,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01189,870,596 - 189,889,485 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01196,800,304 - 196,819,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1172,234,268 - 172,252,725 (+)NCBICelera
Cytogenetic Map1q36NCBI
Tmem159
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955493368,399 - 386,716 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955493368,399 - 386,651 (+)NCBIChiLan1.0ChiLan1.0
TMEM159
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11621,187,479 - 21,210,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1621,187,479 - 21,210,432 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01617,227,549 - 17,250,533 (-)NCBIMhudiblu_PPA_v0panPan3
TMEM159
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl624,209,125 - 24,267,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1624,254,281 - 24,268,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tmem159
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365016,356,709 - 6,369,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM159
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl324,876,639 - 24,910,754 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1324,876,631 - 24,910,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2325,776,868 - 25,782,674 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM159
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1519,278,601 - 19,301,339 (+)NCBI
ChlSab1.1 Ensembl519,278,646 - 19,301,959 (+)Ensembl
Tmem159
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247827,244,332 - 7,259,105 (+)NCBI

Position Markers
Cda0pg10  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371621,191,116 - 21,191,227UniSTSGRCh37
Build 361621,098,617 - 21,098,728RGDNCBI36
Celera1620,500,961 - 20,501,072RGD
Cytogenetic Map16p12UniSTS
HuRef1619,726,322 - 19,726,433UniSTS
GeneMap99-GB4 RH Map16191.13UniSTS
NCBI RH Map16221.2UniSTS
D16S734  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371621,169,421 - 21,169,638UniSTSGRCh37
Build 361621,076,922 - 21,077,139RGDNCBI36
Celera1620,479,254 - 20,479,471RGD
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map16p12UniSTS
HuRef1619,704,764 - 19,704,981UniSTS
Whitehead-YAC Contig Map16 UniSTS
D16S2955  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371621,191,020 - 21,191,274UniSTSGRCh37
Build 361621,098,521 - 21,098,775RGDNCBI36
Celera1620,500,865 - 20,501,119RGD
Cytogenetic Map16p12UniSTS
HuRef1619,726,226 - 19,726,480UniSTS
GeneMap99-GB4 RH Map16192.95UniSTS
Whitehead-RH Map16107.1UniSTS
NCBI RH Map16221.2UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3127
Count of miRNA genes:910
Interacting mature miRNAs:1059
Transcripts:ENST00000233047, ENST00000261388, ENST00000451578, ENST00000572258, ENST00000572599, ENST00000573487, ENST00000573688, ENST00000574092, ENST00000577162
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2234 2149 981 195 843 37 4238 2023 1435 353 1336 1522 171 1105 2688 1
Low 205 834 693 379 1093 378 119 172 2217 66 122 83 4 1 99 100 5 2
Below cutoff 8 51 50 14 50 1 78 1 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001301769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001301775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_125971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005255439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006721069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024450357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF070596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI968069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL694739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW575176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY212918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI821683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB128337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ783556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU448562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX786237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA893031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB054887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000233047   ⟹   ENSP00000233047
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,377 - 21,180,616 (+)Ensembl
RefSeq Acc Id: ENST00000261388   ⟹   ENSP00000261388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,679 - 21,180,609 (+)Ensembl
RefSeq Acc Id: ENST00000451578   ⟹   ENSP00000409879
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,689 - 21,180,220 (+)Ensembl
RefSeq Acc Id: ENST00000572258   ⟹   ENSP00000459481
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,661 - 21,179,609 (+)Ensembl
RefSeq Acc Id: ENST00000572599   ⟹   ENSP00000460687
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,705 - 21,179,612 (+)Ensembl
RefSeq Acc Id: ENST00000573487   ⟹   ENSP00000461828
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,377 - 21,179,987 (+)Ensembl
RefSeq Acc Id: ENST00000573688   ⟹   ENSP00000460102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,170,472 - 21,180,505 (+)Ensembl
RefSeq Acc Id: ENST00000574092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,674 - 21,173,362 (+)Ensembl
RefSeq Acc Id: ENST00000577162   ⟹   ENSP00000461826
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1621,158,710 - 21,166,882 (+)Ensembl
RefSeq Acc Id: NM_001301769   ⟹   NP_001288698
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301771   ⟹   NP_001288700
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301773   ⟹   NP_001288702
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301774   ⟹   NP_001288703
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001301775   ⟹   NP_001288704
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NM_020422   ⟹   NP_065155
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
GRCh371621,169,703 - 21,191,937 (+)NCBI
Build 361621,077,501 - 21,099,431 (+)NCBI Archive
Celera1620,479,745 - 20,501,782 (+)RGD
HuRef1619,705,255 - 19,727,143 (+)RGD
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: NR_125971
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,674 - 21,180,616 (+)NCBI
CHM1_11621,256,940 - 21,279,197 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005255439   ⟹   XP_005255496
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,159,630 - 21,180,616 (+)NCBI
GRCh371621,169,703 - 21,191,937 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721066   ⟹   XP_006721129
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,349 - 21,180,616 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721067   ⟹   XP_006721130
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,349 - 21,178,838 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006721069   ⟹   XP_006721132
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,349 - 21,180,616 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023471   ⟹   XP_016878960
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,349 - 21,177,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023472   ⟹   XP_016878961
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,349 - 21,177,202 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023473   ⟹   XP_016878962
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,641 - 21,177,643 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017023474   ⟹   XP_016878963
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,641 - 21,177,644 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450356   ⟹   XP_024306124
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,641 - 21,178,932 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024450357   ⟹   XP_024306125
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,591 - 21,178,932 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002957832
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,641 - 21,178,932 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001288698 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288700 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288702 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288703 (Get FASTA)   NCBI Sequence Viewer  
  NP_001288704 (Get FASTA)   NCBI Sequence Viewer  
  NP_065155 (Get FASTA)   NCBI Sequence Viewer  
  XP_005255496 (Get FASTA)   NCBI Sequence Viewer  
  XP_006721129 (Get FASTA)   NCBI Sequence Viewer  
  XP_006721130 (Get FASTA)   NCBI Sequence Viewer  
  XP_006721132 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878960 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878961 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878962 (Get FASTA)   NCBI Sequence Viewer  
  XP_016878963 (Get FASTA)   NCBI Sequence Viewer  
  XP_024306124 (Get FASTA)   NCBI Sequence Viewer  
  XP_024306125 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB67598 (Get FASTA)   NCBI Sequence Viewer  
  AAH15812 (Get FASTA)   NCBI Sequence Viewer  
  AAO52682 (Get FASTA)   NCBI Sequence Viewer  
  BAC11122 (Get FASTA)   NCBI Sequence Viewer  
  BAG57032 (Get FASTA)   NCBI Sequence Viewer  
  CAF86723 (Get FASTA)   NCBI Sequence Viewer  
  EAW66854 (Get FASTA)   NCBI Sequence Viewer  
  EAW66855 (Get FASTA)   NCBI Sequence Viewer  
  EAW66856 (Get FASTA)   NCBI Sequence Viewer  
  EAW66857 (Get FASTA)   NCBI Sequence Viewer  
  EAW66858 (Get FASTA)   NCBI Sequence Viewer  
  Q96B96 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_065155   ⟸   NM_020422
- Peptide Label: isoform 2
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005255496   ⟸   XM_005255439
- Peptide Label: isoform X8
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006721129   ⟸   XM_006721066
- Peptide Label: isoform X8
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006721132   ⟸   XM_006721069
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006721130   ⟸   XM_006721067
- Peptide Label: isoform X3
- UniProtKB: I3NI23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288702   ⟸   NM_001301773
- Peptide Label: isoform 3
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot),   I3L288 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001288698   ⟸   NM_001301769
- Peptide Label: isoform 2
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288704   ⟸   NM_001301775
- Peptide Label: isoform 1
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288700   ⟸   NM_001301771
- Peptide Label: isoform 2
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001288703   ⟸   NM_001301774
- Peptide Label: isoform 3
- UniProtKB: Q96B96 (UniProtKB/Swiss-Prot),   I3L288 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016878960   ⟸   XM_017023471
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016878961   ⟸   XM_017023472
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016878963   ⟸   XM_017023474
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016878962   ⟸   XM_017023473
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024306125   ⟸   XM_024450357
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_024306124   ⟸   XM_024450356
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSP00000409879   ⟸   ENST00000451578
RefSeq Acc Id: ENSP00000460687   ⟸   ENST00000572599
RefSeq Acc Id: ENSP00000459481   ⟸   ENST00000572258
RefSeq Acc Id: ENSP00000460102   ⟸   ENST00000573688
RefSeq Acc Id: ENSP00000461828   ⟸   ENST00000573487
RefSeq Acc Id: ENSP00000233047   ⟸   ENST00000233047
RefSeq Acc Id: ENSP00000461826   ⟸   ENST00000577162
RefSeq Acc Id: ENSP00000261388   ⟸   ENST00000261388

Promoters
RGD ID:6793514
Promoter ID:HG_KWN:23220
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000233047,   NM_020422,   UC002DIG.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361621,077,171 - 21,077,671 (+)MPROMDB
RGD ID:7231551
Promoter ID:EPDNEW_H21522
Type:initiation region
Name:TMEM159_1
Description:transmembrane protein 159
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H21520  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381621,158,679 - 21,158,739EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.11-12.1(chr16:14954894-28306843)x3 copy number gain See cases [RCV000051828] Chr16:14954894..28306843 [GRCh38]
Chr16:15048751..28318164 [GRCh37]
Chr16:14956252..28225665 [NCBI36]
Chr16:16p13.11-12.1
pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2
pathogenic
GRCh38/hg38 16p12.3-12.2(chr16:20408020-21244474)x1 copy number loss See cases [RCV000139900] Chr16:20408020..21244474 [GRCh38]
Chr16:20419342..21255795 [GRCh37]
Chr16:20326843..21163296 [NCBI36]
Chr16:16p12.3-12.2
uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:19590412-29814175)x3 copy number gain Ductal breast carcinoma [RCV000207226] Chr16:19590412..29814175 [GRCh37]
Chr16:16p12.3-11.2
uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2
uncertain significance
GRCh37/hg19 16p12.3-11.2(chr16:19424115-30142220)x3 copy number gain See cases [RCV000449403] Chr16:19424115..30142220 [GRCh37]
Chr16:16p12.3-11.2
pathogenic
GRCh37/hg19 16p12.3-12.2(chr16:20258837-21405328)x3 copy number gain See cases [RCV000447220] Chr16:20258837..21405328 [GRCh37]
Chr16:16p12.3-12.2
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2
pathogenic
GRCh37/hg19 16p12.3-11.2(chr16:18238275-30177240)x3 copy number gain See cases [RCV000512428] Chr16:18238275..30177240 [GRCh37]
Chr16:16p12.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p12.3-12.2(chr16:20860025-21334650)x3 copy number gain not provided [RCV000848193] Chr16:20860025..21334650 [GRCh37]
Chr16:16p12.3-12.2
uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:30136 AgrOrtholog
COSMIC TMEM159 COSMIC
Ensembl Genes ENSG00000011638 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000283997 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000233047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000261388 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000409879 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000459481 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000460102 UniProtKB/TrEMBL
  ENSP00000460687 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000461826 UniProtKB/TrEMBL
  ENSP00000461828 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000491056 UniProtKB/Swiss-Prot
  ENSP00000492164 UniProtKB/Swiss-Prot
  ENSP00000492501 UniProtKB/Swiss-Prot
  ENSP00000492842 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000233047 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000261388 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000451578 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000572258 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000572599 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000573487 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000573688 UniProtKB/TrEMBL
  ENST00000577162 UniProtKB/TrEMBL
  ENST00000638934 UniProtKB/Swiss-Prot
  ENST00000639177 UniProtKB/Swiss-Prot
  ENST00000640188 UniProtKB/Swiss-Prot
  ENST00000640514 UniProtKB/Swiss-Prot
GTEx ENSG00000011638 GTEx
  ENSG00000283997 GTEx
HGNC ID HGNC:30136 ENTREZGENE
Human Proteome Map TMEM159 Human Proteome Map
InterPro LDAF1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report hsa:57146 UniProtKB/Swiss-Prot
NCBI Gene 57146 ENTREZGENE
OMIM 611304 OMIM
PANTHER PTHR14275 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA145147935 PharmGKB
UniProt I3L288 ENTREZGENE, UniProtKB/TrEMBL
  I3L319_HUMAN UniProtKB/TrEMBL
  I3NI21_HUMAN UniProtKB/TrEMBL
  I3NI23 ENTREZGENE, UniProtKB/TrEMBL
  Q96B96 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6NMA9 UniProtKB/Swiss-Prot
  B4DEC1 UniProtKB/Swiss-Prot
  O00323 UniProtKB/Swiss-Prot