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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2increases expressionEXP 6480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:15980055 PMID:16357303 PMID:27743861 PMID:29222744
Nr0b2multiple interactionsEXP 6480464CTD[Chenodeoxycholic Acid binds to NR1H4 protein] which results in increased expression of NR0B2 mRNAPMID:19562681
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:16037943 PMID:16269825 PMID:16946559 PMID:19072826 PMID:19562681 PMID:22178739 PMID:22291955 PMID:22540009 PMID:25055961 PMID:27174168
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTDChenodeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:16946559 PMID:24189133 PMID:25582706
Nr0b2multiple interactionsISONR0B2 (Homo sapiens)6480464CTD7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]; [Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan] results in increased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of NR0B2 mRNA; epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]; NR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]PMID:17963371 PMID:19072826 PMID:22178739 PMID:22291955 PMID:33819548
Nr0b2multiple interactionsISONr0b2 (Mus musculus)6480464CTDChenodeoxycholic Acid inhibits the reaction [tris(chloroethyl)phosphate results in decreased expression of NR0B2 protein]; Chenodeoxycholic Acid promotes the reaction [Carbon Tetrachloride results in decreased expression of NR0B2 mRNA]; NR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in increased expression of NR0B2 mRNA]PMID:16946559 PMID:25747392 PMID:35780845
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