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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2decreases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in decreased expression of NR0B2 mRNAPMID:30723492
Nr0b2increases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNAPMID:27317372
Nr0b2multiple interactionsEXP 6480464CTDdioscin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]PMID:27317372
Nr0b2decreases expressionISONr0b2 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in decreased expression of NR0B2 proteinPMID:32579994 PMID:36787806
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNAPMID:17175557
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNAPMID:19181614 PMID:25655198 PMID:33749747
Nr0b2multiple interactionsISONR0B2 (Homo sapiens)6480464CTD[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of NR0B2 mRNAPMID:27344345
Nr0b2multiple interactionsISONr0b2 (Mus musculus)6480464CTD[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of NR0B2 mRNA; [1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of NR0B2 mRNA; [NR1H4 protein results in increased susceptibility to 1-Naphthylisothiocyanate] which results in increased expression of NR0B2 mRNA; [PPARA protein affects the susceptibility to 1-Naphthylisothiocyanate] which affects the expression of NR0B2 mRNA; alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]; NFE2L2 promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NR0B2 mRNA]]; SEW2871 inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]; ursodoxicoltaurine inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR0B2 protein]PMID:19181614 PMID:25655198 PMID:29968724 PMID:30352267 PMID:32579994 PMID:33749747 PMID:36787806
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