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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621032
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr0b2increases expressionEXP 6480464CTDDeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:27743861
Nr0b2increases expressionISONR0B2 (Homo sapiens)6480464CTDDeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:22540009 PMID:25055961
Nr0b2increases expressionISONr0b2 (Mus musculus)6480464CTDDeoxycholic Acid results in increased expression of NR0B2 mRNAPMID:25582706
Nr0b2multiple interactionsISONR0B2 (Homo sapiens)6480464CTD[Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan] results in increased expression of NR0B2 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of NR0B2 mRNAPMID:33819548
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